Maarten Naesens

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. ncbi request reprint Tacrolimus dose requirements and CYP3A5 genotype and the development of calcineurin inhibitor-associated nephrotoxicity in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Ther Drug Monit 32:394-404. 2010
  2. doi request reprint Chronic histological damage in early indication biopsies is an independent risk factor for late renal allograft failure
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium, EU
    Am J Transplant 13:86-99. 2013
  3. ncbi request reprint Replicative senescence in kidney aging, renal disease, and renal transplantation
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Discov Med 11:65-75. 2011
  4. doi request reprint Harnessing the diversity of the human T-cell repertoire: a monitoring tool for transplantation tolerance?
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Eur J Immunol 40:2986-9. 2010
  5. doi request reprint Molecular diagnostics in transplantation
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, 3000 Leuven, Belgium
    Nat Rev Nephrol 6:614-28. 2010
  6. doi request reprint Calcineurin inhibitor nephrotoxicity
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 4:481-508. 2009
  7. pmc Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 3:1829-36. 2008
  8. ncbi request reprint Current target ranges of mycophenolic acid exposure and drug-related adverse events: a 5-year, open-label, prospective, clinical follow-up study in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 30:673-83. 2008
  9. ncbi request reprint Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology, Catholic University Leuven, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 80:509-21. 2006
  10. doi request reprint Reasons for dose reduction of mycophenolate mofetil during the first year after renal transplantation and its impact on graft outcome
    Thomas Vanhove
    Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Belgium
    Transpl Int 26:813-21. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Tacrolimus dose requirements and CYP3A5 genotype and the development of calcineurin inhibitor-associated nephrotoxicity in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals of Leuven, Leuven, Belgium
    Ther Drug Monit 32:394-404. 2010
    ..Prolonged calcineurin inhibitor maintenance therapy in kidney allograft recipients is complicated by the development of chronic irreversible drug-induced nephrotoxicity (CNIT)...
  2. doi request reprint Chronic histological damage in early indication biopsies is an independent risk factor for late renal allograft failure
    M Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium, EU
    Am J Transplant 13:86-99. 2013
    ..The global burden of early chronic histological damage within the first year after transplantation importantly affects the fate of the allografts...
  3. ncbi request reprint Replicative senescence in kidney aging, renal disease, and renal transplantation
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Discov Med 11:65-75. 2011
    ..In a human setting, it remains to be investigated whether cellular senescence plays an active or a bystander role in fibrogenesis and atrophy of renal tissue...
  4. doi request reprint Harnessing the diversity of the human T-cell repertoire: a monitoring tool for transplantation tolerance?
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Eur J Immunol 40:2986-9. 2010
    ..In this Commentary, we discuss the strengths and opportunities of TCR repertoire monitoring, and point towards yet unanswered questions that will become important if the Vβ CDR3-length distribution assay will be clinically applied...
  5. doi request reprint Molecular diagnostics in transplantation
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, 3000 Leuven, Belgium
    Nat Rev Nephrol 6:614-28. 2010
    ..Although this Review focuses on transplantation research and clinical transplantation, the concepts addressed are valid for all translational research...
  6. doi request reprint Calcineurin inhibitor nephrotoxicity
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 4:481-508. 2009
    ..Better insight into the mechanisms underlying calcineurin inhibitor nephrotoxicity might pave the way toward more targeted therapy or prevention of calcineurin inhibitor nephrotoxicity...
  7. pmc Recovery of hyperphosphatoninism and renal phosphorus wasting one year after successful renal transplantation
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 3:1829-36. 2008
    ..Transplant recipients were (1:1) matched for estimated GFR with chronic kidney disease (CKD) patients...
  8. ncbi request reprint Current target ranges of mycophenolic acid exposure and drug-related adverse events: a 5-year, open-label, prospective, clinical follow-up study in renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 30:673-83. 2008
    ..No reduced incidence of MMF-related adverse events (AEs) was observed in either of the 2 trials when MMF concentration-controlled and fixed dosing were compared...
  9. ncbi request reprint Rifampin induces alterations in mycophenolic acid glucuronidation and elimination: implications for drug exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology, Catholic University Leuven, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 80:509-21. 2006
    ..It can be hypothesized that drugs interfering with glucuronidation and excretion will alter (Ac)MPA(G) exposure...
  10. doi request reprint Reasons for dose reduction of mycophenolate mofetil during the first year after renal transplantation and its impact on graft outcome
    Thomas Vanhove
    Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Belgium
    Transpl Int 26:813-21. 2013
    ..MMF dose reductions in ≥ 50% increased the risk of acute rejection but did not compromise graft survival...
  11. doi request reprint Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity
    Christoph Metalidis
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 91:1098-102. 2011
    ....
  12. ncbi request reprint New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and mycophenolic acid: possible consequences for therapeutic drug monitoring in solid organ transplantation
    Hylke de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Ther Drug Monit 31:416-35. 2009
    ..For MPA, the differences in pharmacokinetic behavior between the old and the novel formulation will have implications for TDM, whereas for tacrolimus, this probably will not to be the case...
  13. ncbi request reprint Aortic calcifications and arterial stiffness as predictors of cardiovascular events in incident renal transplant recipients
    Kathleen J Claes
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, KU Leuven, Belgium
    Transpl Int 26:973-81. 2013
    ..These vascular assessments are readily available and easy to perform, making them ideal tools for further risk stratification. (ClinicalTrials.gov number: NCT00547040). ..
