Jose M Benito

Summary

Publications

  1. doi request reprint Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years
    Veronica Briz
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 22:1371-4. 2008
  2. ncbi request reprint CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation
    Jose M Benito
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Infect Dis 192:2142-6. 2005
  3. ncbi request reprint Phenotype and functional characteristics of HIV-specific cytotoxic CD8+ T cells in chronically infected patients: dual effects of highly active antiretroviral therapy
    Jose M Benito
    Hospital Carlos III Sinesio Delgado 10 28029 Madrid, Spain
    J Acquir Immune Defic Syndr 34:255-66. 2003
  4. ncbi request reprint Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy
    Jose Miguel Benito
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 38:373-81. 2005
  5. ncbi request reprint The role of CD8+ T-cell response in HIV infection
    Jose Miguel Benito
    Department of Infectious Diseases, Hospital Carlos III Madrid, Spain
    AIDS Rev 6:79-88. 2004
  6. doi request reprint Suppression of viral replication with highly active antiretroviral therapy has no impact on the functional profile of HIV-specific CD8(+) T cells
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Eur J Immunol 38:1548-58. 2008
  7. ncbi request reprint Enhanced HIV-specific immune responses in chronically HIV-infected patients receiving didanosine plus hydroxyurea
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III Madrid, Spain
    AIDS 18:1251-61. 2004
  8. doi request reprint Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 60:117-23. 2012
  9. doi request reprint IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS 25:1025-33. 2011
  10. doi request reprint Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Spain
    AIDS 27:687-96. 2013

