Luc F Van Gaal

Summary

Affiliation: University Hospital Antwerp
Country: Belgium

Publications

  1. ncbi request reprint New approaches for the management of patients with multiple cardiometabolic risk factors
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Antwerp, Belgium
    J Endocrinol Invest 29:83-9. 2006
  2. ncbi request reprint Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women?
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, University of Antwerp UA, B 2650 Edegem Antwerp, Belgium
    Metabolism 55:650-5. 2006
  3. ncbi request reprint Bariatric surgery to treat type 2 diabetes: what is the recent evidence?
    Luc F Van Gaal
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
    Curr Opin Endocrinol Diabetes Obes 19:352-8. 2012
  4. ncbi request reprint The importance of obesity in diabetes and its treatment with sibutramine
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Belgium
    Int J Obes Relat Metab Disord 25:S24-8. 2001
  5. doi request reprint Weight and blood pressure response to weight management and sibutramine in diabetic and non-diabetic high-risk patients: an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Belgium
    Diabetes Obes Metab 12:26-34. 2010
  6. doi request reprint Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study
    Luc F Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
    Eur Heart J 29:1761-71. 2008
  7. doi request reprint Exploiting the antidiabetic properties of incretins to treat type 2 diabetes mellitus: glucagon-like peptide 1 receptor agonists or insulin for patients with inadequate glycemic control?
    Luc F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10 B 2650 Edegem, Antwerp, Belgium
    Eur J Endocrinol 158:773-84. 2008
  8. doi request reprint Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program
    Luc Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Diabetes Care 31:S229-40. 2008
  9. ncbi request reprint Reducing cardiometabolic risk through selective antagonism of CB1 receptors
    Luc Van Gaal
    Antwerp University Hospital, Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp, Belgium
    Clin Cornerstone 8:S24-9. 2007
  10. ncbi request reprint Mechanisms linking obesity with cardiovascular disease
    Luc F Van Gaal
    University of Antwerp, Faculty of Medicine, Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Nature 444:875-80. 2006

Detail Information

Publications73

  1. ncbi request reprint New approaches for the management of patients with multiple cardiometabolic risk factors
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Antwerp, Belgium
    J Endocrinol Invest 29:83-9. 2006
    ..Rimonabant, the first cannabinoid receptor type 1 (CB1) receptor blocker, reduces weight and waist circumference, and improves lipid and glucose metabolism...
  2. ncbi request reprint Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women?
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, University of Antwerp UA, B 2650 Edegem Antwerp, Belgium
    Metabolism 55:650-5. 2006
    ..21; P=.025). The results from this preliminary study suggest a plausible relation between visceral obesity and endothelial activation, possibly mediated by low-grade inflammation...
  3. ncbi request reprint Bariatric surgery to treat type 2 diabetes: what is the recent evidence?
    Luc F Van Gaal
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
    Curr Opin Endocrinol Diabetes Obes 19:352-8. 2012
    ..Whether the same advantages can be translated into T2DM remains a matter of debate, certainly regarding safety, durability of diabetes recovery and long-term outcome...
  4. ncbi request reprint The importance of obesity in diabetes and its treatment with sibutramine
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Belgium
    Int J Obes Relat Metab Disord 25:S24-8. 2001
    ..Pharmacotherapies such as sibutramine contribute to the management of type 2 diabetes in overweight and obese patients...
  5. doi request reprint Weight and blood pressure response to weight management and sibutramine in diabetic and non-diabetic high-risk patients: an analysis from the 6-week lead-in period of the sibutramine cardiovascular outcomes (SCOUT) trial
    L F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Belgium
    Diabetes Obes Metab 12:26-34. 2010
    ..To assess treatment responses to sibutramine and weight management in diabetic patients during the lead-in period of the Sibutramine Cardiovascular OUTcomes (SCOUT) trial...
  6. doi request reprint Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study
    Luc F Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
    Eur Heart J 29:1761-71. 2008
    ..We report the 2 year efficacy and tolerability data of rimonabant...
  7. doi request reprint Exploiting the antidiabetic properties of incretins to treat type 2 diabetes mellitus: glucagon-like peptide 1 receptor agonists or insulin for patients with inadequate glycemic control?
    Luc F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10 B 2650 Edegem, Antwerp, Belgium
    Eur J Endocrinol 158:773-84. 2008
    ....
  8. doi request reprint Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program
    Luc Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Diabetes Care 31:S229-40. 2008
    ....
