Ron Kooijman

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi request reprint Basal and infection-induced levels of heat shock proteins in human aging
    Rose Njemini
    Gerontology and Geriatrics, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium
    Biogerontology 8:353-64. 2007
  2. ncbi request reprint Regulation of interleukin-8 expression in human prostate cancer cells by insulin-like growth factor-I and inflammatory cytokines
    Ron Kooijman
    Department of Pharmacology, Medical School, Free University of Brussels, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Growth Horm IGF Res 17:383-91. 2007
  3. doi request reprint Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: implications for the prediction of general toxicity and immunotoxicity
    Ron Kooijman
    Department of Pharmacology, Free University of Brussels VUB, Brussels, Belgium
    Toxicol In Vitro 24:1782-9. 2010
  4. doi request reprint Insulin-like growth factor I: a potential neuroprotective compound for the treatment of acute ischemic stroke?
    Ron Kooijman
    Department of Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
    Stroke 40:e83-8. 2009
  5. ncbi request reprint Insulin-like growth factor-I augments interleukin-8 promoter activity through induction of activator protein-1 complex formation
    Ron Kooijman
    Department of Pharmacology, Medical School, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Jette, Belgium
    Int J Biochem Cell Biol 38:1957-64. 2006
  6. ncbi request reprint Regulation of apoptosis by insulin-like growth factor (IGF)-I
    Ron Kooijman
    Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cytokine Growth Factor Rev 17:305-23. 2006
  7. doi request reprint Mild hypothermia reduces activated caspase-3 up to 1 week after a focal cerebral ischemia induced by endothelin-1 in rats
    Tine Zgavc
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Brain Res 1501:81-8. 2013
  8. ncbi request reprint IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase
    Ron Kooijman
    Laboratory for Neuroendocrine Immunology, Department of Pharmacology, Medical School, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cell Signal 15:1091-8. 2003
  9. ncbi request reprint Tumor necrosis factor-alpha activates the extrapituitary PRL promoter in myeloid leukemic cells
    Sarah Gerlo
    Neuroendocrine Immunology Research Group, Department of Pharmacology, Free University of Brussels V U B, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Neuroimmunol 172:206-10. 2006
  10. ncbi request reprint Multiple, PKA-dependent and PKA-independent, signals are involved in cAMP-induced PRL expression in the eosinophilic cell line Eol-1
    Sarah Gerlo
    Laboratory of Neuroendocrine Immunology, Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cell Signal 17:901-9. 2005

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Basal and infection-induced levels of heat shock proteins in human aging
    Rose Njemini
    Gerontology and Geriatrics, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium
    Biogerontology 8:353-64. 2007
    ..The production of Hsp appeared to be related to the circulating levels of C-reactive protein and cytokines...
  2. ncbi request reprint Regulation of interleukin-8 expression in human prostate cancer cells by insulin-like growth factor-I and inflammatory cytokines
    Ron Kooijman
    Department of Pharmacology, Medical School, Free University of Brussels, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Growth Horm IGF Res 17:383-91. 2007
    ....
  3. doi request reprint Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: implications for the prediction of general toxicity and immunotoxicity
    Ron Kooijman
    Department of Pharmacology, Free University of Brussels VUB, Brussels, Belgium
    Toxicol In Vitro 24:1782-9. 2010
    ..In conclusion, new endpoints investigated in this study contribute to the prediction of immunotoxic effects and correct outliers of classical cytotoxicity assays...
  4. doi request reprint Insulin-like growth factor I: a potential neuroprotective compound for the treatment of acute ischemic stroke?
    Ron Kooijman
    Department of Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
    Stroke 40:e83-8. 2009
    ..The purpose of this review is to collect the evidence whether IGF-I is a candidate neuroprotective drug in patients with acute ischemic stroke...
  5. ncbi request reprint Insulin-like growth factor-I augments interleukin-8 promoter activity through induction of activator protein-1 complex formation
    Ron Kooijman
    Department of Pharmacology, Medical School, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Jette, Belgium
    Int J Biochem Cell Biol 38:1957-64. 2006
    ..This finding is in agreement with our previous observation that IGF-I is able to enhance basal IL-8 production in peripheral blood mononuclear cells (PBMC) in the absence of other stimuli...
