Sabine Van Miert

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi request reprint In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Exp Parasitol 108:163-8. 2004
  2. ncbi request reprint Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Belgium
    J Nat Prod 68:674-7. 2005
  3. doi request reprint Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus
    Sheila Maregesi
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 76:195-201. 2010
  4. ncbi request reprint Complement-inhibiting iridoids from Morinda morindoides
    Kanyanga Cimanga
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Nat Prod 66:97-102. 2003
  5. ncbi request reprint Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry
    Abdelaaty A Shahat
    Department of Pharmaceutical Sciences, University of Antwerp, B 2610 Antwerp, Belgium
    Rapid Commun Mass Spectrom 19:2172-8. 2005
  6. ncbi request reprint Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives
    Tim H M Jonckers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Med Chem 45:3497-508. 2002
  7. ncbi request reprint Quality control of roots of Eleutherococcus senticosus by HPLC
    Sandra Apers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Phytochem Anal 16:55-60. 2005
  8. ncbi request reprint Isolation of mangiferin from Bombax malabaricum and structure revision of shamimin
    Abdelaaty A Shahat
    Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt
    Planta Med 69:1068-70. 2003
  9. ncbi request reprint Phytochemical investigation and antioxidant activity of Duranta repens
    Abdelaaty A Shahat
    Pharmacognosy and Chemistry of Medicinal Plants Department, National Research Centre, 12311 Dokki, Cairo, Egypt
    Phytother Res 19:1071-3. 2005
  10. ncbi request reprint Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Bioorg Med Chem 13:661-9. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Exp Parasitol 108:163-8. 2004
    ....
  2. ncbi request reprint Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Belgium
    J Nat Prod 68:674-7. 2005
    ..004 microM, respectively), while the cytotoxicity (L6 cells) was 4.32 +/- 0.04 and 12.7 +/- 2.0 microM, respectively. Isoneocryptolepine (4) was found to act as an inhibitor of beta-hematin formation and as a DNA-intercalating agent...
  3. doi request reprint Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus
    Sheila Maregesi
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 76:195-201. 2010
    ..1 microg/mL). Only a few extracts were active against HIV-2, such as the 80 % MeOH extract from Lannea schweinfurthii (stem bark) and Elaeodedron schlechteranum (root bark), showing IC50 values < 10 microg/mL...
  4. ncbi request reprint Complement-inhibiting iridoids from Morinda morindoides
    Kanyanga Cimanga
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Nat Prod 66:97-102. 2003
    ..In addition to the biologically active flavonoids reported before from the same plant, these complement-inhibiting iridoids may contribute at least in part to the traditional use against rheumatic pains...
  5. ncbi request reprint Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry
    Abdelaaty A Shahat
    Department of Pharmaceutical Sciences, University of Antwerp, B 2610 Antwerp, Belgium
    Rapid Commun Mass Spectrom 19:2172-8. 2005
    ..The opposite behavior was noted for the fragmentation of the deprotonated and sodiated molecules. Radical ions were observed in the high-energy [M+Na]+ CID spectra which provided supporting information on the glycosylation positions...
  6. ncbi request reprint Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives
    Tim H M Jonckers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Med Chem 45:3497-508. 2002
    ..In addition, 2-bromo-, 2-nitro-, and 2-methoxy-9-cyanoneocryptolepine exhibited antitrypanosomal activity in the micromolar range in the absence of obvious cytotoxicity...
  7. ncbi request reprint Quality control of roots of Eleutherococcus senticosus by HPLC
    Sandra Apers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Phytochem Anal 16:55-60. 2005
    ..This method, accepted by the European Pharmacopoeia Commission, will be included in the monograph on Eleutherococcus senticosus roots to assay the content of eleutherosides B and E...
  8. ncbi request reprint Isolation of mangiferin from Bombax malabaricum and structure revision of shamimin
    Abdelaaty A Shahat
    Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt
    Planta Med 69:1068-70. 2003
    ..It was found to be identical to shamimin, a compound for which originally a flavonol structure was proposed, and the structure of which has to be revised...
  9. ncbi request reprint Phytochemical investigation and antioxidant activity of Duranta repens
    Abdelaaty A Shahat
    Pharmacognosy and Chemistry of Medicinal Plants Department, National Research Centre, 12311 Dokki, Cairo, Egypt
    Phytother Res 19:1071-3. 2005
    ..e. the phenylethanoid glycoside acteoside, the iridoid lamiide and the saponin pseudo-ginsenoside-RT1. Acteoside showed an IC50 of 3.05 +/- 0.09 microg/mL in the DPPH assay, while lamiide and pseudo-ginsenoside-RT1 were not active...
  10. ncbi request reprint Antileishmanial activity, cytotoxicity and QSAR analysis of synthetic dihydrobenzofuran lignans and related benzofurans
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Bioorg Med Chem 13:661-9. 2005
    ..12 microg/mL), which was confirmed in an infected macrophage assay (IC50 0.19 microg/mL). QSAR models for the cytotoxic and antileishmanial activity were generated using Quasar receptor surface modelling...
  11. ncbi request reprint Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs
    Sandra Apers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Phytochem Anal 13:202-6. 2002
    ..The latter compound showed a moderate anti-viral activity...
  12. ncbi request reprint Anthranoid compounds with antiprotozoal activity from Vismia orientalis
    Zakaria H Mbwambo
    Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Planta Med 70:706-10. 2004
    ..b. rhodesiense, L. donovani and P. falciparum were in the range of 10 to 50 micrograms/mL. None of the compounds showed antibacterial or antiviral (including also HIV) activity...
  13. ncbi request reprint Interactions of cryptolepine and neocryptolepine with unusual DNA structures
    Lionel Guittat
    Laboratoire de Biophysique, Museum national d histoire naturelle, INSERM UR 565, CNRS UMR 8646, 43, rue Cuvier, 75231 Paris Cedex 5, France
    Biochimie 85:535-47. 2003
    ..These compounds are weak telomerase inhibitors and exhibit a significant preference for triplexes over quadruplexes or duplexes...
  14. ncbi request reprint Structural and solvent effects on the 13C and 15N NMR chemical shifts of indoloquinoline alkaloids: experimental and DFT study
    Jaromír Tousek
    Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, CZ 611 37 Brno, Czech Republic
    Magn Reson Chem 46:42-51. 2008
    ..Solvent effects on the span of the 13C and 15N shielding tensor depended on the type of atom and the data indicated a significant influence of solute-solvent interactions...