I Smolders

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi request reprint Combination of therapeutic mild hypothermia and delayed fluid resuscitation improved survival after uncontrolled haemorrhagic shock in mechanically ventilated rats
    Said Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Resuscitation 62:303-10. 2004
  2. ncbi request reprint The effect of mild hypothermia and induced hypertension on long term survival rate and neurological outcome after asphyxial cardiac arrest in rats
    S Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Vrije Universiteit Brussel, Laarbeeklaan, 101, B 1090 Brussels, Belgium
    Resuscitation 49:73-82. 2001
  3. ncbi request reprint The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermia
    Said Hachimi-Idrissi
    Cerebral Resuscitation Research Group, Department of Critical Care Medicine, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Resuscitation 64:187-92. 2005
  4. ncbi request reprint Resuscitative mild hypothermia as a protective tool in brain damage: is there evidence?
    Said Hachimi-Idrissi
    Critical Care Department and Cerebral Resuscitation Research Group of the Vrije Universiteit Brussel, Brussels, Belgium
    Eur J Emerg Med 11:335-42. 2004
  5. ncbi request reprint S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest
    Said Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Vrije Universiteit van Brussel, Laarbeeklaan, 101, Belgium
    Resuscitation 53:251-7. 2002
  6. ncbi request reprint Postischemic mild hypothermia reduces neurotransmitter release and astroglial cell proliferation during reperfusion after asphyxial cardiac arrest in rats
    S Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, van de Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels B 1090, Belgium
    Brain Res 1019:217-25. 2004
  7. doi request reprint Comparison of the effects of intrathecal administration of levobupivacaine and lidocaine on the prostaglandin E2 and glutamate increases in cerebrospinal fluid: a microdialysis study in freely moving rats
    V J Umbrain
    Department of Anaesthesia, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Br J Anaesth 102:540-5. 2009
  8. ncbi request reprint The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia
    L Bogaert
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium
    Eur J Pharmacol 411:71-83. 2001
  9. ncbi request reprint 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats
    G M Khan
    Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Neuropharmacology 40:657-67. 2001
  10. ncbi request reprint Effects of dietary sucrose on hippocampal serotonin release: a microdialysis study in the freely-moving rat
    I Smolders
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Br J Nutr 86:151-5. 2001

Collaborators

  • L Shi
  • A Michotte
  • E Loyens
  • V J Umbrain
  • Said Hachimi-Idrissi
  • Luc Huyghens
  • Y Michotte
  • G Ebinger
  • S Hachimi-Idrissi
  • R Clinckers
  • Guy Ebinger
  • Yvette Michotte
  • S Sarre
  • L Huyghens
  • G M Khan
  • L Bogaert
  • R A Voskuyl
  • M Danhof
  • O Della Pasqua
  • Duc N Nguyen
  • Johan Schiettecate
  • Martin Zizi
  • Duc Nam Nguyen
  • Xin Yang
  • A Van Hemelrijck
  • Johan Schiettecatte
  • Marcel Van der Auwera
  • L Corne
  • J Moonen

