Carine Michiels

Summary

Affiliation: University of Namur
Country: Belgium

Publications

  1. ncbi request reprint Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, Facultes Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochem Pharmacol 63:321-32. 2002
  2. pmc Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
    Lionel Flamant
    Laboratory of Biochemistry and Cellular Biology URBC, NARILIS NAmur Research Institute for LIfe Sciences FUNDP University of Namur, 5000 Namur, Belgium
    Mol Cancer 9:191. 2010
  3. ncbi request reprint HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases
    C Michiels
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Belgium
    IUBMB Life 52:49-53. 2001
  4. pmc Physiological and pathological responses to hypoxia
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Am J Pathol 164:1875-82. 2004
  5. ncbi request reprint Endothelial cell functions
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    J Cell Physiol 196:430-43. 2003
  6. ncbi request reprint Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions
    C Michiels
    Laboratory of Biochemistry and Cellular Biology, Facult es Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochim Biophys Acta 1497:1-10. 2000
  7. ncbi request reprint Role of the endothelium and blood stasis in the development of varicose veins
    C Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Int Angiol 21:18-25. 2002
  8. ncbi request reprint Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes
    Carine Michiels
    Biochemistry and Cellular Biology Laboratory, University of Namur, Belgium
    Free Radic Biol Med 33:1231-42. 2002
  9. ncbi request reprint Role of the endothelium and blood stasis in the appearance of varicose veins
    C Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Int Angiol 21:1-8. 2002
  10. ncbi request reprint Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology URBC, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Exp Cell Res 312:2908-20. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Identification of the phospholipase A(2) isoforms that contribute to arachidonic acid release in hypoxic endothelial cells: limits of phospholipase A(2) inhibitors
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, Facultes Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochem Pharmacol 63:321-32. 2002
    ..Taken together, these results indicate that the hypoxia-induced increase in PLA(2) activity is mostly due to the activation of sPLA(2)...
  2. pmc Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
    Lionel Flamant
    Laboratory of Biochemistry and Cellular Biology URBC, NARILIS NAmur Research Institute for LIfe Sciences FUNDP University of Namur, 5000 Namur, Belgium
    Mol Cancer 9:191. 2010
    ..Hypoxia is a hallmark of solid tumors and is associated with metastases, therapeutic resistance and poor patient survival...
  3. ncbi request reprint HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases
    C Michiels
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Belgium
    IUBMB Life 52:49-53. 2001
    ..Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively...
  4. pmc Physiological and pathological responses to hypoxia
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Am J Pathol 164:1875-82. 2004
    ..The role of hypoxia in three pathological conditions, myocardial and cerebral ischemia as well as tumorigenesis, is briefly discussed...
  5. ncbi request reprint Endothelial cell functions
    Carine Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    J Cell Physiol 196:430-43. 2003
    ....
  6. ncbi request reprint Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions
    C Michiels
    Laboratory of Biochemistry and Cellular Biology, Facult es Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochim Biophys Acta 1497:1-10. 2000
    ....
  7. ncbi request reprint Role of the endothelium and blood stasis in the development of varicose veins
    C Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Int Angiol 21:18-25. 2002
    ..Hence, the cells are resistant to ischemia and do not release inflammatory mediators and growth factors. These drugs should thus be able to prevent the alterations of the venous wall induced by blood stasis...
  8. ncbi request reprint Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes
    Carine Michiels
    Biochemistry and Cellular Biology Laboratory, University of Namur, Belgium
    Free Radic Biol Med 33:1231-42. 2002
    ..Some of the physiological responses initiated by these transcription factors are also mentioned...
  9. ncbi request reprint Role of the endothelium and blood stasis in the appearance of varicose veins
    C Michiels
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, Namur, Belgium
    Int Angiol 21:1-8. 2002
    ..Hence, the cells are resistant to ischemia and do not release inflammatory mediators and growth factors. These drugs should thus be able to prevent the alterations of the venous wall induced by blood stasis...
  10. ncbi request reprint Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology URBC, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Exp Cell Res 312:2908-20. 2006
    ..Together, all these data underline that hypoxia could mediate its anti-apoptotic role via different transcription factors depending on the cellular context and pro-apoptotic stimuli...
