Leonidas Benetatos

Summary

Publications

  1. ncbi request reprint DLK1-MEG3 imprinted domain microRNAs in cancer biology
    Leonidas Benetatos
    Transfusion Unit, General Hospital of Preveza, Preveza, Greece
    Crit Rev Eukaryot Gene Expr 22:1-15. 2012
  2. ncbi request reprint Delta-like homologue 1 and its role in the bone marrow niche and hematologic malignancies
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Preveza, Greece Electronic address
    Clin Lymphoma Myeloma Leuk 14:451-5. 2014
  3. ncbi request reprint DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist
    Leonidas Benetatos
    Blood Bank, Selefkeias 2, Preveza General Hospital, 48100, Preveza, Greece
    Cell Mol Life Sci 71:4421-30. 2014
  4. ncbi request reprint Polycomb group proteins and MYC: the cancer connection
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Cell Mol Life Sci 71:257-69. 2014
  5. ncbi request reprint MicroRNAs mark in the MLL-rearranged leukemia
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Ann Hematol 92:1439-50. 2013
  6. ncbi request reprint The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
    Leonidas Benetatos
    Transfusion Unit, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Cell Mol Life Sci 70:795-814. 2013
  7. ncbi request reprint Deregulated microRNAs in multiple myeloma
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Cancer 118:878-87. 2012
  8. ncbi request reprint Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Greece
    Clin Lymphoma Myeloma 8:171-5. 2008
  9. ncbi request reprint Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Niarchos Avenue, 45500 Ioannina, Greece
    Ann Hematol 90:1037-45. 2011
  10. ncbi request reprint MEG3 imprinted gene contribution in tumorigenesis
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Int J Cancer 129:773-9. 2011

