Mark de Ridder

Summary

Affiliation: Vrije Universiteit Brussel
Country: Belgium

Publications

  1. pmc NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
    M De Ridder
    Oncology Center, Cancer Research Unit, Academic Hospital Free University Brussels A Z V U B, Laarbeeklaan 101, B 1090, Brussels, Belgium
    Br J Cancer 88:120-4. 2003
  2. ncbi request reprint Lipid a radiosensitizes hypoxic EMT-6 tumor cells: role of the NF-kappaB signaling pathway
    Mark de Ridder
    Academic Hospital Free University Brussels A Z V U B, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 57:779-86. 2003
  3. ncbi request reprint The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase
    Mark de Ridder
    Academic Hospital Free University Brussels, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 66:1473-80. 2006
  4. doi request reprint Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing
    Heng Jiang
    Vrije Universiteit Brussel, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 76:1520-7. 2010
  5. ncbi request reprint Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse
    Mark de Ridder
    Academic Hospital, Free University Brussels, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 60:598-606. 2004
  6. doi request reprint Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer
    Benedikt Engels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:142-8. 2012
  7. doi request reprint Hepatocytes determine the hypoxic microenvironment and radiosensitivity of colorectal cancer cells through production of nitric oxide that targets mitochondrial respiration
    Heng Jiang
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 85:820-7. 2013
  8. doi request reprint Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial
    Samuel Bral
    Department of Radiotherapy, University Hospital Brussels, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1343-9. 2011
  9. doi request reprint Small airways function in breast cancer patients before and after radiotherapy
    Sylvia Verbanck
    Respiratory Division, University Hospital UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Breast Cancer Res Treat 135:857-65. 2012
  10. doi request reprint Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway
    Mark de Ridder
    Oncologisch Centrum UZ Brussel, Department of Radiation Oncology, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Bull Cancer 95:282-91. 2008

