Jean Louis Vincent

Summary

Country: Belgium

Publications

  1. ncbi Organization of intensive care units in Europe: lessons from the EPIC study
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Belgium
    Intensive Care Med 23:1181-4. 1997
  2. ncbi Cardiovascular alterations in septic shock
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    J Antimicrob Chemother 41:9-15. 1998
  3. ncbi Forgoing life support in western European intensive care units: the results of an ethical questionnaire
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 27:1626-33. 1999
  4. ncbi Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, B 1070 Brussels, Belgium
    Clin Infect Dis 34:1084-93. 2002
  5. ncbi Low-dose vasopressin in the treatment of septic shock in sheep
    Qinghua Sun
    Ph D Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Am J Respir Crit Care Med 168:481-6. 2003
  6. ncbi Optimal adrenergic support in septic shock due to peritonitis
    Qinghua Sun
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Anesthesiology 98:888-96. 2003
  7. ncbi Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:589-97. 2006
  8. pmc Case-control study of drug monitoring of β-lactams in obese critically ill patients
    Maya Hites
    Department of Infectious Diseases, Universite Libre de Bruxelles, Brussels, Belgium
    Antimicrob Agents Chemother 57:708-15. 2013
  9. ncbi Use of low tidal volume in septic shock may decrease severity of subsequent acute lung injury
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Shock 22:145-50. 2004
  10. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004

Detail Information

Publications192 found, 100 shown here

  1. ncbi Organization of intensive care units in Europe: lessons from the EPIC study
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Belgium
    Intensive Care Med 23:1181-4. 1997
    ..To study differences related to intensive care unit (ICU) structure and patient demography between the various countries of Western Europe...
  2. ncbi Cardiovascular alterations in septic shock
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    J Antimicrob Chemother 41:9-15. 1998
    ..In this article we will review current knowledge on the factors involved in the cardiovascular alterations of sepsis, the clinical implications of these alterations, and the possibilities for future treatments...
  3. ncbi Forgoing life support in western European intensive care units: the results of an ethical questionnaire
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 27:1626-33. 1999
    ..To determine current views of European intensive care physicians regarding end-of-life decisions...
  4. ncbi Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, B 1070 Brussels, Belgium
    Clin Infect Dis 34:1084-93. 2002
    ..In this article, we discuss the positive and negative results of trials in this field; some of the possible reasons for the negative results are examined, and directions for the future are suggested...
  5. ncbi Low-dose vasopressin in the treatment of septic shock in sheep
    Qinghua Sun
    Ph D Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Am J Respir Crit Care Med 168:481-6. 2003
    ..In this clinically relevant model of septic shock due to peritonitis, vasopressin administration (alone or with norepinephrine) can prolong survival...
  6. ncbi Optimal adrenergic support in septic shock due to peritonitis
    Qinghua Sun
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Anesthesiology 98:888-96. 2003
    ..The authors evaluated optimal adrenergic support using norepinephrine, dopamine, and dobutamine in a clinically relevant model of septic shock...
  7. ncbi Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:589-97. 2006
    ..The optimal adrenergic support in shock is controversial. We investigated whether dopamine administration influences the outcome from shock...
  8. pmc Case-control study of drug monitoring of β-lactams in obese critically ill patients
    Maya Hites
    Department of Infectious Diseases, Universite Libre de Bruxelles, Brussels, Belgium
    Antimicrob Agents Chemother 57:708-15. 2013
    ..No differences were observed in pharmacokinetic variables between the two groups. Routine therapeutic drug monitoring of β-lactams should be continued in obese critically ill patients...
  9. ncbi Use of low tidal volume in septic shock may decrease severity of subsequent acute lung injury
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Shock 22:145-50. 2004
    ..1 +/- 0.5 vs. 9.1 +/- 0.7, P < 0.05). A low-tidal-volume ventilation strategy applied early during septic shock may be beneficial in terms of reducing the amount of lung edema and prolonging survival time...
  10. ncbi Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock
    Yasser Sakr
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 32:1825-31. 2004
    ..To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock...
  11. ncbi The hepatosplanchnic contribution to hyperlactatemia in endotoxic shock: effects of tissue ischemia
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Shock 21:438-43. 2004
    ..In endotoxic shock, GLP is increased, but the liver can metabolize this additional load of lactate, so that the hepatosplanchnic area is not a major source of lactate unless the liver becomes profoundly hypoxic...