Detail Information

Publications16

  1. ncbi request reprint Combination of therapeutic mild hypothermia and delayed fluid resuscitation improved survival after uncontrolled haemorrhagic shock in mechanically ventilated rats
    Said Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Academic Hospital, Free University of Brussels, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Resuscitation 62:303-10. 2004
    ..However, when mild hypothermia and limited fluid resuscitation were combined, the survival rate was the highest...
  2. ncbi request reprint The effect of mild hypothermia and induced hypertension on long term survival rate and neurological outcome after asphyxial cardiac arrest in rats
    S Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Vrije Universiteit Brussel, Laarbeeklaan, 101, B 1090 Brussels, Belgium
    Resuscitation 49:73-82. 2001
    ..we studied the long-term effect of a combined treatment with resuscitative mild hypothermia and induced hypertension on survival rate and neurological outcome after asphyxial cardiac arrest (CA) in rats...
  3. ncbi request reprint The evolution of serum astroglial S-100 beta protein in patients with cardiac arrest treated with mild hypothermia
    Said Hachimi-Idrissi
    Cerebral Resuscitation Research Group, Department of Critical Care Medicine, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Resuscitation 64:187-92. 2005
    ..To study the effects of mild hypothermia on the 24h concentration of serum astroglial of S-100 beta protein in patients who survived cardiac arrest (CA)...
  4. ncbi request reprint Resuscitative mild hypothermia as a protective tool in brain damage: is there evidence?
    Said Hachimi-Idrissi
    Critical Care Department and Cerebral Resuscitation Research Group of the Vrije Universiteit Brussel, Brussels, Belgium
    Eur J Emerg Med 11:335-42. 2004
    ..The clinical application of resuscitative mild hypothermia and its limitations will be summarized in this paper. The evidence for each application and its underlying mechanism will also be reviewed...
  5. ncbi request reprint S-100 protein as early predictor of regaining consciousness after out of hospital cardiac arrest
    Said Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, Vrije Universiteit van Brussel, Laarbeeklaan, 101, Belgium
    Resuscitation 53:251-7. 2002
    ..The purpose of the study was to validate the use of the serum astroglial protein S-100 levels at admission with regard to regaining consciousness after out of hospital CA...
  6. ncbi request reprint Postischemic mild hypothermia reduces neurotransmitter release and astroglial cell proliferation during reperfusion after asphyxial cardiac arrest in rats
    S Hachimi-Idrissi
    Department of Critical Care Medicine and Cerebral Resuscitation Research Group, van de Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels B 1090, Belgium
    Brain Res 1019:217-25. 2004
    ..Thus, postischemic mild hypothermia reduces the excitotoxic process, brain damage, as well as astroglial cell proliferation during reperfusion. Moreover, these results emphasize the trigger effect of dopamine on the excitotoxic pathway...
  7. doi request reprint Comparison of the effects of intrathecal administration of levobupivacaine and lidocaine on the prostaglandin E2 and glutamate increases in cerebrospinal fluid: a microdialysis study in freely moving rats
    V J Umbrain
    Department of Anaesthesia, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Br J Anaesth 102:540-5. 2009
    ..We tested whether levobupivacaine leads to lower PGE(2) levels than lidocaine. Moreover, we compared the release of PGE(2) and glutamate after i.t. injections of levobupivacaine or lidocaine...
  8. ncbi request reprint The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia
    L Bogaert
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium
    Eur J Pharmacol 411:71-83. 2001
    ..The protective mechanism appears to be mainly the attenuation of the ischaemia-induced glutamate release, rather than its effect on cerebral hemodynamics...
  9. ncbi request reprint 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats
    G M Khan
    Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Neuropharmacology 40:657-67. 2001
    ....
  10. ncbi request reprint Effects of dietary sucrose on hippocampal serotonin release: a microdialysis study in the freely-moving rat
    I Smolders
    Department of Pharmaceutical Chemistry and Drug Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Br J Nutr 86:151-5. 2001
    ..A practical implication of the present findings is that dietary sucrose may bias the results of studies investigating brain serotoninergic mechanisms and the effects of (anorectic) drugs interacting with 5HT systems in the hippocampus...
  11. pmc Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain
    R Clinckers
    Department of Pharmaceutical Chemistry and Drug Analysis labo FASC, Farmaceutisch Instituut Gebouw G, Vrije Universiteit Brussel, Brussels, Belgium
    Br J Pharmacol 155:1127-38. 2008
    ..Simultaneously, the impact of acute seizures and efflux transport mechanisms on brain distribution was quantified...
  12. doi request reprint Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures
    E Loyens
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    Seizure 20:602-5. 2011
    ..Our study shows that IRAP(-/-) mice are less sensitive to the development of PTZ-induced seizures and suggests that IRAP is involved in generalized seizure generation...
  13. pmc Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not gamma-aminobutyric acid levels in conscious rats
    I Smolders
    Department of Pharmaceutical Chemistry and Drug Analysi, University Hospital, Vrije Universiteit Brussel, 1090 Brussels, Belgium
    Antimicrob Agents Chemother 46:471-7. 2002
    ..In conclusion, norfloxacin exerts convulsant activity in rats, accompanied by elevations of extracellular hippocampal glutamate levels but not GABA levels, even in the presence of BPAA...
  14. doi request reprint Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats
    V Umbrain
    Department of Anaesthesiology and Pain Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, Belgium
    Br J Anaesth 101:716-22. 2008
    ..In this study, we have investigated whether intrathecal (i.t.) lidocaine administration is accompanied with changes of cerebrospinal fluid (CSF) prostaglandin E(2) (PGE(2)) levels...
  15. ncbi request reprint Formalin-induced spinal glutamate release in freely moving rats: comparison of two spinal microdialysis approaches
    L Shi
    Department of Anesthesiology, AZ VUB, Department of Physiology, Faculty of Medicine, Brussels
    Acta Anaesthesiol Belg 55:43-8. 2004
    ..The loop probe technique in CSF is more reproducible for routine investigation of drug effects, whereas the microdialysis of the dorsal horn provides a useful tool to precisely locate where the release of the neurotransmitters occurs...
  16. ncbi request reprint Differential glutamatergic modulation of monoamine release in the limbic lobe by selective anticonvulsant ionotropic and metabotropic glutamate receptor ligands
    I Smolders
    Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information FASC, Research Group Experimental Pharmacology EFAR Vrije Universiteit Brussel Faculteit Geneeskunde, Brussels
    Verh K Acad Geneeskd Belg 67:371-98. 2005
    ..We show that selective ionotropic and metabotropic glutamate receptor ligands with anticonvulsant properties differentially modulate NAD, DA and 5-HT in rat limbic lobe structures...