Alim Louis Benabid

Summary

Publications

  1. doi Deep brain stimulation: BCI at large, where are we going to?
    Alim Louis Benabid
    Clinatec Institute, Commissariat a l Energie Atomique, Joseph Fourier University, Grenoble, France
    Prog Brain Res 194:71-82. 2011
  2. doi New targets for DBS
    Alim Louis Benabid
    Clinatec, LETI MINATEC, Grenoble, France
    Parkinsonism Relat Disord 18:S21-3. 2012
  3. doi Functional neurosurgery for movement disorders: a historical perspective
    Alim Louis Benabid
    CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
    Prog Brain Res 175:379-91. 2009
  4. ncbi [Stimulation therapies for Parkinson's disease: over the past two decades]
    Alim Louis Benabid
    Académie nationale de médecine, CEA 38054 Grenoble
    Bull Acad Natl Med 194:1273-86. 2010
  5. doi Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    Alim Louis Benabid
    Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
    Lancet Neurol 8:67-81. 2009
  6. ncbi Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
  7. ncbi Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Mov Disord 18:524-30. 2003
  8. ncbi Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
  9. ncbi Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
    Abdelhamid Benazzouz
    Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
    Mov Disord 17:S145-9. 2002
  10. ncbi Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005

Collaborators

Detail Information

Publications47

  1. doi Deep brain stimulation: BCI at large, where are we going to?
    Alim Louis Benabid
    Clinatec Institute, Commissariat a l Energie Atomique, Joseph Fourier University, Grenoble, France
    Prog Brain Res 194:71-82. 2011
    ..For this complex project, all compounds have been designed and are being tested. Experiments were performed in rats and primates for proof of concepts and development of the electroencephalogram (EEG) recognition algorithm...
  2. doi New targets for DBS
    Alim Louis Benabid
    Clinatec, LETI MINATEC, Grenoble, France
    Parkinsonism Relat Disord 18:S21-3. 2012
    ..While these might provide solutions for as yet unsolved problems, attention must be paid to ethical considerations...
  3. doi Functional neurosurgery for movement disorders: a historical perspective
    Alim Louis Benabid
    CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
    Prog Brain Res 175:379-91. 2009
    ..The new field of compensation of deficits will then become part of the field of functional neurosurgery...
  4. ncbi [Stimulation therapies for Parkinson's disease: over the past two decades]
    Alim Louis Benabid
    Académie nationale de médecine, CEA 38054 Grenoble
    Bull Acad Natl Med 194:1273-86. 2010
    ..The subthalamic nucleus is the preferred target in Parkinson's disease. Other treatments such as gene therapy are in the pipeline...
  5. doi Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    Alim Louis Benabid
    Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
    Lancet Neurol 8:67-81. 2009
    ..Further improvements, through basic research and methodological innovations, should make it applicable to earlier stages of the disease and increase its availability to patients in developing countries...
  6. ncbi Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
    ..Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown...
  7. ncbi Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Mov Disord 18:524-30. 2003
    ....
  8. ncbi Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms...
  9. ncbi Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
    Abdelhamid Benazzouz
    Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
    Mov Disord 17:S145-9. 2002
    ..In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN...
  10. ncbi Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
    ..The understanding of the mechanism has opened a new field of research, which will call for reappraisal of the basic effects of electricity on the living tissues...
  11. doi Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantation
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Arch Neurol 65:612-6. 2008
    ..The misplacement of electrodes is a possible explanation for suboptimal response to bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease...
  12. ncbi Off-period dystonia in Parkinson's disease but not generalized dystonia is improved by high-frequency stimulation of the subthalamic nucleus
