Jean Louis Vincent

Summary

Country: Belgium

Publications

  1. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
  2. ncbi request reprint Management of septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 80, B 1070 Brussels, Belgium
    Ann Med 34:606-13. 2002
  3. ncbi request reprint Selective digestive decontamination: for everyone, everywhere?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, 1070, Brussels, Belgium
    Lancet 362:1006-7. 2003
  4. doi request reprint Diagnosis, management and prevention of ventilator-associated pneumonia: an update
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Drugs 70:1927-44. 2010
  5. ncbi request reprint Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
  6. ncbi request reprint Information in the ICU: are we being honest with our patients? The results of a European questionnaire
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Intensive Care Med 24:1251-6. 1998
  7. pmc Is the current management of severe sepsis and septic shock really evidence based?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    PLoS Med 3:e346. 2006
  8. doi request reprint Clinical sepsis and septic shock--definition, diagnosis and management principles
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Langenbecks Arch Surg 393:817-24. 2008
  9. ncbi request reprint Anemia in the intensive care unit
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Can J Anaesth 50:S53-9. 2003
  10. doi request reprint Biomarkers in the critically ill patient: C-reactive protein
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808, Route de Lennik, 1070, Brussels, Belgium
    Crit Care Clin 27:241-51. 2011

Collaborators

Detail Information

Publications181 found, 100 shown here

  1. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
    ..To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients...
  2. ncbi request reprint Management of septic shock
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 80, B 1070 Brussels, Belgium
    Ann Med 34:606-13. 2002
    ..While intensive early resuscitation remains the cornerstone of management, new approaches are beginning to form part of sepsis management protocols and will lead to improved outcomes for patients with this disease process...
  3. ncbi request reprint Selective digestive decontamination: for everyone, everywhere?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, 1070, Brussels, Belgium
    Lancet 362:1006-7. 2003
  4. doi request reprint Diagnosis, management and prevention of ventilator-associated pneumonia: an update
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Drugs 70:1927-44. 2010
    ....
  5. ncbi request reprint Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  6. ncbi request reprint Information in the ICU: are we being honest with our patients? The results of a European questionnaire
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Intensive Care Med 24:1251-6. 1998
    ..We were interested in determining the current practices and views of European intensive care doctors regarding communication with patients and informed consent for interventions...
  7. pmc Is the current management of severe sepsis and septic shock really evidence based?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    PLoS Med 3:e346. 2006
  8. doi request reprint Clinical sepsis and septic shock--definition, diagnosis and management principles
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Langenbecks Arch Surg 393:817-24. 2008
    ..Sepsis remains a common problem in critically ill patients...
  9. ncbi request reprint Anemia in the intensive care unit
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Can J Anaesth 50:S53-9. 2003
  10. doi request reprint Biomarkers in the critically ill patient: C-reactive protein
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808, Route de Lennik, 1070, Brussels, Belgium
    Crit Care Clin 27:241-51. 2011
    ..However, CRP is not specific for sepsis, and serum CRP concentrations need to be interpreted in the context of a full clinical examination and the presence of other signs and symptoms of sepsis...
  11. doi request reprint Is worsening multiple organ failure the cause of death in patients with severe sepsis?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 39:1050-5. 2011
    ..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis...
  12. ncbi request reprint Why do patients who have acute lung injury/acute respiratory distress syndrome die from multiple organ dysfunction syndrome? Implications for management
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, Brussels, Belgium
    Clin Chest Med 27:725-31; abstract x-xi. 2006
    ..Improved understanding of the systemic factors involved in the development and evolution of ARDS and MODS should facilitate the development of new therapeutic agents that will improve outcomes in these patients...
  13. ncbi request reprint Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 26:1793-800. 1998
    ..To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients...
  14. ncbi request reprint Morbidity in hospitalized patients receiving human albumin: a meta-analysis of randomized, controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Crit Care Med 32:2029-38. 2004
    ..To determine the effect of albumin administration on morbidity in acutely ill hospitalized patients...
  15. ncbi request reprint Scoring systems for assessing organ dysfunction and survival
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Clin 16:353-66. 2000
    ....
