Peter Tompa

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. pmc The Levinthal paradox of the interactome
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Protein Sci 20:2074-9. 2011
  2. doi request reprint Predicting the predictive power of IDP ensembles
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, 1113 Budapest, Hungary Electronic address
    Structure 22:177-8. 2014
  3. doi request reprint Intrinsically disordered proteins: a 10-year recap
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Trends Biochem Sci 37:509-16. 2012
  4. doi request reprint Proteomic methods for the identification of intrinsically disordered proteins
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:429-37. 2012
  5. pmc The relationship between proteome size, structural disorder and organism complexity
    Eva Schad
    Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, Budapest, Hungary
    Genome Biol 12:R120. 2011
  6. doi request reprint Structural disorder in proteins brings order to crystal growth in biomineralization
    Lajos Kalmar
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Bone 51:528-34. 2012
  7. doi request reprint Fuzzy complexes: a more stochastic view of protein function
    Monika Fuxreiter
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Adv Exp Med Biol 725:1-14. 2012
  8. doi request reprint Intrinsic structural disorder in cytoskeletal proteins
    Mainak Guharoy
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Cytoskeleton (Hoboken) 70:550-71. 2013
  9. pmc Functional diversity and structural disorder in the human ubiquitination pathway
    Pallab Bhowmick
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 8:e65443. 2013
  10. doi request reprint Increased structural disorder of proteins encoded on human sex chromosomes
    Hedi Hegyi
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Biosyst 8:229-36. 2012

Collaborators

Detail Information

Publications17

  1. pmc The Levinthal paradox of the interactome
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Protein Sci 20:2074-9. 2011
    ..We surmise that this non-deterministic temporal continuum could not be reconstructed de novo under present conditions...
  2. doi request reprint Predicting the predictive power of IDP ensembles
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, 1050 Brussels, Belgium Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, 1113 Budapest, Hungary Electronic address
    Structure 22:177-8. 2014
    ..The article by Schwalbe and colleagues in this issue of Structure combines NMR and SAXS constraints to generate structural ensembles that unveil important functional and pathological features. ..
  3. doi request reprint Intrinsically disordered proteins: a 10-year recap
    Peter Tompa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Trends Biochem Sci 37:509-16. 2012
    ..I show that the evidence for the generality and importance of this phenomenon is now so insurmountable that it demands the inclusion of 'unstructural' biology into mainstream biology and biochemistry textbooks...
  4. doi request reprint Proteomic methods for the identification of intrinsically disordered proteins
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:429-37. 2012
    ..Thus, such proteins are likely to remain soluble under these extreme conditions, making acid treatment and/or heat treatment suitable for substantial enrichment of intrinsically unfolded proteins in the soluble fraction...
  5. pmc The relationship between proteome size, structural disorder and organism complexity
    Eva Schad
    Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, Budapest, Hungary
    Genome Biol 12:R120. 2011
    ..As intrinsic protein disorder has been linked with complex responses to environmental stimuli and communication between cells, an additional possibility is that structural disorder may effectively increase the complexity of species...
  6. doi request reprint Structural disorder in proteins brings order to crystal growth in biomineralization
    Lajos Kalmar
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Bone 51:528-34. 2012
    ....
  7. doi request reprint Fuzzy complexes: a more stochastic view of protein function
    Monika Fuxreiter
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Adv Exp Med Biol 725:1-14. 2012
    ..As confirmed by all the other chapters of the book, we will show that new cases of fuzziness pop up at an accelerating pace, underscoring that this phenomenon presents a widespread novel paradigm of protein structure and function...
  8. doi request reprint Intrinsic structural disorder in cytoskeletal proteins
    Mainak Guharoy
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    Cytoskeleton (Hoboken) 70:550-71. 2013
    ..This pattern entails special consequences, in which the manifold functional advantages of structural disorder, most pronounced in regulatory and signaling functions, are all exploited by nature...
  9. pmc Functional diversity and structural disorder in the human ubiquitination pathway
    Pallab Bhowmick
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 8:e65443. 2013
    ....
  10. doi request reprint Increased structural disorder of proteins encoded on human sex chromosomes
    Hedi Hegyi
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Mol Biosyst 8:229-36. 2012
    ....
  11. doi request reprint Structural characterization of intrinsically disordered proteins by NMR spectroscopy
    Simone Kosol
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels 1050, Belgium
    Molecules 18:10802-28. 2013
    ..Here, we address NMR experiments and strategies that enable the generation of detailed structural models of IDPs. ..
  12. doi request reprint pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins
    Mihaly Varadi
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, European Molecular Biology Laboratory, Hamburg Unit, EMBL c o DESY, Hamburg, Germany, CEA, CNRS, UJF Grenoble 1, Protein Dynamics and Flexibility, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, Grenoble 38027, France, Indiana University School of Medicine Indianapolis, IN, USA, Department of Chemistry, Center of Magnetic Resonance CERM, University of Florence, Sesto Fiorentino, Italy, Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN, USA, Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Molecular Medicine and USF Health Byrd Alzheimer s Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region
    Nucleic Acids Res 42:D326-35. 2014
    ..The availability of the pE-DB database is expected to promote the development of new modeling methods and leads to a better understanding of how function arises from disordered states. ..
  13. doi request reprint From protein sequence to dynamics and disorder with DynaMine
    Elisa Cilia
    1 MLG, Departement d informatique, Universite Libre de Bruxelles, Boulevard du Triomphe, CP 212, 1050 Brussels, Belgium 2 Interuniversity Institute of Bioinformatics in Brussels, ULB VUB, La Plaine Campus, Triomflaan, BC building, 6th Floor, CP 263, 1050 Brussels, Belgium
    Nat Commun 4:2741. 2013
    ..DynaMine provides molecular biologists with an important new method that grasps the dynamical characteristics of any protein of interest, as we show here for human p53 and E1A from human adenovirus 5...
  14. pmc Structural disorder in eukaryotes
    Rita Pancsa
    VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 7:e34687. 2012
    ..We conclude that protists have been the evolutionary hot-bed of experimentation with structural disorder, in a period when structural disorder was actively invented and the major functional classes of disordered proteins established...
  15. doi request reprint Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions
    Lajos Kalmar
    Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Karolina ut 29, H 1113 Budapest, Hungary
    J Mol Biol 424:125-31. 2012
    ..Based on bioinformatic predictions, we suggest that fly-casting mechanisms enabled by long disordered regions in NMD complexes are exploited for the underlying effective long-range communication...
  16. doi request reprint Identification of intrinsically disordered proteins by a special 2D electrophoresis
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Methods Mol Biol 896:215-22. 2012
    ....
  17. doi request reprint Structural disorder and local order of hNopp140
    Agnes Tantos
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Biochim Biophys Acta 1834:342-50. 2013
    ..In all, our data suggest that this protein falls into the pre-molten globule state of IDPs, with a significant tendency to become ordered in the presence of its partner as demonstrated in the presence of transcription factor IIB (TFIIB)...