The incidence and outcome of septic shock patients in the absence of early-goal directed therapyBenjamin C H Ho
Department of Intensive Care, University of Melbourne, Melbourne, Australia
Crit Care 10:R80. 2006
..CONCLUSION: In an Australian teaching hospital candidates for EGDT were uncommon and, in the absence of an EGDT protocol, their mortality was lower than that reported with EGDT...
Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injurySean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
J Crit Care 24:129-40. 2009
..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
Septic acute kidney injury in critically ill patients: clinical characteristics and outcomesSean M Bagshaw
Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
Clin J Am Soc Nephrol 2:431-9. 2007
..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
- Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery--a prospective cohort study
Anja Haase-Fielitz
Department of Intensive Care, Austin Health, Melbourne, Australia
Crit Care Med 37:553-60. 2009
..To compare the value of novel with conventional serum biomarkers in the prediction of acute kidney injury (AKI) in adult cardiac surgical patients according to preoperative renal function...
- Long-term effect of a Medical Emergency Team on mortality in a teaching hospital
Daryl Jones
Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Resuscitation 74:235-41. 2007
..To assess the effect of a Medical Emergency Team (MET) service on patient mortality in the 4 years since its introduction into a teaching hospital...
- Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Studley Road, Heidelberg, VIC 3084, Australia
Crit Care 13:R45. 2009
..The primary objective was to evaluate the rate, characteristics and outcomes of very old (age >or= 80 years) patients admitted to intensive care units (ICUs)...
- Renal blood flow and function during recovery from experimental septic acute kidney injury
Christoph Langenberg
Austin and Repatriation Medical Centre, Department of Intensive Care, 3084, Heidelberg, Victoria, Australia
Intensive Care Med 33:1614-8. 2007
..To measure renal blood flow (RBF) and renal function during recovery from experimental septic acute kidney injury (AKI)...
- Recent trials in critical care nephrology
Rinaldo Bellomo
Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia, USA
Contrib Nephrol 165:299-309. 2010
....
- Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery
Anja Haase-Fielitz
Department of Intensive Care, Austin Health, Melbourne, Australia
J Am Soc Nephrol 20:1393-403. 2009
..In summary, this study identifies COMT LL homozygosity as an independent risk factor for shock, AKI, and hospital stay after cardiac surgery. (ClinicalTrials.gov number, NCT00334009)...
- The impact of Rapid Response System on delayed emergency team activation patient characteristics and outcomes--a follow-up study
Paolo Calzavacca
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Resuscitation 81:31-5. 2010
..To evaluate the impact of Rapid Response System (RRS) maturation on delayed Medical Emergency Team (MET) activation and patient characteristics and outcomes...
- N-Acetylcysteine does not artifactually lower plasma creatinine concentration
Michael Haase
Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia
Nephrol Dial Transplant 23:1581-7. 2008
..However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR)...
- Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep
Rohit Ramchandra
Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
Am J Physiol Regul Integr Comp Physiol 297:R1247-53. 2009
..There was little correlation between the changes in RSNA and renal blood flow, suggesting that the renal vasodilatation was mediated mainly by other mechanisms...
- Characteristics and outcomes of patients receiving a medical emergency team review for respiratory distress or hypotension
Jon L Quach
Department of Intensive Care, Austin Hospital, University of Melbourne, Heidelberg, Victoria 3084, Australia
J Crit Care 23:325-31. 2008
..To describe the characteristics and outcomes of patients receiving a medical emergency team (MET) review for the MET syndromes of respiratory distress or hypotension and to assess the effect of delayed MET activation on their outcomes...
- A prospective study of factors influencing the outcome of patients after a Medical Emergency Team review
Paolo Calzavacca
Department of Intensive Care and Department of Medicine, Austin Hospital, Heidelberg, Melbourne, Vic, Australia
Intensive Care Med 34:2112-6. 2008
..To identify factors that predict outcome in patients receiving a Medical Emergency Team review...
- Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest
Rinaldo Bellomo
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 5 Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
Crit Care 15:R90. 2011
..Hyperoxia has recently been reported as an independent risk factor for mortality in patients resuscitated from cardiac arrest. We examined the independent relationship between hyperoxia and outcomes in such patients...
- The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury
Anja Haase-Fielitz
Department of Intensive Care, Austin Health, Melbourne, Australia
Nephrol Dial Transplant 24:3349-54. 2009
..The choice of definition of acute kidney injury (AKI) might, at least in part, account for such variability...
- Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
Michael Haase
Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
Crit Care Med 35:1324-31. 2007
..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
- External validation of severity scoring systems for acute renal failure using a multinational database
Shigehiko Uchino
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 33:1961-7. 2005
..A large, multiple-center database might be needed to improve the discrimination and calibration of acute renal failure scoring system...