  16. ncbi request reprint Drotrecogin alpha (activated): the treatment for severe sepsis?
    Jean Louis Vincent
    Free University of Brussels, Erasme University Hospital, Department of Intensive Care, Route de Lennik, 808, B 1070 Brussels, Belgium
    Expert Opin Biol Ther 7:1763-77. 2007
    ..Ongoing studies will help define which patients are most likely to benefit, perhaps with the help of biochemical markers...
  17. ncbi request reprint Evolving concepts in sepsis definitions
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Clin 25:665-75, vii. 2009
    ....
  18. ncbi request reprint Cultural differences in end-of-life care
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 29:N52-5. 2001
    ..Open discussion of these issues and some change in our attitude toward life and death are needed to enable such patients to have a pain-free, dignified death...
  19. ncbi request reprint EPIC II: sepsis around the world
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Minerva Anestesiol 74:293-6. 2008
  20. ncbi request reprint International study of the prevalence and outcomes of infection in intensive care units
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    JAMA 302:2323-9. 2009
    ..Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections...
  21. ncbi request reprint Ventilator associated pneumonia: risk factors and preventive measures
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free Unversity of Brussels, Belgium
    J Chemother 13:211-7. 2001
    ..Methods to improve host defense include early nutrition. Immunostimulatory therapies, such as interferon and granulocyte colony stimulating factor, require further research to confirm their place in the prevention or management of VAP...
  22. ncbi request reprint Infection/inflammation and hemostasis
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Curr Hematol Rep 2:407-10. 2003
    ..Among these agents, recombinant activated protein C has been shown to improve outcome, which is an exciting development in the search for effective treatments for patients with severe sepsis...
  23. ncbi request reprint Which therapeutic interventions in critical care medicine have been shown to reduce mortality in prospective, randomized, clinical trials? A survey of candidates for the Belgian Board Examination in Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 28:1616-20. 2000
    ....
  24. ncbi request reprint Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium Electronic address
    Lancet Respir Med 2:380-6. 2014
    ..We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality...
  25. pmc Critical care--where have we been and where are we going?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 17:S2. 2013
    ....
  26. doi request reprint A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:2069-79. 2013
    ..To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation...
  27. ncbi request reprint Management of the critically ill patient with severe sepsis
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    J Chemother 11:524-9. 1999
    ..Further research will allow better definition of the septic patient according to immune status and enable more effective targeting of future anti-sepsis treatments...
  28. ncbi request reprint Critical care nephrology: a multidisciplinary approach
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:24-31. 2007
    ..Acute renal failure in the ICU frequently occurs as part of multiple organ failure (MOF)...
  29. ncbi request reprint [The intensive care department]
    J L Vincent
    Rev Med Brux 23:163-6. 2002
    ..The quality of care, clinical, scientific and personal, offered by the Department of Intensive Care at Erasme Hospital has earned it the high level reputation for which it is renowned in Belgium, and indeed worldwide...
  30. ncbi request reprint Management of sepsis in the critically ill patient: key aspects
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Expert Opin Pharmacother 7:2037-45. 2006
    ..Every effort must be made to identify sepsis early so as to optimise the patient's chances of a good outcome...
  31. ncbi request reprint Sepsis and cirrhosis: many similarities
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Acta Gastroenterol Belg 73:472-8. 2010
    ..This article reviews the similarities and differences between sepsis and cirrhosis and defines the basis for the treatment of severe sepsis in cirrhotic patients...
  32. ncbi request reprint Microbial resistance: lessons from the EPIC study. European Prevalence of Infection
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Intensive Care Med 26:S3-8. 2000
    ....
  33. ncbi request reprint Efficacy of allogeneic red blood cell transfusions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 21:209-19. 2007
    ..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
  34. ncbi request reprint A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 23:400-5. 2005
    ..Treatment using the PMX cartridge is safe and may improve cardiac and renal dysfunction due to sepsis or septic shock. Further studies are needed to prove this effectiveness...
  35. ncbi request reprint The last 100 years of sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium 1070
    Am J Respir Crit Care Med 173:256-63. 2006
    ..Despite these changes, mortality rates remain unacceptably high and continued progress, particularly in early diagnosis and therapy, is urgently needed...