  9. ncbi request reprint Reducing cardiometabolic risk through selective antagonism of CB1 receptors
    Luc Van Gaal
    Antwerp University Hospital, Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp, Belgium
    Clin Cornerstone 8:S24-9. 2007
    ..In addition, these findings suggest that CB1 receptor antagonists such as rimonabant may offer a potential new approach to managing obesity and associated cardiometabolic risk factors...
  10. ncbi request reprint Mechanisms linking obesity with cardiovascular disease
    Luc F Van Gaal
    University of Antwerp, Faculty of Medicine, Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Nature 444:875-80. 2006
    ..We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health...
  11. ncbi request reprint Long-term health considerations in schizophrenia: metabolic effects and the role of abdominal adiposity
    Luc F Van Gaal
    Antwerp University Hospital, Department of Diabetology, Metabolism and Clinical Nutrition, Edegem, Antwerp, Belgium
    Eur Neuropsychopharmacol 16:S142-8. 2006
    ....
  12. ncbi request reprint Modern, new pharmacotherapy for obesity. A gastrointestinal approach
    L Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Wilrjikstraat 10 Edegem, 2650 Antwerp, Belgium
    Best Pract Res Clin Gastroenterol 18:1049-72. 2004
  13. ncbi request reprint Rationale and options for combination therapy in the treatment of Type 2 diabetes
    L F Van Gaal
    University Hospital of Antwerp, Faculty of Medicine, Department of Diabetology, Metabolism and Clinical Nutrition, Wilrijkstraat 10, 2650 Edegem Antwerp, Belgium
    Diabetologia 46:M44-50. 2003
    ..g. an insulin sensitizer, could target better major underlying defects of Type 2 diabetes and thereby provide a better approach for controlling the entire glycaemic risk...
  14. doi request reprint Identification and functional characterization of novel mutations in the melanocortin-4 receptor
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
    Obes Facts 3:304-11. 2010
    ..Melanocortin-4 receptor (MC4R) deficiency is the most common cause of monogenic obesity. In the present study, we screened the MC4R gene for mutations in a population of overweight and obese children and adolescents...
  15. doi request reprint No important role for genetic variation in the Chibby gene in monogenic and complex obesity
    Jasmijn K Van Camp
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium
    Mol Biol Rep 40:4491-8. 2013
    ..Several novel variations were found, but no definite role in the pathogenesis of obesity could be confirmed. Results from the association analysis suggest that common variation in CBY is not a cause for obesity in the Belgian population...
  16. doi request reprint Identification and functional characterization of a missense mutation in resistin in two patients with severe obesity and insulin resistance
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Eur J Endocrinol 164:927-36. 2011
    ..In this study, we hypothesized that mutations in the resistin encoding gene, RETN, may cause a monogenic form of obesity...
  17. ncbi request reprint Hemostasis and fibrinolysis in non-diabetic overweight and obese men and women. Is there still a role for leptin?
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp Unviersity Hospital, University of Antwerp, Antwerp, Belgium
    Eur J Endocrinol 155:477-84. 2006
    ....
  18. ncbi request reprint Prevalence of rare MC3R variants in obese cases and lean controls
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Endocrine 44:386-90. 2013
    ..02 % in lean controls. Ultimately, cosegregation studies combined with comprehensive functional analysis is required to determine the potential pathogenic role of rare MC3R variants in causing human obesity...
  19. doi request reprint Identification of mutations in the NUCB2/nesfatin gene in children with severe obesity
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1 2610 Antwerp, Belgium
    Mol Genet Metab 107:729-34. 2012
    ..In conclusion, we have identified the first genetic variants in the NUCB2 gene in obese individuals, although further functional characterization will be essential to verify disease causality of the mutations...
  20. doi request reprint Mutation analysis of WNT10B in obese children, adolescents and adults
    Jasmijn K Van Camp
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium
    Endocrine 44:107-13. 2013
    ..3 %) and familial co-segregation of the most promising variant in patients could not be demonstrated. Therefore, we conclude that variations in WNT10B do not contribute to human monogenic obesity in our population...
  21. pmc Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females
    Margot Berings
    Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
    PLoS ONE 7:e45145. 2012
    ....
  22. ncbi request reprint Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    Luc F Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem Antwerp, Belgium
    Lancet 365:1389-97. 2005
    ..We assessed the effect of rimonabant, a selective CB1 blocker, on bodyweight and cardiovascular risk factors in overweight or obese patients...
