Koen Van Laere

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. doi request reprint Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain
    Koen Van Laere
    Department of Imaging and Pathology, Nuclear Medicine, University Hospital and KU Leuven, Leuven, Belgium
    J Nucl Med 54:1285-93. 2013
  2. doi request reprint Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven and KU Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 40:254-61. 2013
  3. doi request reprint Equivalent dynamic human brain NK1-receptor occupancy following single-dose i.v. fosaprepitant vs. oral aprepitant as assessed by PET imaging
    K Van Laere
    Division of Nuclear Medicine, K U Leuven and University Hospital Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:243-50. 2012
  4. doi request reprint Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo
    Koen Van Laere
    Department of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium
    Neurobiol Aging 33:620.e1-8. 2012
  5. doi request reprint The cost effectiveness of 123I-FP-CIT SPECT imaging in patients with an uncertain clinical diagnosis of parkinsonism
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven Gasthuisberg, E901, Herestraat 49, 3000 Leuven, Belgium
    Eur J Nucl Med Mol Imaging 35:1367-76. 2008
  6. doi request reprint Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital and K U Leuven, Leuven, Belgium
    J Nucl Med 49:439-45. 2008
  7. ncbi request reprint Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital and KU Leuven, Belgium
    Neuroimage 39:1533-41. 2008
  8. doi request reprint EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:434-42. 2010
  9. doi request reprint Combined striatal binding and cerebral influx analysis of dynamic 11C-raclopride PET improves early differentiation between multiple-system atrophy and Parkinson disease
    Koen Van Laere
    Division of Nuclear Medicine, Leuven University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 51:588-95. 2010
  10. doi request reprint Relationship of type 1 cannabinoid receptor availability in the human brain to novelty-seeking temperament
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Arch Gen Psychiatry 66:196-204. 2009

Detail Information

Publications85

  1. doi request reprint Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain
    Koen Van Laere
    Department of Imaging and Pathology, Nuclear Medicine, University Hospital and KU Leuven, Leuven, Belgium
    J Nucl Med 54:1285-93. 2013
    ....
  2. doi request reprint Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven and KU Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 40:254-61. 2013
    ..We have developed a novel PDE10A PET ligand, (18)F-JNJ42259152, and describe here its human dynamic biodistribution, safety and dosimetry...
  3. doi request reprint Equivalent dynamic human brain NK1-receptor occupancy following single-dose i.v. fosaprepitant vs. oral aprepitant as assessed by PET imaging
    K Van Laere
    Division of Nuclear Medicine, K U Leuven and University Hospital Leuven, Leuven, Belgium
    Clin Pharmacol Ther 92:243-50. 2012
    ..Aprepitant plasma concentration profiles were comparable for the two dosage forms. The study illustrates the utility of PET imaging in determining central bioequivalence in a limited number of subjects...
  4. doi request reprint Regional changes in type 1 cannabinoid receptor availability in Parkinson's disease in vivo
    Koen Van Laere
    Department of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium
    Neurobiol Aging 33:620.e1-8. 2012
    ..These data demonstrate regional changes in CB1 availability in PD in vivo, but do not support a role for dysregulation of CB1 levels in the pathogenesis of LID...
  5. doi request reprint The cost effectiveness of 123I-FP-CIT SPECT imaging in patients with an uncertain clinical diagnosis of parkinsonism
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven Gasthuisberg, E901, Herestraat 49, 3000 Leuven, Belgium
    Eur J Nucl Med Mol Imaging 35:1367-76. 2008
    ..As the model was developed before application of the diagnostic technique in real practice, a predictive validity assessment was performed based on data from a large nationwide patient registry in these patients...
  6. doi request reprint Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital and K U Leuven, Leuven, Belgium
    J Nucl Med 49:439-45. 2008
    ..We have used whole-body PET/CT to characterize the biodistribution and dosimetry of a novel high-affinity, subtype-selective radioligand, (18)F-MK-9470, in healthy male and female subjects...
  7. ncbi request reprint Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital and KU Leuven, Belgium
    Neuroimage 39:1533-41. 2008
    ..In vivo PET of the CB1R will likely improve our understanding of the ECS in several neurological and psychiatric disorders...
