Affiliation: Vrije Universiteit Brussel
Van Lint S, Renmans D, Broos K, Goethals L, Maenhout S, Benteyn D, et al
. Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells. Cancer Immunol Res. 2016;4:146-56 pubmed publisher
..As such, we provide a platform and a mechanistic rationale for the clinical testing of i.t. administration of TriMix mRNA. ..
Breckpot K, Escors D, Arce F, Lopes L, Karwacz K, Van Lint S, et al
. HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7. J Virol. 2010;84:5627-36 pubmed publisher
..In conclusion, we demonstrated TLR-dependent DC activation by lentiviral vectors, explaining their immunogenicity. These data allow the rational development of strategies to manipulate the host's immune response to the transgene. ..
Breckpot K, Emeagi P, Thielemans K. Lentiviral vectors for anti-tumor immunotherapy. Curr Gene Ther. 2008;8:438-48 pubmed
..In conclusion, this review highlights the potential of lentiviral vectors as a generally applicable 'off-the-shelf' therapeutic for anti-tumor immunotherapy. ..