Jean Louis Vincent

Summary

Country: Belgium

Publications

  1. ncbi request reprint Classification, incidence, and outcomes of sepsis and multiple organ failure
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:64-74. 2007
  2. doi request reprint A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:2069-79. 2013
  3. ncbi request reprint The last 100 years of sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium 1070
    Am J Respir Crit Care Med 173:256-63. 2006
  4. ncbi request reprint Management of sepsis in the critically ill patient: key aspects
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Expert Opin Pharmacother 7:2037-45. 2006
  5. ncbi request reprint [The intensive care department]
    J L Vincent
    Rev Med Brux 23:163-6. 2002
  6. ncbi request reprint A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 23:400-5. 2005
  7. ncbi request reprint Critical care nephrology: a multidisciplinary approach
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:24-31. 2007
  8. ncbi request reprint A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Bruxelles, Belgium
    Intensive Care Med 27:1578-83. 2001
  9. doi request reprint Microcirculatory alterations in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Hosp Pract (1995) 37:107-12. 2009
  10. ncbi request reprint Intensive care and emergency medicine: progress over the past 25 years
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Chest 129:1061-7. 2006

Collaborators

Detail Information

Publications169 found, 100 shown here

  1. ncbi request reprint Classification, incidence, and outcomes of sepsis and multiple organ failure
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:64-74. 2007
    ..Sepsis and multiple organ failure are common complications in intensive care unit (ICU) patients and are associated with considerable morbidity and mortality...
  2. doi request reprint A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 41:2069-79. 2013
    ..To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation...
  3. ncbi request reprint The last 100 years of sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium 1070
    Am J Respir Crit Care Med 173:256-63. 2006
    ..Despite these changes, mortality rates remain unacceptably high and continued progress, particularly in early diagnosis and therapy, is urgently needed...
  4. ncbi request reprint Management of sepsis in the critically ill patient: key aspects
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Expert Opin Pharmacother 7:2037-45. 2006
    ..Every effort must be made to identify sepsis early so as to optimise the patient's chances of a good outcome...
  5. ncbi request reprint [The intensive care department]
    J L Vincent
    Rev Med Brux 23:163-6. 2002
    ..The quality of care, clinical, scientific and personal, offered by the Department of Intensive Care at Erasme Hospital has earned it the high level reputation for which it is renowned in Belgium, and indeed worldwide...
  6. ncbi request reprint A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 23:400-5. 2005
    ..Treatment using the PMX cartridge is safe and may improve cardiac and renal dysfunction due to sepsis or septic shock. Further studies are needed to prove this effectiveness...
  7. ncbi request reprint Critical care nephrology: a multidisciplinary approach
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 156:24-31. 2007
    ..Acute renal failure in the ICU frequently occurs as part of multiple organ failure (MOF)...
  8. ncbi request reprint A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, 1070 Bruxelles, Belgium
    Intensive Care Med 27:1578-83. 2001
    ..To evaluate the safety of liposomal PGE1 (TLC C-53) in patients with acute respiratory distress syndrome (ARDS), and determine its efficacy in improving oxygenation and reducing ventilator dependency...
  9. doi request reprint Microcirculatory alterations in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Hosp Pract (1995) 37:107-12. 2009
    ..Whether monitoring the microcirculation can be used to guide therapy remains unclear and requires further study, and this is an exciting field of ongoing research...
  10. ncbi request reprint Intensive care and emergency medicine: progress over the past 25 years
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme University Hospital, Route de Lennik 808, 1070 Brussels, Belgium
    Chest 129:1061-7. 2006
    ....
  11. ncbi request reprint Acute hypercapnia improves indices of tissue oxygenation more than dobutamine in septic shock
    Zhen Wang
    Department of Intensive Care, Erasme Hospital, Route de Lennik 808, 1070 B Brussels, Belgium
    Am J Respir Crit Care Med 177:178-83. 2008
    ..Hypercapnia has similar hemodynamic effects to those of a dobutamine infusion and may have relevance in the management of septic shock...
  12. ncbi request reprint Management of the critically ill patient with severe sepsis
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    J Chemother 11:524-9. 1999
    ..Further research will allow better definition of the septic patient according to immune status and enable more effective targeting of future anti-sepsis treatments...
  13. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis
    Jean Louis Vincent
    Erasme University Hospital, Department of Intensive Care, Route de Lennik, 808, B 1070 Brussels, Belgium
    Expert Rev Anti Infect Ther 4:537-47. 2006
    ..Administration of drotrecogin alfa (activated) is associated with an increased risk of bleeding and its use is contraindicated in patients with a high risk of bleeding or recent hemorrhagic events...