  8. doi request reprint EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:434-42. 2010
    ..The guidelines intend to present information specifically adapted to European practice. The information provided should be taken in the context of local conditions and regulations...
  9. doi request reprint Combined striatal binding and cerebral influx analysis of dynamic 11C-raclopride PET improves early differentiation between multiple-system atrophy and Parkinson disease
    Koen Van Laere
    Division of Nuclear Medicine, Leuven University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 51:588-95. 2010
    ..We investigated whether the differential diagnostic value of (11)C-raclopride PET could be improved by dynamic scan analysis combining D2R binding and regional tracer influx...
  10. doi request reprint Relationship of type 1 cannabinoid receptor availability in the human brain to novelty-seeking temperament
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Arch Gen Psychiatry 66:196-204. 2009
    ..Positron emission tomography using fluorine 18-labeled MK-9470 now enables quantification of type 1 cannabinoid receptors (CB1R) in the brain...
  11. doi request reprint Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo
    Koen Van Laere
    Division of Nuclear Medicine, Leuven University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 51:1413-7. 2010
    ..Animal and postmortem human data suggest that mutant huntingtin represses CB1 transcription. Our aim was to measure CB1 levels in the brains of Huntington disease (HD) patients in vivo...
  12. ncbi request reprint Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain
    Cindy Casteels
    Division of Nuclear Medicine, University Hospital Gasthuisberg and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 47:1858-66. 2006
    ..Also, the feasibility of individual rat brain statistical parametric mapping (SPM) was explored for (18)F-FDG and DAT imaging of a 6-hydroxydopamine (6OHDA) model of Parkinson's disease...
  13. doi request reprint Regional brain activity in functional dyspepsia: a H(2)(15)O-PET study on the role of gastric sensitivity and abuse history
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Gastroenterology 139:36-47. 2010
    ..Therefore, we aimed to determine the influence of gastric sensitivity and abuse history on gastric sensation scores and brain activity in homeostatic-afferent, emotional-arousal, and cortical-modulatory brain regions in FD...
  14. doi request reprint In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease
    Cindy Casteels
    Division of Nuclear Medicine, KU Leuven and University Hospital Leuven, Belgium
    Brain Res 1316:153-62. 2010
    ....
  15. ncbi request reprint Metabolic-dopaminergic mapping of the 6-hydroxydopamine rat model for Parkinson's disease
    Cindy Casteels
    Division of Nuclear Medicine, KU Leuven and University Hospital Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 35:124-34. 2008
    ..Here, we have characterized this model in vivo by multitracer imaging [glucose metabolism and dopamine transporter (DAT)] in relation to behavioral and histological parameters...
  16. pmc Measuring extrastriatal dopamine release during a reward learning task
    Elske Vrieze
    Department of Psychiatry, University Hospital Leuven, Belgium
    Hum Brain Mapp 34:575-86. 2013
    ..Conclusions: These findings support the hypothesis that DA release in mOFC, vmPFC, and dACC regions plays an important role in reinforcement learning in the human brain...
  17. doi request reprint Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease
    Kim Serdons
    Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    J Med Chem 52:1428-37. 2009
    ..The preliminary results strongly suggest that this new fluorinated compound is a promising candidate as an Abeta plaque imaging agent for the study of patients with AD...
  18. doi request reprint Anatomy-based reconstruction of FDG-PET images with implicit partial volume correction improves detection of hypometabolic regions in patients with epilepsy due to focal cortical dysplasia diagnosed on MRI
    Karolien Goffin
    Division of Nuclear Medicine and Medical Imaging Center, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:1148-55. 2010
    ....
  19. ncbi request reprint Non-invasive grading of brain tumours using dynamic amino acid PET imaging: does it work for 11C-methionine?
    Gerard Moulin-Romsee
    Division of Nuclear Medicine, University Hospital Leuven and K U Leuven, Herestraat 49, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 34:2082-7. 2007
    ..In many centres, (11)C-methionine (MET) is used for tumour imaging, but no clinical studies on the use of dynamic scanning for grading have been performed...