- Fluid management in septic acute kidney injury and cardiorenal syndromes
Rinaldo Bellomo
Department of Intensive Care, Austin Health, Heidelberg, Melbourne, Vic, Australia
Contrib Nephrol 165:206-18. 2010
..Thus, accurate assessment of fluid status and careful definition of targets are needed to improve clinical outcomes. Controlled studies of conservative versus liberal fluid management in patients with AKI or CRS seem justified...
- Early and sustained systemic and renal hemodynamic effects of intravenous radiocontrast
Takao Saotome
Howard Florey Institute, University of Melbourne, Parkville, Vic, Australia
Blood Purif 29:339-46. 2010
..To measure the extended renal hemodynamic changes induced by intravenous radiocontrast...
- Effects of saline or albumin resuscitation on standard coagulation tests
Rinaldo Bellomo
Department of Intensive Care, Austin Hospital, Melbourne, Vic
Crit Care Resusc 11:250-6. 2009
..To explore whether fluid resuscitation with normal saline or 4% albumin is associated with differential changes in routine clinical coagulation tests...
- Long term effect of a medical emergency team on cardiac arrests in a teaching hospital
Daryl Jones
Department of Intensive Care, Alfred Hospital, Commercial Road, Prahran, Melbourne, Victoria 3181, Australia
Crit Care 9:R808-15. 2005
..Our findings show sustainability and suggest that, for every 17 MET calls, one cardiac arrest might be prevented...
- Effect of the medical emergency team on long-term mortality following major surgery
Daryl Jones
Australian and New Zealand Intensive Care Research Centre ANZIC RC, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, 3004, Australia
Crit Care 11:R12. 2007
..The purpose of the present study was to assess the effect of the MET and other variables on long-term mortality in this patient population...
- Ciné phase-contrast magnetic resonance imaging for the measurement of renal blood flow
John R Prowle
Department of Intensive Care, Austin Health, Melbourne, Australia
Contrib Nephrol 165:329-36. 2010
..We have recently assessed the feasibility of measuring RBF by means of CPC-MRI in 2 critically ill patients with septic acute kidney injury and were able to compare such measurements to those obtained in a normal volunteer...
- Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial
Michael Haase
Intensive Care Unit, Austin Hospital, University of Melbourne, Australia
Am J Kidney Dis 50:296-304. 2007
..However, standard hemodialysis membranes achieve only little diffusive removal of circulating cytokines. Modified membranes may enable both successful IHD treatment and simultaneous diffusive cytokine removal...
- A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury
Sean M Bagshaw
Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
Nephrol Dial Transplant 24:2739-44. 2009
..When unknown, current recommendations are to estimate a baseline SCr by the MDRD equation. However, the MDRD approach assumes a glomerular filtration rate of approximately 75 mL/min/1.73 m(2). This method has not been validated...
- Variability of blood glucose concentration and short-term mortality in critically ill patients
Moritoki Egi
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia
Anesthesiology 105:244-52. 2006
..Decreasing the variability of blood glucose concentration might be an important aspect of glucose management...
- Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults
Michael Haase
Department of Intensive Care, Austin Health, Melbourne, Australia
Ann Thorac Surg 88:124-30. 2009
....
- The epidemiology and outcome of medical emergency team call patients treated with non-invasive ventilation
Antoine G Schneider
Intensive Care Unit, Austin Health 145 Studley Road Heidelberg, Melbourne, Victoria 3084, Australia
Resuscitation 82:1218-23. 2011
..However, NIV is sometimes used by the Medical Emergency Team (MET) as respiratory support for ward patients...
- Circuit start during continuous renal replacement therapy in vasopressor-dependent patients: the impact of a slow blood flow protocol
In Byung Kim
Department of Intensive Care Medicine, Austin Hospital, Melbourne, Vic, Australia
Blood Purif 32:1-6. 2011
..In vasopressor-dependent patients, we evaluated the impact of a slow blood flow protocol on hypotension when starting continuous renal replacement therapy (CRRT)...
- Pilot randomised double-blind controlled trial of high-dose spironolactone in critically ill patients receiving a frusemide infusion
Yogesh Apte
Department of Intensive Care, Austin Hospital, Melbourne, Vic
Crit Care Resusc 10:306-11. 2008
..Spironolactone is an aldosterone antagonist that promotes natriuresis and may attenuate such hypernatraemia, but its effect in this setting has not been previously studied...
- Features and outcome of patients receiving multiple Medical Emergency Team reviews
Paolo Calzavacca
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Resuscitation 81:1509-15. 2010
..Accordingly, we studied the characteristics and outcome of patients receiving one MET call and compared them with those receiving multiple MET reviews...