  14. ncbi request reprint Microbial resistance: lessons from the EPIC study. European Prevalence of Infection
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Intensive Care Med 26:S3-8. 2000
    ....
  15. doi request reprint Acute kidney injury, acute lung injury and septic shock: how does mortality compare?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Contrib Nephrol 174:71-7. 2011
    ....
  16. ncbi request reprint Sepsis and cirrhosis: many similarities
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Acta Gastroenterol Belg 73:472-8. 2010
    ..This article reviews the similarities and differences between sepsis and cirrhosis and defines the basis for the treatment of severe sepsis in cirrhotic patients...
  17. ncbi request reprint Efficacy of allogeneic red blood cell transfusions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 21:209-19. 2007
    ..In this article, several key factors influencing the systemic and regional efficacy of blood transfusion will be reviewed...
  18. pmc Clinical review: Respiratory monitoring in the ICU - a consensus of 16
    Laurent Brochard
    Department of Intensive Care, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, 1211 Geneva, Switzerland
    Crit Care 16:219. 2012
    ..In this consensus paper, we provide an overview of the important parameters that can and should be monitored in the critically ill patient with respiratory failure and discuss how the data provided can impact on clinical management...
  19. pmc Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Ann Intensive Care 2:13. 2012
    ..abstract:..
  20. pmc Microcirculatory alterations: potential mechanisms and implications for therapy
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Ann Intensive Care 1:27. 2011
    ..In conclusion, microcirculatory alterations may play an important role in the development of sepsis-related organ dysfunction. At this stage, therapies to target microcirculation specifically are still being investigated...
  21. doi request reprint Diagnostic and prognostic markers in sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Expert Rev Anti Infect Ther 11:265-75. 2013
    ..Some biomarkers may also be useful for prognosis and guiding therapy. Here, the authors will review our changing approaches to sepsis diagnosis and discuss some of the markers that seem most relevant at the present time...
  22. doi request reprint Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 16:182-6. 2013
    ....
  23. doi request reprint Septic shock: new pharmacotherapy options or better trial design?
    Jean Louis Vincent
    Universite Libre de Bruxelles, Erasme University Hospital, Department of Intensive Care, Route de Lennik, 808 1070 Brussels, Belgium
    Expert Opin Pharmacother 14:561-70. 2013
    ....
  24. pmc Intra-arrest hypothermia during cardiac arrest: a systematic review
    Sabino Scolletta
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 16:R41. 2012
    ..Therapeutic hypothermia is largely used to protect the brain following return of spontaneous circulation (ROSC) after cardiac arrest (CA), but it is unclear whether we should start therapeutic hypothermia earlier, that is, before ROSC...
  25. doi request reprint The pulmonary artery catheter
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Monit Comput 26:341-5. 2012
    ..Adequate and continued training are required to ensure that PAC-derived data are correctly interpreted and applied...
  26. doi request reprint The changing pattern of acute respiratory distress syndrome over time: a comparison of two periods
    Charalampos Pierrakos
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Eur Respir J 40:589-95. 2012
    ..Patients with ARDS are now older and more severely ill. Sepsis-related ARDS is more frequent whereas trauma-related and/or transfusion-related ARDS has decreased. MOF still represents the most frequent cause of death...
  27. pmc Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT)
    Alain Vuylsteke
    Department of Anaesthesia and Intensive Care, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, CB23 3RE, UK
    Crit Care 15:R271. 2011
    ....
  28. pmc suPAR as a prognostic biomarker in sepsis
    Katia Donadello
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, 808, Route de Lennik 1070, Brussels, Belgium
    BMC Med 10:2. 2012
    ..This narrative review provides a descriptive overview of the clinical value of this biomarker in the diagnosis, prognosis and therapeutic guidance of sepsis...
  29. doi request reprint ICU nephrology: the implications of cardiovascular alterations in the acutely ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Bruxelles, Belgium
    Kidney Int 81:1060-6. 2012
    ..In this text, we will return to the basic physiology of cardiac output and its components so that we can better understand the effects of cardiovascular alterations in critically ill patients, and how best to treat them...
  30. pmc Effects of changes in arterial pressure on organ perfusion during septic shock
    Aurélie Thooft
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:R222. 2011
    ..The aim of this study was to assess the effects of increasing MAP using norepinephrine (NE) on hemodynamic and metabolic variables and on microvascular reactivity in patients with septic shock...