  36. ncbi request reprint A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Bruxelles, Belgium
    Intensive Care Med 27:1578-83. 2001
    ..To evaluate the safety of liposomal PGE1 (TLC C-53) in patients with acute respiratory distress syndrome (ARDS), and determine its efficacy in improving oxygenation and reducing ventilator dependency...
  37. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis
    Jean Louis Vincent
    Erasme University Hospital, Department of Intensive Care, Route de Lennik, 808, B 1070 Brussels, Belgium
    Expert Rev Anti Infect Ther 4:537-47. 2006
    ..Administration of drotrecogin alfa (activated) is associated with an increased risk of bleeding and its use is contraindicated in patients with a high risk of bleeding or recent hemorrhagic events...
  38. ncbi request reprint Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock
    Zhen Wang
    Department of Intensive Care, Erasme Hospital, Route de Lennik 808, 1070 B Brussels, Belgium
    Am J Respir Crit Care Med 177:178-83. 2008
    ..Hypercapnia has similar hemodynamic effects to those of a dobutamine infusion and may have relevance in the management of septic shock...
  39. ncbi request reprint Intensive care and emergency medicine: progress over the past 25 years
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Chest 129:1061-7. 2006
    ....
  40. doi request reprint Acute kidney injury, acute lung injury and septic shock: how does mortality compare?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Contrib Nephrol 174:71-7. 2011
    ....
  41. doi request reprint Microcirculatory alterations in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Hosp Pract (1995) 37:107-12. 2009
    ..Whether monitoring the microcirculation can be used to guide therapy remains unclear and requires further study, and this is an exciting field of ongoing research...
  42. pmc Clinical review: Respiratory monitoring in the ICU - a consensus of 16
    Laurent Brochard
    Department of Intensive Care, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, 1211 Geneva, Switzerland
    Crit Care 16:219. 2012
    ..In this consensus paper, we provide an overview of the important parameters that can and should be monitored in the critically ill patient with respiratory failure and discuss how the data provided can impact on clinical management...
  43. pmc Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Ann Intensive Care 2:13. 2012
    ..abstract:..
  44. pmc Microcirculatory alterations: potential mechanisms and implications for therapy
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Ann Intensive Care 1:27. 2011
    ..In conclusion, microcirculatory alterations may play an important role in the development of sepsis-related organ dysfunction. At this stage, therapies to target microcirculation specifically are still being investigated...
  45. doi request reprint Diagnostic and prognostic markers in sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Expert Rev Anti Infect Ther 11:265-75. 2013
    ..Some biomarkers may also be useful for prognosis and guiding therapy. Here, the authors will review our changing approaches to sepsis diagnosis and discuss some of the markers that seem most relevant at the present time...
  46. doi request reprint Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 16:182-6. 2013
    ....
  47. doi request reprint Septic shock: new pharmacotherapy options or better trial design?
    Jean Louis Vincent
    Universite Libre de Bruxelles, Erasme University Hospital, Department of Intensive Care, Route de Lennik, 808 1070 Brussels, Belgium
    Expert Opin Pharmacother 14:561-70. 2013
    ....
  48. pmc Intra-arrest hypothermia during cardiac arrest: a systematic review
    Sabino Scolletta
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 16:R41. 2012
    ..Therapeutic hypothermia is largely used to protect the brain following return of spontaneous circulation (ROSC) after cardiac arrest (CA), but it is unclear whether we should start therapeutic hypothermia earlier, that is, before ROSC...
  49. ncbi request reprint The pulmonary artery catheter
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Monit Comput 26:341-5. 2012
    ..Adequate and continued training are required to ensure that PAC-derived data are correctly interpreted and applied...
  50. ncbi request reprint The changing pattern of acute respiratory distress syndrome over time: a comparison of two periods
    Charalampos Pierrakos
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Eur Respir J 40:589-95. 2012
    ..Patients with ARDS are now older and more severely ill. Sepsis-related ARDS is more frequent whereas trauma-related and/or transfusion-related ARDS has decreased. MOF still represents the most frequent cause of death...