- Renal vascular resistance in sepsis
Christoph Langenberg
Departments of Intensive Care and Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
Nephron Physiol 104:p1-11. 2006
..A high cardiac output and the use of large animals predict a decreased RVR, while a decreased cardiac output and the use of small animals predict an increased RVR...
- A pilot randomised controlled comparison of continuous veno-venous haemofiltration and extended daily dialysis with filtration: effect on small solutes and acid-base balance
Ian Baldwin
Department of Intensive Care, Austin Health, 3084, Heidelberg, Australia
Intensive Care Med 33:830-5. 2007
..Recently, extended intermittent dialytic techniques have been proposed for the treatment of ARF. The aim of this study was to compare these two approaches...
- Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study
Michael Haase
Department of Intensive Care, Austin Health, Melbourne, 145 Studley Rd, Heidelberg 3084, Australia
Crit Care 12:R96. 2008
..Urinary interleukin-18 (IL-18) measured during the immediate postoperative period could be a promising predictor of acute kidney injury following adult cardiac surgery...
- Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome
Andrew Davies
FRACP, FJFICM, Intensive Care Unit, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
JAMA 302:1888-95. 2009
..It caused an epidemic of critical illness and some patients developed severe acute respiratory distress syndrome (ARDS) and were treated with extracorporeal membrane oxygenation (ECMO)...
- Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
Crit Care Resusc 9:60-8. 2007
..We systematically reviewed the literature comparing loop diuretics with control in the management of ARF...
- Patient monitoring and the timing of cardiac arrests and medical emergency team calls in a teaching hospital
Daryl Jones
Intensive Care, Alfred Hospital, Monash University, Melbourne, Australia
Intensive Care Med 32:1352-6. 2006
..Increased overnight utilization and earlier MET activation may further reduce the incidence of cardiac arrests at our hospital...
- Insertion side, body position and circuit life during continuous renal replacement therapy with femoral vein access
In Byung Kim
Department of Intensive Care Medicine, Austin Hospital, Studley Road, Melbourne, VIC 3084, Australia
Blood Purif 31:42-6. 2011
..We investigated if there is an association between choice of insertion side and body position and its changes and circuit life during CRRT with femoral vein access...
- Bench-to-bedside review: The MET syndrome--the challenges of researching and adopting medical emergency teams
Augustine Tee
Department of Intensive Care, Austin Hospital, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
Crit Care 12:205. 2008
..It appears likely that the accumulation of evidence from different settings and situations, though methodologically imperfect, will increase the rationale and logic of RRS. A conclusive randomised controlled trial is unlikely to occur...
- A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients
Sean M Bagshaw
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
Nephrol Dial Transplant 23:1569-74. 2008
..The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to this system. It is currently unknown whether there are advantages between these criteria...
- Acute renal failure in critically ill patients: a multinational, multicenter study
Shigehiko Uchino
Department of Intensive Care, Austin Hospital, Melbourne, Australia
JAMA 294:813-8. 2005
..87; 95% CI, 1.07-3.28; P = .03). CONCLUSION: In this multinational study, the period prevalence of ARF requiring RRT in the ICU was between 5% and 6% and was associated with a high hospital mortality rate...
- The biochemical effects of restricting chloride-rich fluids in intensive care
Nor azim Mohd Yunos
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 39:2419-24. 2011
..To determine the biochemical effects of restricting the use of chloride-rich intravenous fluids in critically ill patients...
- Blood glucose on day of intensive care unit admission as a surrogate of subsequent glucose control in intensive care
Moritoki Egi
Department of Intensive Care, Western Hospital, Footscray, Victoria, Australia
J Crit Care 21:197-202. 2006
..This observation makes it possible to use Glu(1) as a surrogate of glucose control during ICU stay and opens the door to understanding ICU glucose control across the whole of Australia and New Zealand...
- Fluid administration and the kidney
John R Prowle
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Curr Opin Crit Care 16:332-6. 2010
..This review focuses on recent studies examining fluid administration and renal function in critical illness to critically examine conventional justifications for fluid administration...
- The effects of saline or albumin resuscitation on acid-base status and serum electrolytes
Rinaldo Bellomo
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 34:2891-7. 2006
..However, overall differences between the types of fluid are minor, whereas the volume of fluid administered is a much stronger predictor of such changes, which are also influenced by illness severity and the passage of time...