  23. doi request reprint Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid
    Kim Van Hoorenbeeck
    Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 20:172-7. 2012
    ..At baseline, a link exists between inflammation and SDB. Oxidative stress is reflected by UA at baseline and the concentration decreases after treatment according to improvements in SDB...
  24. ncbi request reprint Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Antwerp, Belgium
    Thromb Haemost 94:1190-5. 2005
    ..HDL-chol was found to be the only factor independently determining both factors. In conclusion, in overweight and obese women, PAI-1 activity was inversely related to serum adiponectin, independent of visceral adipose tissue...
  25. ncbi request reprint Low fasting triglycerides: hallmark of the healthy large hip?
    Johannes B Ruige
    Ghent University Hospital, Department of Endocrinology, Ghent, Belgium
    Obesity (Silver Spring) 17:1621-6. 2009
    ..Metabolic risk of unfavorable body fat distribution may be modulated by lower triglyceride storage capacity...
  26. doi request reprint Common melanocortin-3 receptor variants are not associated with obesity, although rs3746619 does influence weight in obese individuals
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium
    Endocrine 38:289-93. 2010
    ..However, further research including replication of our results is necessary to elucidate the role of MC3R in complex obesity...
  27. doi request reprint Association study of MC4R with complex obesity and replication of the rs17782313 association signal
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Mol Genet Metab 103:71-5. 2011
    ..In conclusion, we could replicate the previously reported association between rs17782313 and complex obesity. Furthermore, our data do not support the hypothesis that a SNP in MC4R causes the rs17782313 association signal...
  28. ncbi request reprint Fasting-based estimates of insulin sensitivity in overweight and obesity: a critical appraisal
    Johannes B Ruige
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium
    Obesity (Silver Spring) 14:1250-6. 2006
    ..To identify simple methods to estimate the degree of insulin resistance...
  29. doi request reprint Association between polymorphisms of the Nesfatin gene, NUCB2, and obesity in men
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Mol Genet Metab 103:282-6. 2011
    ..Nevertheless, further research including replication of our results and elucidation of the molecular mechanism remains necessary...
  30. ncbi request reprint PAI-1 activity, but not fibrinogen or von Willebrand factor, is inversely related to LDL particle size in type 2 diabetes
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp University Hospital, Antwerp, Belgium
    Diabetes Metab Res Rev 24:141-7. 2008
    ..However, it is not clear whether these associations are independent of visceral adiposity or other components of the metabolic syndrome such as triglycerides or insulin resistance...
  31. ncbi request reprint Neuroendocrine tumor markers and enterochromaffin-like cell hyper/dysplasia in type 1 diabetes
    Christophe E M De Block
    Department of Endocrinology Diabetology, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Diabetes Care 27:1387-93. 2004
    ..We evaluated whether chromogranin A (CgA), 5-hydroxyindole acetic acid (5-HIAA), and neuron-specific enolase (NSE) contribute to screening for ECL cell hyper/dysplasia...
  32. ncbi request reprint Impact of overweight on chronic microvascular complications in type 1 diabetic patients
    Christophe E M De Block
    Department of Diabetology, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Diabetes Care 28:1649-55. 2005
    ..To investigate a possible association of BMI with retinopathy and neuropathy in type 1 diabetes. Retinopathy and neuropathy may not only be related to glycemic control and diabetes duration but also to blood pressure and BMI...
  33. doi request reprint Association of SIRT1 gene variation with visceral obesity
    Armand V Peeters
    Department of Biomedical Sciences, Center for Medical Genetics, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium
    Hum Genet 124:431-6. 2008
    ..Our data suggest that genetic variation in SIRT1 increases the risk for obesity, and that SIRT1 genotype correlates with visceral obesity parameters in obese men...
  34. ncbi request reprint Current concepts in gastric motility in diabetes mellitus
    Christophe E M De Block
    Department of Diabetology and Endocrinology, Faculty of Medicine, University of Antwerp, University Hospital Antwerp UZA, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Curr Diabetes Rev 2:113-30. 2006
    ..Understanding the current advances is key to the development of novel therapeutic strategies and for making rational choices in the management of diabetic gastroparesis...
  35. doi request reprint Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Obes Facts 4:473-7. 2011
    ..Therefore, we set out to replicate the reported association with rs7498665 in our Belgian study population and to extend our study with an additional tagSNP for the SH2B1 gene region...