  51. pmc Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT)
    Alain Vuylsteke
    Department of Anaesthesia and Intensive Care, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, CB23 3RE, UK
    Crit Care 15:R271. 2011
    ....
  52. pmc suPAR as a prognostic biomarker in sepsis
    Katia Donadello
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, 808, Route de Lennik 1070, Brussels, Belgium
    BMC Med 10:2. 2012
    ..This narrative review provides a descriptive overview of the clinical value of this biomarker in the diagnosis, prognosis and therapeutic guidance of sepsis...
  53. doi request reprint ICU nephrology: the implications of cardiovascular alterations in the acutely ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Kidney Int 81:1060-6. 2012
    ..In this text, we will return to the basic physiology of cardiac output and its components so that we can better understand the effects of cardiovascular alterations in critically ill patients, and how best to treat them...
  54. pmc Effects of changes in arterial pressure on organ perfusion during septic shock
    Aurélie Thooft
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:R222. 2011
    ..The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock...
  55. pmc Massive bleeding in polytrauma: how can we make progress?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:196. 2011
    ..In the present commentary, we reflect on how we can move forward in the management of severely bleeding trauma patients in the current environment...
  56. pmc Fluid management: the pharmacoeconomic dimension
    J L Vincent
    Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care 4:S33-5. 2000
    ..Rigorously designed pharmacoeconomic studies are needed to delineate the costs and benefits of various approaches to fluid management...
  57. pmc Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
    Lucie Seyler
    Department of Infectious Diseases, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 15:R137. 2011
    ..We studied whether these recommendations met optimal pharmacokinetic criteria for broad-spectrum antibiotic levels in septic shock patients undergoing CRRT...
  58. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
    ..The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia...
  59. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
    ..The purpose of this study was to evaluate the dose and duration of drotrecogin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis...
  60. pmc Withdrawing may be preferable to withholding
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:226-9. 2005
    ..In this article, I will provide arguments why, although the two actions are indeed ethically equivalent, withdrawing life-sustaining therapy may in fact be preferable to withholding...
  61. pmc Sepsis biomarkers: a review
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 14:R15. 2010
    ..Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy...
  62. pmc How can the response to volume expansion in patients with spontaneous respiratory movements be predicted?
    Sarah Heenen
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808, B 1070 Brussels, Belgium
    Crit Care 10:R102. 2006
    ..The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements...
  63. pmc Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies
    Jean Louis Vincent
    Department of Intensive Care, University of Brussels, Erasme Hospital, Brussels, Belgium
    Crit Care 9:R331-43. 2005
    ....
  64. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
    ..Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes...
  65. pmc Characteristics and outcomes of cancer patients in European ICUs
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care 13:R15. 2009
    ..The aim of this study was to assess the characteristics of critically ill cancer patients, and to evaluate their prognosis...
  66. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
    ..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes...
  67. pmc Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Bruxelles, Belgium
    Crit Care 14:R53. 2010
    ..The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients...
  68. pmc Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R126. 2010
    ..The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock...
  69. pmc Infections of respiratory or abdominal origin in ICU patients: what are the differences?
    Elena Volakli
    Dept of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:R32. 2010
    ..We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival...
  70. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
    ....
  71. pmc Cerebral microcirculation is impaired during sepsis: an experimental study
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R140. 2010
    ..Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock...
  72. pmc The PIRO concept: I is for infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 7:252-5. 2003
  73. pmc Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 9:R745-54. 2005
    ..Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome...
  74. pmc Role of iron in anaemic critically ill patients: it's time to investigate!
    Michael Piagnerelli
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 8:306-7. 2004
    ..Little information is available on the precise role of alterations of iron metabolism in the development of iron anaemia in critically ill patients...
  75. pmc Surviving sepsis: a guide to the guidelines
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 12:162. 2008
    ..The revised guidelines are far from perfect, but they represent the best available synthesis of contemporary knowledge in this area and as such should be promoted...
  76. doi request reprint Evolving concepts in sepsis definitions
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Nurs Clin North Am 23:29-39. 2011
    ..Systems, such as PIRO, that can characterize patients according to their likely prognosis and response to a specific therapy need to be further developed so that treatments can be appropriately directed for individual patients...