    Olivier Detante
    Department of Biological and Clinical Neurosciences, INSERM, Joseph Fourier University, Department of Neurology, CHU Grenoble, Grenoble, France
    Adv Neurol 94:309-14. 2004
    ..Assuming that the mechanism of action of STN-HFS is similar regardless of the cause of dystonia, our findings suggest that the STN is not similarly involved in off-period dystonia of IPD and others dystonias...
  13. ncbi Deep brain stimulation: what does it offer?
    Alim Louis Benabid
    Department of Clinical Neurosciences, University Joseph Fourier, Grenoble, France
    Adv Neurol 91:293-302. 2003
  14. ncbi Postoperative management of subthalamic nucleus stimulation for Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S188-97. 2002
    ..Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects...
  15. ncbi Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats
    Véronique Sgambato-Faure
    INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
    J Neuropathol Exp Neurol 64:936-47. 2005
    ....
  16. ncbi Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
  17. ncbi Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
    Serge Pinto
    Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
    Mov Disord 20:1507-15. 2005
    ..These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems...
  18. ncbi Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Mov Disord 22:2436-9. 2007
    ..A close monitoring of patients and an anticipation of IPG replacement in the case of a low-battery signal are recommended...
  19. ncbi The role of the temporal pole in the genesis of temporal lobe seizures
    Philippe Kahane
    Neurophysiopathology of the Epilepsy, Grenoble University Hospital, Grenoble, France
    Epileptic Disord 4:S51-8. 2002
    ..However a clear-cut distinction between the two groups remains rather difficult in the absence of intracerebral recordings...
  20. ncbi Globus pallidus internus stimulation in primary generalized dystonia: a H215O PET study
    Olivier Detante
    Department of Biological and Clinical Neurosciences, Grenoble University Hospital, Grenoble, France
    Brain 127:1899-908. 2004
    ..According to the present study, generalized dystonia is associated with prefrontal overactivation which can be reversed by effective GPi DBS...
  21. doi Effects of magnetic resonance imaging in patients with implanted deep brain stimulation systems
    Valerie Fraix
    Department of Neurology and Neurosurgery, Magnetic Resonance Imaging Unit, University Hospital of Grenoble, INSERM U836, Grenoble Neuroscience Institute, Joseph Fourier University, Grenoble, France
    J Neurosurg 113:1242-5. 2010
    ..The aim of this study was to study the effects of MR imaging on the electrical settings of deep brain stimulation (DBS) systems and their clinical consequences...
  22. ncbi Isolation and characterisation of mesenchymal stem cells from adult mouse bone marrow
    Philippe Tropel
    INSERM U318, Grenoble, France
    Exp Cell Res 295:395-406. 2004
    ..Therefore, mMSCs will be an important tool to study the in vivo behaviour and fate of this cell type after grafting in mouse pathology models...
  23. ncbi Pretargeting for the implantation of stimulation electrodes into the subthalamic nucleus: a comparative study of magnetic resonance imaging and ventriculography
    Sorin Breit
    INSERM U 318, Department of Neurobiology, University Joseph Fourier, Grenoble, France
    Neurosurgery 58:ONS83-95. 2006
    ..The purpose of this study was to evaluate the accuracy of the preoperative MRI targeting as compared with ventriculography in terms of both the STN target as well as the internal landmarks...
  24. ncbi Comparison of two techniques to postoperatively localize the electrode contacts used for subthalamic nucleus stimulation
    Serge Pinto
    Department of Neurology, Centre Hospitalier Universitaire de Grenoble, and INSERM U318, Neurosciences Précliniques, Grenoble, France
    Neurosurgery 60:285-92; discussion 292-4. 2007
    ..To our knowledge, this is the first study attempting to compare the "gold standard" of stereotactic accuracy (Vg) with the anatomic resolution provided by MRI scans...
  25. ncbi Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
    ....
  26. ncbi Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys
    Bradley A Wallace
