Chantal Mathieu

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. pmc Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:2464-71. 2012
  2. doi request reprint How long should a long acting insulin analogue be?
    Chantal Mathieu
    Endocrinology, UZ Gasthuisberg, Herestraat 49, 3000 KU Leuven, Belgium
    Diabetes Res Clin Pract 100:170-2. 2013
  3. pmc Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension
    Chantal Mathieu
    Clinical and Experimental Endocrinology, UZ Herestraat 49, BOX 902, Room 08 43, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1154-62. 2013
  4. doi request reprint Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction
    Michael Maris
    Laboratory of Clinical and Experimental Endocrinology, Herestraat 49, KU Leuven, Leuven, Belgium
    J Proteome Res 12:347-62. 2013
  5. ncbi request reprint Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
  6. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
  7. doi request reprint Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
  8. doi request reprint Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, Herestraat 49, O and N1, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:221-7. 2010
  9. doi request reprint 1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: a comparison dose-titration study
    Gabriela Bomfim Ferreira
    Laboratory for Clinical and Experimental Endocrinology LEGENDO, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:160-5. 2013
  10. ncbi request reprint 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice
    Gabriela B Ferreira
    Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Immunol 192:4210-20. 2014

Collaborators

Detail Information

Publications50

  1. pmc Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:2464-71. 2012
    ..To compare ultra-long-acting insulin degludec with glargine for efficacy and safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral antidiabetic drugs (OADs)...
  2. doi request reprint How long should a long acting insulin analogue be?
    Chantal Mathieu
    Endocrinology, UZ Gasthuisberg, Herestraat 49, 3000 KU Leuven, Belgium
    Diabetes Res Clin Pract 100:170-2. 2013
    ....
  3. pmc Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex T1): a 26-week randomized, treat-to-target trial with a 26-week extension
    Chantal Mathieu
    Clinical and Experimental Endocrinology, UZ Herestraat 49, BOX 902, Room 08 43, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:1154-62. 2013
    ..This study investigated the efficacy and safety of insulin degludec (IDeg) once daily (OD), varying injection timing day to day in subjects with type 1 diabetes...
  4. doi request reprint Role of the saturated nonesterified fatty acid palmitate in beta cell dysfunction
    Michael Maris
    Laboratory of Clinical and Experimental Endocrinology, Herestraat 49, KU Leuven, Leuven, Belgium
    J Proteome Res 12:347-62. 2013
    ..This study contributes to a better understanding and revealed novel mechanisms of palmitate-induced beta cell dysfunction and death and may provide new targets for drug discovery...
  5. ncbi request reprint Vitamin D and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat, Leuven, Belgium
    Endocrinol Metab Clin North Am 39:419-46, table of contents. 2010
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  6. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  7. doi request reprint Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Proteome Res 11:941-71. 2012
    ..These findings provide new insights on the molecular basis of DC tolerogenicity induced by 1,25(OH)(2)D(3) and/or DEX, which may lead to the discovery of new pathways involved in DC immunomodulation...
  8. doi request reprint Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, Herestraat 49, O and N1, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 121:221-7. 2010
    ..In conclusion, we validate T cells as direct targets for 1,25(OH)2D3 and provide this optimized in vitro model to improve our understanding of the role of vitamin D as a direct regulator of T cell responses...
  9. doi request reprint 1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: a comparison dose-titration study
    Gabriela Bomfim Ferreira
    Laboratory for Clinical and Experimental Endocrinology LEGENDO, University Hospital Gasthuisberg, KU Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:160-5. 2013
    ..This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  10. ncbi request reprint 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice
    Gabriela B Ferreira
    Laboratory of Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Immunol 192:4210-20. 2014
    ..Altogether, these results argue for the potential of 1,25D3-mDCs to restore Ag-specific immune tolerance and arrest autoimmune disease progression in vivo. ..
  11. ncbi request reprint Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved
    Dieter Rondas
    Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Proteome Res 12:4193-206. 2013
    ..These data illustrate the beneficial effects of GLP-1 on human islets under immune attack, leading to a better understanding of the underlying mechanisms involved, a prerequisite for improving therapies for diabetic patients. ..
