W Robberecht

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. doi request reprint Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2
    P Van Damme
    Department of Neurology, University Hospital Leuven, Leuven, Belgium
    Neurology 76:2066-72. 2011
  2. ncbi request reprint Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons
    L van den Bosch
    Laboratory of Neurobiology, Department of Neurology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Neurol Sci 180:29-34. 2000
  3. ncbi request reprint Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis
    M Dewil
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neuropathol Appl Neurobiol 33:499-509. 2007
  4. ncbi request reprint The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS
    P Van Damme
    Department of Neurology, Leuven University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Eur J Neurol 17:754-6. 2010
  5. ncbi request reprint Abnormal intracellular ca(2+)homeostasis and disease
    L Missiaen
    Laboratory of Physiology, K U Leuven Campus Gasthuisberg O N, Leuven, Belgium
    Cell Calcium 28:1-21. 2000
  6. ncbi request reprint Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity
    L van den Bosch
    Laboratory of Neurobiology, Department of Neurology, University of Leuven, Leuven, Belgium
    Brain Res Bull 53:383-8. 2000
  7. pmc Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse
    I Taes
    Laboratory of Neurobiology and Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Neurology 74:1687-93. 2010
  8. ncbi request reprint Excitotoxicity and amyotrophic lateral sclerosis
    P Van Damme
    Neurobiology, Campus Gasthuisberg, Leuven, Belgium
    Neurodegener Dis 2:147-59. 2005
  9. ncbi request reprint Oxidative stress in amyotrophic lateral sclerosis
    W Robberecht
    Department of Neurology, University Hospital Gasthuisberg, University of Leuven, School of Medicine, Belgium
    J Neurol 247:I1-6. 2000
  10. ncbi request reprint Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death
    J Krishnan
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    Exp Neurol 200:301-10. 2006