  20. doi request reprint Preclinical evaluation of 18F-JNJ41510417 as a radioligand for PET imaging of phosphodiesterase-10A in the brain
    Sofie Celen
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    J Nucl Med 51:1584-91. 2010
    ..PDE10A inhibitors are pursued as drugs for treatment of neuropsychiatric disorders. We have synthesized and evaluated (18)F-JNJ41510417 as a selective and high-affinity radioligand for in vivo brain imaging of PDE10A using PET...
  21. ncbi request reprint Motor- and food-related metabolic cerebral changes in the activity-based rat model for anorexia nervosa: a voxel-based microPET study
    Kris van Kuyck
    Laboratory of Experimental Functional Neurosurgery, Department of Neuroscience and Psychiatry, K U Leuven Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium
    Neuroimage 35:214-21. 2007
    ..001). Thus, in the ABA model metabolic changes are present in brain areas related to disease status and weight loss, which share several characteristics with the human disease...
  22. doi request reprint Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging
    Michel Koole
    Nuclear Medicine, University Hospital and K U Leuven, Leuven, Belgium
    J Nucl Med 50:818-22. 2009
    ..We have characterized the biodistribution and dosimetry of (18)F-3'-F-6-OH-BTA1 ((18)F-GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy elderly human subjects...
  23. doi request reprint An in vivo [18F]MK-9470 microPET study of type 1 cannabinoid receptor binding in Wistar rats after chronic administration of valproate and levetiracetam
    Karolien Goffin
    Division of Nuclear Medicine and MOSAIC, University Hospital Leuven and Katholieke Universiteit Leuven, Leuven, Belgium
    Neuropharmacology 54:1103-6. 2008
    ..This increase in CB1R tracer binding and possibly signaling may represent a supplementary and new mechanism of VPA, but not LEV, since activation of CB1Rs has been shown to decrease excitability and excitotoxicity on-demand...
  24. doi request reprint Longitudinal microPET imaging of brain glucose metabolism in rat lithium-pilocarpine model of epilepsy
    Karolien Goffin
    Division of Nuclear Medicine and MOSAIC, University Hospital Leuven and Katholieke Universiteit Leuven, Leuven, Belgium
    Exp Neurol 217:205-9. 2009
    ..Metabolic differences on D3 between SS and no SS animals need further study to investigate potential use as an early marker of epileptogenesis...
  25. doi request reprint Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging
    Nele Evens
    Laboratory for Radiopharmacy, IMIR K U Leuven, O and N2, Herestraat 49, Bus 821, BE 3000 Leuven, Belgium
    Bioorg Med Chem 19:4499-505. 2011
    ..Optimized derivatives of GW405833 that are less susceptible to metabolism will need to be developed in order to provide a useful tracer for CB₂R quantification with PET...
  26. doi request reprint Whole-body biodistribution and radiation dosimetry of the cannabinoid type 2 receptor ligand [11C]-NE40 in healthy subjects
    Rawaha Ahmad
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Mol Imaging Biol 15:384-90. 2013
    ..In this study we have investigated the safety and tolerability of [11C]-NE40, a CB2R positron emission tomography (PET) ligand, in healthy human male subjects and determined its biodistribution and radiation dosimetry...
  27. pmc New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation
    Daisy van Veghel
    Laboratory for Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Campus Gasthuisberg O and N2, Herestraat 49 box 821, 3000 Leuven, Belgium
    ACS Chem Neurosci 4:624-34. 2013
    ..Nevertheless, it appears that ligands with higher binding affinities will be required to allow in vivo imaging of TRPV1 via PET...
  28. doi request reprint Influence of chronic bromocriptine and levodopa administration on cerebral type 1 cannabinoid receptor binding
    Cindy Casteels
    Division of Nuclear Medicine, University Hospital Leuven, 3000 Leuven, Belgium
    Synapse 64:617-23. 2010
    ..The aim of this study was to investigate the in vivo effect of the commonly used antiparkinsonian drugs, levodopa (L-DOPA) and bromocriptine, on type 1 cannabinoid (CB1) receptors, using the PET radioligand [(18)F]MK-9470...