  31. pmc Massive bleeding in polytrauma: how can we make progress?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 15:196. 2011
    ..In the present commentary, we reflect on how we can move forward in the management of severely bleeding trauma patients in the current environment...
  32. pmc Fluid management: the pharmacoeconomic dimension
    J L Vincent
    Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care 4:S33-5. 2000
    ..Rigorously designed pharmacoeconomic studies are needed to delineate the costs and benefits of various approaches to fluid management...
  33. pmc Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy
    Lucie Seyler
    Department of Infectious Diseases, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 15:R137. 2011
    ..We studied whether these recommendations met optimal pharmacokinetic criteria for broad-spectrum antibiotic levels in septic shock patients undergoing CRRT...
  34. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
    ..The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia...
  35. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
    ..The purpose of this study was to evaluate the dose and duration of drotrecogin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis...
  36. pmc Withdrawing may be preferable to withholding
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:226-9. 2005
    ..In this article, I will provide arguments why, although the two actions are indeed ethically equivalent, withdrawing life-sustaining therapy may in fact be preferable to withholding...
  37. pmc Sepsis biomarkers: a review
    Charalampos Pierrakos
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 14:R15. 2010
    ..Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific therapies or assessing the response to therapy...
  38. pmc How can the response to volume expansion in patients with spontaneous respiratory movements be predicted?
    Sarah Heenen
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik, 808, B 1070 Brussels, Belgium
    Crit Care 10:R102. 2006
    ..The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements...
  39. pmc Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies
    Jean Louis Vincent
    Department of Intensive Care, University of Brussels, Erasme Hospital, Brussels, Belgium
    Crit Care 9:R331-43. 2005
    ....
  40. pmc Management of bleeding following major trauma: a European guideline
    Donat R Spahn
    Department of Anesthesiology, University Hospital Zurich, Zurich, Switzerland
    Crit Care 11:R17. 2007
    ..Evidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes...
  41. pmc Characteristics and outcomes of cancer patients in European ICUs
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care 13:R15. 2009
    ..The aim of this study was to assess the characteristics of critically ill cancer patients, and to evaluate their prognosis...
  42. pmc Management of bleeding following major trauma: an updated European guideline
    Rolf Rossaint
    Department of Anaesthesiology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
    Crit Care 14:R52. 2010
    ..Evidence-based recommendations are needed to guide the acute management of the bleeding trauma patient, which when implemented may improve patient outcomes...
  43. pmc Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Bruxelles, Belgium
    Crit Care 14:R53. 2010
    ..The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients...
  44. pmc Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R126. 2010
    ..The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock...
  45. pmc Infections of respiratory or abdominal origin in ICU patients: what are the differences?
    Elena Volakli
    Dept of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:R32. 2010
    ..We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival...
  46. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
    ....
  47. pmc Cerebral microcirculation is impaired during sepsis: an experimental study
    Fabio Silvio Taccone
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R140. 2010
    ..Cerebral microcirculatory alterations may play a role; however, experimental data are scarce. This study sought to investigate whether the cerebral microcirculation is altered in a clinically relevant animal model of septic shock...
  48. pmc The PIRO concept: I is for infection
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 7:252-5. 2003
  49. pmc Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 9:R745-54. 2005
    ..Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome...
  50. pmc Role of iron in anaemic critically ill patients: it's time to investigate!
    Michael Piagnerelli
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 8:306-7. 2004
    ..Little information is available on the precise role of alterations of iron metabolism in the development of iron anaemia in critically ill patients...
  51. doi request reprint Evolving concepts in sepsis definitions
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Nurs Clin North Am 23:29-39. 2011
    ..Systems, such as PIRO, that can characterize patients according to their likely prognosis and response to a specific therapy need to be further developed so that treatments can be appropriately directed for individual patients...
  52. ncbi request reprint Metabolic support in sepsis and multiple organ failure: more questions than answers
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 35:S436-40. 2007
    ....
  53. ncbi request reprint Vasopressin in hypotensive and shock states
    Jean Louis Vincent
    Service des Soins Intensifs, Hopital Universitaire Erasme, Route de Lennik 808, Brussels B 1070, Belgium
    Crit Care Clin 22:187-97, v. 2006
    ....
  54. pmc Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care 10:R74. 2006
    ....
  55. ncbi request reprint How to approach sepsis today?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Contrib Nephrol 144:350-61. 2004
  56. ncbi request reprint Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Anesthesiology 108:31-9. 2008
    ..The authors investigated the relation of blood transfusion to mortality in European intensive care units (ICUs)...