    Department of Clinical and INSERM U318 Preclinical Neurosciences, University Joseph Fourier, Grenoble, France
    Brain 130:2129-45. 2007
    ..In summary, these results indicated that STN alteration offered neuroprotection to dopaminergic cells that would normally die as part of the disease process...
  27. ncbi Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study
    Serge Pinto
    INSERM U318, Grenoble, France
    Brain 127:602-15. 2004
    ..STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson's disease dysarthria...
  28. doi Deep brain stimulation for obsessive-compulsive disorder: subthalamic nucleus target
    Stephan Chabardes
    Universite Joseph Fourier, Grenoble, France Clinique de Neurochirurgie, Centre Hospitalier Universitaire, Grenoble, France INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France Electronic address
    World Neurosurg 80:S31.e1-8. 2013
    ..In particular, we discuss the recent experience and preliminary results of our group after 6 months of nonmotor STN-DBS in patients with severe OCD. ..
  29. ncbi Chemoarchitectonic heterogeneities in the primate zona incerta: clinical and functional implications
    John Mitrofanis
    Department of Clinical Neurosciences, University of Joseph Fourier, Grenoble, France
    J Neurocytol 33:429-40. 2004
    ..Such clinical stimulations could well involve other systems, including those of arousal, attention and visceral control...
  30. doi L1-penalized N-way PLS for subset of electrodes selection in BCI experiments
    Andrey Eliseyev
    Foundation Nanosciences, Grenoble, France
    J Neural Eng 9:045010. 2012
    ..The L1-Penalized NPLS was applied for the binary self-paced BCI system calibration, providing selection of electrodes subset. Our BCI system is designed for animal research, in particular for research in non-human primates...
  31. doi Iterative N-way partial least squares for a binary self-paced brain-computer interface in freely moving animals
    Andrey Eliseyev
    Foundation Nanosciences, Grenoble, France
    J Neural Eng 8:046012. 2011
    ..The BCI system was validated by experiments in freely moving animals under conditions close to those in a natural environment...
  32. ncbi Anatomy of the temporal pole region
    Stephan Chabardes
    Neurosurgery Department, Grenoble University Hospital, Grenoble, France
    Epileptic Disord 4:S9-15. 2002
    ..Understanding the anatomical and functional organization of the temporal pole enables us to hypothesize about the role played by this structure in the pathogenesis of the forms of epilepsy originating in mesial temporal lobe structures...
  33. pmc Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains
    Cécile Moro
    CEA, LETI, Clinatec, Grenoble 38054, France
    BMC Neurosci 14:40. 2013
    ..In addition, we examine whether NIr influences behavioural activity in both strains after MPTP treatment. We tested for various locomotive parameters in an open-field test, namely velocity, high mobility and immobility...
  34. pmc Pedunculopontine Nucleus Area Oscillations during Stance, Stepping and Freezing in Parkinson's Disease
    Valerie Fraix
    University Hospital, Department of Neurology, Grenoble, France Joseph Fourier University, Grenoble, France INSERM, U836, Grenoble Institute of Neuroscience, Grenoble, France
    PLoS ONE 8:e83919. 2013
    ..Our results confirm the role of the PPNa in the regulation of gait and suggest that, in Parkinson disease, gait difficulties could be related to an imbalance between low and higher frequencies. ..
  35. ncbi A putative generalized model of the effects and mechanism of action of high frequency electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, Grenoble Cedex 9, France
    Acta Neurol Belg 105:149-57. 2005
    ..iv) Retrograde activation of upstream neuronal structures, as reported in the external pallidum during stimulation of STN, might be responsible of additional jamming-like effects due to collisions with descending spikes...
  36. doi Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease
    Valerie Fraix
    Department of Neurology, University Hospital of Grenoble and INSERM U836, Joseph Fourier University, 38000 Grenoble, France
    Clin Neurophysiol 119:2513-8. 2008
    ..To study the effects of subthalamic nucleus (STN) stimulation on motor cortex excitability in Parkinson's disease (PD)...