  29. ncbi request reprint Statistical parametric mapping of (99m)Tc-ECD SPECT in idiopathic Parkinson's disease and multiple system atrophy with predominant parkinsonian features: correlation with clinical parameters
    Koen Van Laere
    Division of Nuclear Medicine, Leuven University Hospital, Leuven, Belgium
    J Nucl Med 45:933-42. 2004
    ..In addition, a voxel-based covariance analysis was performed with disease-specific parameters and clinical patient data such as disease duration, medication, and clinical subscores...
  30. pmc Construction and evaluation of quantitative small-animal PET probabilistic atlases for [¹⁸F]FDG and [¹⁸F]FECT functional mapping of the mouse brain
    Cindy Casteels
    Division of Nuclear Medicine, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
    PLoS ONE 8:e65286. 2013
    ..Also, the feasibility of mouse brain statistical parametric mapping (SPM) was explored for [(18)F]FDG and [(18)F]FECT imaging of 6-hydroxydopamine-lesioned (6-OHDA) mice...
  31. doi request reprint Preclinical evaluation and quantification of [¹⁸F]MK-9470 as a radioligand for PET imaging of the type 1 cannabinoid receptor in rat brain
    Cindy Casteels
    Division of Nuclear Medicine, KU Leuven and University Hospital Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 39:1467-77. 2012
    ..We characterized the kinetics of [(18)F]MK-9470 and evaluated its ability to quantify CB1 receptor availability in the rat brain...
  32. doi request reprint Type 1 cannabinoid receptor mapping with [18F]MK-9470 PET in the rat brain after quinolinic acid lesion: a comparison to dopamine receptors and glucose metabolism
    Cindy Casteels
    Division of Nuclear Medicine, KU Leuven and University Hospital Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:2354-63. 2010
    ....
  33. doi request reprint In vivo characterization and dynamic receptor occupancy imaging of TPA023B, an alpha 2/alpha 3/alpha 5 subtype selective gamma-aminobutyric acid-a partial agonist
    Koen Van Laere
    Division of Nuclear Medicine, K U Leuven, Belgium
    Biol Psychiatry 64:153-61. 2008
    ....
  34. doi request reprint Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model
    Caroline Vandeputte
    Division of Nuclear Medicine, KU Leuven, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 39:1796-806. 2012
    ..The purpose of this study was to evaluate CB(1) and CB(2) receptor binding over time in vivo in a rat photothrombotic stroke model using PET...
  35. doi request reprint Synthesis and biological evaluation of [¹¹C]SB366791: a new PET-radioligand for in vivo imaging of the TRPV1 receptor
    Daisy van Veghel
    Laboratory for Radiopharmacy, KU Leuven, Leuven, Belgium
    Nucl Med Biol 40:141-7. 2013
    ..In this study, we report the synthesis and biological evaluation of a carbon-11 labelled analogue of N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) which was reported as a specific high-affinity antagonist for TRPV1...
  36. doi request reprint 18F-FDG labeling of mesenchymal stem cells and multipotent adult progenitor cells for PET imaging: effects on ultrastructure and differentiation capacity
    Esther Wolfs
    Division of Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
    J Nucl Med 54:447-54. 2013
    ....
  37. doi request reprint Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa
    Nathalie Gerard
    Division of Nuclear Medicine, University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    Biol Psychiatry 70:777-84. 2011
    ..The endocannabinoid system is a possible target in the treatment of eating disorders. We used positron emission tomography to investigate the type 1 cannabinoid receptor (CB1R) in bulimic and anorectic patients...
  38. doi request reprint Influence of chronic nicotine administration on cerebral type 1 cannabinoid receptor binding: an in vivo micro-PET study in the rat using [18F]MK-9470
    Nathalie Gerard
    Division of Nuclear Medicine, E901, Catholic University Leuven and University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Mol Neurosci 42:162-7. 2010
    ..These results also suggest that chronic nicotine usage is unlikely to interfere with human PET imaging using this radioligand...