Collaborators

Detail Information

Publications46

  1. doi request reprint Impact of antiretroviral therapy on chemokine (C-C motif) receptor 5 expression in HIV patients followed for over 2 years
    Veronica Briz
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 22:1371-4. 2008
    ..Therefore, the activity of chemokine (C-C motif) receptor 5 antagonists should not differ before and following HIV suppression on HAART...
  2. ncbi request reprint CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation
    Jose M Benito
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Infect Dis 192:2142-6. 2005
    ..Thus, activation of CD8(+) T cells does not seem to be associated with the extent of CD4(+) T cell recovery beyond the first year of successful HAART...
  3. ncbi request reprint Phenotype and functional characteristics of HIV-specific cytotoxic CD8+ T cells in chronically infected patients: dual effects of highly active antiretroviral therapy
    Jose M Benito
    Hospital Carlos III Sinesio Delgado 10 28029 Madrid, Spain
    J Acquir Immune Defic Syndr 34:255-66. 2003
    ..Distinct functional defects seem to limit their efficacy in HIV infection, although they have been not fully elucidated...
  4. ncbi request reprint Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy
    Jose Miguel Benito
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 38:373-81. 2005
    ..So far, it is unclear to what extent immune activation may influence the evolution of CD4 T-cell counts in patients on HAART...
  5. ncbi request reprint The role of CD8+ T-cell response in HIV infection
    Jose Miguel Benito
    Department of Infectious Diseases, Hospital Carlos III Madrid, Spain
    AIDS Rev 6:79-88. 2004
    ..Very recently, longitudinal and cross-sectional studies in large populations of patients have demonstrated that viral evolution is in part driven by HIV-specific T-cell responses...
  6. doi request reprint Suppression of viral replication with highly active antiretroviral therapy has no impact on the functional profile of HIV-specific CD8(+) T cells
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Eur J Immunol 38:1548-58. 2008
    ..Thus, it is still uncertain whether multifunctional CD8 responses are the cause or consequence of low plasma viremia...
  7. ncbi request reprint Enhanced HIV-specific immune responses in chronically HIV-infected patients receiving didanosine plus hydroxyurea
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III Madrid, Spain
    AIDS 18:1251-61. 2004
    ..The role of hydroxyurea (HU) in the treatment of HIV infection remains controversial. HU potentiates didanosine (ddI) antiviral activity and might exert immunomodulatory effects...
  8. doi request reprint Differences in virological response to peginterferon-α plus ribavirin in HIV-positive patients coinfected with HCV subtypes 1a or 1b
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 60:117-23. 2012
    ..The impact of these variables is more pronounced in HIV/Hepatitis C virus (HCV)-coinfected individuals, in whom treatment response rates are lower...
  9. doi request reprint IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS 25:1025-33. 2011
    ....
  10. doi request reprint Interferon-stimulated genes are associated with peginterferon/ribavirin treatment response regardless of IL28B alleles in hepatitis C virus/HIV-coinfected patients
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Spain
    AIDS 27:687-96. 2013
    ....
  11. ncbi request reprint Evolution of T-cell responses to hepatitis C virus (HCV) during pegylated interferon plus ribavirin treatment in HCV-monoinfected and in HCV/HIV-coinfected patients
    Laura Capa
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Antivir Ther 12:459-68. 2007
    ..As in HIV infection, virus replication could drive or be contained by T-cell immunity. We have examined the effect of HIV coinfection and of suppression of HCV replication with therapy on HCV-specific T-cell responses...
  12. ncbi request reprint Differences in cellular activation and apoptosis in HIV-infected patients receiving protease inhibitors or nonnucleoside reverse transcriptase inhibitors
    Jose M Benito
    Service of Infectious Diseases, Instituto de Salud Carlos III, Madrid 28035, Spain
    AIDS Res Hum Retroviruses 18:1379-88. 2002
    ..If PIs provide a positive effect on CD4(+) counts beyond an antiviral effect, mechanisms other than apoptosis should be involved...
  13. ncbi request reprint HCV-specific T-cell responses in HIV/hepatitis C virus-coinfected patients on highly active antiretroviral therapy are comparable to those observed in hepatitis C virus-monoinfected individuals
    Norma I Rallon
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 57:1-8. 2011
    ..We compared HCV-specific T-cell responses between HIV/HCV-coinfected patients, showing complete viral suppression, and HCV-monoinfected patients...
  14. doi request reprint No major differences in the functional profile of HIV Gag and Nef-specific CD8+ responses between long-term nonprogressors and typical progressors
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 24:1185-95. 2008
    ..LTNP show higher levels of CD8(+) responses against polyclonal stimuli than progressors. However, HIV-specific CD8(+) responses do not differ between them except for a more preserved ability of cells from LTNP to expand in vitro...
  15. pmc Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Antimicrob Chemother 67:1246-9. 2012
    ..We explore whether IL28B protein [interferon (IFN)-λ3] plasma levels may vary according to IL28B genotype and/or following pegylated IFN-α/ribavirin therapy...
  16. doi request reprint Low-level exposure to HIV induces virus-specific T cell responses and immune activation in exposed HIV-seronegative individuals
    Clara Restrepo
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Immunol 185:982-9. 2010