  37. ncbi Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulation
    Elena Moro
    Department of Clinical and Biological Neurosciences and INSERM U318, Joseph Fourier University, CHU de Grenoble, Grenoble, France
    Brain 125:2408-17. 2002
    ..In addition, the persistence of levodopa intake after surgery might hinder this beneficial process...
  38. ncbi Deep-brain stimulation in Parkinson's disease: long-term efficacy and safety - What happened this year?
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences and Joseph Fourier Grenoble University, Centre Hospitalier Universitaire Albert Michallon, Grenoble, France
    Curr Opin Neurol 18:623-30. 2005
    ..High-frequency stimulation of the subthalamic nucleus has become the surgical therapy of choice. This review concentrates on recent data on long-term results and side-effects, after 12 years of practice using this technique...
  39. ncbi Functional neuronal differentiation of bone marrow-derived mesenchymal stem cells
    Philippe Tropel
    Neurosciences Précliniques, INSERM U318, Universite Joseph Fourier, CHU de Grenoble, Grenoble, France
    Stem Cells 24:2868-76. 2006
    ....
  40. doi Monophasic but not biphasic pulses induce brain tissue damage during monopolar high-frequency deep brain stimulation
    Brigitte Piallat
    INSERM U836 Université Joseph Fourier Commissariat à l Energie Atomique Centre Hospitalier Universiatire, Grenoble Institute of Neurosciences, Grenoble, France
    Neurosurgery 64:156-62; discussion 162-3. 2009
    ..The aim of the present study was to quantify the evolution of a potentially deleterious effect of HFS according to the duration and/or intensity in monophasic and biphasic conditions...
  41. ncbi Deep brain stimulation for Parkinson's disease
    Alim Louis Benabid
    Grenoble, France
    Mov Disord 21:S168-70. 2006
  42. ncbi The temporopolar cortex plays a pivotal role in temporal lobe seizures
    Stephan Chabardes
    Department of Neurosurgery, CHU Michallon, Grenoble, France
    Brain 128:1818-31. 2005
    ..Moreover, the involvement of the TP cortex at the onset of the seizures is a good predicting factor for postoperative seizure outcome...
  43. ncbi Deep brain stimulation for Parkinson's disease
    Alim Louis Benabid
    INSERM U318 Preclinical Neurosciences, Joseph Fourier University, Pavillon B, University Hospital, 38043, Grenoble, France
    Curr Opin Neurobiol 13:696-706. 2003
    ..Long-term changes, neural plasticity and neural protection might be induced in the network. Similar effects of stimulation and lesioning have led to the extension of this technique for other targets and diseases...
  44. pmc Control of neuronal network organization by chemical surface functionalization of multi-walled carbon nanotube arrays
    Jie Liu
    CEA, LETI MINATEC, Grenoble, France
    Nanotechnology 22:195101. 2011
    ..We propose that chemical functionalization represents a method of choice for developing applications in which neuronal patterning on MWNT-A substrates is required...
  45. ncbi What the future holds for deep brain stimulation
    Alim Louis Benabid
    CEA Minatec LETI, Clinatec building 4022, 17 Avenue des Martyrs, 38054, Grenoble, France
    Expert Rev Med Devices 4:895-903. 2007
    ..Technological development will enhance and refine the effects of high-frequency stimulation, and allow further extension of this method to new targets and new indications...
  46. doi De novo and long-term l-Dopa induce both common and distinct striatal gene profiles in the hemiparkinsonian rat
    Michele El Atifi-Borel
    Institut National de la Sante et de la Recherche Medicale, Grenoble, France
    Neurobiol Dis 34:340-50. 2009
    ..Processes such as growth, synaptogenesis, neurogenesis and cell proliferation may be particularly relevant to the long-term action of l-Dopa...
  47. ncbi Antiepileptic effect of high-frequency stimulation of the subthalamic nucleus (corpus luysi) in a case of medically intractable epilepsy caused by focal dysplasia: a 30-month follow-up: technical case report
    Alim Louis Benabid
    Department of Neurosurgery, University Hospital of Grenoble, and INSERM Research Unit U318, Grenoble, France
    Neurosurgery 50:1385-91; discussion 1391-2. 2002
    ..We were encouraged by the known relationship between the STN and the nigral system, as well as by our experience with high-frequency stimulation of the STN in Parkinsonian patients...