  12. doi request reprint Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine
    Roger Bouillon
    Clinical and Experimental Endocrinology, KU Leuven, Department of Endocrinology, Herestraat 49 ON1, BOX 902, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 98:E1283-304. 2013
    ..Public health authorities around the world recommend widely variable supplementation strategies for adults, whereas several professional organizations, including The Endocrine Society, recommend higher supplementation...
  13. ncbi request reprint Oleate-induced beta cell dysfunction and apoptosis: a proteomic approach to glucolipotoxicity by an unsaturated fatty acid
    Michael Maris
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Herestraat 49, Catholic University of Leuven, Leuven, Belgium
    J Proteome Res 10:3372-85. 2011
    ..The present findings provide new insights in oleate-induced beta cell dysfunction and identify target proteins for preservation of functional beta cell mass in type 2 diabetes...
  14. ncbi request reprint Vitamin D insufficiency: implications for the immune system
    Femke Baeke
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Herestraat 49 ON1 bus 902, 3000 Leuven, Belgium
    Pediatr Nephrol 25:1597-606. 2010
    ..In this review, specific attention is given to the effects of 1,25(OH)(2)D(3) on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function...
  15. pmc Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
    ..Prospective vitamin D supplementation studies with multiple noncalcemic endpoints are needed to define the benefits of an optimal vitamin D status...
  16. doi request reprint High glucose induces dysfunction in insulin secretory cells by different pathways: a proteomic approach
    Michael Maris
    Laboratory for Experimental Medicine and Endocrinology, Herestraat 49, Catholic University of Leuven, Leuven, Belgium
    J Proteome Res 9:6274-87. 2010
    ..The present findings provide new insights in glucotoxicity and identify key target proteins for the prevention and treatment of beta cell dysfunction in type 2 diabetes...
  17. doi request reprint 1,25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo
    Gabriela Bomfim Ferreira
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven KUL, 3000 Leuven, Belgium
    Diabetes Metab Res Rev 27:933-41. 2011
    ..1,25(OH)2D3, the active form of vitamin D3, fosters the development of tolerogenic dendritic cells. This study aimed to evaluate the effects of 1,25(OH)2D3 on murine dendritic cell behaviour in vitro and in vivo...
  18. ncbi request reprint Novel insights in the immune function of the vitamin D system: synergism with interferon-beta
    Evelyne van Etten
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, O and N1 bus 902, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:546-51. 2007
    ....
  19. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3-induced down-regulation of the checkpoint proteins, Chk1 and Claspin, is mediated by the pocket proteins p107 and p130
    Lieve Verlinden
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 103:411-5. 2007
    ....
  20. ncbi request reprint Vitamin D resistance
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Campus Gasthuisberg, Onderwijs and Navorsing 1, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 20:627-45. 2006
    ..Taken together, the vitamin D endocrine system not only regulates calcium homeostasis but affects several systems mainly by altering gene expression but also by ligand-independent actions...
  21. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
    ..As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease...
  22. ncbi request reprint Vitamin D and diabetes: the odd couple
    Tom L Van Belle
    Clinical and Experimental Endocrinology, Katholieke Universiteit KU Leuven, Campus Gasthuisberg, O and N 1 Herestraat 49, BOX 902, 3000 Leuven, Belgium
    Trends Endocrinol Metab 24:561-8. 2013
    ..This should be possible by implementing global guidelines and by focusing on daily dietary supplementation with small doses of vitamin D. ..
  23. ncbi request reprint Vitamin D action: lessons from VDR and Cyp27b1 null mice
    Roger Bouillon
    Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 ON1 bus 902, 300 Leuven, Belgium
    Pediatr Endocrinol Rev 10:354-66. 2013
    ..We will compare the findings in VDR- and Cyp27bi-null mice with findings in man to elucidate what is presently understood of the vitamin D endocrine system and to identify the still outstanding questions...
  24. doi request reprint The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease
    Lieve Verlinden
    Laboratorium voor Klinische en Experimentele Endocrinologie, KU Leuven, Herestraat 49, bus 902, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 136:107-11. 2013
    ..These results indicate that TX527 may have a therapeutic value in the setting of inflammatory bowel disease. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  25. doi request reprint Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
    Lancet 377:924-31. 2011
    ....