  11. pmc Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide
    Jean Philippe Cosse
    Laboratory of Biochemistry and Cellular Biology URBC, FUNDP University of Namur, 5000 Namur, Belgium
    Neoplasia 11:976-86. 2009
    ..These effects occurred in a p53-independent manner. These data evidenced that hypoxia decreased the responsiveness of HepG2 cells to etoposide at least by two independent pathways involving p53 inhibition and c-jun activation...
  12. pmc Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity
    Audrey Sermeus
    URBC, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Mol Cancer 7:27. 2008
    ..it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection...
  13. ncbi request reprint ERK and calcium in activation of HIF-1
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:448-53. 2002
    ..Altogether, these results suggest that calcium and calmodulin would act upstream of ERK in the hypoxia signal transduction pathway leading to enhanced HIF-1 transcriptional activity...
  14. ncbi request reprint Role of ERK and calcium in the hypoxia-induced activation of HIF-1
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Belgium
    J Cell Physiol 194:30-44. 2003
    ..All together, these results suggest that calcium and calmodulin would act upstream of ERK in the hypoxia signal transduction pathway...
  15. ncbi request reprint Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    J Biol Chem 280:9336-44. 2005
    ..All these data suggest a potential anti-apoptotic role of HIF-1 that could protect cells against apoptosis under hypoxia by overexpression of the Mcl-1 protein...
  16. doi request reprint Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1
    Sebastien Toffoli
    Laboratory of Biochemistry and Cellular Biology, FUNDP University of Namur, 61 rue de Bruxelles, Namur, Belgium
    Angiogenesis 12:47-67. 2009
    ..All together, these results demonstrate a clear pro-angiogenic effect of intermittent hypoxia...
  17. pmc Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types
    Audrey Sermeus
    Laboratory of Biochemistry and Cellular Biology URBC, Narilis, University of Namur FUNDP, Belgium
    PLoS ONE 7:e47519. 2012
    ..A better understanding of these cell-to-cell variations is crucial in order to overcome hypoxia-induced resistance and to ameliorate cancer therapy...
  18. ncbi request reprint Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology, Facultes Universitaires Notre Dame de la Paix, 5000 Namur, Belgium
    Exp Cell Res 295:340-9. 2004
    ..This observation is an important data in understanding how tumor growth can occur in challenging environmental conditions...
  19. ncbi request reprint c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, FUNDP, 61 rue de Bruxelles, Namur, 5000, Belgium
    Exp Cell Res 265:114-24. 2001
    ....
  20. pmc TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells
    Lionel Flamant
    URBC NARILIS, University of Namur FUNDP, 61 rue de Bruxelles, 5000, Namur, Belgium
    BMC Cancer 12:391. 2012
    ..The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells...
  21. doi request reprint NDRG1 and CRK-I/II are regulators of endothelial cell migration under Intermittent Hypoxia
    Sebastien Toffoli
    Laboratory of Biochemistry and Cellular Biology, FUNDP University of Namur, Namur, Belgium
    Angiogenesis 12:339-54. 2009
    ..These results give news insight regarding the effects of IH on endothelial cell migration and hence on neoangiogenesis...
  22. doi request reprint Hypoxia regulates inflammatory gene expression in endothelial cells
    Lionel Flamant
    Laboratory of Biochemistry and Cellular Biology URBC, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Exp Cell Res 315:733-47. 2009
    ..On the other hand, a clear response to hypoxia was observed with HIF-1 probably playing an important role in this process...
  23. ncbi request reprint Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    J Biol Chem 278:31277-85. 2003
    ....
  24. doi request reprint BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway
    Jean Philippe Cosse
    Laboratory of Biochemistry and Cellular Biology URBC, NAmur Research Institute for LIfe Science NARILIS, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochem Pharmacol 80:1160-9. 2010
    ....
  25. doi request reprint Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis
    Sebastien Pyr dit Ruys
    URBC, University of Namur FUNDP, B 5000 Namur, Belgium
    Biochim Biophys Acta 1793:1676-90. 2009
    ..These results are important to better understand cancer development since they highlight a HIF-1 independent mechanism, which may be involved in metastasis...
