H Wildiers

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. ncbi request reprint Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology
    Hans Wildiers
    Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Lancet Oncol 8:1101-15. 2007
  2. pmc Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors
    Alena M Pfeil
    Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium
    BMC Cancer 14:201. 2014
  3. ncbi request reprint Issues in the adjuvant treatment of common tumors (with a focus on breast cancer) in older adults (age >70)
    H Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 23:x339-41. 2012
  4. doi request reprint Delivery of adjuvant sequential dose-dense FEC-Doc to patients with breast cancer is feasible, but dose reductions and toxicity are dependent on treatment sequence
    H Wildiers
    Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium
    Breast Cancer Res Treat 114:103-12. 2009
  5. ncbi request reprint Mastering chemotherapy dose reduction in elderly cancer patients
    Hans Wildiers
    Department of General Medical Oncology Multidisciplinary Breast Centre, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Cancer 43:2235-41. 2007
  6. doi request reprint Atropine, hyoscine butylbromide, or scopolamine are equally effective for the treatment of death rattle in terminal care
    Hans Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    J Pain Symptom Manage 38:124-33. 2009
  7. doi request reprint Relative dose intensity of chemotherapy and its impact on outcomes in patients with early breast cancer or aggressive lymphoma
    Hans Wildiers
    Multidisciplinary Breast Centre, University Hospital Gasthuisberg, Leuven, Belgium
    Crit Rev Oncol Hematol 77:221-40. 2011
  8. doi request reprint Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer
    H Wildiers
    Department of General Medical Oncology Multidisciplinary Breast Centre, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 123:463-9. 2010
  9. doi request reprint Neoadjuvant capecitabine and docetaxel (plus trastuzumab): an effective non-anthracycline-based chemotherapy regimen for patients with locally advanced breast cancer
    H Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Ann Oncol 22:588-94. 2011
  10. doi request reprint A pilot study to investigate the feasibility and cardiac effects of pegylated liposomal doxorubicin (PL-DOX) as adjuvant therapy in medically fit elderly breast cancer patients
    Hans Wildiers
    Multidisciplinary Breast Centre, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Rev Oncol Hematol 67:133-8. 2008

Detail Information

Publications58

  1. ncbi request reprint Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology
    Hans Wildiers
    Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Lancet Oncol 8:1101-15. 2007
    ..The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults...
  2. pmc Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors
    Alena M Pfeil
    Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium
    BMC Cancer 14:201. 2014
    ..Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk factors...
  3. ncbi request reprint Issues in the adjuvant treatment of common tumors (with a focus on breast cancer) in older adults (age >70)
    H Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 23:x339-41. 2012
    ..age-related physiological changes can decrease tolerance of classical chemotherapy regimens, indicating the need for close monitoring and preventive measures...
  4. doi request reprint Delivery of adjuvant sequential dose-dense FEC-Doc to patients with breast cancer is feasible, but dose reductions and toxicity are dependent on treatment sequence
    H Wildiers
    Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium
    Breast Cancer Res Treat 114:103-12. 2009
    ....
  5. ncbi request reprint Mastering chemotherapy dose reduction in elderly cancer patients
    Hans Wildiers
    Department of General Medical Oncology Multidisciplinary Breast Centre, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Cancer 43:2235-41. 2007
    ..Each of these topics will be reviewed here trying to give concrete recommendations for clinical practice...
  6. doi request reprint Atropine, hyoscine butylbromide, or scopolamine are equally effective for the treatment of death rattle in terminal care
    Hans Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    J Pain Symptom Manage 38:124-33. 2009
    ..9 hours. These data suggest that there are no significant differences in effectiveness or survival time among atropine, hyoscine butylbromide, and scopolamine in the treatment of death rattle...
  7. doi request reprint Relative dose intensity of chemotherapy and its impact on outcomes in patients with early breast cancer or aggressive lymphoma
    Hans Wildiers
    Multidisciplinary Breast Centre, University Hospital Gasthuisberg, Leuven, Belgium
    Crit Rev Oncol Hematol 77:221-40. 2011
    ..The definition of "full dose" is, however, unclear. Older age and higher disease stage may be associated with reduced RDI, and G-CSF improved the chances of higher RDI in most studies...
  8. doi request reprint Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer
    H Wildiers
    Department of General Medical Oncology Multidisciplinary Breast Centre, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 123:463-9. 2010
    ..Furthermore, toxicity was significant...
