Karine H Hellemans

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. ncbi request reprint Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release
    Geert A Martens
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels
    J Biol Chem 282:21134-44. 2007
  2. pmc Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase
    Karine H Hellemans
    Diabetes Research Center, Brussels Free University VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
    PLoS ONE 4:e7266. 2009
  3. ncbi request reprint Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity
    Karine Hellemans
    Diabetes Research Center DRC, Brussels Free University VUB, Belgium
    FEBS J 274:6094-105. 2007
  4. ncbi request reprint Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
  5. ncbi request reprint Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Exp Cell Res 278:184-97. 2002
  6. ncbi request reprint Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Hepatol 37:788-96. 2002
  7. ncbi request reprint Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussel Jette, Belgium
    Gastroenterology 124:184-201. 2003
  8. ncbi request reprint PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Vrije Universiteit Brussel, 1090 Brussels, Belgium
    J Lipid Res 44:280-95. 2003
  9. ncbi request reprint Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
  10. pmc Clusters of conserved beta cell marker genes for assessment of beta cell phenotype
    Geert A Martens
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 6:e24134. 2011

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release
    Geert A Martens
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels
    J Biol Chem 282:21134-44. 2007
    ..Down-regulation of HADHSC causes an elevated secretory activity suggesting that this enzyme protects against inappropriately high insulin levels and hypoglycemia...
  2. pmc Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase
    Karine H Hellemans
    Diabetes Research Center, Brussels Free University VUB, and JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
    PLoS ONE 4:e7266. 2009
    ....
  3. ncbi request reprint Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity
    Karine Hellemans
    Diabetes Research Center DRC, Brussels Free University VUB, Belgium
    FEBS J 274:6094-105. 2007
    ..These observations indicate that PPARalpha and RXR regulate beta-cell susceptibility to long-chain fatty acid toxicity by increasing the rates of beta-oxidation and by involving peroxisomes in fatty acid metabolism...
  4. ncbi request reprint Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
    ..Our observations may explain prior divergent results obtained following retinoid administration to cultured stellate cells or to animals subjected to fibrogenic stimuli...
  5. ncbi request reprint Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    Exp Cell Res 278:184-97. 2002
    ..Our study shows that inhibition of histone deacetylases by TSA reduces expression of fibrosis-related genes in skin fibroblasts and this coincides by alterations in the TGF-beta(1) signaling pathway...
  6. ncbi request reprint Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Hepatol 37:788-96. 2002
    ..TSA retained a more quiescent phenotype in spite of culture conditions that favor transdifferentiation into activated HSC...
  7. ncbi request reprint Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels, Laarbeeklaan 103, 1090 Brussel Jette, Belgium
    Gastroenterology 124:184-201. 2003
    ..In a second part of the study, the effect of a PPAR-beta agonist on acute liver injury was evaluated...
  8. ncbi request reprint PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation
    Karine Hellemans
    Laboratory of Molecular Liver Cell Biology, Vrije Universiteit Brussel, 1090 Brussels, Belgium
    J Lipid Res 44:280-95. 2003
    ....
  9. ncbi request reprint Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
    ..We investigated the effect of two statins on the proliferation rate and protein steady state levels of hepatic stellate cells (HSC)...
  10. pmc Clusters of conserved beta cell marker genes for assessment of beta cell phenotype
    Geert A Martens
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    PLoS ONE 6:e24134. 2011
    ..This panel was then used to compare isolated versus laser capture microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators...
  11. pmc Protein markers for insulin-producing beta cells with higher glucose sensitivity
    Geert A Martens
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    PLoS ONE 5:e14214. 2010
    ..Beta cell-selective proteins were also identified through comparison with rat brain and liver tissue and with purified islet alpha cells, after geometrical normalization using 6 stably expressed reference proteins...
  12. ncbi request reprint Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout
    Pascale Bardoux
    Institut Cochin, U567 INSERM, UMR8104 Centre National de la Recherche Scientifique, Universite Rene Descartes, Department GDPM, 24 Rue du Faubourg Saint Jacques 75014 Paris, France
    Diabetes 54:1357-63. 2005
    ..Altered insulin secretion was associated with peripheral insulin resistance in whole animals. It can be concluded that COUP-TFII is a new, important regulator of glucose homeostasis and insulin sensitivity...