  6. ncbi request reprint Regulation of apoptosis by insulin-like growth factor (IGF)-I
    Ron Kooijman
    Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cytokine Growth Factor Rev 17:305-23. 2006
    ..This phenomenon may explain the efficacy of IGF-I as an inhibitor of apoptosis in many different cell types and in the presence of different apoptogenic stimuli...
  7. doi request reprint Mild hypothermia reduces activated caspase-3 up to 1 week after a focal cerebral ischemia induced by endothelin-1 in rats
    Tine Zgavc
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Brain Res 1501:81-8. 2013
    ..Furthermore, the hypothermic treatment did not affect the CBF in the Et-1 model. These findings indicate that in the Et-1 model, hypothermia exerts a long lasting effect on stroke-induced apoptosis...
  8. ncbi request reprint IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase
    Ron Kooijman
    Laboratory for Neuroendocrine Immunology, Department of Pharmacology, Medical School, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cell Signal 15:1091-8. 2003
    ..Collectively, our results suggest that basal JNK activity and activation of the MEK-ERK pathway are required for upregulation of IL-8 by IGF-I in HL-60 cells...
  9. ncbi request reprint Tumor necrosis factor-alpha activates the extrapituitary PRL promoter in myeloid leukemic cells
    Sarah Gerlo
    Neuroendocrine Immunology Research Group, Department of Pharmacology, Free University of Brussels V U B, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Neuroimmunol 172:206-10. 2006
    ..Our findings might have clinical relevance in view of recent data indicating leukocyte-derived PRL is involved in auto-immune and hematological disorders...
  10. ncbi request reprint Multiple, PKA-dependent and PKA-independent, signals are involved in cAMP-induced PRL expression in the eosinophilic cell line Eol-1
    Sarah Gerlo
    Laboratory of Neuroendocrine Immunology, Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cell Signal 17:901-9. 2005
    ..We postulate that cAMP induces PRL expression via two different signalling pathways: a PKA-dependent pathway leading to the phosphorylation of CREB, and a PKA-independent pathway leading to the phosphorylation of p38...
  11. pmc The neuroprotective effect of post ischemic brief mild hypothermic treatment correlates with apoptosis, but not with gliosis in endothelin-1 treated rats
    Tine Zgavc
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
    BMC Neurosci 13:105. 2012
    ..Apoptosis was determined using caspase-3 immunohistochemistry, phagocytic cells were visualized by CD-68 expression and astrogliosis was studied by glial fibrillary acidic protein (GFAP) staining...
  12. ncbi request reprint Igf-I inhibits spontaneous apoptosis in human granulocytes
    Ron Kooijman
    Department of Pharmacology, Medical School, Vrije Universiteit Brussel, B 1090 Brussels, Belgium
    Endocrinology 143:1206-12. 2002
    ..These observations indicate that IGF-I may promote granulocyte functions by increasing granulocyte longevity...
  13. ncbi request reprint Modulation of prolactin expression in human T lymphocytes by cytokines
    Sarah Gerlo
    Laboratory of Neuroendocrine Immunology, Department of Pharmacology, Free University of Brussels VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Neuroimmunol 162:190-3. 2005
    ..PRL mRNA expression was inhibited to a lesser extent by IL-1beta, which decreased PRL mRNA levels to 58% of control values...
  14. pmc The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia
    An Gaëlle Ceulemans
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Neuropharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Neuroinflammation 7:74. 2010
    ..We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection...
  15. pmc Mild hypothermia causes differential, time-dependent changes in cytokine expression and gliosis following endothelin-1-induced transient focal cerebral ischemia
    An Gaëlle Ceulemans
    Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
    J Neuroinflammation 8:60. 2011
    ..This study is the first to investigate whether this neuroprotection occurs through modulation of the neuroinflammatory response after stroke in a time-dependent manner...
