K Rombouts

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi request reprint Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Jette, Belgium
    J Hepatol 34:230-8. 2001
  2. pmc Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Br J Pharmacol 134:224-32. 2001
  3. ncbi request reprint Trichostatin A, lead compound for development of antifibrogenic drugs
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Acta Gastroenterol Belg 64:239-46. 2001
  4. ncbi request reprint Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Exp Cell Res 278:184-97. 2002
  5. ncbi request reprint Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Hepatol 37:788-96. 2002
  6. ncbi request reprint Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
  7. pmc Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gut 53:1180-9. 2004
  8. ncbi request reprint Nuclear localization of TRK-A in liver cells
    Andrea Bonacchi
    Department of Medicina Interna, University of Florence, Italy
    Histol Histopathol 23:327-40. 2008
  9. ncbi request reprint Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    Sara Aleffi
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 42:1339-48. 2005
  10. pmc Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells
    Hendrik Reynaert
    Laboratory for Liver Cell Biology, Vrije Universiteit Brussel VUB, Belgium
    Br J Pharmacol 146:77-88. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Jette, Belgium
    J Hepatol 34:230-8. 2001
    ..This study aims at evaluating the effect of aldosterone on extracellular matrix synthesis by rat hepatic stellate cells...
  2. pmc Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Belgium
    Br J Pharmacol 134:224-32. 2001
    ....
  3. ncbi request reprint Trichostatin A, lead compound for development of antifibrogenic drugs
    K Rombouts
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Acta Gastroenterol Belg 64:239-46. 2001
    ..Hyperacetylation of histone H4 showed to be maximal at 10(-7) M TSA. Primary hepatic stellate cells were more affected by TSA than subcultured stellate cells...
  4. ncbi request reprint Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Exp Cell Res 278:184-97. 2002
    ..Our study shows that inhibition of histone deacetylases by TSA reduces expression of fibrosis-related genes in skin fibroblasts and this coincides by alterations in the TGF-beta(1) signaling pathway...
  5. ncbi request reprint Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Hepatol 37:788-96. 2002
    ..TSA retained a more quiescent phenotype in spite of culture conditions that favor transdifferentiation into activated HSC...
  6. ncbi request reprint Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
    ..We investigated the effect of two statins on the proliferation rate and protein steady state levels of hepatic stellate cells (HSC)...
  7. pmc Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gut 53:1180-9. 2004
    ....
  8. ncbi request reprint Nuclear localization of TRK-A in liver cells
    Andrea Bonacchi
    Department of Medicina Interna, University of Florence, Italy
    Histol Histopathol 23:327-40. 2008
    ..We conclude that nuclear localization of the intracellular domain of Trk-A is observed constitutively in liver cells such as HSC, while in other cell types it could be induced in response to soluble factors...
  9. ncbi request reprint Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    Sara Aleffi
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 42:1339-48. 2005
    ..In conclusion, ObR activation in HSCs leads to increased expression of proinflammatory and proangiogenic cytokines, indicating a complex role for leptin in the regulation of the liver wound-healing response...
  10. pmc Somatostatin at nanomolar concentration reduces collagen I and III synthesis by, but not proliferation of activated rat hepatic stellate cells
    Hendrik Reynaert
    Laboratory for Liver Cell Biology, Vrije Universiteit Brussel VUB, Belgium
    Br J Pharmacol 146:77-88. 2005
    ..Our findings imply that in vivo antifibrotic effects of somatostatin could result partially from a direct action of somatostatin on HSC, but other, in vivo effects are probably also involved...
  11. ncbi request reprint Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B
    Ilaria Petrai
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    Int J Biochem Cell Biol 40:1764-74. 2008
    ..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor...
  12. ncbi request reprint Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
    ..Our observations may explain prior divergent results obtained following retinoid administration to cultured stellate cells or to animals subjected to fibrogenic stimuli...
  13. ncbi request reprint PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Vrije Universiteit Brussel, 1090 Brussels, Belgium
    J Lipid Res 44:280-95. 2003
    ....
  14. ncbi request reprint Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells
    Alessandra Caligiuri
    Dipartimento di Medicina Interna, Universita di Firenze, Italy
    Gastroenterology 124:504-20. 2003
    ..The aim of this study was to evaluate the possible direct antifibrogenic effects of canrenone, the active metabolite of spironolactone, in activated human hepatic stellate cells...
  15. ncbi request reprint Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussel Jette, Belgium
    Gastroenterology 124:184-201. 2003
    ..In a second part of the study, the effect of a PPAR-beta agonist on acute liver injury was evaluated...
  16. doi request reprint MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Exp Cell Res 314:1444-54. 2008
    ..In conclusion, the present study indicates that MARCKS play a major key role in PDGF-BB-induced chemotaxis in activated hHSC...
  17. ncbi request reprint Fibrosis in chronic liver diseases: diagnosis and management
    Massimo Pinzani
    Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    J Hepatol 42:S22-36. 2005
  18. ncbi request reprint Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells
    Roberto G Romanelli
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I 50134 Florence, Italy
    Am J Physiol Gastrointest Liver Physiol 290:G120-8. 2006
    ..We conclude that TPO exerts biological actions on cultured hepatoblastoma cells via activation of c-Mpl and its downstream signaling...