Collaborators

Detail Information

Publications22

  1. doi request reprint Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2
    P Van Damme
    Department of Neurology, University Hospital Leuven, Leuven, Belgium
    Neurology 76:2066-72. 2011
    ..Intermediate CAG repeat expansions in ataxin 2 (ATXN2), the causative gene of spinocerebellar ataxia type 2 (SCA2), have been implicated in sporadic ALS. We studied ATXN2 in a large cohort of patients with sporadic and familial ALS...
  2. ncbi request reprint Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons
    L van den Bosch
    Laboratory of Neurobiology, Department of Neurology, University of Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Neurol Sci 180:29-34. 2000
    ..This indicates that despite the abundant expression of GluR2, this subunit is excluded from a subset of AMPA receptors and that the activation of these receptors is responsible for the selective motor neuron death...
  3. ncbi request reprint Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis
    M Dewil
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Campus Gasthuisberg, Leuven, Belgium
    Neuropathol Appl Neurobiol 33:499-509. 2007
    ..From these results, we conclude that the loss of phospho-Akt could be involved in motor neurone death in ALS, and that therapies upregulating phospho-Akt thus might be of clinical relevance...
  4. ncbi request reprint The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS
    P Van Damme
    Department of Neurology, Leuven University Hospital, Herestraat 49, 3000 Leuven, Belgium
    Eur J Neurol 17:754-6. 2010
    ..Mutations in fused in sarcoma (FUS) were recently identified as a cause of familial amyotrophic lateral sclerosis (ALS). The frequency of occurrence of mutations in FUS in sets of patients with familial ALS remains to be established...
  5. ncbi request reprint Abnormal intracellular ca(2+)homeostasis and disease
    L Missiaen
    Laboratory of Physiology, K U Leuven Campus Gasthuisberg O N, Leuven, Belgium
    Cell Calcium 28:1-21. 2000
    ..In some instances, disease-causing mutations or abnormalities provide us with new insights into the cell biology of the various Ca(2+)transporters...
  6. ncbi request reprint Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity
    L van den Bosch
    Laboratory of Neurobiology, Department of Neurology, University of Leuven, Leuven, Belgium
    Brain Res Bull 53:383-8. 2000
    ..dorsal horn neurons was observed after short KA exposures indicating that the selective vulnerability of motor neurons to excitotoxicity is related to the presence of Ca(2+)-permeable AMPA receptors...
  7. pmc Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse
    I Taes
    Laboratory of Neurobiology and Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Leuven, Belgium
    Neurology 74:1687-93. 2010
    ..However, the precise role of tau in motor neuron degeneration remains uncertain...
  8. ncbi request reprint Excitotoxicity and amyotrophic lateral sclerosis
    P Van Damme
    Neurobiology, Campus Gasthuisberg, Leuven, Belgium
    Neurodegener Dis 2:147-59. 2005
    ..All this information could help to develop new and better therapeutic strategies that could protect motor neurons from excitotoxicity...
  9. ncbi request reprint Oxidative stress in amyotrophic lateral sclerosis
    W Robberecht
    Department of Neurology, University Hospital Gasthuisberg, University of Leuven, School of Medicine, Belgium
    J Neurol 247:I1-6. 2000
    ....
  10. ncbi request reprint Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death
    J Krishnan
    Laboratory of Neurobiology, K U Leuven, Campus Gasthuisberg, Leuven, Belgium
    Exp Neurol 200:301-10. 2006
    ..These results show that activation of the heat shock response protects cells against mutant SOD1-dependent cell death, but that Hsp27 is not an essential component of the stress response leading to protection...
  11. doi request reprint Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype
    D Lambrechts
    Center for Transgene Technology and Gene Therapy, KU Leuven, Leuven, Belgium
    J Med Genet 46:840-6. 2009
    ..46 males vs females; 95% CI = 1.19 to 1.80; p = 7.8 10E-5), even after correction for publication bias and multiple testing...
  12. ncbi request reprint Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques
    P A Theys
    Department of Neurology, University Hospital Gasthuisberg, Leuven, Belgium
    J Neurol 246:438-42. 1999
    ..Furthermore, the amyotrophic lateral sclerosis disease process seems preferentially to affect MNFCV...
  13. doi request reprint Differential contribution of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons
    J N Chabwine
    Department of Molecular and Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 23:1168-76. 2009
    ..The high NKCC1 activity in DRGNs is important for maintaining high [Cl(-)](i), whereas lower NKCC1 activity in MNs allows large [Cl(-)](i) variations during neuronal activity...
  14. doi request reprint Genetics of amyotrophic lateral sclerosis
    W Robberecht
    Dept Neurology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    J Neurol 247:VI/2-6. 2000
    ..A genetic component is also thought to at least contribute to the pathogenesis of sporadic ALS. Their identification is now possible thanks to progress in molecular genetics...
  15. ncbi request reprint Amyotrophic lateral sclerosis: pathogenesis
    R H Brown
    Department of Neurology, University of Leuven School of Medicine, University Hospital Gasthuisberg, Belgium
    Semin Neurol 21:131-9. 2001
    ..Ultimately, it is hoped that insights from these types of studies will improve the prospects for developing meaningful therapies of ALS...
  16. doi request reprint Crosstalk between astrocytes and motor neurons: what is the message?
    L van den Bosch
    Neurobiology, K U Leuven, Campus Gasthuisberg O and N2, Herestraat 49, Leuven, Belgium
    Exp Neurol 211:1-6. 2008
    ..As a consequence, understanding the interactions between motor neurons and astrocytes in health and disease may have important therapeutic implications...
  17. ncbi request reprint D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis
    W Robberecht
    Department of Neurology and Laboratory for Neurobiology, University Hospital Gasthuisberg, Leuven, Belgium
    Neurology 47:1336-9. 1996
    ..We describe two families with ALS and one apparently sporadic ALS patient who are heterozygous for the D90A mutation. One patient had the unusual phenotype of focal nonprogressing motor neuron disease...
  18. ncbi request reprint Protective effect of parvalbumin on excitotoxic motor neuron death
    L van den Bosch
    Neurobiology, Laboratory of Physiology, Campus Gasthuisberg, Herestraat 49, Leuven, Belgium
    Exp Neurol 174:150-61. 2002
    ..Overexpression of a high-affinity Ca(2+) buffer such as PV protects the motor neuron from excitotoxicity and this protective effect depends upon the mode of Ca(2+) entry into the cell...
  19. ncbi request reprint Genetic markers of ALS
    W Robberecht
    Department of Neurology, University Hospital Leuven, University of Leuven, School of Medicine, Belgium
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:S57-9. 2000
    ..Other mutations are under investigation and confirmed results are eagerly awaited...
  20. pmc Coexistence of CADASIL and Alzheimer's disease
    V Thijs
    Department of Neurology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    J Neurol Neurosurg Psychiatry 74:790-2. 2003
    ..Mutations in the APP, PSEN1, and PSEN2 genes were not identified. Neuropathological findings of Alzheimer's disease may be found in CADASIL patients...
  21. ncbi request reprint Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    B Oosthuyse
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 28:131-8. 2001
    ..Acute ischemia is known to cause nonselective neuronal death. Our results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons...
  22. ncbi request reprint A case of hemiparesis associated with cranial nerve lesions due to intravascular lymphomatosis(2003:4b)
    Y De Bruecker
    Department of Radiology, University Hospitals, Catholic University of Leuven, Leuven, Belgium
    Eur Radiol 13:1753-5. 2003
    ..Intravascular lymphomatosis should be taken into account in the differential diagnosis of repeated cerebral ischemia of unclear aetiology...