  14. ncbi request reprint The impact of renal allograft function on exposure and elimination of mycophenolic acid (MPA) and its metabolite MPA 7-O-glucuronide
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Catholic University of Leuven, Leuven, Belgium
    Transplantation 84:362-73. 2007
    ..In contrast to these studies, other studies have associated renal impairment with higher MPA exposure. The reason for these inconsistencies is not clear...
  15. pmc Donor age and renal P-glycoprotein expression associate with chronic histological damage in renal allografts
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Am Soc Nephrol 20:2468-80. 2009
    ..In addition, ABCB1 genotype and expression of P-glycoprotein in renal tubular epithelial cells determine susceptibility to chronic tubulointerstitial damage of transplanted kidneys...
  16. pmc Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD
    Ruben Poesen
    Department of Microbiology and Immunology, Division of Nephrology, University Hospitals Leuven, Belgium
    Clin J Am Soc Nephrol 8:1508-14. 2013
    ..From this information, it is inferred that estimated GFR is not a suitable proxy of the clearance of these solutes. Formal clearance studies have, however, not been performed to date...
  17. ncbi request reprint Stability of mycophenolic acid and glucuronide metabolites in human plasma and the impact of deproteinization methodology
    Henriette de Loor
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Chim Acta 389:87-92. 2008
    ..Like other acyl glucuronide metabolites, AcMPAG has a limited stability, but this aspect has received little attention...
  18. doi request reprint The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients
    Hylke de Jonge
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Pharmacogenomics 12:1281-91. 2011
    ..Because tacrolimus is metabolized by CYP3A isoenzymes, this SNP might affect tacrolimus pharmacokinetics...
  19. ncbi request reprint Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 82:1074-84. 2006
    ..MPAG is excreted into the bile via the multidrug resistance-associated protein 2 (MRP2/ABCC2), which is essential for enterohepatic (re)circulation (EHC) of MPA(G)...
  20. doi request reprint A prospective, open-label, observational clinical cohort study of the association between delayed renal allograft function, tacrolimus exposure, and CYP3A5 genotype in adult recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Clin Ther 32:2012-23. 2010
    ..New-onset diabetes after transplantation (NODAT) is a known adverse effect of tacrolimus therapy and has been associated with DGF...
  21. ncbi request reprint The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, Laboratory of Absorption and Digestion, University Hospitals Leuven, Belgium
    Clin Pharmacol Ther 78:351-61. 2005
    ....
  22. doi request reprint Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients
    Dirk R Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, University of Leuven, Leuven, Belgium
    Pharmacogenet Genomics 18:861-8. 2008
    ..The aim of this study was to examine the influence of the CYP3A4, CYP3A5, and MDR1 single nucleotide polymorphisms on changes in tacrolimus exposure and dosing in renal allograft recipients treated with fluconazole...
  23. doi request reprint Urinary connective tissue growth factor is associated with human renal allograft fibrogenesis
    Christoph Metalidis
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Transplantation 96:494-500. 2013
    ..Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model...
  24. ncbi request reprint Subclinical peritubular capillaritis at 3 months is associated with chronic rejection at 1 year
    Evelyne Lerut
    Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium
    Transplantation 83:1416-22. 2007
    ..Peritubular capillaritis has been associated with chronic rejection, but the characteristics of subclinical lesions in peritubular capillaries are unknown...
  25. doi request reprint The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis
    Björn Meijers
    1 Department of Nephrology, UZ Leuven, Leuven, Belgium 2 Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
    Kidney Int 85:636-40. 2014
    ..Thus, this study does not support an absolute, eGFR-independent, suPAR concentration cutoff as a biomarker for underlying FSGS pathology and questions the validity of relative, eGFR-dependent suPAR cutoff values...
  26. pmc Calcium metabolism in the early posttransplantation period
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Clin J Am Soc Nephrol 4:665-72. 2009
    ..Both the abrupt cessation of calcium-containing phosphorus binders and vitamin D (analogs) at the time of surgery and the recovery of renal function may be hypothesized to affect serum calcium levels in this period...
  27. pmc Effects of gastric emptying on oral mycophenolic acid pharmacokinetics in stable renal allograft recipients
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Belgium
    Br J Clin Pharmacol 63:541-7. 2007
    ..Previous studies in healthy subjects and diabetes patients have suggested that MPA pharmacokinetics are influenced by gastric emptying, but this has not been demonstrated directly...
  28. pmc Renal cell carcinoma in the allograft: what is the role of polyomavirus?
    Valerie Neirynck
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Brussels, Belgium
    Case Rep Nephrol Urol 2:125-34. 2012
    ..Surgical removal of the allograft and cessation of the immunosuppressive therapy resulted in complete resolution of the metastatic disease...
  29. ncbi request reprint Drug interaction between mycophenolate mofetil and rifampin: possible induction of uridine diphosphate-glucuronosyltransferase
    Dirk R J Kuypers
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, B 3000 Leuven, Belgium
    Clin Pharmacol Ther 78:81-8. 2005
    ....
  30. doi request reprint Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes
    Maarten Naesens
    Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 80:1364-76. 2011
    ..Thus, measurement of specific immune gene expression in protocol biopsies may be warranted to predict the development of subsequent chronic injury in histologically quiescent grafts and as a means to titrate immunosuppressive therapy...