  12. pmc Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 9:R745-54. 2005
    ..Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome...
  13. ncbi Effect of vasopressin on sublingual microcirculation in a patient with distributive shock
    Marc J Dubois
    Department of Intensive Care Medicine, Erasme Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 29:1020-3. 2003
    ..To assess the sublingual microcirculation in a patient during vasopressin administration for a distributive shock after cardiopulmonary bypass...
  14. doi Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis
    Fabio Silvio Taccone
    1Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium 2Department of Anesthesia and Intensive Care, ZOL St Jan, Genk, Belgium 3Department of Neurosurgery, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Crit Care Med 42:e114-22. 2014
    ..We studied the evolution of microvascular blood flow, brain oxygen tension (PbO2), and metabolism in a clinically relevant animal model of septic shock...
  15. ncbi Beneficial effects of alkaline phosphatase in septic shock
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:2182-7. 2006
    ..The aim of this study was to investigate whether administration of alkaline phosphatase is beneficial in a clinically relevant septic shock model...
  16. ncbi The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:403-8. 2006
    ..To evaluate the effects of dobutamine on microcirculatory blood flow alterations in patients with septic shock...
  17. ncbi Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or ringer's lactate-does it really make a difference?
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 27:520-6. 2007
    ..v. fluid did not affect outcome...
  18. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    ..To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units...
  19. ncbi Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock
    Xinrong He
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 40:2833-40. 2012
    ..We studied whether tetrahydrobiopterin administration exerts beneficial effects in an ovine septic shock model...
  20. doi Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock
    Fuhong Su
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Shock 34:243-9. 2010
    ..Combination of this selective iNOS inhibitor with NE allowed a higher arterial pressure and renal blood flow to be maintained...
  21. ncbi Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis
    Colin L Verdant
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:2875-81. 2009
    ..To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion...
  22. ncbi Can changes in renal function predict variations in β-lactam concentrations in septic patients?
    Giuseppe Stefano Casu
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 42:422-8. 2013
    ..Routine TDM should be considered to adapt β-lactam doses in this setting. ..
  23. pmc Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
    Lucie Seyler
    Department of Infectious Diseases, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 15:R137. 2011
    ..We studied whether these recommendations met optimal pharmacokinetic criteria for broad-spectrum antibiotic levels in septic shock patients undergoing CRRT...
  24. ncbi Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:791-9. 2013
    ..We investigated which factors may influence microcirculatory alterations in patients with severe sepsis and whether these are independently associated with mortality...
  25. doi Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients
    Eva Ocampos-Martinez
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 39:332-7. 2012
    ..A high CL(Cr) was the variable most strongly associated with insufficient drug concentrations...
  26. pmc Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Bruxelles, Belgium
    Crit Care 14:R53. 2010
    ..The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients...
  27. ncbi A new regimen for continuous infusion of vancomycin during continuous renal replacement therapy
    Marjorie Beumier
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik, 808, 1070 Bruxelles, Belgium
    J Antimicrob Chemother 68:2859-65. 2013
    ..However, this approach has not been well studied in patients on continuous renal replacement therapy (CRRT). The aim of this study was to evaluate the adequacy of a new CI vancomycin regimen in septic patients undergoing CRRT...
  28. ncbi Rapid alterations in transferrin sialylation during sepsis
    Michael Piagnerelli
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 24:48-52. 2005
    ..Further studies including measurement of blood neuraminidase concentration and activity are needed to understand the process and exact role of SA decrease in septic patients...
  29. ncbi Sublingual capnometry tracks microcirculatory changes in septic patients
    Jacques Creteur
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 32:516-23. 2006
    ..To test the hypothesis that microcirculatory blood flow is the main determinant of sublingual carbon dioxide pressure in patients with septic shock...
  30. ncbi Euglycemic hyperinsulinemia in severe sepsis and septic shock
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Eur Surg Res 38:495-502. 2006
    ..We raised the hypothesis that euglycemic hyperinsulinemia (EH) might improve the outcome from septic shock due to peritonitis...
  31. ncbi Infection Probability Score (IPS): A method to help assess the probability of infection in critically ill patients
    Daliana Peres Bota
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 31:2579-84. 2003
    ..To develop a simple score to help assess the presence or absence of infection in critically ill patients using routinely available variables...