  39. ncbi request reprint 99mTc-ciprofloxacin planar and tomographic imaging for the diagnosis of infection in the postoperative spine: experience in 48 patients
    Frederic De Winter
    Division of Nuclear Medicine, Ghent University Hospital, Gent, Belgium
    Eur J Nucl Med Mol Imaging 31:233-9. 2004
    ..Taking this limitation into account, we advise planar and SPET imaging at 3 h post injection and an interval of at least 6 months after surgery to minimise the likelihood of false positives...
  40. doi request reprint Towards a neurocircuitry in anorexia nervosa: evidence from functional neuroimaging studies
    Kris van Kuyck
    Laboratory for Experimental Functional Neurosurgery, Department of Neurosciences, K U Leuven Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium
    J Psychiatr Res 43:1133-45. 2009
    ..The insights of the current review may ultimately lead to the development of new treatments...
  41. doi request reprint A PET brain reporter gene system based on type 2 cannabinoid receptors
    Caroline Vandeputte
    Division of Nuclear Medicine, University Hospital and K U Leuven, Leuven, Belgium
    J Nucl Med 52:1102-9. 2011
    ..Here we report the first, to our knowledge, PET reporter system for imaging gene expression in the intact brain...
  42. doi request reprint Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
    Natalie Nelissen
    Laboratory for Cognitive Neurology, K U Leuven, Leuven, Belgium
    J Nucl Med 50:1251-9. 2009
    ....
  43. doi request reprint Successful anterior capsulotomy in comorbid anorexia nervosa and obsessive-compulsive disorder: case report
    Johan Barbier
    Departmentsof Neurosciences and Psychiatry, Katholieke Universiteit Leuven, Leuven, Belgium
    Neurosurgery 69:E745-51; discussion E751. 2011
    ..Both disorders have common features, and anterior capsulotomy is a last-resort treatment for OCD. We document the effect of bilateral anterior capsulotomy in a patient with comorbid AN and OCD...
  44. doi request reprint Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia
    Jenny Ceccarini
    Division of Nuclear Medicine, University Hospitals Leuven and Department of Imaging and Pathology, KU Leuven, Leuven, Belgium
    Neuroimage 79:304-12. 2013
    ..In SCZ-F patients, it is associated with negative symptoms and depression scores...
  45. doi request reprint Optimized in vivo detection of dopamine release using 18F-fallypride PET
    Jenny Ceccarini
    Division of Nuclear Medicine, University Hospital and Katholieke Universiteit, Leuven, Belgium
    J Nucl Med 53:1565-72. 2012
    ....
  46. ncbi request reprint Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression
    Erwin Lauwers
    Laboratory for Neurobiology and Gene Therapy, K U Leuven, Leuven, Belgium
    Neurobiol Aging 28:248-57. 2007
    ..MicroSPECT imaging enables non-invasive imaging of the neurodegeneration allowing longitudinal follow-up in this new animal model for Parkinson's disease and the evaluation of neuroprotective drugs...
  47. doi request reprint Interictal type 1 cannabinoid receptor binding is increased in female migraine patients
    Bart J Van der Schueren
    Center for Clinical Pharmacology, University Hospital Gasthuisberg, Leuven, Belgium
    Headache 52:433-40. 2012
    ..To compare binding of the type 1 cannabinoid receptor (CB1R) between migraine patients and healthy volunteers...
  48. doi request reprint Evaluation of three MRI-based anatomical priors for quantitative PET brain imaging
    Kathleen Vunckx
    Department of Nuclear Medicine, KU Leuven, Leuven, Belgium
    IEEE Trans Med Imaging 31:599-612. 2012
    ..The performance of the segmentation-based prior is quite sensitive to the accuracy of the segmentation. In contrast to the joint entropy-prior, the Bowsher-prior is easily tuned and does not suffer from convergence problems...
  49. doi request reprint Micro-positron emission tomography imaging of rat brain metabolism during expression of contextual conditioning
    Laura Luyten
    Division of Experimental Neurosurgery and Neuroanatomy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Neurosci 32:254-63. 2012
    ..We also observed hypermetabolism in the same cluster in rats expressing contextual anxiety compared with rats expressing cued fear. Our results provide novel evidence for a role of the BST in the expression of contextual anxiety...