  9. doi request reprint Neoadjuvant capecitabine and docetaxel (plus trastuzumab): an effective non-anthracycline-based chemotherapy regimen for patients with locally advanced breast cancer
    H Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Ann Oncol 22:588-94. 2011
    ..To evaluate capecitabine-docetaxel (XT), with trastuzumab (H) in human epidermal growth factor receptor 2 (HER2)-positive disease, in inoperable locally advanced breast cancer (LABC)...
  10. doi request reprint A pilot study to investigate the feasibility and cardiac effects of pegylated liposomal doxorubicin (PL-DOX) as adjuvant therapy in medically fit elderly breast cancer patients
    Hans Wildiers
    Multidisciplinary Breast Centre, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Rev Oncol Hematol 67:133-8. 2008
    ..SRI may be a useful tool in the follow-up of elderly patients treated with anthracyclines, allowing early initiation of preventive measures in order to prevent further irreversible cardiac damage...
  11. doi request reprint Prospective study to assess fluid accumulation and tenosynovial changes in the aromatase inhibitor-induced musculoskeletal syndrome: 2-year follow-up data
    A Lintermans
    Department of Obstetrics and Gynecology, KU Leuven, Leuven, Belgium
    Ann Oncol 24:350-5. 2013
    ..Looking into its pathophysiology, 6 months of AI therapy thickens the tendon sheath with intra-articular fluid (IAF) retention and loss of grip strength. We here report 24-month follow-up data...
  12. doi request reprint Clinicopathological features of inflammatory versus noninflammatory locally advanced nonmetastatic breast cancer
    B Brouwers
    Multidisciplinary Breast Centre, Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    Tumour Biol 29:211-6. 2008
    ..It is mainly a clinical diagnosis. The aim of this study was to compare IBC to clinically diagnosed noninflammatory locally advanced nonmetastatic breast cancer, also called cLABC...
  13. ncbi request reprint Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Leuven, Belgium
    Ann Oncol 23:2578-84. 2012
    ..We here applied the 2011 St Gallen surrogate definition for breast cancer subclassification using tumor grade instead of Ki67...
  14. doi request reprint Prediction of lymph node involvement in breast cancer from primary tumor tissue using gene expression profiling and miRNAs
    A Smeets
    Multidisciplinary Breast Centre University Hospital, Herestraat 49, B 3000 Leuven, Belgium
    Breast Cancer Res Treat 129:767-76. 2011
    ..Moreover, our data suggest a general deregulation of the miRNA machinery that is potentially responsible for lymph node invasion...
  15. ncbi request reprint Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer
    P Neven
    Department of Obstetrics and Gynaecology, Multidisciplinary Breast Centre, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Breast Cancer Res Treat 110:153-9. 2008
    ..The negative association between the oestrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER-2) in breast cancer travels in both directions. ER+ tumours are less likely HER-2+ and HER-2+ tumours are less likely ER+...
  16. doi request reprint Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients
    T Vandorpe
    Multidisciplinary Breast Centre, University Hospitals Leuven, Leuven, Belgium
    Breast Cancer Res Treat 128:429-35. 2011
    ..The mildly higher incidence of ALN metastasis in lobular cancers in univariable analysis is not due to the lobular subtype, but due to confounding factors that interact with lymph node involvement...
  17. ncbi request reprint Triple negative breast cancer: a study from the point of view of basal CK5/6 and HER-1
    S Pintens
    Department of Pathology, UZ Leuven, Leuven, Belgium
    J Clin Pathol 62:624-8. 2009
    ..The aim of this study was to investigate to what extent CK5/6 and HER-1 characterise the group of triple negative breast cancers...
  18. doi request reprint The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast 22:254-62. 2013
    ..0291). Change in CA15.3 impacts on prognosis (distant metastasis) differently in different breast cancer phenotypes. A decrease in CA15.3 may be informative of improved prognosis in basal like and HER2 like breast cancer...
  19. doi request reprint Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC)
    C Vulsteke
    Department of General Medical Oncology and Laboratory of Experimental Oncology, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 24:1513-25. 2013
    ..To assess the impact of single-nucleotide polymorphisms (SNPs) on predefined severe adverse events in breast cancer (BC) patients receiving (neo-)adjuvant 5-fluorouracil (FU), epirubicin and cyclophosphamide (FEC) chemotherapy...