  32. ncbi Microvascular blood flow is altered in patients with sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Am J Respir Crit Care Med 166:98-104. 2002
    ..The topical application of acetylcholine totally reversed these alterations. In conclusion, microvascular blood flow alterations are frequent in patients with sepsis and are more severe in patients with a worse outcome...
  33. ncbi Drotrecogin alfa (activated) for severe sepsis: could we consider a shorter treatment period in patients with a favorable course?
    David Ahishakiye
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 1070 Brussels, Belgium
    J Crit Care 24:590-4. 2009
    ..The objective of this study was to develop a model to identify patients in whom drotrecogin alfa (activated) (DAA) might be administered for periods shorter than the recommended 96 hours...
  34. ncbi Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 31:834-40. 2003
    ..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)...
  35. doi Continuous infusion of vancomycin in septic patients receiving continuous renal replacement therapy
    Cecilia Covajes
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles ULB, Route de Lennik 808, 1070 Brussels, Belgium
    Int J Antimicrob Agents 41:261-6. 2013
    ..Most patients with adequate drug concentrations received a daily dose of 16-35 mg/kg. The intensity of CRRT directly influenced vancomycin concentrations on Day 1 of therapy...
  36. doi Effects of fluids on microvascular perfusion in patients with severe sepsis
    Gustavo Ospina-Tascon
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium
    Intensive Care Med 36:949-55. 2010
    ..To evaluate the effects of fluid administration on microcirculatory alterations in sepsis...
  37. doi Can changes in arterial pressure be used to detect changes in cardiac index during fluid challenge in patients with septic shock?
    Charalampos Pierrakos
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 38:422-8. 2012
    ..However, in clinical practice CI values are often not available. We evaluated whether changes in mean arterial pressure (MAP) correlate with changes in CI after fluid challenge in patients with septic shock...
  38. ncbi Pulse pressure variations to predict fluid responsiveness: influence of tidal volume
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:517-23. 2005
    ..To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness...
  39. ncbi Effects of fluid challenge on gastric mucosal PCO2 in septic patients
    Eliezer Silva
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:423-9. 2004
    ..To determine the effects of fluid challenge on systemic hemodynamic variables and gastric intramucosal partial pressure of carbon dioxide (PCO(2)) in septic patients...
  40. ncbi Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver
    Daliana Peres Bota
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    J Lab Clin Med 146:347-51. 2005
    ..Moreover, the predictive power of CRP and PCT for infection was similar for patients with and without cirrhosis...
  41. ncbi Use of the pulmonary artery catheter is not associated with worse outcome in the ICU
    Yasser Sakr
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
    Chest 128:2722-31. 2005
    ..In critically ill patients, the impact of pulmonary artery catheter (PAC) use on outcome is debatable. We investigated the epidemiology of PAC use in European ICUs and its relation to outcome...
  42. ncbi C-reactive protein levels correlate with mortality and organ failure in critically ill patients
    Suzana M A Lobo
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 123:2043-9. 2003
    ..This study assessed the association between early serum CRP concentrations and the development of organ failure and mortality in ICU patients...
  43. doi Is worsening multiple organ failure the cause of death in patients with severe sepsis?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 39:1050-5. 2011
    ..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis...
  44. ncbi Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 34:1918-24. 2006
    ..We investigated whether DAA can influence microcirculatory alterations in patients with severe sepsis...
  45. ncbi Do all nonsurvivors of cardiogenic shock die with a low cardiac index?
    Noelle Lim
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 124:1885-91. 2003
    ..To characterize the hemodynamic course of cardiogenic shock and to relate the cause of death to ongoing cardiac failure or multiple organ dysfunction...
  46. ncbi Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Am Heart J 147:91-9. 2004
    ..We hypothesized that microvascular blood flow alterations are present in patients with severe heart failure and cardiogenic shock...
  47. ncbi Microvascular response to red blood cell transfusion in patients with severe sepsis
    Yasser Sakr
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 35:1639-44. 2007
    ..The effects of red blood cell transfusions on microvascular perfusion are not well defined. We investigated the effects of red blood cell transfusion on sublingual microvascular perfusion in patients with sepsis...
  48. ncbi International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
    ..Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections...
  49. doi Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Int J Antimicrob Agents 37:531-5. 2011
    ..The therapeutic benefit of high-dose aminoglycoside therapy should be balanced with its potential renal effects in septic patients receiving CRRT...