  26. ncbi request reprint Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia
    Sébastien Paris
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    FEBS Lett 579:105-14. 2005
    ..Mutation of two of the three HREs present in this promoter completely inhibited the hypoxia-induced increase in luciferase activity...
  27. doi request reprint The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells
    Laurine Mattart
    Research Unit of Cellular Biology, NARILIS Namur Research Institute for Life Sciences, University of Namur FUNDP, Namur, Belgium
    Cell Signal 24:199-213. 2012
    ....
  28. pmc Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines
    Jean Philippe Cosse
    Laboratory of Biochemistry and Cellular Biology URBC, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Mol Cancer 6:61. 2007
    ..However, the mechanisms underlying this resistance still need deeper understanding. The aim of this study was to investigate the effect of hypoxia on this process since hypoxia is one of the hallmarks of tumor environment...
  29. ncbi request reprint Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1alpha
    Sebastien Toffoli
    Laboratory of Biochemistry and Cellular Biology, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochim Biophys Acta 1773:1558-71. 2007
    ....
  30. ncbi request reprint Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
    Benoit Vlaminck
    Laboratory of Biochemistry and Cellular Biology, FUNDP University of Namur, Belgium
    FEBS J 274:5533-42. 2007
    ..These findings show, for the first time, that echinomycin has a dual effect on HIF-1 activity under normoxic and hypoxic conditions, demonstrating that this molecule cannot be used in cancer treatment...
  31. ncbi request reprint CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
    Jean Pascal Piret
    Laboratoire de Biologie et Biochimie Cellulaire, FUNDP, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:443-7. 2002
    ..These different data suggest a possible antiapoptotic role of HIF-1. More experiments are needed to define if HIF-1 actually plays an active role in cell death protection and to determine the exact mechanism underlying this effect...
  32. ncbi request reprint Role for casein kinase 2 in the regulation of HIF-1 activity
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Namur, Belgium
    Int J Cancer 117:764-74. 2005
    ..Since HIF-1 plays a major role in tumor angiogenesis and since CK2 has been described to be overexpressed in tumor cells, this new pathway of regulation can be one more way for tumor cells to survive...
  33. ncbi request reprint Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level
    Antoine Hubert
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    J Cell Sci 119:3351-62. 2006
    ..Since CK2 activity is increased in hypoxic conditions, this process provides one more mechanism to ensure enhanced HIF-1 activity under such conditions...
  34. pmc A hybrid assembly by encapsulation of human cells within mineralised beads for cell therapy
    Philippe Dandoy
    Laboratory of Inorganic Materials Chemistry, The University of Namur, FUNDP, Namur, Belgium
    PLoS ONE 8:e54683. 2013
    ....
  35. ncbi request reprint Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain
    Gaetan Michel
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochim Biophys Acta 1578:73-83. 2002
    ..These results bring new insights on the specificity of the protein/DNA interactions for HIF-1 towards HRE...
  36. doi request reprint Surface properties and cell adhesion onto allylamine-plasma and amine-plasma coated glass coverslips
    Marianne Crespin
    Unité de Recherche en Biologie Cellulaire, Narilis, University of Namur FUNDP, URBC, 61 rue de Bruxelles, 5000, Namur, Belgium
    J Mater Sci Mater Med 22:671-82. 2011
    ..A correlation could be observed between wettability and cell proliferation except for C coated surface, indicating that more complex processes than hydrophilicity alone are taking place that affect cell functions...
  37. pmc Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells
    Michael Pierre
    Molecular Biology Research Unit URBM, University of Namur FUNDP, Namur, Belgium
    BMC Cancer 10:176. 2010
    ....
  38. ncbi request reprint Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology, Facultes Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochem Pharmacol 67:611-20. 2004
    ..Taken together, these results emphasize the central role played by mitochondria in the initiation of apoptosis in HepG2 cells exposed to oxidant agents...
  39. doi request reprint Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination
    Anne Catherine Wéra
    a NARILIS Research Center in Physics of Matter and Radiation and
    Radiat Res 179:273-81. 2013
    ..The RBE value of 1.9 ± 0.4 obtained for a 10% survival support this observation...
  40. ncbi request reprint Is HIF-1alpha a pro- or an anti-apoptotic protein?