  16. ncbi request reprint Mechanism of prostaglandin (PG)E2-induced prolactin expression in human T cells: cooperation of two PGE2 receptor subtypes, E-prostanoid (EP) 3 and EP4, via calcium- and cyclic adenosine 5'-monophosphate-mediated signaling pathways
    Sarah Gerlo
    Laboratory of Neuroendocrine Immunology, Department of Pharmacology, Free University of Brussels, Laarbeeklaan 103, B 1090 Brussels, Belgium
    J Immunol 173:5952-62. 2004
    ..Mutation of a C/EBP responsive element at -214 partially abolished the response of the leukocyte prolactin promoter to PGE(2), cAMP, and ionomycin plus cAMP...
  17. pmc Spontaneously hypertensive rats display reduced microglial activation in response to ischemic stroke and lipopolysaccharide
    Deborah De Geyter
    Department of Pharmacology, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
    J Neuroinflammation 9:114. 2012
    ..We aimed to compare the susceptibility to ischemia in hypertensive rats with those in normotensive controls in a rat model for induction of ischemic stroke in conscious animals...
  18. doi request reprint Attenuation of IGF-I receptor signaling inhibits serum-induced proliferation of prostate cancer cells
    Eddy Himpe
    Medical School, Department of Pharmacology, Vrije Universiteit Brussel, Belgium
    Growth Horm IGF Res 21:252-9. 2011
    ..In this study, we addressed the role of IGF-I as a serum factor on the growth of two androgen-independent cell lines (Du145 and PC3) and one androgen-dependent cell line (LNCaP)...
  19. doi request reprint Modulation of cytokine production by cyclic adenosine monophosphate analogs in human leukocytes
    Sarah Gerlo
    Lab of Eukaryotic Gene Expression and Signal Transduction, Department of Physiology, University Gent, Brussels, Belgium
    J Interferon Cytokine Res 30:883-91. 2010
    ..We speculate that selective effects of PKA and EPAC on cytokine production in leukocyte subsets open up therapeutic possibilities using selective activators or inhibitors of EPAC or PKA...
  20. ncbi request reprint Astrocytic beta(2)-adrenergic receptors: from physiology to pathology
    Guy Laureys
    Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Belgium
    Prog Neurobiol 91:189-99. 2010
    ..In this review we focus on the physiological functions of astrocytic beta(2)-adrenergic receptors, and their possible impact in disease states...
  21. doi request reprint Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the phosphatidylinositol-3 kinase pathway
    Eddy Himpe
    Laboratory of Pharmacology FARC, Medical School, Vrije Universiteit Brussel VUB, Brussels, Belgium
    J Endocrinol 199:69-80. 2008
    ..We therefore speculate that other downstream targets of PI3K are involved in the delay of neutrophil apoptosis by IGF1, possibly through stabilization of the mitochondrial membrane...
  22. doi request reprint Insulin-like growth factor-I receptor signal transduction and the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) pathway
    Eddy Himpe
    Department of Pharmacology, Medical School, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Biofactors 35:76-81. 2009
    ..Theoretically, dysregulation of CIS or SOCS may affect IGF-I-mediated effects on body growth, cell differentiation, proliferation, and cell survival...
  23. ncbi request reprint Insulin-like growth factor-I stimulates IL-10 production in human T cells
    Ron Kooijman
    Department of Pharmacology, Medical School, Free University of Brussels VUB, Laarbeeklaan 103, B 1090, Belgium
    J Leukoc Biol 76:862-7. 2004
    ....
  24. ncbi request reprint Regulation of prolactin expression in leukemic cell lines and peripheral blood mononuclear cells
    Sarah Gerlo
    Department of Pharmacology, Free University of Brussels V U B, Laarbeeklaan 103, B 1090, Brussels, Belgium
    J Neuroimmunol 135:107-16. 2003
    ....
  25. doi request reprint High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain
    Ann Massie
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group of Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium
    J Comp Neurol 511:155-72. 2008
    ..7 to 1.6% of the amount in the cerebellum as measured by real-time PCR...
  26. pmc Prolactin in man: a tale of two promoters
    Sarah Gerlo
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Belgium
    Bioessays 28:1051-5. 2006
    ..Importantly, the TE insertion might provide a context for some of the conflicting results obtained in studies of PRL function in mice and man...
  27. pmc Protein hormones and immunity
    Keith W Kelley
    Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, 227 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 21:384-92. 2007
    ..Homeostasis during inflammation is achieved by a balance between cytokines and endocrine hormones...