    ....
  17. pmc The expansion ability but not the quality of HIV-specific CD8(+) T cells is associated with protective human leucocyte antigen class I alleles in long-term non-progressors
    Mariola Lopez
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Immunology 134:305-13. 2011
    ..Furthermore, these attributes of HIV-specific CD8(+) T are not restored by HAART; thus, adjuvant therapies and vaccines that induce and/or normalize the expansion ability of HIV-specific T cells are required...
  18. doi request reprint Evolution of the functional profile of HIV-specific CD8+ T cells in patients with different progression of HIV infection over 4 years
    Alejandra Peris-Pertusa
    Molecular Biology Laboratory, Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 55:29-38. 2010
    ..Interestingly, VS do not seem to restore the polyfunctional profile of HIV-specific CD8T-cell responses...
  19. doi request reprint Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy
    Jose M Benito
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Infect Dis 198:1466-73. 2008
    ..We analyzed the influence of T cell activation and of suppression of viremia with antiretroviral therapy on this system, as well as its role in CD4(+) cell restoration after long-term antiretroviral therapy...
  20. ncbi request reprint Triple combination therapy for hepatitis C with telaprevir exhibits greater early antiviral activity than with boceprevir
    Jose M Benito
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Antivir Ther 18:709-15. 2013
    ..No head-to-head studies comparing TLV and BOC have been performed so far...
  21. doi request reprint HIV rebound after discontinuation of antiretroviral therapy increases and expands HIV-specific CD8+ responses but has no impact on its functionality
    Mariola Lopez
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 24:1197-201. 2008
    ..Thus, a higher functionality of CD8(+) responses does not seem to be the consequence of low-level virus replication...
  22. doi request reprint Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients
    Amanda Fernandez-Rodriguez
    Unidad de coinfección HIV hepatitis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    AIDS 27:163-73. 2013
    ..We also explore the behavior of plasma cytokine levels...
  23. doi request reprint Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 53:1291-5. 2011
    ..Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response...
  24. doi request reprint Longitudinal assessment of interleukin 7 plasma levels in HIV-infected patients in the absence of and under antiretroviral therapy
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Acquir Immune Defic Syndr 58:436-41. 2011
    ..We tested this hypothesis in a longitudinal study examining the evolution of IL-7 and CD4 counts in 2 different scenarios...
  25. doi request reprint Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline
    Norma I Rallon
    Hospital Carlos III, Madrid, Spain bDuke Clinical Research Institute, Durham, North Carolina, USA
    AIDS 25:269-71. 2011
    ..No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection...
  26. ncbi request reprint Influence of HCV genotype and co-infection with human immunodeficiency virus on CD4(+) and CD8(+) T-cell responses to hepatitis C virus
    Laura Capa
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Med Virol 79:503-10. 2007
    ..Both the prevalence and breadth of CD4(+) and CD8(+) responses were lower in co-infected patients, independently of the HCV genotype...
  27. doi request reprint HIV Gag-specific immune response mediated by double negative (CD3(+)CD4(-)CD8(-)) T cells in HIV-exposed seronegative individuals
    Clara Restrepo
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Med Virol 85:200-9. 2013
    ..DN T-cells in Group A individuals can display differential HIV-specific immune responses, which might contribute to the low susceptibility to infection with HIV shown by individuals in Group A...
  28. ncbi request reprint Influence of human T cell lymphotropic virus type 2 coinfection on virological and immunological parameters in HIV type 1-infected patients
    Sylvina Bassani
    Service of Infectious Diseases, Hospital Carlos III, Madrid, 28029, Spain
    Clin Infect Dis 44:105-10. 2007
    ..Human T cell lymphotropic virus type 2 (HTLV-2) infection is not rare among injection drug users with human immunodeficiency virus (HIV) infection and may exert a protective role in the progression of HIV disease...
  29. doi request reprint Impact of IL28B polymorphisms on response to peginterferon and ribavirin in HIV–hepatitis C virus-coinfected patients with prior nonresponse or relapse
    Pablo Labarga
    Hospital Carlos III, Madrid, Spain
    AIDS 25:1131-3. 2011
    ..1 (2.7-90.9)], prior relapse [9.6 (1.5-62.4)] and ribavirin plasma trough concentrations at week 4 [4.9 (1.3-18.4)]. IL28B-CC only predicted response in prior nonresponders carrying HCV genotypes 1/4 [25.1 (1.9-337)]...
  30. doi request reprint Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients
    Norma I Rallon
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS 24:F23-9. 2010
    ..Information is lacking for HIV/HCV-coinfected individuals and/or other HCV genotypes...
  31. ncbi request reprint Short communication: Does interleukin-28B single nucleotide polymorphisms influence the natural history of hepatitis B?
    Luz Martin-Carbonero
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 28:1262-4. 2012
    ..2% vs. 44.9%; p=0.3. Thus, the interleukin-28B (IL-28B) genotype does not seem to have a role in the development of chronic hepatitis B among HIV-infected patients...
  32. doi request reprint The changing face of hepatitis C in the new era of direct-acting antivirals
    Vincent Soriano
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Antiviral Res 97:36-40. 2013