Collaborators

Detail Information

Publications34

  1. pmc NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase
    M De Ridder
    Oncology Center, Cancer Research Unit, Academic Hospital Free University Brussels A Z V U B, Laarbeeklaan 101, B 1090, Brussels, Belgium
    Br J Cancer 88:120-4. 2003
    ..Contrasting to other studies, our data show that inhibition of NF-kappaB may impair the radioresponse of tumour cells through downregulation of iNOS...
  2. ncbi request reprint Lipid a radiosensitizes hypoxic EMT-6 tumor cells: role of the NF-kappaB signaling pathway
    Mark de Ridder
    Academic Hospital Free University Brussels A Z V U B, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 57:779-86. 2003
    ..This study examines whether lipid A may directly modulate the radioresponse of tumor cells by activating inducible nitric oxide synthase (iNOS) or cyclooxygenase-2 (COX-2) through nuclear factor-kappaB (NF-kappaB) signaling...
  3. ncbi request reprint The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase
    Mark de Ridder
    Academic Hospital Free University Brussels, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 66:1473-80. 2006
    ..To explore whether antitumor immunoadjuvant OM-174 can stimulate immune cells to produce interferon-gamma (IFN-gamma) and thereby radiosensitize tumor cells...
  4. doi request reprint Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing
    Heng Jiang
    Vrije Universiteit Brussel, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 76:1520-7. 2010
    ..This study examined whether activation of iNOS (a) directly in tumor cells or (b) in bystander macrophages may improve radioresponse through sparing of oxygen...
  5. ncbi request reprint Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse
    Mark de Ridder
    Academic Hospital, Free University Brussels, Oncology Center, Cancer Research Unit, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 60:598-606. 2004
    ..This study examines whether activated macrophages may radiosensitize tumor cells through the release of proinflammatory mediators...
  6. doi request reprint Phase II study of preoperative helical tomotherapy with a simultaneous integrated boost for rectal cancer
    Benedikt Engels
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:142-8. 2012
    ..In addition, it is associated with considerable toxicity. As an alternative strategy, we explored prospectively, preoperative helical tomotherapy with a simultaneous integrated boost (SIB)...
  7. doi request reprint Hepatocytes determine the hypoxic microenvironment and radiosensitivity of colorectal cancer cells through production of nitric oxide that targets mitochondrial respiration
    Heng Jiang
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 85:820-7. 2013
    ..To determine whether host hepatocytes may reverse hypoxic radioresistance through nitric oxide (NO)-induced oxygen sparing, in a model relevant to colorectal cancer (CRC) liver metastases...
  8. doi request reprint Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial
    Samuel Bral
    Department of Radiotherapy, University Hospital Brussels, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1343-9. 2011
    ..Validation of a prospective, risk-adapted strategy for early-stage non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT)...
  9. doi request reprint Small airways function in breast cancer patients before and after radiotherapy
    Sylvia Verbanck
    Respiratory Division, University Hospital UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Breast Cancer Res Treat 135:857-65. 2012
    ..The TT modality did not lead to any such changes...
  10. doi request reprint Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway
    Mark de Ridder
    Oncologisch Centrum UZ Brussel, Department of Radiation Oncology, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Bull Cancer 95:282-91. 2008
    ..Second, tumor associated macrophages can produce high levels of NO that may radiosensitize bystander tumor cells. Our ongoing research is focused on combining immunostimulatory and radiosensitizing strategies...
  11. doi request reprint Toxicity and outcome results of a class solution with moderately hypofractionated radiotherapy in inoperable Stage III non-small cell lung cancer using helical tomotherapy
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel UZB, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 77:1352-9. 2010
    ..To prospectively assess the feasibility, toxicity, and local control of a class solution protocol of moderately hypofractionated tomotherapy in Stage III, inoperable, locally advanced non-small-cell lung cancer patients...
  12. pmc Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy
    Harijati Versmessen
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Jette, Brussels, Belgium
    BMC Cancer 12:495. 2012
    ..Tomotherapy uses an integrated computed tomography scanner to improve treatment accuracy, aiming to reduce the adverse effects of radiotherapy...
  13. doi request reprint Clinical evaluation of a robotic 6-degree of freedom treatment couch for frameless radiosurgery
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 83:467-74. 2012
    ....
  14. doi request reprint Daily megavoltage computed tomography in lung cancer radiotherapy: correlation between volumetric changes and local outcome
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:1338-42. 2011
    ..To assess the predictive or comparative value of volumetric changes, measured on daily megavoltage computed tomography during radiotherapy for lung cancer...
  15. doi request reprint IFN-gamma+ CD8+ T lymphocytes: possible link between immune and radiation responses in tumor-relevant hypoxia
    Mark de Ridder
    Radiotherapie, Oncologisch Centrum, UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 71:647-51. 2008
    ..Therefore, immune and radiation responses are likely to be allied in the hypoxic tumor microenvironment, and CD8+ T cells may bridge immunostimulatory and radiosensitizing strategies...
  16. pmc Scapula alata in early breast cancer patients enrolled in a randomized clinical trial of post-surgery short-course image-guided radiotherapy
    Nele Adriaenssens
    Breast Clinic, Oncologic Surgery, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    World J Surg Oncol 10:86. 2012
    ..We evaluated the risk factors associated with SA and the relationship of SA with ipsilateral shoulder/arm morbidity in a series of patients enrolled in a trial of post-surgery radiotherapy (RT)...
  17. doi request reprint Setup accuracy of the Novalis ExacTrac 6DOF system for frameless radiosurgery
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 82:1627-35. 2012
    ..This study was designed to measure the detection and positioning accuracy of the ExacTrac/Novalis Body (ET/NB) for rotations and to compare the accuracy of the frameless with the frame-based radiosurgery technique...
  18. doi request reprint Volumetric imaging by megavoltage computed tomography for assessment of internal organ motion during radiotherapy for cervical cancer