  50. ncbi request reprint Evaluation of anatomy based reconstruction for partial volume correction in brain FDG-PET
    Kristof Baete
    Department of Nuclear Medicine, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Neuroimage 23:305-17. 2004
    ..004). The patient study confirmed the applicability of A-MAP in clinical practice. Conclusion: A-MAP is a promising technique for voxel-based partial volume correction of FDG-PET of the human brain...
  51. doi request reprint Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging
    Nele Evens
    Laboratory for Radiopharmacy, K U Leuven, 3000 Leuven, Belgium
    Nucl Med Biol 36:455-65. 2009
    ..Imaging of the CB(2) receptor has been unsuccessful so far. We synthesized and evaluated a carbon-11- and a fluorine-18-labeled 2-oxoquinoline derivative as new PET tracers with high specificity and affinity for the CB(2) receptor...
  52. ncbi request reprint Direct comparison of 18F-FDG and 11C-methionine PET in suspected recurrence of glioma: sensitivity, inter-observer variability and prognostic value
    Koen Van Laere
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 32:39-51. 2005
    ..The aim of this study was to compare directly both radioligands in this setting...
  53. doi request reprint Small animal PET imaging of the type 1 cannabinoid receptor in a rodent model for anorexia nervosa
    Cindy Casteels
    Division of Nuclear Medicine, University Hospital and KU Leuven, Herestraat 49 bus 7003, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 41:308-21. 2014
    ....
  54. doi request reprint In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232
    Eric D Hostetler
    Merck Research Laboratories, West Point, Pennsylvania E D H, A D J, S S B, H F, Z Z, M P, L G, K R, M W, S O, P M H G S, S N G, I M B, C A S, S A K, C C L, R J H, C S, J J C, J L E Division of Nuclear Medicine, University Hospital and KU Leuven, Leuven, Belgium T d G, K V L Lab Radiopharmacy KU Leuven, Leuven, Belgium G B Merck Sharp and Dohme, Brussels, Belgium T R, R D, I D L Merck Clinical Pharmacology, Upper Gwynedd, Pennsylvania W P K
    J Pharmacol Exp Ther 347:478-86. 2013
    ..Therefore, it is unlikely that antagonism of central CGRP-R is required for migraine efficacy. However, it is not known whether high central CGRP-R antagonism may provide additional therapeutic benefit. ..
  55. doi request reprint Fluoro-D-glucose-micro positron emission tomography as a diagnostic tool to confirm brain death in a murine donor lung injury model
    Shana Wauters
    Laboratory for Experimental Thoracic Surgery, KU Leuven, Leuven, Belgium
    J Surg Res 180:343-8. 2013
    ..The purpose of our study was to validate BD in mice using small-animal positron emission tomography...
  56. doi request reprint Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H(2)(15)O-PET study
    Lukas Van Oudenhove
    Department of Neurosciences, Psychiatry Division, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 105:913-24. 2010
    ....
  57. ncbi request reprint Ictal perfusion patterns associated with single MRI-visible focal dysplastic lesions: implications for the noninvasive delineation of the epileptogenic zone
    Patrick Dupont
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Epilepsia 47:1550-7. 2006
    ....
  58. doi request reprint Neuronuclear assessment of patients with epilepsy
    Karolien Goffin
    Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
    Semin Nucl Med 38:227-39. 2008
    ..Potential new therapeutic targets may be discovered using this translational approach...
  59. doi request reprint 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Catholic University Leuven, Leuven, Belgium
    Ann Neurol 68:319-29. 2010
    ..Its availability, however, is limited by the need for an on-site cyclotron. Validation of the (18)F-labeled PIB derivative (18)F-flutemetamol could significantly enhance access to this novel technology...
  60. doi request reprint The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain
    Cindy Casteels
    Division of Nuclear Medicine, KU Leuven and University Hospital Gasthuisberg, Herestraat 49 bus 7003, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 37:1164-73. 2010
    ..Using small animal PET and ex vivo autoradiography, we examined the influence of pentobarbital and isoflurane anaesthesia on the rat brain uptake of [(18)F]MK-9470, a radioligand for the type 1 cannabinoid receptor...