  36. ncbi request reprint Resting metabolic rate is an important predictor of serum adiponectin concentrations: potential implications for obesity-related disorders
    Johannes B Ruige
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Antwerp, Belgium
    Am J Clin Nutr 82:21-5. 2005
    ..Little is known about the regulation of adiponectin. Animal studies suggest local regulation by adipocytokines or alterations in energy expenditure, and studies in humans suggest regulation by alcohol intake and ethnicity...
  37. doi request reprint Identification of three novel genetic variants in the melanocortin-3 receptor of obese children
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:152-9. 2011
    ..Second, they show that caution is called for the interpretation of newly discovered mutations in MC3R...
  38. pmc A Delphi study to construct a CanMEDS competence based inventory applicable for workplace assessment
    Nele R M Michels
    Skills Lab, Faculty of Medicine and Health Sciences, University of Antwerp, Campus Drie Eiken, Antwerp 2610, Belgium
    BMC Med Educ 12:86. 2012
    ..We aimed to construct a competence inventory applicable as an instrument to measure the content validity of workplace based assessment tools, such as portfolio...
  39. ncbi request reprint Monogenic and complex forms of obesity: insights from genetics reveal the leptin-melanocortin signaling pathway as a common player
    Doreen Zegers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Crit Rev Eukaryot Gene Expr 22:325-43. 2012
    ....
  40. ncbi request reprint Autoimmune gastropathy in type 1 diabetic patients with parietal cell antibodies: histological and clinical findings
    Christophe E M De Block
    Department of Endocrinology Diabetology, Faculty of Medicine, University of Antwerp, University Hospital Antwerp, Edegem, Belgium
    Diabetes Care 26:82-8. 2003
    ..We examined whether iron deficiency anemia, pernicious anemia, and autoimmune gastritis, which may predispose to gastric tumors, were more frequent in PCA+ than in PCA- patients...
  41. ncbi request reprint Visceral fat as a determinant of fibrinolysis and hemostasis
    Ilse Mertens
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
    Semin Vasc Med 5:48-55. 2005
    ..PAI-1 secretion by adipose tissue has been suggested to have a more local effect, playing a role in tissue remodeling during the development of obesity...
  42. ncbi request reprint Opposite effects of insulin-like molecules and leptin in coronary heart disease of type 2 diabetes Preliminary data
    Johannes B Ruige
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Antwerp, Belgium
    Int J Cardiol 111:19-25. 2006
    ..Leptin and insulin have been reported to be risk factors for coronary heart disease (CHD) in the general population, but their role in type 2 diabetes still remains unclear...
  43. ncbi request reprint Sleep-disordered breathing, obesity, and airway inflammation in children and adolescents
    Stijn L Verhulst
    Department of Pediatrics, University of Antwerp, Wilrijk, Belgium
    Chest 134:1169-75. 2008
    ....
  44. ncbi request reprint Autoimmune gastritis in type 1 diabetes: a clinically oriented review
    Christophe E M De Block
    Department of Diabetology Endocrinology, Antwerp University Hospital and University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    J Clin Endocrinol Metab 93:363-71. 2008
    ..This review addresses the epidemiology, pathogenesis, diagnosis, clinical consequences, and management of autoimmune gastritis in type 1 diabetic patients...
  45. ncbi request reprint The role of the leptin-melanocortin signalling pathway in the control of food intake
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
    Crit Rev Eukaryot Gene Expr 19:267-87. 2009
    ..Together, these data demonstrate the importance of this pathway in the regulation of food intake and the pathogenesis of obesity...
  46. ncbi request reprint Obesity, health issues, and cardiovascular disease
    Luc F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp University Hospital, Antwerp, Belgium
    Semin Vasc Med 5:1-2. 2005
  47. ncbi request reprint Health risks of lipodystrophy and abdominal fat accumulation: therapeutic possibilities with leptin and human growth hormone
    Luc F Van Gaal
    Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Antwerp, Belgium
    Growth Horm IGF Res 13:S4-9. 2003
    ..Both the origin of LD and its treatment deserve more attention and further research in clinical settings...
  48. ncbi request reprint Body surface area in normal-weight, overweight, and obese adults. A comparison study
    Johan Verbraecken
    Department of Pulmonary Medicine, University Hospital Antwerp, 2650 Edegem, Belgium
    Metabolism 55:515-24. 2006
    ..Although Mosteller's formula is recommended based on its simplicity and suitability for laboratory and clinical work in adults, accuracy studies in whites with 3-dimensional one-pass whole-body scanning are needed...
