Karlijn van der Ven

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi Neuropharmaceuticals in the environment: mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays
    Karlijn van der Ven
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Environ Toxicol Chem 25:2645-52. 2006
  2. ncbi Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio)
    Karlijn van der Ven
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 141:408-17. 2005
  3. ncbi Effects of the antidepressant mianserin in zebrafish: molecular markers of endocrine disruption
    Karlijn van der Ven
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Chemosphere 65:1836-45. 2006
  4. ncbi Effluent impact assessment using microarray-based analysis in common carp: a systems toxicology approach
    Lotte N Moens
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlann 171, B 2020 Antwerp, Belgium
    Chemosphere 67:2293-304. 2007
  5. ncbi Molecular responses during cadmium-induced stress in Daphnia magna: integration of differential gene expression with higher-level effects
    Anneleen Soetaert
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 83:212-22. 2007
  6. ncbi An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio)
    Marijke De Wit
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Gen Comp Endocrinol 167:190-201. 2010
  7. ncbi Nickel and binary metal mixture responses in Daphnia magna: molecular fingerprints and (sub)organismal effects
    Tine Vandenbrouck
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp UA, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 92:18-29. 2009
  8. ncbi Patterns of gene expression in carp liver after exposure to a mixture of waterborne and dietary cadmium using a custom-made microarray
    Hans Reynders
    Department of Biology, Research Unit Ecophysiology, Biochemistry and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 80:180-93. 2006
  9. ncbi Molecular impact of propiconazole on Daphnia magna using a reproduction-related cDNA array
    Anneleen Soetaert
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Belgium
    Comp Biochem Physiol C Toxicol Pharmacol 142:66-76. 2006
  10. ncbi Effect of copper exposure on gene expression profiles in Chlamydomonas reinhardtii based on microarray analysis
    An Jamers
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Aquat Toxicol 80:249-60. 2006