  20. ncbi request reprint Adjuvant therapy for postmenopausal ER-positive breast cancer. Why tamoxifen still has a future? The Leuven point of view
    P Neven
    Multidisciplinary Breast Center Department of Obstetrics and Gynecology, UZ Leuven, Catholic University Leuven, Leuven, Belgium
    Int J Gynecol Cancer 16:505-10. 2006
  21. ncbi request reprint Prognostic implications of lobular breast cancer histology: New insights from a single hospital cross-sectional study and SEER data
    O Brouckaert
    Multidisciplinary Breast Centre, University Hospital Leuven, Leuven, Belgium Electronic address
    Breast 23:371-7. 2014
    ..We hypothesize that nodal status may influence the hazard of relapse since time of diagnosis differently in invasive ductal carcinoma (IDC) and ILC...
  22. doi request reprint Breast cancer phenotype, nodal status and palpability may be useful in the detection of overdiagnosed screening-detected breast cancers
    O Brouckaert
    Multidisciplinary Breast Center, University Hospital Leuven, Leuven
    Ann Oncol 24:1847-52. 2013
    ..Screening is often criticized for leading to overdiagnosis and overtreatment. However, few have attempted to identify overdiagnosed cases...
  23. pmc Matrix metalloproteinase expression patterns in luminal A type breast carcinomas
    J Decock
    Laboratory for Experimental Oncology LEO, Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Dis Markers 23:189-96. 2007
    ..The current study aimed at defining an RNA expression profile of various MMPs in breast cancer and correlating their expression with clinicopathological parameters...
  24. ncbi request reprint A prospective assessment of musculoskeletal toxicity and loss of grip strength in breast cancer patients receiving adjuvant aromatase inhibitors and tamoxifen, and relation with BMI
    A Lintermans
    Department of Oncology, KU Leuven, Herestraat 49, 3000, Louvain, Belgium
    Breast Cancer Res Treat 146:109-16. 2014
    ..The inverse relationship between BMI extremes and grip strength change was confirmed in this large group of AI-patients. ..
  25. doi request reprint The rs1800716 variant in CYP2D6 is associated with an increased double endometrial thickness in postmenopausal women on tamoxifen
    A S Dieudonné
    Department of Oncology, KU Leuven, Leuven
    Ann Oncol 25:90-5. 2014
    ..We test the association between genetic variability in CYP450 enzymes and the increase in double endometrial thickness (DET) as measured through transvaginal ultrasound (TVU)...
  26. ncbi request reprint Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age
    T Van Mieghem
    Department of Obstetrics and Gynaecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 106:127-33. 2007
    ..It is unknown whether circulating estrogens affect HER-2 expression. We hypothesize that the postmenopausal body mass index (BMI) as a surrogate marker for bio-available estrogens, is inversely associated with HER-2 over-expression...
  27. doi request reprint Aromatase inhibitor-induced loss of grip strength is body mass index dependent: hypothesis-generating findings for its pathogenesis
    A Lintermans
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospitals Leuven, Belgium
    Ann Oncol 22:1763-9. 2011
    ..Here, we report the final results and assess the relationship between grip strength and body mass index (BMI)...
  28. doi request reprint Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users
    A S Dieudonné
    Department of Obstetrics and Gynecology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Breast Cancer Res Treat 118:531-8. 2009
    ..They support clinical trials prospectively testing the effect of CYP2D6 genetic variability in response to tamoxifen before denying this drug to breast cancer patients only based on their CYP2D6*4 status...
  29. ncbi request reprint Plasma gelatinase levels in patients with primary breast cancer in relation to axillary lymph node status, Her2/neu expression and other clinicopathological variables
    J Decock
    Laboratory for Experimental Oncology LEO, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Exp Metastasis 22:495-502. 2005
    ..However, this increase was too small to be of clinical use. Furthermore, no relationship was found between plasma gelatinase levels, total or active, and any of the clinicopathological prognostic factors...
  30. doi request reprint A double-blind randomized phase II study on the efficacy of topical eye treatment in the prevention of docetaxel-induced dacryostenosis
    B Leyssens
    Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 21:419-23. 2010
    ..We investigate the efficacy of eyedrops containing corticosteroids (CS) versus artificial tears (AT) in patients receiving weekly docetaxel in the prevention of dacryostenosis...
  31. doi request reprint Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study
    C Kenis
    Department of General Medical Oncology and Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 24:1306-12. 2013
    ....
  32. ncbi request reprint A phase 1 study of vinflunine in combination with trastuzumab for the treatment for HER2-positive metastatic breast cancer
    R Paridaens
    Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Borst Centrum, Belgium
    Cancer Chemother Pharmacol 70:503-11. 2012
    ..To determine the recommended dose (RD) of vinflunine in combination with trastuzumab in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) and to investigate potential pharmacokinetic (PK) interactions...
  33. doi request reprint Challenges in treating older cancer patients: breast cancer
    H Wildiers
    Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    Ann Oncol 19:vii99-103. 2008
  34. ncbi request reprint Pharmacology of anticancer drugs in the elderly population
    Hans Wildiers
    Laboratory of Experimental Oncology, and Department of Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Pharmacokinet 42:1213-42. 2003
    ..This review attempts to elucidate the factors that can influence the pharmacokinetics of anticancer drugs frequently used in the elderly, and the clinical or biochemical parameters that form the basis for dose adjustments with age...
  35. doi request reprint Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer
    Ruxandra Jurcut
    Department of Cardiovascular Diseases, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    J Am Soc Echocardiogr 21:1283-9. 2008
    ..Doppler myocardial imaging-based velocity, strain, and strain rate measurements have been shown to sensitively quantify abnormalities in cardiac function in other settings...
  36. doi request reprint Triple-negative breast cancer
    Gert Stockmans
    Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat, Leuven, Belgium
    Curr Opin Oncol 20:614-20. 2008
    ..We would like to describe recent pathological and genetic advancements and their possible implications on the development of new treatment strategies...
  37. doi request reprint Detection and monitoring of cardiotoxicity-what does modern cardiology offer?
    Ruxandra Jurcut
    Department of Cardiology, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium
    Support Care Cancer 16:437-45. 2008
    ..This parameter is, however, insensitive to subtle changes in myocardial function as they occur in early cardiotoxicity...
  38. ncbi request reprint Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence
    H Wildiers
    Laboratory of Experimental Oncology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Cancer 40:284-90. 2004
    ..Mechanisms other than trapping are likely to be involved in the chemosensitising capacity of CA4DP...
  39. doi request reprint Relationship between age and axillary lymph node involvement in women with breast cancer
    Hans Wildiers
    Multidisciplinary Breast Centre and Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    J Clin Oncol 27:2931-7. 2009
    ..To study the relation between the presence of axillary lymph node (LN) involvement and age in breast cancer...
  40. ncbi request reprint Taxanes in elderly breast cancer patients
    Hans Wildiers
    Department of Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, Leuven B 3000, Belgium
    Cancer Treat Rev 30:333-42. 2004
    ..In general however, weekly taxanes are a reasonable option for older patients with metastatic breast cancer...
  41. doi request reprint Prospective assessment of the endometrium in postmenopausal breast cancer patients treated with fulvestrant
    Leilani Morales
    Department of Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Breast Cancer Res Treat 117:77-81. 2009
    ..Furthermore, no new uterine pathologies were detected, indicating that fulvestrant behaves as a pure antiestrogen at the uterine level...
  42. ncbi request reprint Adjuvant chemotherapy in elderly patients with breast cancer: where are we?
    Hans Wildiers
    Department of Medical Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium
    Curr Opin Oncol 17:566-72. 2005
    ..This review summarizes the current knowledge and provides guidelines for the use of adjuvant chemotherapy in elderly patients with breast cancer...
  43. ncbi request reprint Safety and efficacy of weekly docetaxel in frail and/or elderly patients with metastatic breast cancer: a phase II study
    Randal D'hondt
    Department of Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Anticancer Drugs 15:341-6. 2004
    ....
  44. doi request reprint Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
    Ben Van Calster
    Multidisciplinary Breast Centre, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 113:181-7. 2009
    ..To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status...
  45. ncbi request reprint Death rattle: prevalence, prevention and treatment
    Hans Wildiers
    Department of Oncology, Gasthuisberg University Hospital Leuven, Leuven, Belgium
    J Pain Symptom Manage 23:310-7. 2002
    ..Administration of subcutaneous hyoscine hydrobromide, as a bolus or continuous infusion, is effective therapy for real DR and is comfortable for the patient and caregivers...
  46. doi request reprint Weekly paclitaxel versus weekly docetaxel in elderly or frail patients with metastatic breast carcinoma: a randomized phase-II study of the Belgian Society of Medical Oncology
    Benoit Beuselinck
    Medical Oncology Department, Catholic University Leuven, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Crit Rev Oncol Hematol 75:70-7. 2010
    ..They display different, but acceptable toxicity profiles, with levels of antitumoral efficacy comparable to those previously reported for 3-weekly regimens...