    Jean Pascal Piret
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochem Pharmacol 64:889-92. 2002
    ..This review is aimed to describe the different mechanisms that account for these opposite effects of HIF-1alpha...
  41. ncbi request reprint Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression
    Jean Philippe Cosse
    Laboratory of Biochemistry and Cellular Biology, FUNDP University of Namur, 5000 Namur, Belgium
    Anticancer Agents Med Chem 8:790-7. 2008
    ..The aim of this review is to provide a description of known hypoxia-induced mechanisms of chemoresistance at a cellular level...
  42. ncbi request reprint Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, , 61 rue de Bruxelles, 5000 Namur, Belgium
    Free Radic Biol Med 31:847-55. 2001
    ..In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed...
  43. doi request reprint Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types
    Audrey Sermeus
    Laboratory of Biochemistry and Cellular Biology URBC, Narilis, University of Namur, Namur, Belgium
    J Cell Physiol 228:2365-76. 2013
    ..J. Cell. Physiol. 228: 2365-2376, 2013. © 2013 Wiley Periodicals, Inc. ..
  44. ncbi request reprint Mitochondrial respiratory chain as a new target for anti-ischemic molecules
    Najat Bouaziz
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Eur J Pharmacol 441:35-45. 2002
    ..This anti-ischemic activity is probably due to a protection of complexes I and III of the mitochondrial respiratory chain...
  45. doi request reprint Comparison of X-ray and alpha particle effects on a human cancer and endothelial cells: Survival curves and gene expression profiles
    Helene Riquier
    URBC NARILIS
    Radiother Oncol 106:397-403. 2013
    ..It is thus important to better characterise the response of both types of cells to irradiation. This study investigated the effects of X-ray and alpha particle irradiation on cancer and endothelial cells...
  46. doi request reprint Autophagy as a mediator of chemotherapy-induced cell death in cancer
    Annick Notte
    URBC NARILIS, University of Namur FUNDP, 61 rue de Bruxelles, Namur, Belgium
    Biochem Pharmacol 82:427-34. 2011
    ..In this paper, we propose a putative mechanism that could reconcile these two opposite observations...
  47. pmc Hybrid shell engineering of animal cells for immune protections and regulation of drug delivery: towards the design of "artificial organs"
    Philippe Dandoy
    Laboratory of Inorganic Materials Chemistry, Department of Chemistry, The University of Namur FUNDP, Namur, Belgium
    PLoS ONE 6:e20983. 2011
    ..At the same time, the number of patients who require full organ transplantations is augmenting. Consequently, new strategies for cell transplantation are the subject of great interest...
  48. ncbi request reprint Effect of hydroxyethylrutosides on hypoxial-induced neutrophil adherence to umbilical vein endothelium
    I H Roland
    Laboratoire de Biochimie et Biologie Cellulaire, Facultes Universitaires Notre Dame de la Paix, Namur, Belgium
    Cardiovasc Drugs Ther 12:375-81. 1998
    ....
  49. ncbi request reprint Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, Facultés Universitaires de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    FEBS Lett 460:251-6. 1999
    ..At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation...
  50. ncbi request reprint ERK activation upon hypoxia: involvement in HIF-1 activation
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, Facultés Universitaires de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    FEBS Lett 468:53-8. 2000
    ..These results evidence the role of mitogen-activated protein kinase in the transcriptional response to hypoxia...
  51. ncbi request reprint Radioimmunotherapy with radioactive nanoparticles: biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area
    V Bouchat
    Research center in Physics of Matter and Radiation, Laboratoire d Analyses par Réactions Nucléaires, University of Namur, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Med Phys 37:1826-39. 2010
    ....
  52. ncbi request reprint Radioimmunotherapy with radioactive nanoparticles: first results of dosimetry for vascularized and necrosed solid tumors
    V Bouchat
    Laboratoire d Analyses par Réactions Nucléaires, University of Namur FUNDP, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Med Phys 34:4504-13. 2007
    ....
  53. ncbi request reprint A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence
    G Michel
    Laboratoire de Chimie Moleculaire Structurale, Facultes Universitaires, Notre Dame de la Paix, Namur, Belgium
    J Biomol Struct Dyn 18:169-79. 2000
    ..From these results, we postulate that the specificity of HIF-1 toward its DNA sequence could be driven by the HIF-1alpha subunit. The predicted model will be verified by X-Ray currently ongoing...