- Defining and classifying acute renal failure: from advocacy to consensus and validation of the RIFLE criteria
Rinaldo Bellomo
Department of Intensive Care and Department of Medicine, Austin Hospital and University of Melbourne, Heidelberg, Melbourne, Australia
Intensive Care Med 33:409-13. 2007
..This editorial aims to summarize and interpret recent findings concerning the application of the RIFLE criteria to the assessment of the epidemiology and the prediction of the outcome of ARF...
- Antecedents to cardiac arrests in a hospital equipped with a medical emergency team
JOSEPH VETRO
Austin Hospital, Melbourne, Vic, Australia
Crit Care Resusc 13:162-6. 2011
..Antecedents to cardiac arrests in a MET-equipped hospital have not been assessed...
- Fluid resuscitation and the septic kidney: the evidence
Elisa Licari
Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
Contrib Nephrol 156:167-77. 2007
....
- Angiotensin II in experimental hyperdynamic sepsis
Li Wan
Howard Florey Institute, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia
Crit Care 13:R190. 2009
..However, unlike other vasopressors, its systemic, regional blood flow and renal functional effects in hypotensive hyperdynamic sepsis have not been investigated...
- A technique for the simultaneous measurement of renal ATP, blood flow and pH in a large animal model of septic shock
Clive May
Howard Florey Institute, University of Melbourne, Melbourne, Vic, Australia
Crit Care Resusc 9:30-3. 2007
..Simultaneous measurement of renal blood flow, renal ATP, renal pH and mean arterial pressure (MAP) might help investigators understand the mechanisms responsible for acute renal failure (ARF) in sepsis...
- The pursuit of a high central venous oxygen saturation in sepsis: growing concerns
Rinaldo Bellomo
Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Victoria 3084, Australia
Crit Care 12:130. 2008
..Until such studies are completed, basing international treatment guidelines on a single centre study performed in what may turn out to be a highly atypical environment would seem premature...
- Vasoactive drugs and acute kidney injury
Rinaldo Bellomo
Department of Intensive Care and Medicine, Austin Hospital, Melbourne, Australia
Crit Care Med 36:S179-86. 2008
..Whether it is superior to noradrenaline in this setting remains uncertain, and more studies are needed before recommendations can be made...
- Oliguria as predictive biomarker of acute kidney injury in critically ill patients
John R Prowle
Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
Crit Care 15:R172. 2011
..During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated...
- Pathophysiology of septic acute kidney injury: what do we really know?
Li Wan
Department of Intensive Care, Austin Hospital, Melbourne, Australia
Crit Care Med 36:S198-203. 2008
..If this were to happen, our therapeutic approaches would also be profoundly altered...
- Characteristics and outcomes of patients receiving a medical emergency team review for acute change in conscious state or arrhythmias
Andrew W Downey
Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
Crit Care Med 36:477-81. 2008
....
- The impact of experimental hypoperfusion on subsequent kidney function
Takao Saotome
Howard Florey Institute, University of Melbourne, Parkville, Vic, Australia
Intensive Care Med 36:533-40. 2010
..To investigate the short- and medium-term renal hemodynamic and functional responses to both short and sustained hypoperfusion...
- A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery-associated acute kidney injury: a prospective cohort study
Michael Haase
Department of Intensive Care, Austin Health, Melbourne, Australia
J Thorac Cardiovasc Surg 138:1370-6. 2009
..In this study we compared these classifications with regard to (1) the detection of acute kidney injury, (2) their agreement according to the grading of acute kidney injury across classes, and (3) their prognostic value...
- Percutaneous versus surgical tracheostomy: A randomized controlled study with long-term follow-up
William Silvester
Austin Hospital, Melbourne, Australia
Crit Care Med 34:2145-52. 2006
..006). Long-term follow-up revealed no complications in either group. CONCLUSIONS: Both percutaneous tracheostomies and surgical tracheostomies can be safely performed at the bedside by experienced, skilled practitioners...
- A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients
Murad G Ibrahim
Department of Intensive Care and Department of Medicine, University of Melbourne, Austin Hospital, Melbourne, Vic, Australia
Crit Care Resusc 8:187-91. 2006
..However, in this pilot assessment, these high levels failed to increase observed nocturnal sleep or induce other observable benefits in tracheostomised ICU patients...
- Circadian rhythm of blood glucose values in critically ill patients
Moritoki Egi
Department of Intensive Care, Austin Hospital, Heidelberg, Victoria, Australia
Crit Care Med 35:416-21. 2007
..To test whether there is a circadian rhythm of blood glucose control in critically ill patients and whether morning blood glucose is an accurate surrogate of overall blood glucose control...
- The concept of acute kidney injury and the RIFLE criteria
John A Kellum
Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA, and Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Contrib Nephrol 156:10-6. 2007
..The term acute kidney injury has subsequently been proposed to distinguish this new concept from the older terminology of failure...