    ..The future will probably see a progressive marginalization of residual HCV populations, with increasing over-representation of illegal immigrants, alcohol abusers, intravenous drug users and the mentally disabled...
  33. doi request reprint Mechanisms involved in CD4 cell gains in HIV-infected patients switched to raltegravir
    Carolina Garrido
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 26:551-7. 2012
    ..The relative contribution of each mechanism in CD4 restoration in patients with suppressed viremia switching antiretrovirals is unclear...
  34. ncbi request reprint Differences in disease progression in a cohort of long-term non-progressors after more than 16 years of HIV-1 infection
    Berta Rodes
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 18:1109-16. 2004
    ..It is unclear whether resistance to immunologic damage in long-term non-progressors (LTNP) will last indefinitely or whether it merely represents the extreme of a Gaussian distribution, and therefore progression will occur eventually...
  35. doi request reprint Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia
    Norma Rallón
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    J Antimicrob Chemother 68:2616-25. 2013
    ..Herein, we analysed distinct phenotypic markers of immune recovery in patients with undetectable viraemia for 8 years, taking as reference untreated patients and healthy controls...
  36. doi request reprint Elevated TGF-β1 levels might protect HCV/ HIV-coinfected patients from liver fibrosis
    Norma I Rallon
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Eur J Clin Invest 41:70-6. 2011
    ....
  37. ncbi request reprint Human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in an HIV-positive patient coinfected with human T lymphotropic virus type 2 following initiation of antiretroviral therapy
    Carlos Toro
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    Clin Infect Dis 45:e118-20. 2007
    ....
  38. ncbi request reprint CD38 expression on CD8 T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy
    Jose Miguel Benito
    Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 20:227-33. 2004
    ....
  39. ncbi request reprint Long-term suppression of plasma viremia with highly active antiretroviral therapy despite virus evolution and very limited selection of drug-resistant genotypes
    Nonia Pariente
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Cantoblanco, Madrid, Spain
    J Med Virol 73:350-61. 2004
    ..5% of the patients. The results indicate successful suppression of HIV-1 under HAART for extended time periods, indistinguishable for patients in which evidence of virus evolution could or could not be documented...
  40. ncbi request reprint Host factors involved in low susceptibility to HIV infection
    Clara Restrepo
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS Rev 13:30-40. 2011
    ..The better understanding of this protection may lead to novel preventive and immunotherapeutic approaches, including vaccines...
  41. ncbi request reprint Evolution of genotypic and phenotypic resistance to Enfuvirtide in HIV-infected patients experiencing prolonged virologic failure
    Eva Poveda
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Med Virol 74:21-8. 2004
    ..In summary, single mutations at the HR1 env region result in significant loss of susceptibility to ENF. Despite virologic failure, these patients may maintain elevated CD4+ counts through a reduction in their overall immune activation...
  42. ncbi request reprint Immunological and virological effects of structured treatment interruptions following exposure to hydroxyurea plus didanosine
    Jose Miguel Benito
    Department of Infectious Diseases, Hospital Carlos III, Madrid 28029, Spain
    AIDS Res Hum Retroviruses 22:734-43. 2006
    ..Nef-specific CD8+ responses might contribute to a better virological control of HIV replication following treatment interruptions in HIV-infected individuals and might be boosted by the immunomodulatory effect of HU...
  43. ncbi request reprint Mitochondrial DNA depletion in HIV-infected patients with chronic hepatitis C and effect of pegylated interferon plus ribavirin therapy
    Carmen de Mendoza
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS 21:583-8. 2007
    ..Information on the impact of therapy with pegylated interferon (pegIFN) plus ribavirin on mtDNA is scarce and conflicting results have been reported...
  44. ncbi request reprint Prevalence of X4 tropic HIV-1 variants in patients with differences in disease stage and exposure to antiretroviral therapy
    Eva Poveda
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    J Med Virol 79:1040-6. 2007
    ..In summary, X4 viruses are particularly frequent among antiretroviral-experienced patients with high viral loads, irrespective of the CD4 count. Thus, CCR5 antagonists should be used with special caution in this subset of patients...
  45. ncbi request reprint Impact of ethnicity and HIV type 1 subtype on response to first-line antiretroviral therapy
    Eva Ramírez de Arellano
    Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 23:891-4. 2007
    ..In a multivariate analysis neither HIV subtype nor ethnicity was associated with different CD4 gains at any given time point, suggesting that reconstitution of CD4+ T cells under HAART is not influenced by ethnicity...
  46. ncbi request reprint [Adaptive cell immune response against the hepatitis C virus infection]
    Norma Ibón Rallón
    Laboratorio de Biologia Molecular, Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Espana
    Med Clin (Barc) 129:469-76. 2007
    ..An integral interpretation of the numerous experimental findings may allow a better understanding of the immune mechanisms involved in the inability of the immune system to successfully control chronic HCV infection...