Detail Information

Publications16

  1. ncbi Neuropharmaceuticals in the environment: mianserin-induced neuroendocrine disruption in zebrafish (Danio rerio) using cDNA microarrays
    Karlijn van der Ven
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Environ Toxicol Chem 25:2645-52. 2006
    ..Based on the specific molecular impact and the effects on reproduction, we conclude that further investigation of the adverse effects on the brain-liver-gonad axis is needed for a correct ecological risk assessment of antidepressants...
  2. ncbi Development and application of a brain-specific cDNA microarray for effect evaluation of neuro-active pharmaceuticals in zebrafish (Danio rerio)
    Karlijn van der Ven
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Comp Biochem Physiol B Biochem Mol Biol 141:408-17. 2005
    ..This new genomic tool successfully detected gene expression effects of exposure to chlorpromazine in the brain of zebrafish. Reported gene expression effects are found to be consistent with literature data for other laboratory animals...
  3. ncbi Effects of the antidepressant mianserin in zebrafish: molecular markers of endocrine disruption
    Karlijn van der Ven
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Chemosphere 65:1836-45. 2006
    ..This argues in favor of pathway-driven analysis of gene expression results compared to gene-per-gene analysis...
  4. ncbi Effluent impact assessment using microarray-based analysis in common carp: a systems toxicology approach
    Lotte N Moens
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlann 171, B 2020 Antwerp, Belgium
    Chemosphere 67:2293-304. 2007
    ..Our results demonstrate the benefit of toxicogenomic tools in a "systems toxicology" approach, involving the integration of adverse effects of chemicals and stressors across multiple levels of biological complexity...
  5. ncbi Molecular responses during cadmium-induced stress in Daphnia magna: integration of differential gene expression with higher-level effects
    Anneleen Soetaert
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 83:212-22. 2007
    ..Furthermore, cadmium affected the expression of genes coding for proteins involved in molecular pathways associated with immune response, stress response, cell adhesion, visual perception and signal transduction in the present study...
  6. ncbi An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio)
    Marijke De Wit
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Gen Comp Endocrinol 167:190-201. 2010
    ..Overall, this study demonstrated that a proteomics approach can lift the biological interpretation of microarrays to a higher level, and moreover, opens a window for identification of possible new biomarkers...
  7. ncbi Nickel and binary metal mixture responses in Daphnia magna: molecular fingerprints and (sub)organismal effects
    Tine Vandenbrouck
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp UA, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 92:18-29. 2009
    ..These findings, although indicative of the complex nature of mixture toxicity evaluation, underline the potential of a toxicogenomics approach in gaining more mechanistic information on the effects of single compounds and mixtures...
  8. ncbi Patterns of gene expression in carp liver after exposure to a mixture of waterborne and dietary cadmium using a custom-made microarray
    Hans Reynders
    Department of Biology, Research Unit Ecophysiology, Biochemistry and Toxicology Group, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Aquat Toxicol 80:180-93. 2006
    ....
  9. ncbi Molecular impact of propiconazole on Daphnia magna using a reproduction-related cDNA array
    Anneleen Soetaert
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Belgium
    Comp Biochem Physiol C Toxicol Pharmacol 142:66-76. 2006
    ..We have demonstrated the potential of microarray analysis in toxicity screening with D. magna. The use of vitellogenin mRNA as a rapid biomarker of reproductive effects in chronic toxicity studies with cladocerans is suggested...
  10. ncbi Effect of copper exposure on gene expression profiles in Chlamydomonas reinhardtii based on microarray analysis
    An Jamers
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Aquat Toxicol 80:249-60. 2006
    ....
  11. ncbi Daphnia magna and ecotoxicogenomics: gene expression profiles of the anti-ecdysteroidal fungicide fenarimol using energy-, molting- and life stage-related cDNA libraries
    Anneleen Soetaert
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Chemosphere 67:60-71. 2007
    ..This study suggests that this Daphnia magna microarray is of great further value for the elucidation of molecular mechanisms of toxicity and for the future development of specific biomarkers for hazard characterization...
  12. ncbi Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches
    Marijke De Wit
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Antwerp, Belgium
    Chemosphere 74:96-105. 2008
    ..Summarizing, these results enabled us to hypothesize several working mechanisms of TBBPA and demonstrated the potential of a combined genome and proteome approach to generate detailed mechanistic toxicological information...
  13. ncbi Ecotoxicological risk assessment using DNA chips and cellular reporters
    Johan Robbens
    Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171 B 2020, Antwerp, Belgium
    Trends Biotechnol 25:460-6. 2007
    ..Some important technical and interpretative hurdles still need to be overcome before a full implementation of ecotoxicogenomics in regulatory settings will occur...
  14. ncbi Use of suppression subtractive hybridization PCR for the development of cDNA arrays for the detection of endocrine disruption in carp (Cyprinus carpio)
    Lotte N Moens
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Comp Biochem Physiol Part D Genomics Proteomics 2:18-33. 2007
    ..These results indicate the discriminating power of the developed array, and its usefulness to describe the toxicological mode of action of endocrine disruptive chemicals...
  15. ncbi Expression profiling of endocrine-disrupting compounds using a customized Cyprinus carpio cDNA microarray
    Lotte N Moens
    Department of Biology, Laboratory for Ecophysiology, Biochemistry and Toxicology, Intelligent Systems Laboratory, University of Antwerp, B 2020 Antwerp, Belgium
    Toxicol Sci 93:298-310. 2006
    ..Overall, our findings suggest that the developed cDNA array has great promise to screen new and existing chemicals on their endocrine-disruptive potential and to identify distinct classes of EDCs...
  16. ncbi Determination of diazepam in aquatic samples by capillary liquid chromatography-electrospray tandem mass spectrometry
    Karlijn van der Ven
    Department of Biology, Laboratory of Ecophysiology, Biochemistry and Toxicology, University of Antwerp RUCA, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Chemosphere 57:967-73. 2004
    ..Applying this assay we have detected diazepam in 'in/effluent samples' collected in Belgium and demonstrated the applicability for water analysis without off-line pre-concentration of the analyte...