  77. pmc Red blood cell transfusion in the critically ill patient
    Christophe Lelubre
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Ann Intensive Care 1:43. 2011
    ..Emphasis is placed on the importance of personalizing blood transfusion according to physiological endpoints rather than arbitrary thresholds...
  78. ncbi request reprint Type of fluid in severe sepsis and septic shock
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Minerva Anestesiol 77:1190-6. 2011
    ..We will then briefly summarize the limited evidence to support use of one fluid type over another, and provide general suggestions for fluid use in these patients...
  79. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Curr Drug Saf 2:227-31. 2007
    ....
  80. ncbi request reprint Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Anesthesiology 108:31-9. 2008
    ..The authors investigated the relation of blood transfusion to mortality in European intensive care units (ICUs)...
  81. ncbi request reprint Critically elucidating the role of selenium
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Anaesthesiol 21:148-54. 2008
    ..To assess the current role of selenium supplementation in critically ill patients...
  82. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  83. ncbi request reprint Physiology and pathophysiology of the vasopressinergic system
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 22:243-52. 2008
    ....
  84. ncbi request reprint [Acute renal failure in the intensive care unit: which technique of renal replacement therapy?]
    J L Vincent
    Service des Soins Intensifs, Hopital Erasme, U L B, Bruxelles
    Rev Med Brux 29:S9-13. 2008
    ..In the future, new markers of renal dysfunction may facilitate treatment choices...
  85. doi request reprint Current management of sepsis in critically ill adult patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Expert Rev Anti Infect Ther 9:847-56. 2011
    ..We will review current approaches to each of these categories...
  86. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
    ....
  87. doi request reprint We should abandon randomized controlled trials in the intensive care unit
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 38:S534-8. 2010
    ..In this article, we will discuss the limitations of randomized controlled trials in the intensive care unit population and highlight the importance of considering other study designs in the challenging intensive care unit environment...
  88. ncbi request reprint The pulmonary artery catheter: in medio virtus
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:3093-6. 2008
    ..To clarify the role of the pulmonary artery catheter in the intensive care unit...
  89. pmc Insulin-treated diabetes is not associated with increased mortality in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R12. 2010
    ..This was a planned substudy from the European observational Sepsis Occurrence in Acutely ill Patients (SOAP) study to investigate the possible impact of insulin-treated diabetes on morbidity and mortality in ICU patients...
  90. ncbi request reprint Severity of illness
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Semin Respir Crit Care Med 31:31-8. 2010
    ..This article reviews the most commonly used severity of illness scoring systems and discusses some of their uses and limitations...
  91. doi request reprint Intensive care unit-acquired weakness: framing the topic
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:S296-8. 2009
    ..Management, therefore, relies on limiting its short- and long-term effects. One method by which this may be achieved is to reduce sedative use and promote early mobilization and exercise...
  92. pmc Clinical review: scoring systems in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:207. 2010
    ..All these scoring systems will need to be updated with time as ICU populations change and new diagnostic, therapeutic and prognostic techniques become available...
  93. doi request reprint ARDS of early or late onset: does it make a difference?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels
    Chest 137:81-7. 2010
    ..We used data from a large, multicenter observational study to assess whether late-onset ARDS was similarly associated with worse outcomes compared with early-onset ARDS...
  94. ncbi request reprint Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis
    Colin L Verdant
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:2875-81. 2009
    ..To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion...
  95. doi request reprint Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 38:283-7. 2010
    ..We present ten reasons why we believe this approach is not appropriate and may even be detrimental...
  96. ncbi request reprint Dopamine versus norepinephrine: is one better?
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Minerva Anestesiol 75:333-7. 2009
    ..Observational studies have provided conflicting results regarding the effects of these two drugs on outcomes, and results from a recently completed randomized controlled trial are eagerly waited...
  97. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome
    Jean Louis Vincent
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Belgium
    Crit Care Med 37:1874-80. 2009
    ..To evaluate the safety and efficacy of active site inactivated recombinant factor VIIa (FFR-rFVIIa) in patients with acute respiratory distress syndrome...