  61. ncbi request reprint Anatomically standardised 99mTc-ECD brain perfusion SPET allows accurate differentiation between healthy volunteers, multiple system atrophy and idiopathic Parkinson's disease
    Tommy Bosman
    Division of Nuclear Medicine, P7, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
    Eur J Nucl Med Mol Imaging 30:16-24. 2003
    ..In conclusion, using age- and gender-matched healthy volunteer data and anatomical standardisation, it is possible to differentiate between IPD and MSA with high discriminating power in clinically relevant circumstances...
  62. ncbi request reprint Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT
    Satish K Chitneni
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, BE 3000, Leuven, Belgium
    Nucl Med Biol 35:75-82. 2008
    ..We report an improved radiosynthesis procedure and affinity data and have analyzed both brain tissue and plasma samples for the presence of radiometabolites as a function of time post intravenous injection of [(18)F]FECT to rats...
  63. doi request reprint In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis
    Karolien Goffin
    Division of Nuclear Medicine, University Hospital Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Brain 134:1033-40. 2011
    ..The decreased type 1 cannabinoid receptor availability in the insula may play a role in surround inhibition and prevention of seizure propagation...
  64. doi request reprint Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study
    Jenny Ceccarini
    Division of Nuclear Medicine, University Hospitals Leuven, KU Leuven, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 40:1582-94. 2013
    ..Secondly, levels of anandamide (AEA) in the nucleus accumbens (NAcc) were investigated in the same animals using in vivo microdialysis and correlated with the changes in CB1R binding...
  65. doi request reprint Autoimmune-mediated encephalitis
    Philippe Demaerel
    Department of Radiology, University Hospitals K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Neuroradiology 53:837-51. 2011
    ..This report is based on a review of the literature (except the literature in Japanese) and own findings in patients with autoimmune-mediated encephalitis...
  66. ncbi request reprint Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
    Karolien Goffin
    Katholieke Universiteit Leuven, Leuven, Belgium
    Exp Neurol 205:501-5. 2007
    ..Finally, our data suggest that the model can be used for studies aiming at identifying the mechanisms of seizure clustering...
  67. doi request reprint Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents
    Kim Serdons
    Laboratory for Radiopharmacy, Katholieke Universiteit Leuven, Leuven, Belgium
    J Med Chem 52:7090-102. 2009
    ..Its polar plasma radiometabolites do not cross the blood-brain barrier. The preliminary results strongly suggest that this new fluorinated compound is a promising candidate as a PET brain amyloid imaging agent...
  68. doi request reprint Long term clinical outcome of peripheral nerve stimulation in patients with chronic peripheral neuropathic pain
    Frank Van Calenbergh
    Department of Neurosurgery, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Surg Neurol 72:330-5; discussion 335. 2009
    ..In recent years we have witnessed a renewed interest for PNS. The aim of the present study was to evaluate the long-term clinical efficacy of PNS in a group of patients with peripheral neuropathic pain treated with PNS since the 1980s...
  69. ncbi request reprint 99mTc ciprofloxacin imaging for the diagnosis of infection in the postoperative spine
    Filip Gemmel
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Nucl Med Commun 25:277-83. 2004
    ....
  70. doi request reprint Characterization of the inflammatory response in a photothrombotic stroke model by MRI: implications for stem cell transplantation
    Caroline Vandeputte
    Division of Nuclear Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Mol Imaging Biol 13:663-71. 2011
    ..The aim of this study was to evaluate the specificity of magnetic resonance imaging (MRI) contrast in a photothrombotic (PT) stroke model with and without engraftment of superparamagnetic iron oxide (SPIO)-labeled stem cells...
  71. ncbi request reprint Paradoxical Interictal Cerebral Cortical Hypermetabolism on Brain FDG PET in Sturge-Weber Syndrome
    Mohamad Al-Makhzomi
    From the Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium and Department of Pediatrics, University Hospital Leuven, Leuven, Belgium
    Clin Nucl Med 36:313-4. 2011
    ..Although the exact mechanism underlying this paradoxical hypermetabolism remains unclear, it may play an important role in the pathophysiologic progression of SWS...