  26. doi request reprint Vitamin D in thyroid tumorigenesis and development
    Isabelle Clinckspoor
    Laboratory of Clinical and Experimental Endocrinology, KU Leuven, bus 902, Herestraat 49, 3000 Leuven, Belgium
    Prog Histochem Cytochem 48:65-98. 2013
    ..Altered 1,25(OH)2D3-VDR signalling does not influence normal thyroid development nor thyrocyte function, but does affect C-cell function, at least in rodents. If these findings also apply to humans deserves further study. ..
  27. doi request reprint Antigen-based vs. systemic immunomodulation in type 1 diabetes: the pros and cons
    Sofie Robert
    Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Leuven, Belgium
    Islets 5:53-66. 2013
    ..In order for future strategies to be effective, new well-defined biomarkers need to be developed and the extrapolation process of dose, timing and frequency from in vivo models to patients needs to be carefully reconsidered...
  28. ncbi request reprint Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: relevance for type 1 diabetes
    Tatiana Takiishi
    Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven, Belgium
    Pediatr Diabetes 14:81-9. 2013
    ..In this review, we will mainly focus on vitamin D as a component of immune regulation and on the role of vitamin D in antigen-specific and non-specific therapies with potential relevance for type 1 diabetes (T1D)...
  29. pmc Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
    Tatiana Takiishi
    Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium
    J Clin Invest 122:1717-25. 2012
    ..Therefore, we believe this method could be an effective treatment strategy for type 1 diabetes in humans...
  30. doi request reprint Immune and cell therapy in type 1 diabetes: too little too late?
    Pieter Gillard
    University Hospital Leuven, Department of Experimental Medicine and Endocrinology, KULeuven, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Biol Ther 11:609-21. 2011
    ..Therapies that aim at protecting or restoring endogenous insulin secretion might help in decreasing the risk of severe hypoglycemia and long-term complications...
  31. doi request reprint Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act
    Wim Janssens
    Division of Respiratory Medicine, University Hospital Gasthuisberg KUL Herestraat 49, 3000 Leuven, Belgium
    Am J Respir Crit Care Med 179:630-6. 2009
    ..A further challenge of such studies is to define optimal serum 25-OHD levels for such noncalcemic endpoints...
  32. doi request reprint Vitamin D in autoimmune, infectious and allergic diseases: a vital player?
    Tom L Van Belle
    Laboratory for Experimental Medicine and Endocrinology, Catholic University Leuven, Herestraat 49, Leuven, Belgium
    Best Pract Res Clin Endocrinol Metab 25:617-32. 2011
    ..We also discuss how vitamin D influences the immune responses in each of those conditions based on the data generated using patient samples or preclinical models of each of these diseases...
  33. ncbi request reprint Economic aspects of diabetic foot care in a multidisciplinary setting: a review
    Giovanni A Matricali
    Multidisciplinary Diabetic Foot Clinic, U Z Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Diabetes Metab Res Rev 23:339-47. 2007
    ..To evaluate the economic aspects of diabetic foot care in a multidisciplinary setting...
  34. doi request reprint Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes
    Liesbeth Viaene
    Department of Nephrology, KU Leuven, UZ Gasthuisberg, Leuven, Belgium
    Am J Nephrol 36:497-508. 2012
    ..The present study aimed to elucidate this issue and to define the pathogenic role of p-cresyl sulfate (PCS), indoxyl sulfate (IndS), and fibroblast growth factor 23 (FGF23)...
  35. pmc Vildagliptin: a new oral treatment for type 2 diabetes mellitus
    Chantal Mathieu
    Department of Endocrinology, Katholieke Universiteit Leuven, UZ Gasthuisberg, Herestraat 49, Leuven, Belgium
    Vasc Health Risk Manag 4:1349-60. 2008
    ....
  36. ncbi request reprint Vitamin d and diabetes
    Tatiana Takiishi
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, UZ Gasthuisberg, O and N I Herestraat 49 bus 902, 3000, Leuven, Belgium
    Rheum Dis Clin North Am 38:179-206. 2012
    ..This article reviews the role of vitamin D in the pathogenesis of T1D and T2D, focusing on the therapeutic potential for vitamin D in the prevention/intervention of T1D and T2D as well as its complications...