  50. ncbi Microcirculatory effects of angiotensin II inhibitors in patients with severe heart failure
    Diamantino Ribeiro Salgado
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, Brussels, Belgium
    Clin Hemorheol Microcirc 54:87-98. 2013
    ..The renin-angiotensin system is activated in patients with acute severe heart failure, and increased levels of angiotensin II could contribute to microcirculatory defects in these patients...
  51. ncbi Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetin alfa in critically ill patients: results of a randomized, double-blind, placebo-controlled trial
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:1661-7. 2006
    ..Secondary objectives were to compare pharmacodynamic and safety profiles between active treatment and placebo in these patients...
  52. ncbi Fever control in septic shock: beneficial or harmful?
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, 1070 B, Belgium
    Shock 23:516-20. 2005
    ..Antipyretic interventions including acetaminophen and external cooling were associated with lower circulating HSP70 levels. These data challenge the temperature control practices often used routinely in acutely ill patients...
  53. pmc Reducing mortality in sepsis: new directions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Crit Care 6:S1-18. 2002
    ....
  54. ncbi Use of the sequential organ failure assessment score as a severity score
    André Carlos Kajdacsy-Balla Amaral
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:243-9. 2005
    ..To evaluate whether the SOFA score can be used to develop a model to predict intensive care unit (ICU) mortality in different countries...
  55. ncbi Post mortem examination in the intensive care unit: still useful?
    George Dimopoulos
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:2080-5. 2004
    ..Post mortem examination rates have decreased worldwide and their usefulness has been challenged. The aim of this study was to compare ante- versus post mortem findings in a multidisciplinary ICU...
  56. doi ARDS of early or late onset: does it make a difference?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels
    Chest 137:81-7. 2010
    ..We used data from a large, multicenter observational study to assess whether late-onset ARDS was similarly associated with worse outcomes compared with early-onset ARDS...
  57. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
    ..To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients...
  58. ncbi The epidemiology of acute respiratory failure in critically ill patients(*)
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Chest 121:1602-9. 2002
    ..To describe the risk factors for the development of and mortality resulting from acute respiratory failure (ARF) in a large patient population...
  59. ncbi Septic shock of early or late onset: does it matter?
    Oscar Roman-Marchant
    Department of Intensive Care Medicine, Erasme University Hospital, Free University of Brussels, Belgium
    Chest 126:173-8. 2004
    ..To determine possible differences in morbidity and mortality between early and late onset of septic shock in ICU patients...
  60. ncbi The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction
    Daliana Peres Bota
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 28:1619-24. 2002
    ..To compare outcome prediction using the Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA), two of the systems most commonly used to evaluate organ dysfunction in the intensive care unit (ICU)...
  61. doi ICU nephrology: the implications of cardiovascular alterations in the acutely ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Kidney Int 81:1060-6. 2012
    ..In this text, we will return to the basic physiology of cardiac output and its components so that we can better understand the effects of cardiovascular alterations in critically ill patients, and how best to treat them...
  62. ncbi Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests
    Valerie Siraux
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 33:2479-86. 2005
    ..To compare a low-dose (1 microg) corticotropin stimulation test with the more standard (250 microg) test for the diagnosis of relative adrenal insufficiency...
  63. ncbi Are infections due to resistant pathogens associated with a worse outcome in critically ill patients?
    Daliana Peres-Bota
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    J Infect 47:307-16. 2003
    ..To evaluate the outcome of critically ill patients infected with antimicrobial resistant microorganisms, and to analyse the factors involved in the development of antimicrobial resistance...
  64. pmc Effects of changes in arterial pressure on organ perfusion during septic shock
    Aurélie Thooft
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:R222. 2011
    ..The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock...
  65. ncbi Evidence-based medicine in the ICU: important advances and limitations
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Chest 126:592-600. 2004
    ..Here, we will outline the limitations and advances of EBM in intensive care medicine, by discussing the key findings in the last few years from studies of therapeutic agents for ICU patients...
  66. ncbi Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, Brussels, Belgium
    Clin Chest Med 27:725-31; abstract x-xi. 2006
    ..Improved understanding of the systemic factors involved in the development and evolution of ARDS and MODS should facilitate the development of new therapeutic agents that will improve outcomes in these patients...