  49. doi request reprint Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis
    Sven Francque
    Department of Gastroenterology and Hepatology, Diabetes and Metabolism cAbdominal Surgery dPathology, Antwerp University Hospital, Antwerp, Belgium
    Eur J Gastroenterol Hepatol 22:1449-57. 2010
    ..We earlier showed in an animal model that steatosis, in the absence of fibrosis or inflammation, induces a significant rise in portal pressure. The relevance of these findings for human pathology is unknown till date...
  50. doi request reprint Analysis of genetic variations in the resistin gene shows no associations with obesity in women
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
    Obesity (Silver Spring) 16:905-7. 2008
    ..After Kruskal-Wallis analysis, we found that there was no difference in BMI between the genotypes for all variants. Together, these results suggest that these variants in resistin are not associated with obesity in the female population...
  51. ncbi request reprint Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women
    Machteld Wauters
    Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Belgium
    Obes Res 10:394-400. 2002
    ..We evaluated whether leptin levels and polymorphisms in the leptin receptor (LEPR) gene were associated with energy expenditure phenotypes...
  52. ncbi request reprint Delayed gastric emptying and gastric autoimmunity in type 1 diabetes
    Christophe E M De Block
    Department of Endocrinology Diabetology, Faculty of Medicine, University of Antwerp, University Hospital Antwerp, Edegem, Belgium
    Diabetes Care 25:912-7. 2002
    ..We studied gastric motility in diabetes in relation to PCA status, autonomic nerve function, HbA(1c), thyroid-stimulating hormone (TSH), Helicobacter pylori (HP), acid production, and gastric histology...
  53. ncbi request reprint Portfolio assessment during medical internships: How to obtain a reliable and feasible assessment procedure?
    Nele R M Michels
    University of Antwerp, Belgium
    Educ Health (Abingdon) 22:313. 2009
    ..A portfolio is used to mentor and assess students' clinical performance at the workplace. However, students and raters often perceive the portfolio as a time-consuming instrument...
  54. ncbi request reprint Metabolic syndrome in youth: a cross-sectional school-based survey
    Dirk Vissers
    University College of Antwerp, Department of Health Sciences Physiotherapy, and Antwerp University Hospital, Department of Diabetology, Metabolism and Clinical Nutrition, Antwerp, Belgium
    Acta Paediatr 96:1809-13. 2007
    ..VSE provides practice-oriented education in which young people learn a specific occupation. Previously we reported VSE to be the type of education with the highest prevalence of overweight and obesity...
  55. ncbi request reprint Fainting and hemolysis during blood sampling in youngsters: prevalence study
    Dirk Vissers
    University College of Antwerp, Department of Health Sciences Nursing and Physiotherapy, Antwerp, Belgium
    Int J Nurs Stud 45:760-4. 2008
    ..To assess the incidence of fainting and hemolysis in taking blood samples from adolescents in a school setting...
  56. doi request reprint The effect of whole body vibration short-term exercises on respiratory gas exchange in overweight and obese women
    Dirk Vissers
    Department of Health Sciences, Artesis University College of Antwerp, Van Aertselaerstraat 31, 2170 Merksem, Antwerp, Belgium
    Phys Sportsmed 37:88-94. 2009
    ..To assess the effect of whole body vibration on oxygen uptake and carbon dioxide production among overweight and obese women...
  57. doi request reprint The effect of weight loss on sleep-disordered breathing in obese teenagers
    Stijn L Verhulst
    Department of Pediatrics, University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 17:1178-83. 2009
    ..These findings are in favor of considering weight loss as a first-line treatment for SDB in obese children and adolescents...
  58. doi request reprint The prevalence, anatomical correlates and treatment of sleep-disordered breathing in obese children and adolescents
    Stijn L Verhulst
    Department of Pediatrics, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Sleep Med Rev 12:339-46. 2008
    ..On the other hand, there are limited data on the effects of weight loss and of treatment with continuous positive airway pressure on the severity of sleep apnea in obese children and adolescents...
  59. pmc Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution
    Stijn L Verhulst
    Department of Pediatrics, University Hospital of Antwerp, Wilrijk, Belgium
    Arch Dis Child 92:205-8. 2007
    ..To determine the prevalence of sleep-disordered breathing (SDB) in a clinical sample of overweight and obese children and adolescents, and to examine the contribution of fat distribution...
  60. doi request reprint Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants
    Armand Peeters
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium
    Endocrine 36:103-9. 2009
    ..Our data thus indicate that K121Q, rs7566605, and rs894160 are not major contributing factors for obesity...