    Christine Collen
    Department of Radiotherapy, Oncology Centre University Hospital Brussels UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 77:1590-5. 2010
    ..To assess the internal organ motion of the cervix and uterus by megavoltage computed tomography (MVCT) during intensity-modulated radiotherapy (IMRT)...
  19. pmc Implementation of HybridArc treatment technique in preoperative radiotherapy of rectal cancer: dose patterns in target lesions and organs at risk as compared to helical Tomotherapy and RapidArc
    Thierry Gevaert
    Department of Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Radiat Oncol 7:120. 2012
    ..This study compared this new technique to helical Tomotherapy, and RapidArc, in preoperative radiotherapy of rectal cancer...
  20. pmc Short course radiotherapy with simultaneous integrated boost for stage I-II breast cancer, early toxicities of a randomized clinical trial
    Hilde Van Parijs
    Department of Radiotherapy, UZ Brussel, Brussels, Belgium
    Radiat Oncol 7:80. 2012
    ..hypofractionated Tomotherapy (TT) for post-operative treatment of breast cancer. The purpose of the trial is to compare whether TT can reduce heart and pulmonary toxicity. We evaluate early toxicities...
  21. pmc Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer
    Benedikt Engels
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Radiat Oncol 7:34. 2012
    ..For inoperable patients, we evaluated in this study intensity-modulated and image-guided radiotherapy (IMRT-IGRT) by helical tomotherapy...
  22. doi request reprint Single fraction versus fractionated linac-based stereotactic radiotherapy for vestibular schwannoma: a single-institution experience
    Christine Collen
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Int J Radiat Oncol Biol Phys 81:e503-9. 2011
    ..To evaluate and compare outcomes for patients with vestibular schwannoma (VS) treated in a single institution with linac-based stereotactic radiosurgery (SRS) or by fractionated stereotactic radiotherapy (SRT)...
  23. doi request reprint Parotid gland sparing with helical tomotherapy in head-and-neck cancer
    Mia Voordeckers
    Department of Radiation Oncology, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 84:443-8. 2012
    ..This study evaluated the ability of helical tomotherapy to spare the function of the parotid glands in patients with head-and-neck cancer by analyzing dose-volume histograms, salivary gland scintigraphy, and quality of life assessment...
  24. doi request reprint Computer-aided analysis of star shot films for high-accuracy radiation therapy treatment units
    Tom Depuydt
    Radiotherapy Department, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Phys Med Biol 57:2997-3011. 2012
    ..06 and 0.18 mm, respectively. The methodology described in this work can be used to monitor mechanical performance constancy of high-accuracy treatment devices, with means available in a clinical radiation therapy environment...
  25. doi request reprint Toxicity report of a phase 1/2 dose-escalation study in patients with inoperable, locally advanced nonsmall cell lung cancer with helical tomotherapy and concurrent chemotherapy
    Samuel Bral
    Department of Radiation Oncology, Oncology Center, Brussels University Hospital, Brussels, Belgium
    Cancer 116:241-50. 2010
    ....
  26. doi request reprint Geometric accuracy of a novel gimbals based radiation therapy tumor tracking system
    Tom Depuydt
    Radiotherapy Department, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, Brussels, Belgium
    Radiother Oncol 98:365-72. 2011
    ..VERO is a novel platform for image guided stereotactic body radiotherapy. Orthogonal gimbals hold the linac-MLC assembly allowing real-time moving tumor tracking. This study determines the geometric accuracy of the tracking...
  27. doi request reprint Preoperative helical tomotherapy and megavoltage computed tomography for rectal cancer: impact on the irradiated volume of small bowel
    Benedikt Engels
    Department of Radiation Oncology, Oncologisch Centrum UZ Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 74:1476-80. 2009
    ..The aim of this study was to explore to what extent helical tomotherapy and daily megavolt (MV) CT imaging may reduce the irradiated volume of small bowel...
  28. doi request reprint An in-house developed resettable MOSFET dosimeter for radiotherapy
    Dirk Verellen
    UZ Brussel, Oncologisch Centrum, Radiotherapie, Brussels, Belgium
    Phys Med Biol 55:N97-109. 2010
    ..An in-house developed resettable MOSFET-based dosimetry system is proposed. The system has been validated and is currently used for in vivo entrance dose measurement in clinical routine for simple (open field) treatment configurations...
  29. doi request reprint Prediction of response to neoadjuvant radiotherapy in patients with locally advanced rectal cancer by means of sequential 18FDG-PET
    Hendrik Everaert
    Department of Nuclear Medicine, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 80:91-6. 2011
    ....
  30. doi request reprint Hypoxic tumor cell radiosensitization through nitric oxide
    Mark de Ridder
    UZ Brussel, Oncologisch Centrum, Dienst Radiotherapie, Laarbeeklaan 101, B 1090 Brussels, Belgium
    Nitric Oxide 19:164-9. 2008
    ..Our findings indicate a rationale for combining immunostimulatory and radiosensitizing strategies in the future...
  31. doi request reprint Assessment of intrafractional movement and internal motion in radiotherapy of rectal cancer using megavoltage computed tomography
    Koen Tournel
    UZ Brussel, Oncologisch Centrum, Department of Radiotherapy, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 71:934-9. 2008
    ..In clinical protocols, however, margins originating from traditional setup procedures are still being applied. This work investigates whether this modality can aid in redefining treatment margins...
  32. ncbi request reprint The role of chemotherapy in the treatment of low-grade glioma. A review of the literature
    Bart Neyns
    Medische Oncologie, Oncologisch Centrum, Academisch Ziekenhuis Vrije Universiteit Brussel AZ VUB, Brussel, Belgium
    Acta Neurol Belg 105:137-43. 2005
    ....
  33. pmc Early contralateral shoulder-arm morbidity in breast cancer patients enrolled in a randomized trial of post-surgery radiation therapy
    Nele Adriaenssens
    Breast Clinic, Oncological Surgery, UZ Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium
    Breast Cancer (Auckl) 6:79-93. 2012
    ..Shoulder/arm morbidity is a common complication of breast cancer surgery and radiotherapy (RT), but little is known about acute contralateral morbidity...
  34. ncbi request reprint Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, NB40, Cleveland, OH 44195, USA
    Haematologica 90:810-7. 2005
    ..BM hypoxia is crucial for normal hematopoiesis. However, how BM hypoxia and MM affect each other is unknown. We addressed this topic in the 5T2MM mouse model...