  67. ncbi Association between the TNF-2 allele and a better survival in cardiogenic shock
    Olivier Appoloni
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Chest 125:2232-7. 2004
    ..We explored a possible association between TNF-alpha, interleukin (IL)-6, IL-10, transforming growth factor (TGF)-beta, and interferon (IFN)-gamma cytokine polymorphisms, their in vivo production, and mortality from cardiogenic shock...
  68. ncbi Comparison of continuous thermodilution and bolus cardiac output measurements in septic shock
    Qinghua Sun
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 28:1276-80. 2002
    ..To compare continuous (CCO) and bolus (BCO) thermodilution cardiac output measurement techniques over a wide range of cardiac outputs and blood temperatures in a septic sheep model...
  69. ncbi Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital and University of Brussels, Brussels, Belgium
    Crit Care Med 33:2266-77. 2005
    ..To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis...
  70. ncbi Oxygen transport-the oxygen delivery controversy
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:1990-6. 2004
  71. ncbi Beneficial effects of ethyl pyruvate in septic shock from peritonitis
    Fuhong Su
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Arch Surg 142:166-71. 2007
    ..Infusion of ethyl pyruvate (EP) solution can improve outcome in a clinically relevant, large- animal model of septic shock resulting from fecal peritonitis...
  72. ncbi The changing pattern of acute respiratory distress syndrome over time: a comparison of two periods
    Charalampos Pierrakos
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Eur Respir J 40:589-95. 2012
    ..Patients with ARDS are now older and more severely ill. Sepsis-related ARDS is more frequent whereas trauma-related and/or transfusion-related ARDS has decreased. MOF still represents the most frequent cause of death...
  73. doi Current management of sepsis in critically ill adult patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Expert Rev Anti Infect Ther 9:847-56. 2011
    ..We will review current approaches to each of these categories...
  74. ncbi How to approach sepsis today?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 144:350-61. 2004
  75. pmc suPAR as a prognostic biomarker in sepsis
    Katia Donadello
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, 808, Route de Lennik 1070, Brussels, Belgium
    BMC Med 10:2. 2012
    ..This narrative review provides a descriptive overview of the clinical value of this biomarker in the diagnosis, prognosis and therapeutic guidance of sepsis...
  76. doi Sublingual and muscular microcirculatory alterations after cardiac arrest: a pilot study
    Katia Donadello
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Resuscitation 82:690-5. 2011
    ..We investigated microvascular density and reactivity in the early phase following cardiac arrest...
  77. ncbi Management of sepsis in the critically ill patient: key aspects
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Expert Opin Pharmacother 7:2037-45. 2006
    ..Every effort must be made to identify sepsis early so as to optimise the patient's chances of a good outcome...
  78. ncbi Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care Med 31:1659-67. 2003
    ..To assess the effects of different doses of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in patients with septic shock...
  79. pmc Insulin-treated diabetes is not associated with increased mortality in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R12. 2010
    ..This was a planned substudy from the European observational Sepsis Occurrence in Acutely ill Patients (SOAP) study to investigate the possible impact of insulin-treated diabetes on morbidity and mortality in ICU patients...
  80. ncbi Management of septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 80, B 1070 Brussels, Belgium
    Ann Med 34:606-13. 2002
    ..While intensive early resuscitation remains the cornerstone of management, new approaches are beginning to form part of sepsis management protocols and will lead to improved outcomes for patients with this disease process...
  81. pmc Cerebral microcirculation is impaired during sepsis: an experimental study
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R140. 2010
    ..Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock...
  82. ncbi Efficacy of allogeneic red blood cell transfusions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 21:209-19. 2007
    ..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
  83. doi Cardiovascular and microvascular responses to mild hypothermia in an ovine model
    Xinrong He
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Resuscitation 83:760-6. 2012
    ..The aim of this study was to evaluate the cardiovascular and microvascular responses to mild therapeutic hypothermia (MTH) in an ovine model...
  84. pmc Optimal meropenem concentrations to treat multidrug-resistant Pseudomonas aeruginosa septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Antimicrob Agents Chemother 56:2129-31. 2012
    ..High MEM dosage may represent a valuable therapeutic option for infection due to multidrug-resistant (MDR) strains, and drug monitoring would allow rapid regimen adjustment in clinical practice...
  85. ncbi Drotrecogin alfa: a new approach in the treatment of severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    Expert Opin Biol Ther 2:659-64. 2002
    ..Although associated with an increased risk of bleeding, this is usually procedure-related rather than spontaneous. Although costly, this is a drug that effectively reduces mortality rates in patients with severe sepsis...