  37. ncbi request reprint Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory
    Annapaula Giulietti
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    Diabetes Res Clin Pract 77:47-57. 2007
    ..From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes...
  38. doi request reprint Novel insights into the global proteome responses of insulin-producing INS-1E cells to different degrees of endoplasmic reticulum stress
    Wannes D'Hertog
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    J Proteome Res 9:5142-52. 2010
    ..In conclusion, INS-1E cells are highly sensitive to ER stress, leading to important post-transcriptional and post-translational modifications that may contribute to β-cell dysfunction and death...
  39. ncbi request reprint Proteomics analysis of cytokine-induced dysfunction and death in insulin-producing INS-1E cells: new insights into the pathways involved
    Lut Overbergh
    Laboratory for Experimental Medicine and Endocrinology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, BOX 902, B 3000 Leuven, Belgium
    Mol Cell Proteomics 6:2180-99. 2007
    ..The present findings may open new avenues for the understanding and prevention of beta-cell loss in type 1 diabetes...
  40. pmc Analysis of Pregnancy Outcomes Using the New IADPSG Recommendation Compared with the Carpenter and Coustan Criteria in an Area with a Low Prevalence of Gestational Diabetes
    Katrien Benhalima
    Department of Endocrinology, UZ Leuven and KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Int J Endocrinol 2013:248121. 2013
    ..736), and in 1.4% of NGT women (P = 0.007). Conclusion. Using the IADPSG criteria, more women are identified as having GDM, and these women carry an increased risk for adverse gestational outcome compared to women without GDM...
  41. doi request reprint The role of blood glucose monitoring in non-insulin treated type 2 diabetes: what is the evidence?
    Katrien Benhalima
    Department of Diabetes and Endocrinology, UZ Gasthuisberg, Catholic University of Leuven, Belgium
    Prim Care Diabetes 6:179-85. 2012
    ..We review the conflicting evidence on the use of SMBG in insulin-naïve T2DM patients...
  42. ncbi request reprint Vitamin D and cancer
    Roger Bouillon
    Laboratory for Experimental Medicine and Endocrinology, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 102:156-62. 2006
    ....
  43. doi request reprint Decreased miR-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease
    Maarten Hulsmans
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Herestraat 49, PB 705, 3000 Leuven, Belgium
    J Clin Endocrinol Metab 97:E1213-8. 2012
    ..Weight loss after bariatric surgery leads to significant improvement of obesity-related comorbidities. MicroRNA (miR), a class of small noncoding RNA, have been implicated as negative regulators of inflammatory processes...
  44. doi request reprint Cytokine signalling in the beta-cell: a dual role for IFNgamma
    Conny Gysemans
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, UZ Gasthuisberg O and N, Katholieke Universiteit Leuven, Herestraat 49, bus 902, B 3000 Leuven, Belgium
    Biochem Soc Trans 36:328-33. 2008
    ..Transcription factors drive this dual role, with STAT-1 driving beta-cell destruction and IRF-1 possibly playing a role in up-regulation of protective pathways induced by IFNgamma...
  45. ncbi request reprint Inhaled human insulin ((insulin human [rDNA origin]) Inhalation Powder) in diabetes mellitus
    Chantal Mathieu
    UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Expert Opin Drug Metab Toxicol 2:779-91. 2006
    ..Availability of inhaled insulin may increase insulin acceptance and thus improve glycaemic control in patients with diabetes...
  46. ncbi request reprint Vitamin D3 and the immune system: maintaining the balance in health and disease
    Femke Baeke
    LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Nutr Res Rev 20:106-18. 2007
    ....
  47. doi request reprint Gestational diabetes: update of screening strategy and diagnostic criteria
    Katrien Benhalima
    Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium
    Curr Opin Obstet Gynecol 25:462-7. 2013
    ..To review recently published studies examining new data on screening strategies and diagnostic criteria for gestational diabetes (GDM)...
  48. doi request reprint Glycated hemoglobin in pregnancies at increased risk for gestational diabetes mellitus
    Johan Verhaeghe
    Department of Obstetrics and Gynecology, Health Sciences Campus Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 161:157-62. 2012
    ..We sought to identify clinical and metabolic correlates of HbA(1c) in pregnancies at increased risk for gestational diabetes mellitus (GDM)...