  57. pmc A reappraisal for the use of pulmonary artery catheters
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 10:S1. 2006
  58. doi request reprint We should abandon randomized controlled trials in the intensive care unit
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 38:S534-8. 2010
    ..In this article, we will discuss the limitations of randomized controlled trials in the intensive care unit population and highlight the importance of considering other study designs in the challenging intensive care unit environment...
  59. ncbi request reprint Dopamine versus norepinephrine: is one better?
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Minerva Anestesiol 75:333-7. 2009
    ..Observational studies have provided conflicting results regarding the effects of these two drugs on outcomes, and results from a recently completed randomized controlled trial are eagerly waited...
  60. ncbi request reprint Relevance of albumin in modern critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 23:183-91. 2009
    ..Albumin may be useful in some patients, especially those with hypoalbuminaemia at risk of complications or those with liver insufficiency. Further studies are needed to clarify what precise role albumin has in today's ICU...
  61. doi request reprint Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 38:283-7. 2010
    ..We present ten reasons why we believe this approach is not appropriate and may even be detrimental...
  62. doi request reprint Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis
    Colin L Verdant
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:2875-81. 2009
    ..To determine the relationship between sublingual and intestinal mucosal microcirculatory perfusion...
  63. doi request reprint ARDS of early or late onset: does it make a difference?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels
    Chest 137:81-7. 2010
    ..We used data from a large, multicenter observational study to assess whether late-onset ARDS was similarly associated with worse outcomes compared with early-onset ARDS...
  64. doi request reprint Severity of illness
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Belgium
    Semin Respir Crit Care Med 31:31-8. 2010
    ..This article reviews the most commonly used severity of illness scoring systems and discusses some of their uses and limitations...
  65. pmc Insulin-treated diabetes is not associated with increased mortality in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:R12. 2010
    ..This was a planned substudy from the European observational Sepsis Occurrence in Acutely ill Patients (SOAP) study to investigate the possible impact of insulin-treated diabetes on morbidity and mortality in ICU patients...
  66. pmc Clinical review: scoring systems in the critically ill
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, Belgium
    Crit Care 14:207. 2010
    ..All these scoring systems will need to be updated with time as ICU populations change and new diagnostic, therapeutic and prognostic techniques become available...
  67. doi request reprint A multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial assessing safety and efficacy of active site inactivated recombinant factor VIIa in subjects with acute lung injury or acute respiratory distress syndrome
    Jean Louis Vincent
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Belgium
    Crit Care Med 37:1874-80. 2009
    ..To evaluate the safety and efficacy of active site inactivated recombinant factor VIIa (FFR-rFVIIa) in patients with acute respiratory distress syndrome...
  68. doi request reprint Non-heart-beating donation: ethical aspects
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Transplant Proc 41:576-8. 2009
    ....
  69. doi request reprint Logistics of large international trials: the good, the bad, and the ugly
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:S75-9. 2009
    ..In this article we will discuss the good, the bad, and the potentially ugly side of international clinical trials in intensive care...
  70. doi request reprint Critically elucidating the role of selenium
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Curr Opin Anaesthesiol 21:148-54. 2008
    ..To assess the current role of selenium supplementation in critically ill patients...
  71. doi request reprint Critical care: advances and future perspectives
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Lancet 376:1354-61. 2010
    ....
  72. ncbi request reprint [Acute renal failure in the intensive care unit: which technique of renal replacement therapy?]
    J L Vincent
    Service des Soins Intensifs, Hopital Erasme, U L B, Bruxelles
    Rev Med Brux 29:S9-13. 2008
    ..In the future, new markers of renal dysfunction may facilitate treatment choices...
  73. pmc Surviving sepsis: a guide to the guidelines
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Crit Care 12:162. 2008
    ..The revised guidelines are far from perfect, but they represent the best available synthesis of contemporary knowledge in this area and as such should be promoted...
  74. ncbi request reprint Physiology and pathophysiology of the vasopressinergic system
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Best Pract Res Clin Anaesthesiol 22:243-52. 2008
    ....
  75. ncbi request reprint Drotrecogin alfa (activated) in the treatment of severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Curr Drug Saf 2:227-31. 2007
    ....
  76. doi request reprint The pulmonary artery catheter: in medio virtus
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 36:3093-6. 2008
    ..To clarify the role of the pulmonary artery catheter in the intensive care unit...
  77. doi request reprint Defining sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium
    Clin Chest Med 29:585-90, vii. 2008
    ....
  78. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  79. pmc Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:S9-12. 2005
    ....
