Peter Tompa

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi Intrinsically disordered proteins: a 10-year recap
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Trends Biochem Sci 37:509-16. 2012
  2. ncbi The Levinthal paradox of the interactome
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Protein Sci 20:2074-9. 2011
  3. ncbi Proteomic methods for the identification of intrinsically disordered proteins
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:429-37. 2012
  4. ncbi The relationship between proteome size, structural disorder and organism complexity
    Eva Schad
    Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, Budapest, Hungary
    Genome Biol 12:R120. 2011
  5. ncbi Structural disorder in proteins brings order to crystal growth in biomineralization
    Lajos Kalmar
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Bone 51:528-34. 2012
  6. ncbi Fuzzy complexes: a more stochastic view of protein function
    Monika Fuxreiter
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Adv Exp Med Biol 725:1-14. 2012
  7. ncbi Structural disorder in eukaryotes
    Rita Pancsa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 7:e34687. 2012
  8. ncbi Increased structural disorder of proteins encoded on human sex chromosomes
    Hedi Hegyi
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Biosyst 8:229-36. 2012
  9. ncbi Identification of intrinsically disordered proteins by a special 2D electrophoresis
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:215-22. 2012
  10. ncbi Structural disorder and local order of hNopp140
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Biochim Biophys Acta 1834:342-50. 2013

Collaborators

Detail Information

Publications11

  1. ncbi Intrinsically disordered proteins: a 10-year recap
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Trends Biochem Sci 37:509-16. 2012
    ..I show that the evidence for the generality and importance of this phenomenon is now so insurmountable that it demands the inclusion of 'unstructural' biology into mainstream biology and biochemistry textbooks...
  2. ncbi The Levinthal paradox of the interactome
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Protein Sci 20:2074-9. 2011
    ..We surmise that this non-deterministic temporal continuum could not be reconstructed de novo under present conditions...
  3. ncbi Proteomic methods for the identification of intrinsically disordered proteins
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:429-37. 2012
    ..Thus, such proteins are likely to remain soluble under these extreme conditions, making acid treatment and/or heat treatment suitable for substantial enrichment of intrinsically unfolded proteins in the soluble fraction...
  4. ncbi The relationship between proteome size, structural disorder and organism complexity
    Eva Schad
    Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, Budapest, Hungary
    Genome Biol 12:R120. 2011
    ..As intrinsic protein disorder has been linked with complex responses to environmental stimuli and communication between cells, an additional possibility is that structural disorder may effectively increase the complexity of species...
  5. ncbi Structural disorder in proteins brings order to crystal growth in biomineralization
    Lajos Kalmar
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Bone 51:528-34. 2012
    ....
  6. ncbi Fuzzy complexes: a more stochastic view of protein function
    Monika Fuxreiter
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Adv Exp Med Biol 725:1-14. 2012
    ..As confirmed by all the other chapters of the book, we will show that new cases of fuzziness pop up at an accelerating pace, underscoring that this phenomenon presents a widespread novel paradigm of protein structure and function...
  7. ncbi Structural disorder in eukaryotes
    Rita Pancsa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 7:e34687. 2012
    ..We conclude that protists have been the evolutionary hot-bed of experimentation with structural disorder, in a period when structural disorder was actively invented and the major functional classes of disordered proteins established...
  8. ncbi Increased structural disorder of proteins encoded on human sex chromosomes
    Hedi Hegyi
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Biosyst 8:229-36. 2012
    ....
  9. ncbi Identification of intrinsically disordered proteins by a special 2D electrophoresis
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:215-22. 2012
    ....
  10. ncbi Structural disorder and local order of hNopp140
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Biochim Biophys Acta 1834:342-50. 2013
    ..In all, our data suggest that this protein falls into the pre-molten globule state of IDPs, with a significant tendency to become ordered in the presence of its partner as demonstrated in the presence of transcription factor IIB (TFIIB)...
  11. ncbi Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions
    Lajos Kalmar
    Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, H 1113 Budapest, Hungary
    J Mol Biol 424:125-31. 2012
    ..Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication...