Wim Vanden Berghe

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. doi request reprint Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
    Katarzyna Szarc vel Szic
    Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling PPES, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
    PLoS ONE 9:e87850. 2014
  2. doi request reprint Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes
    Wim Vanden Berghe
    Laboratory of Protein Science, Proteomics and Epigenetic Signaling PPES, Department of Biomedical Sciences, University Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium
    Pharmacol Res 65:565-76. 2012
  3. ncbi request reprint Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots
    Wim Vanden Berghe
    Ghent University Ugent, Department of Physiology, Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ledeganckstraat, Ghent, Belgium
    Endocr Metab Immune Disord Drug Targets 11:247-61. 2011
  4. ncbi request reprint Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?
    Wim Vanden Berghe
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Curr Drug Metab 11:436-50. 2010
  5. pmc Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Gent University, Gent, Belgium
    EMBO J 27:1682-93. 2008
  6. doi request reprint Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: possible partners in the combat against inflammation
    Ilse M E Beck
    Department of Physiology, Ghent University, Belgium
    Biochem Pharmacol 77:1194-205. 2009
  7. ncbi request reprint Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Ethnopharmacol 113:510-6. 2007
  8. ncbi request reprint Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 282:4253-64. 2007
  9. ncbi request reprint Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Gent, Belgium
    Cancer Res 66:4852-62. 2006
  10. pmc Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Endocr Rev 30:830-82. 2009

Collaborators

Detail Information

Publications31

  1. doi request reprint Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
    Katarzyna Szarc vel Szic
    Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling PPES, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
    PLoS ONE 9:e87850. 2014
    ....
  2. doi request reprint Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes
    Wim Vanden Berghe
    Laboratory of Protein Science, Proteomics and Epigenetic Signaling PPES, Department of Biomedical Sciences, University Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium
    Pharmacol Res 65:565-76. 2012
    ..In this review will discuss the possible epigenetic contributions of dietary polyphenols in cancer chemoprevention...
  3. ncbi request reprint Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots
    Wim Vanden Berghe
    Ghent University Ugent, Department of Physiology, Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ledeganckstraat, Ghent, Belgium
    Endocr Metab Immune Disord Drug Targets 11:247-61. 2011
    ....
  4. ncbi request reprint Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?
    Wim Vanden Berghe
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Curr Drug Metab 11:436-50. 2010
    ....
  5. pmc Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Gent University, Gent, Belgium
    EMBO J 27:1682-93. 2008
    ..These findings unveil a novel aspect within the GR-mediated NF-kappaB-targeting anti-inflammatory mechanism...
  6. doi request reprint Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: possible partners in the combat against inflammation
    Ilse M E Beck
    Department of Physiology, Ghent University, Belgium
    Biochem Pharmacol 77:1194-205. 2009
    ..In conclusion, these results could entail a new therapeutic strategy using lower drug concentrations, potentially leading to a more beneficial side-effect profile...
  7. ncbi request reprint Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Ethnopharmacol 113:510-6. 2007
    ..Umbiliferrae) also revealed immunomodulatory NFkappaB activities. These species are good candidates for further activity-monitored fractionation to identify active constituents...
  8. ncbi request reprint Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity
    Mary Kaileh
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    J Biol Chem 282:4253-64. 2007
    ....
  9. ncbi request reprint Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Gent, Belgium
    Cancer Res 66:4852-62. 2006
    ..As constitutive NF-kappaB and MSK activity are hallmarks of aggressive metastatic ER-deficient breast cancer, the MSK signaling pathway may become an attractive target for chemotherapy...
  10. pmc Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
    Ilse M E Beck
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Endocr Rev 30:830-82. 2009
    ....
  11. pmc A fully dissociated compound of plant origin for inflammatory gene repression
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Proc Natl Acad Sci U S A 102:15827-32. 2005
    ..Taken together, this compound may be a lead compound of a class of antiinflammatory agents with fully dissociated properties and might thus hold great potential for therapeutic use...
  12. doi request reprint Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders
    Katarzyna Szarc vel Szic
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, Gent, Belgium
    Biochem Pharmacol 80:1816-32. 2010
    ..This may allow to improve healthy aging by reversing disease prone epimutations involved in chronic inflammatory and metabolic disorders...
  13. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
    ..This effect represents, together with phosphorylation of nucleosome components such as histone H3, an essential step leading to selective transcriptional activation of NF-kappaB-dependent gene expression...
  14. doi request reprint The versatile role of MSKs in transcriptional regulation
    Linda Vermeulen
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Trends Biochem Sci 34:311-8. 2009
    ..Here, we review the current knowledge on MSK activation and its molecular targets, focusing on recent insights into the role of MSKs at multiple levels of transcriptional regulation...
  15. pmc Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1
    Karolien De Bosscher
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Ghent, Belgium
    Cell Mol Life Sci 71:143-63. 2014
    ..In conclusion, our data support the hypothesis that a ligand-induced differential conformation of GR yields a different transcription factor cross-talk profile. ..
  16. pmc Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells
    Matladi N Ndlovu
    Laboratory of Eukaryotic Gene Expression and Signal Transduction, Department of Physiology, University of Ghent, K L Ledeganckstraat 35, Ghent, Belgium
    Mol Cell Biol 29:5488-504. 2009
    ....
  17. ncbi request reprint Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics
    Wim Vanden Berghe
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Biochem Pharmacol 72:1114-31. 2006
    ..We will therefore discuss in this review the multilayered interplay of NF-kappaB signaling and epigenome dynamics, in achieving appropriate gene expression responses and transcriptional activity...
  18. ncbi request reprint A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein
    Nathalie Dijsselbloem
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Molecular Biology, Ghent University, Ghent, Belgium
    J Immunol 178:5048-57. 2007
    ..Moreover, analysis of IL-6 mRNA levels in bone marrow-derived p53 null vs wild-type dendritic cells confirms a role for p53 in the reduction of NF-kappaB-dependent gene expression, mediated by genistein...
  19. doi request reprint Acculturation strategies and mental health in gay, lesbian, and bisexual youth
    Nele Cox
    Department of Sociology, Ghent University, Ghent, Belgium
    J Youth Adolesc 39:1199-210. 2010
    ..LGB youth who identify with the LGB community score significantly lower on this internalized homonegativity...
  20. ncbi request reprint Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens
    An De Naeyer
    Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Nat Prod 67:1829-32. 2004
    ..6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay...
  21. pmc Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation
    Ilse M Beck
    Laboratory of Experimental Cancer Research LECR, Department of Radiation Therapy and Experimental Cancer Research, Ghent University, Ghent, Belgium
    PLoS ONE 8:e69115. 2013
    ....
  22. ncbi request reprint Role of glucocorticoids in dopamine-related neuropsychiatric disorders
    Kathleen Van Craenenbroeck
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, LEGEST, Department of Molecular Biology, Ghent University Ugent, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Mol Cell Endocrinol 245:10-22. 2005
    ..In this review, molecular and mechanistic aspects of glucocorticoid effects on brain function and behavior will be discussed with specific reference to dopamine signaling...
  23. ncbi request reprint Regulation of NF-kappaB transcriptional activity
    Linda Vermeulen
    Laboratory for Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Cancer Treat Res 130:89-102. 2006
    ..Here, we review current knowledge of NF-kappaB signal transduction, focusing on the regulation of its transcriptional activity by post-translational modification of the NF-kappaB subunits...
  24. ncbi request reprint The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression
    Karolien De Bosscher
    Department of Molecular Biology, Ghent University, K L Ledeganckstraat 35, 9000 Gent, Belgium
    Endocr Rev 24:488-522. 2003
    ..The various molecular pathways proposed so far are discussed in more detail...
  25. doi request reprint Molecular insight in the multifunctional activities of Withaferin A
    Wim Vanden Berghe
    Laboratory of Eukaryotic Gene Expression and Signal Transduction LEGEST, Department of Physiology, Ghent University, Gent, Belgium
    Biochem Pharmacol 84:1282-91. 2012
    ..This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A...
  26. ncbi request reprint A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis
    Pieter Dewint
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    J Immunol 180:2608-15. 2008
    ..Therefore, we conclude that GR monomers are sufficient for inhibition of inflammation in vivo...
  27. ncbi request reprint Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy
    Nathalie Dijsselbloem
    Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, KL Ledeganckstraat 35, B 9000, Belgium
    Biochem Pharmacol 68:1171-85. 2004
    ....
  28. doi request reprint Direct and transgenerational impact on Daphnia magna of chemicals with a known effect on DNA methylation
    Michiel B Vandegehuchte
    Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, J Plateaustraat 22, B 9000 Ghent, Belgium
    Comp Biochem Physiol C Toxicol Pharmacol 151:278-85. 2010
    ..We also demonstrated a transgenerational alteration in an epigenetic system in D. magna, which indicates the possibility of transgenerational inheritance of environment-induced epigenetic changes in non-exposed subsequent generations...
  29. doi request reprint Identification and functional characterization of the human EXT1 promoter region
    Ivy Jennes
    Department of Medical Genetics, University of Antwerp, and Antwerp University Hospital, Edegem, Belgium
    Gene 492:148-59. 2012
    ....
  30. ncbi request reprint Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Biochem Pharmacol 64:963-70. 2002
    ..Additionally, we describe how other posttranslational modifications, such as acetylation and methylation of transcription factors or of the chromatin environment, may also affect NF-kappaB transcriptional activity...
  31. ncbi request reprint General and minority stress in an LGB population in Flanders
    Nele Cox
    Ghent University, Department of Sociology, Ghent, Belgium
    J LGBT Health Res 4:181-94. 2008
    ..Finally, both general and minority stressors, especially the internal stressors, are found to have an important effect on depressive outcomes...