  47. ncbi request reprint Unexpected interactions between nicotinamide and CPT-11 in a rhabdomyosarcoma tumor model
    Hans Wildiers
    Laboratory of Experimental Oncology LEO, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Anticancer Res 23:4055-9. 2003
    ..Great care is required when combining nicotinamide with anticancer drugs, since unexpected pharmacokinetic and pharmacodynamic alterations might occur...
  48. doi request reprint Short-term outcome of primary operated early breast cancer by hormone and HER-2 receptors
    Olivier Brouckaert
    Multidisciplinary Breast Centre, UZLeuven, Leuven 3000, Belgium
    Breast Cancer Res Treat 115:349-58. 2009
    ..We here report the short-term disease-free interval (DFI) of operable breast cancers by their joint hormone receptor/HER-2 phenotype...
  49. ncbi request reprint Intra-hepatic Mitomycin C bolus infusion in the treatment of extensive liver metastases of breast cancer
    Toon Maes
    Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 110:135-42. 2008
    ..In the treatment of extensive liver metastasis of breast cancer (LMBC), locally administered Mitomycin C (MMC) to the liver might be an effective approach with limited toxicity...
  50. ncbi request reprint Debilitating musculoskeletal pain and stiffness with letrozole and exemestane: associated tenosynovial changes on magnetic resonance imaging
    Leilani Morales
    Department of General Medical Oncology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Breast Cancer Res Treat 104:87-91. 2007
    ..However, the pathogenesis and anatomic correlate of musculoskeletal pains have not been thoroughly evaluated. Moreover, the impact of AI-induced musculoskeletal symptoms on normal daily functioning needs to be further explored...
  51. ncbi request reprint International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency
    Stuart M Lichtman
    Memorial Sloan Kettering Cancer Centre, New York, USA
    Eur J Cancer 43:14-34. 2007
    ..Pharmacokinetic and pharmacodynamic data of anticancer agents in the elderly are needed in order to maximise efficacy whilst avoiding unacceptable toxicity...
  52. doi request reprint Phase I/II pharmacokinetic study of pemetrexed and epirubicin in patients with locally advanced or metastatic breast cancer
    Robert Paridaens
    Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Clin Breast Cancer 7:861-6. 2007
    ..Pemetrexed and epirubicin are each active in patients with advanced/metastatic breast cancer (MBC). This phase I/II study evaluated these drugs as a combination regimen...
  53. ncbi request reprint Fertility preservation in (breast) cancer patients: is it safe?
    Hans Wildiers
    J Clin Oncol 24:5335-6; author reply 5337-8. 2006
  54. ncbi request reprint Detection of micrometastatic disease and monitoring of perioperative tumor cell dissemination in primary operable breast cancer patients using real-time quantitative reverse transcription-PCR
    Mohamed Saad Ismail
    Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium and National Cancer Institute, Cairo, Egypt
    Clin Cancer Res 10:196-201. 2004
    ..We aimed to apply the technique on bone marrow (BM) of primary operable BC patients. Pre- and postoperative PB samples of these patients were further analyzed to investigate possible shedding of CK19+ cells during the operation...
  55. doi request reprint Does estrogen receptor negative/progesterone receptor positive breast carcinoma exist?
    Leen De Maeyer
    J Clin Oncol 26:335-6; author reply 336-8. 2008
  56. ncbi request reprint Association between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related
    Huei Jean Huang
    Division of Gynaecologic Oncology in Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Breast Cancer Res Treat 91:81-7. 2005
    ..518). The study confirms an age-related inverse relationship between HER-2/neu and PR only in women age>45 years but not in women age<or=45 years...
  57. ncbi request reprint International Society of Geriatric Oncology Chemotherapy Taskforce: evaluation of chemotherapy in older patients--an analysis of the medical literature
    Stuart M Lichtman
    Memorial Sloan Kettering Cancer Center, Commack, New York 11725, USA
    J Clin Oncol 25:1832-43. 2007
    ..In addition, data already accumulated need to be reanalyzed by age to aid in the management of the older cancer patient...
  58. doi request reprint In early-stage breast cancer, the estrogen receptor interacts with correlation between human epidermal growth factor receptor 2 status and age at diagnosis, tumor grade, and lymph node involvement
    Patrick Neven
    J Clin Oncol 26:1768-9; author reply 1769-71. 2008