Detail Information

Publications20

  1. ncbi request reprint DLK1-MEG3 imprinted domain microRNAs in cancer biology
    Leonidas Benetatos
    Transfusion Unit, General Hospital of Preveza, Preveza, Greece
    Crit Rev Eukaryot Gene Expr 22:1-15. 2012
    ..Moreover, as they can be detected in patients' serum, are easy to obtain, and can be used as adjuvant diagnostic biomarkers with the potential of monitoring disease progression and response to treatment...
  2. ncbi request reprint Delta-like homologue 1 and its role in the bone marrow niche and hematologic malignancies
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Preveza, Greece Electronic address
    Clin Lymphoma Myeloma Leuk 14:451-5. 2014
    ..In this review, the effects of DLK1 on mesenchymal stem cells and the bone marrow microenvironment with perspectives are discussed...
  3. ncbi request reprint DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist
    Leonidas Benetatos
    Blood Bank, Selefkeias 2, Preveza General Hospital, 48100, Preveza, Greece
    Cell Mol Life Sci 71:4421-30. 2014
    ..Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin. ..
  4. ncbi request reprint Polycomb group proteins and MYC: the cancer connection
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Cell Mol Life Sci 71:257-69. 2014
    ..In this review, we summarize recent data on the PcG and MYC interactions in cancer, and the putative involvement of microRNAs in the equation. ..
  5. ncbi request reprint MicroRNAs mark in the MLL-rearranged leukemia
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Ann Hematol 92:1439-50. 2013
    ..Direct drug targeting of MLL has been difficult to achieve, and in this context, microRNA expression modulation represents an attractive approach. ..
  6. ncbi request reprint The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
    Leonidas Benetatos
    Transfusion Unit, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Cell Mol Life Sci 70:795-814. 2013
    ..The potential clinical implications of this data are also discussed...
  7. ncbi request reprint Deregulated microRNAs in multiple myeloma
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Cancer 118:878-87. 2012
    ..Further studies are needed to better understand their role in myelomagenesis and their therapeutic potential...
  8. ncbi request reprint Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Greece
    Clin Lymphoma Myeloma 8:171-5. 2008
    ..MEG3 represents an imprinted gene maternally expressed in humans that encodes a nontranslated product. In this survey, we studied the methylation status of the specific gene in multiple myeloma (MM)...
  9. ncbi request reprint Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Niarchos Avenue, 45500 Ioannina, Greece
    Ann Hematol 90:1037-45. 2011
    ..As such, SNK/PLK2 could represent a potential pathogenetic factor, although additional studies are necessary to verify its exact role in disease pathogenesis...
  10. ncbi request reprint MEG3 imprinted gene contribution in tumorigenesis
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Int J Cancer 129:773-9. 2011
    ..MEG3 could represent a tumor suppressor gene located in chromosome 14q32 and its association with tumorigenesis is growing every day...
  11. ncbi request reprint CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes
    Leonidas Benetatos
    Department of Hematology, University Hospital of Ioannina, Niarchos Avenue, 45500 Ioannina, Greece
    Leuk Res 34:148-53. 2010
    ..Our findings suggest that these genes are abnormally methylated in AML and MDS patients, and methylation of MEG3 confers worse overall prognosis. The MEG3 methylation status may serve as a useful biomarker in leukemia...
  12. ncbi request reprint Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia
    Eleftheria Hatzimichael
    Department of Haematology, University Hospital of Ioannina, St Niarchou Av, 45 500 Ioannina, Greece
    Leuk Res 33:1272-5. 2009
    ..Further evaluation in a larger sample of patients is needed in order to enhance our statistical power and to test our hypothesis that CDKN2A methylation status can become a useful prognostic biomarker...
  13. ncbi request reprint Bcl2-interacting killer CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications
    Eleftheria Hatzimichael
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Leuk Lymphoma 53:1709-13. 2012
    ..These findings warrant validation in larger cohorts of patients and suggest therapeutic utility for agents that enhance BIK expression...
  14. ncbi request reprint Study of specific genetic and epigenetic variables in multiple myeloma
    Eleftheria Hatzimichael
    Department of Hematology, University Hospital of Ioannina, Ioannina, Greece
    Leuk Lymphoma 51:2270-4. 2010
    ..Further evaluation in a larger sample of patients is needed in order to better define the prognostic and clinical value, if any, of MTHFR 1298 polymorphisms and CDKN2A and Snk/Plk2 methylation in the pathogenesis of MM...
  15. ncbi request reprint Von Hippel-Lindau methylation status in patients with multiple myeloma: a potential predictive factor for the development of bone disease
    Eleftheria Hatzimichael
    Department of Haematology, Haematology Research Laboratory, University Hospital of Ioannina, Ioannina, Greece
    Clin Lymphoma Myeloma 9:239-42. 2009
    ..Whether it represents an early or late event of the disease merits additional study. Additional studies regarding the serum levels of HIF-1alpha and vascular endothelial growth factor would be mechanistically interesting...
  16. ncbi request reprint Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome
    Leonidas Benetatos
    Blood Bank, General Hospital of Preveza, Preveza, Greece
    Int J Cancer 133:267-74. 2013
    ..They can also form networks with upstream and downstream important factors, in which EZH2 represent the stabilizing factor of the pathway. As such non-coding RNAs affect the epigenetic modifications leading to malignant transformation...
  17. pmc Gene mutations and molecularly targeted therapies in acute myeloid leukemia
    Eleftheria Hatzimichael
    Department of Hematology, University of Ioannina Ioannina, Greece
    Am J Blood Res 3:29-51. 2013
    ....
  18. ncbi request reprint Peripheral blood flow cytometry based diagnosis in primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma: implications for more extensive use
    Leonidas Benetatos
    Department of Haematology, University Hospital of Ioannina, Greece
    Cytometry B Clin Cytom 76:102-6. 2009
    ..Perhaps, more than one antibody should be used in primary cutaneous aggressive epidermotropic CD8-positive T-cell lymphomas, in order to be more accurate in the diagnosis and so in the classification of such diseases...
  19. doi request reprint The absence of CDKN1C (p57KIP2) promoter methylation in myeloid malignancies also characterizes plasma cell neoplasms
    Eleftheria Hatzimichael
    Br J Haematol 141:557-8. 2008
  20. ncbi request reprint Non-secretory multiple myeloma with involvement of the hand as initial manifestation
    Leonidas Benetatos
    Leuk Lymphoma 47:1677-9. 2006