Affiliation: Vrije Universiteit Brussel
Magez S, Radwanska M, Drennan M, Fick L, Baral T, Allie N, et al
. Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage-derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing. J Infect Dis. 2007;196:954-62 pubmed
..In conclusion, the control of T. congolense infection depends on macrophage/neutrophil-derived soluble TNF and intact TNFp55 signaling, which induces trypanolytic nitric oxide...
Magez S, Radwanska M. African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis. Future Microbiol. 2009;4:1075-87 pubmed publisher
Magez S, Stijlemans B, Baral T, De Baetselier P. VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology. Microbes Infect. 2002;4:999-1006 pubmed
..Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology. ..
Magez S, Radwanska M, Stijlemans B, Xong H, Pays E, De Baetselier P. A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule. J Biol Chem. 2001;276:33458-64 pubmed
Magez S, Stijlemans B, Caljon G, Eugster H, De Baetselier P. Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-alpha induction. Infect Immun. 2002;70:1342-51 pubmed
Magez S, Caljon G, Tran T, Stijlemans B, Radwanska M. Current status of vaccination against African trypanosomiasis. Parasitology. 2010;137:2017-27 pubmed publisher
..This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology. ..
Cnops J, Kauffmann F, De Trez C, Baltz T, Keirsse J, Radwanska M, et al
. Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection. Parasite Immunol. 2016;38:642-7 pubmed publisher
..This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs. ..
Magez S, Truyens C, Merimi M, Radwanska M, Stijlemans B, Brouckaert P, et al
. P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J Infect Dis. 2004;189:527-39 pubmed
Magez S, Caljon G. Mouse models for pathogenic African trypanosomes: unravelling the immunology of host-parasite-vector interactions. Parasite Immunol. 2011;33:423-9 pubmed publisher