  54. pmc PGF(2alpha), a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment
    T Arnould
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Namur, Belgium
    Am J Pathol 159:345-57. 2001
    ..These results suggest that PGF(2alpha), a prostanoid abundantly released by the endothelium of hypoxic or ischemic tissues, is a chemoattractant molecule that might be involved in the early recruitment of neutrophils in ischemic organs...
  55. ncbi request reprint HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5'UTR
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, Facultés Universitaires de la Paix, 61 rue de Bruxelles, Namur, 5000, Belgium
    Biochem Biophys Res Commun 261:534-40. 1999
    ..Finally, we demonstrate that HIF1A gene transcription is dependent on Sp1 binding sites and that the 5'UTR sequence also contains other important cis-acting elements...
  56. doi request reprint Molecular aspects of cancer cell resistance to chemotherapy
    Magali Rebucci
    URBC NARILIS, University of Namur FUNDP, Belgium
    Biochem Pharmacol 85:1219-26. 2013
    ..Perspectives to develop more efficient treatment, using genomic signature or more specific biomarkers to characterize putative resistance mechanisms in patients before choosing the more appropriate treatment, will also be discussed...
  57. doi request reprint Comparison of the clonogenic survival of A549 non-small cell lung adenocarcinoma cells after irradiation with low-dose-rate beta particles and high-dose-rate X-rays
    Anne Catherine Wéra
    Department of Physics, University of Namur, Belgium
    Int J Radiat Biol 88:253-7. 2012
    ..This work investigates the phosphorus beta irradiation ((32)P) dose response on the clonogenicity of human A549 non-small cell lung adenocarcinoma cells and compares it to high-dose-rate X-irradiations results...
  58. doi request reprint Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours
    S Toffoli
    Laboratory of Biochemistry and Cellular Biology URBC, University of Namur FUNDP, 61 rue de Bruxelles, Namur, Belgium
    FEBS J 275:2991-3002. 2008
    ..In this article, we review the effects of intermittent hypoxia on tumour and endothelial cells as well as its impacts on tumour development...
  59. ncbi request reprint Hypoxia-induced increase in intracellular calcium concentration in endothelial cells: role of the Na(+)-glucose cotransporter
    N Berna
    Laboratoire de Biochimie et Biologie Cellulaire, , 61, rue de Bruxelles, B-5000 Namur, Belgium
    J Cell Biochem 84:115-31. 2001
    ....
  60. ncbi request reprint Effects of homocysteine on the cellular responses of murine endothelial cells cultured in vitro
    A Tacheny
    Department of Biology, Laboratory of Cellular Biochemistry and Biology, University of Namur FUNDP, Namur, Belgium
    Ann N Y Acad Sci 973:550-4. 2002
    ..The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-alpha was used as a positive control...
  61. ncbi request reprint Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies
    Philippe Martinive
    Unit of Pharmacology and Therapeutics FATH 5349, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Cancer Res 66:11736-44. 2006
    ..Our observations also underscore the potential of drugs targeting HIF-1alpha to resensitize the tumor vasculature to anticancer treatments...
  62. ncbi request reprint Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
    Steve Bonello
    Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Lazarettstr 36, D 80636 Munich, Germany
    Arterioscler Thromb Vasc Biol 27:755-61. 2007
    ..We therefore aimed to elucidate the link between these 2 important redox-sensitive transcription factors...
  63. pmc Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner
    Daniela Flügel
    Fachbereich Chemie, Abteilung Biochemie, Universitat Kaiserslautern, Erwin Schrödinger Str Geb 54, D 67663 Kaiserslautern, Germany
    Mol Cell Biol 27:3253-65. 2007
    ..Thus, the direct regulation of HIF-1alpha stability by GSK-3 may influence physiological processes or pathophysiological situations such as metabolic diseases or tumors...
  64. ncbi request reprint Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia
    Gregor Theilmeier
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Blood 99:4486-93. 2002
    ..05). In conclusion, hypercholesterolemia primes platelets for recruitment via VWF, GPIb alpha, and P-selectin to lesion-prone sites, before lesions are detectable...