  61. ncbi request reprint Sleep-disordered breathing and uric acid in overweight and obese children and adolescents
    Stijn L Verhulst
    University of Antwerp, Department of Pediatrics, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium
    Chest 132:76-80. 2007
    ....
  62. ncbi request reprint The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men
    Armand Peeters
    Department of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium
    Endocrine 31:138-41. 2007
    ..A trend for an association was seen for fat mass (unadjusted P = 0.099; adjusted P = 0.033). Our data indicate that the G1422A polymorphism in the CNR1 gene is associated with increased abdominal adiposity in obese men...
  63. ncbi request reprint Variants in the FTO gene are associated with common obesity in the Belgian population
    Armand Peeters
    Center for Medical Genetics, Department of Biomedical Sciences, University of Antwerp UA and University of Antwerp Hospital, Antwerp, Belgium
    Mol Genet Metab 93:481-4. 2008
    ..Both SNPs were significantly associated with obesity, enabling us to replicate earlier findings from Caucasian cohorts in a Belgian population sample...
  64. doi request reprint Overweight in adolescents: differences per type of education. Does one size fit all?
    Dirk Vissers
    University College of Antwerp, Department of Health Sciences, Antwerp, Belgium
    J Nutr Educ Behav 40:65-71. 2008
    ..To assess the lifestyle and prevalence of overweight among 16- to 18-year-old adolescents attending 4 different types of secondary education (SE)...
  65. doi request reprint Association of the BDNF Val66Met variation with obesity in women
    Sigri Beckers
    Department of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium
    Mol Genet Metab 95:110-2. 2008
    ....
  66. doi request reprint Effect of long-term whole body vibration training on visceral adipose tissue: a preliminary report
    Dirk Vissers
    Department of Health Sciences Physiotherapy, University College of Antwerp, Antwerp, Belgium
    Obes Facts 3:93-100. 2010
    ..To determine the effect of whole body vibration (WBV), combined with caloric restriction, on weight, body composition and metabolic risk factors in overweight and obese adults...
  67. ncbi request reprint The safety of obesity drugs
    Luc F Van Gaal
    Expert Opin Drug Saf 6:475-6; author reply 477-8. 2007
  68. ncbi request reprint Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial
    Robert J Heine
    VU University Medical Center, Amsterdam, The Netherlands
    Ann Intern Med 143:559-69. 2005
    ..Physicians may use either insulin or exenatide injections for patients with type 2 diabetes mellitus who have poor glycemic control despite taking oral blood glucose-lowering drugs...
  69. ncbi request reprint Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
    Andre J Scheen
    Division of Diabetes, Nutrition and Metabolic Disorders, CHU Sart Tilman, University of Liege, Liege, Belgium
    Lancet 368:1660-72. 2006
    ..The aim of the RIO-Diabetes trial was to assess the efficacy and safety of rimonabant in overweight or obese patients with type 2 diabetes that was inadequately controlled by metformin or sulphonylureas...
  70. ncbi request reprint Leisure-time activity is an important determinant of long-term weight maintenance after weight loss in the Sibutramine Trial on Obesity Reduction and Maintenance (STORM trial)
    Marleen A van Baak
    Department of Human Biology, Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 78:209-14. 2003
    ..The success rate of long-term maintenance of weight loss in obese patients is usually low. To improve the success rate, determinants of long-term weight maintenance must be identified...
  71. ncbi request reprint [CB1 receptor inhibition and glucose metabolism: role of rimonabant in type 2 diabetes]
    Andre J Scheen
    Service de Diabetologie, Nutrition et Maladies Metaboliques, CHU Sart Tilman, 4000 Liege, Belgique
    Rev Med Suisse 4:1812-7. 2008
    ....
  72. ncbi request reprint Rimonabant as an adjunct therapy in overweight/obese patients with type 2 diabetes
    Andre J Scheen
    Eur Heart J 28:1401-2; author reply 1402. 2007
  73. ncbi request reprint Time course of oxidative stress status in the postprandial and postabsorptive states in type 1 diabetes mellitus: relationship to glucose and lipid changes
    BegoƱa Manuel-Y-Keenoy
    University of Antwerp Campus Drie Eiken, Metabolic Research Unit T4 37, Universiteitsplein 1, B 2610 Wilrijk Antwerp, Belgium
    J Am Coll Nutr 24:474-85. 2005
    ..The aim of this study was to compare oxidative stress status (OSS) with blood glucose and lipid changes during the fasting, postprandial and postabsorptive phases in type 1 diabetes mellitus...