  80. pmc Ethics roundtable debate: A patient dies from an ICU-acquired infection related to methicillin-resistant Staphylococcus aureus--how do you defend your case and your team?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 9:5-9. 2005
    ..The family decides to sue. We present how experts from four different countries assess the medicolegal issues involved in this case...
  81. ncbi request reprint Nosocomial infection and outcome
    Jean Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Nutrition 18:713-4. 2002
  82. ncbi request reprint Epidemiology and outcome in renal failure
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Bruxelles, Belgium
    Int J Artif Organs 27:1013-8. 2004
    ..In this review we will discuss the epidemiology of ARF within the limitations imposed by comparing studies that use different definitions and focus on different patient populations...
  83. doi request reprint Intensive care unit-acquired weakness: framing the topic
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care Med 37:S296-8. 2009
    ..Management, therefore, relies on limiting its short- and long-term effects. One method by which this may be achieved is to reduce sedative use and promote early mobilization and exercise...
  84. ncbi request reprint Infection control in the intensive care unit
    Jean Louis Vincent
    Free University of Brussels, Department of Intensive Care, Erasme Hospital, Brussels, Belgium
    Expert Rev Anti Infect Ther 2:795-805. 2004
    ....
  85. pmc The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is dopamine rather than norepinephrine
    Jean Louis Vincent
    Head, Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care 7:6-8. 2003
  86. ncbi request reprint Evidence-based medicine in the ICU: important advances and limitations
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Chest 126:592-600. 2004
    ..Here, we will outline the limitations and advances of EBM in intensive care medicine, by discussing the key findings in the last few years from studies of therapeutic agents for ICU patients...
  87. ncbi request reprint Oxygen transport-the oxygen delivery controversy
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 30:1990-6. 2004
  88. ncbi request reprint Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium
    Crit Care Med 31:834-40. 2003
    ..To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated)...
  89. ncbi request reprint Ethical principles in end-of-life decisions in different European countries
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Swiss Med Wkly 134:65-8. 2004
    ..Here we will discuss the current situation across Europe, based on the findings from three large international studies...
  90. pmc Red blood cell transfusion in the critically ill patient
    Christophe Lelubre
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Ann Intensive Care 1:43. 2011
    ..Emphasis is placed on the importance of personalizing blood transfusion according to physiological endpoints rather than arbitrary thresholds...
  91. ncbi request reprint Safety of human albumin--serious adverse events reported worldwide in 1998-2000
    J L Vincent
    Department of Intensive Care, Hopital Erasme, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Br J Anaesth 91:625-30. 2003
    ..A more accurate estimate may be possible during a period such as 1998-2000, when awareness regarding albumin safety was heightened by publication of a meta-analysis...
  92. pmc Reducing mortality in sepsis: new directions
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital Free University of Brussels, Brussels, Belgium
    Crit Care 6:S1-18. 2002
    ....
  93. pmc The International Sepsis Forum's frontiers in sepsis: High cardiac output should be maintained in severe sepsis
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, University of Brussels, Brussels, Belgium
    Crit Care 7:276-8. 2003
  94. pmc The PIRO concept: O is for organ dysfunction
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care 7:260-4. 2003
  95. ncbi request reprint Anemia and blood transfusion in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
    JAMA 288:1499-507. 2002
    ..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
  96. ncbi request reprint Give your patient a fast hug (at least) once a day
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Crit Care Med 33:1225-9. 2005
    ....
  97. ncbi request reprint Does disseminated intravascular coagulation lead to multiple organ failure?
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, Brussels 1070, Belgium
    Crit Care Clin 21:469-77. 2005
    ..This article discusses the evidence for and against a key role for disseminated intravascular coagulation in the pathogenesis of multiple organ failure...
  98. ncbi request reprint New therapeutic implications of anticoagulation mediator replacement in sepsis and acute respiratory distress syndrome
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 28:S83-5. 2000
    ....
  99. pmc Issues in contemporary fluid management
    J L Vincent
    Universite Libre de Bruxelles, Brussels, Belgium
    Crit Care 4:S1-2. 2000
    ..Experimental models can make an important contribution in gathering such evidence. Rigorous pharmacoeconomic studies are also needed to define the benefits and costs of differing fluid regimens...
  100. ncbi request reprint Update on sepsis: pathophysiology and treatment
    J L Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Acta Clin Belg 55:79-87. 2000
    ....
  101. ncbi request reprint Infection in critically ill patients: clinical impact and management
    Jean Louis Vincent
    Department of Intensive Care Medicine, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Curr Opin Infect Dis 16:309-13. 2003
    ..The aim of this review is to summarize recent developments in the epidemiology, diagnosis and management of infection in critically ill patients...