  72. pmc [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor
    H Donald Burns
    Imaging Research, Merck Research Laboratories, West Point, PA 19486, USA
    Proc Natl Acad Sci U S A 104:9800-5. 2007
    ..In addition, it allows demonstration of target engagement and noninvasive dose-occupancy studies to aid in dose selection for clinical trials of CB1R inverse agonists...
  73. doi request reprint The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake
    Carol Addy
    Merck Research Laboratories, Boston, MA 02115, USA
    Cell Metab 7:68-78. 2008
    ..Mechanism-of-action studies suggest that engagement of the CB1R by taranabant leads to weight loss by reducing food intake and increasing energy expenditure and fat oxidation...
  74. ncbi request reprint Visualizing out-of-body experience in the brain
    Dirk De Ridder
    Department of Neurosurgery and Ear, Nose, and Throat, University Hospital Antwerp, Antwerp University, Antwerp, Belgium
    N Engl J Med 357:1829-33. 2007
    ..We suggest that activation of these regions is the neural correlate of the disembodiment that is part of the out-of-body experience...
  75. doi request reprint Labelling and biological evaluation of [(11)C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor
    Nele Evens
    Laboratory for Radiopharmacy, K U Leuven, Leuven 3000, Belgium
    Nucl Med Biol 35:793-800. 2008
    ....
  76. ncbi request reprint In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans
    Koen Van Laere
    Eur J Nucl Med Mol Imaging 34:1719-26. 2007
  77. ncbi request reprint Decreased 5-HT2a receptor binding in patients with anorexia nervosa
    Kurt Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
    J Nucl Med 44:163-9. 2003
    ..It was our aim to investigate the central 5-HT(2a) receptor binding index using SPECT brain imaging...
  78. ncbi request reprint Abeta amyloid deposition in the language system and how the brain responds
    Natalie Nelissen
    Cognitive Neurology Laboratory, KU Leuven, Belgium
    Brain 130:2055-69. 2007
    ..Functional reorganization of the language system in response to Abeta amyloid-related brain injury exists in early-stage AD and determines the degree of anomia more than Abeta amyloid load per se does...
  79. ncbi request reprint Cognitive deficits during status epilepticus and time course of recovery: a case report
    Wim Van Paesschen
    Department of Neurology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Epilepsia 48:1979-83. 2007
    ....
  80. ncbi request reprint Age and gender effects on normal regional cerebral blood flow
    Anne Sophie Pirson
    AJNR Am J Neuroradiol 27:1161-2; author reply 1162-3. 2006
  81. pmc Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1
    Arvid Suls
    Neurogenetics Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerpen, Belgium
    Brain 131:1831-44. 2008
    ....
  82. ncbi request reprint The use of SPECT and PET in routine clinical practice in epilepsy
    Wim Van Paesschen
    Department of Neurology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Curr Opin Neurol 20:194-202. 2007
    ..The aim of this article is to give a subjective review of the usefulness of single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging in clinical practice in epilepsy for 2007...
  83. ncbi request reprint Status gelasticus after temporal lobectomy: ictal FDG-PET findings and the question of dual pathology involving hypothalamic hamartomas
    Andre Palmini
    Neurology Service and Epilepsy Surgery Program, Hospital Sao Lucas da PUCRS, Porto Alegre, Brazil
    Epilepsia 46:1313-6. 2005
    ....
  84. ncbi request reprint Small animal positron emission tomography during vagus nerve stimulation in rats: a pilot study
    Stefanie Dedeurwaerdere
    Laboratory for Clinical and Experimental Neurophysiology, Department of Neurology, Ghent University Hospital, Ghent, Belgium
    Epilepsy Res 67:133-41. 2005
    ..05) was found. Acute and chronic VNS induced changes in glucose metabolism in regions important for seizure control (hippocampus and striatum). Our results promote further brain research on VNS using small animal PET in rats...
  85. ncbi request reprint Quantification of Parkinson's disease-related network expression with ECD SPECT
    Thomas Eckert
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Eur J Nucl Med Mol Imaging 34:496-501. 2007
    ..In the current study, we utilized a new, fully automated voxel-based method to quantify network expression in ECD SPECT images from patients with classical PD, patients with multiple system atrophy (MSA), and healthy control subjects...