  86. ncbi Classification, incidence, and outcomes of sepsis and multiple organ failure
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:64-74. 2007
    ..Sepsis and multiple organ failure are common complications in intensive care unit (ICU) patients and are associated with considerable morbidity and mortality...
  87. ncbi Metabolic support in sepsis and multiple organ failure: more questions than answers
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 35:S436-40. 2007
    ....
  88. ncbi Beneficial effects of recombinant human activated protein C in a ewe model of septic shock
    Zhen Wang
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 35:2594-600. 2007
    ..To investigate the effects of activated protein C (APC) in a clinically relevant animal model of septic shock...
  89. doi Cerebral autoregulation is influenced by carbon dioxide levels in patients with septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles ULB, Route de Lennik, 808, 1070, Brussels, Belgium
    Neurocrit Care 12:35-42. 2010
    ..The purpose of this study was to evaluate the influence of PaCO2 on the cerebral autoregulatory capacity in patients with septic shock...
  90. doi Critical care: advances and future perspectives
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Lancet 376:1354-61. 2010
    ....
  91. doi Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock
    Diamantino Ribeiro Salgado
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Shock 35:542-9. 2011
    ....
  92. pmc Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies
    Jean Louis Vincent
    Department of Intensive Care, University of Brussels, Erasme Hospital, Brussels, Belgium
    Crit Care 9:R331-43. 2005
    ....
  93. ncbi Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock
    Jean Charles Preiser
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Shock 20:465-8. 2003
    ..In the presence of endotoxin, ODQ administration increased MBF and prevented the restoration of FBF. Hence, selective inhibition of sGC may increase splanchnic blood flow in septic shock...
  94. ncbi Microcirculatory alterations in cardiac surgery: effects of cardiopulmonary bypass and anesthesia
    Daniel De Backer
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Ann Thorac Surg 88:1396-403. 2009
    ..Heterogeneity in microvascular perfusion is associated with impaired tissue oxygenation. We hypothesized that cardiac surgery with or without cardiopulmonary bypass (CPB) could induce microvascular alterations...
  95. ncbi Microcirculatory abnormalities in patients with severe influenza A (H1N1) infection
    Diamantino R Salgado
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles ULB, 808 Route de Lennik, B 1070 Brussels, Belgium
    Can J Anaesth 57:940-6. 2010
    ..This study was designed to evaluate the degree of microcirculatory abnormalities in patients with severe influenza A (H1N1) infection...
  96. doi Nonhematological organ dysfunction and positive fluid balance are important determinants of outcome in adults with severe dengue infection: a multicenter study from India
    Linda Schmitz
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    J Crit Care 26:441-8. 2011
    ..The purpose of the study was to explore determinants of outcome in adults with dengue hemorrhagic fever or dengue shock syndrome...
  97. ncbi Comparison of clinical and post-mortem findings in intensive care unit patients
    Calliope Maris
    Department of Pathology, Erasme University Hospital, 808 Route de Lennik, Brussels, 1070, Belgium
    Virchows Arch 450:329-33. 2007
    ..Although the incidence of unexpected findings with clinical significance was low, post-mortem examination remains a valuable source of pertinent information that may improve the management of ICU patients...
  98. pmc How can the response to volume expansion in patients with spontaneous respiratory movements be predicted?
    Sarah Heenen
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808, B 1070 Brussels, Belgium
    Crit Care 10:R102. 2006
    ..The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements...
  99. ncbi The prognostic value of muscle StO2 in septic patients
    Jacques Creteur
    Erasme University Hospital, Free University of Brussels, Department of Intensive Care, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 33:1549-56. 2007
    ..To quantify sepsis-induced alterations in changes in muscle tissue oxygenation (StO(2)) after an ischemic challenge using near-infrared spectroscopy (NIRS), and to test the hypothesis that these alterations are related to outcome...
  100. ncbi Drotrecogin alfa (activated) in the treatment of severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Curr Drug Saf 2:227-31. 2007
    ....
  101. doi Biomarkers in the critically ill patient: C-reactive protein
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808, Route de Lennik, 1070, Brussels, Belgium
    Crit Care Clin 27:241-51. 2011
    ..However, CRP is not specific for sepsis, and serum CRP concentrations need to be interpreted in the context of a full clinical examination and the presence of other signs and symptoms of sepsis...