Research Topics
| Louis MaesSummaryAffiliation: University of Antwerp Country: Belgium Publications
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Detail Information
Publications
Intravenous and Subcutaneous Toxicity and Absorption Kinetics in Mice and Dogs of the Antileishmanial Triterpene Saponin PX-6518Louis Maes
Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, Antwerp B 2060, Belgium
Molecules 18:4803-15. 2013..It was decided not to pursue further drug development for PX-6518 because of the hepatotoxic risk...
Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamstersLouis Maes
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171 V523, B 2610 Wilrijk, Belgium
Antimicrob Agents Chemother 48:2056-60. 2004..However, multiple-dose pharmacological, toxicological, and pharmacokinetic studies are still needed before it can become a valid drug candidate for development...- In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania speciesLouis Maes
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
Antimicrob Agents Chemother 48:130-6. 2004..This study concludes that triterpenoid saponins from M. balansae show promising in vitro and in vivo antileishmanial potential and can be considered as new lead structures in the search for novel antileishmanial drugs... - Phytochemical and biological investigations of Elaeodendron schlechteranumSheila M Maregesi
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerpen, Belgium
J Ethnopharmacol 129:319-26. 2010..The aim of this study was to identify the putative active constituents of the plant... - Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and IcacinaceaeMarieke Vermeersch
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
Phytother Res 23:1404-10. 2009..petelotii. This study indicates that the 13,28-epoxy-oleanane triterpene moiety is essential for selective antileishmania potential and that several other plant species could still be explored for antileishmania drug discovery... - In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cellsRaquel Inocêncio da Luz
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
Antimicrob Agents Chemother 53:5197-203. 2009..In conclusion, the proposed conditioning protocol further contributes toward a more standardized laboratory model for evaluation of the drug sensitivities of field isolates... - α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPBKoen Steert
Department of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
ChemMedChem 5:1734-48. 2010..8; however, in vitro whole-organism screening against a panel of protozoan parasites did not fully correlate with the observed inhibition of the cysteine protease... - Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infectionMaartje Deschacht
Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Wilrijk, Belgium
Parasitology 139:1429-37. 2012..An increased NO production was observed 6 h after infection. Finally, induction of cell death is probably not essential in the survival of the parasite within the macrophage... - Antiprotozoal and antiangiogenic saponins from Apodytes dimidiataKenn Foubert
Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
Phytochemistry 72:1414-23. 2011.... - In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania speciesRaquel Andreia Inocêncio da Luz
Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, 2020 Antwerp, Belgium
J Antimicrob Chemother 66:350-3. 2011.... - Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burdenManu Vanaerschot
Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
PLoS ONE 6:e23120. 2011..Our results therefore highlight the need to closely monitor drug efficacy in the field, especially in the context of the Kala-azar elimination programme ongoing in the Indian subcontinent... - Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analoguesGitte Van Baelen
Laboratory of Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
Bioorg Med Chem 17:7209-17. 2009..However, this compound was not active in the Plasmodium berghei mouse model. Structure-activity relationships are discussed and compared with related naturally occurring compounds... - Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocolSarah Hendrickx
Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium
PLoS Negl Trop Dis 6:e1664. 2012..These findings may have important relevance to resistance mechanism investigations and the likelihood of resistance development and detection in the field... - In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differencesMarieke Vermeersch
Laboratory for Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical, and Veterinary Sciences, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
Antimicrob Agents Chemother 53:3855-9. 2009..Axenic systems can be recommended only for compounds for which no cellular mechanisms are involved, for example, amphotericin B and miltefosine... - Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditionsEly Bénéré
Laboratory of Microbiology, Parasitology and Hygiene LMPH, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
Parasitol Res 110:1315-9. 2012..The underlying mechanisms still need to be elucidated, but assemblage-linked differences in the expression of the genes coding for flavohemoglobin or A-type flavoprotein may certainly deserve further attention... - Leishmania-macrophage interactions: insights into the redox biologyTim Van Assche
Laboratory of Microbiology Parasitology, and Hygiene, University of Antwerp, B 2020 Antwerp, Belgium
Free Radic Biol Med 51:337-51. 2011..In respect to antileishmanial therapy, the effects of current drugs on parasite-macrophage redox biology and its involvement in the development of drug resistance and treatment failure are presented... - Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivativesIbrahim El Sayed
Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein, 1, 2610, Antwerp, Belgium
J Med Chem 52:2979-88. 2009..The most efficient compounds showed antiplasmodial activities in the nanomolar range. N(1),N(1)-Diethyl-N(4)-(5-methyl-5H-indolo[2,3-b]quinolin-8-yl)pentane-1,4-diamine 11c showed an IC(50) of 0.01 microM and a selectivity index of 1800... - LC-MS analysis of 13,28-epoxy-oleanane saponins in Maesa spp. extracts with antileishmanial activityKenn Foubert
Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
Phytochem Anal 20:159-67. 2009..Saponins are natural products that are well known for a wide range of biological activities. For saponins of Maesa balansae, selective antileishmanial activity has been described... - Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkiiLiene Dhooghe
Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
Phytochemistry 71:785-91. 2010..3+/-3.8 microM, but the selectivity was rather limited. Thus, these constituents may contribute, at least in part, to the antimalarial use of O. kirkii in traditional medicine... - Linking in vitro and in vivo survival of clinical Leishmania donovani strainsManu Vanaerschot
Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
PLoS ONE 5:e12211. 2010..Treating patients imposes an additional stress on the parasite and sodium stibogluconate (SSG) was used for over 70 years in the Indian subcontinent... - Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007)Paul Cos
Laboratory of Microbiology, Parasitology and Hygiene LMPH, Department of Pharmaceutical Sciences, University of Antwerp, Belgium
Planta Med 74:1323-37. 2008..If available, chemical structures, antiviral activity and selectivity, mechanism of action, and structure-activity relationship are presented... - Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stressIlse Van Brussel
Laboratory of Cellular and Molecular Cardiology, University of Antwerp, Wilrijk, Antwerp, Belgium
PLoS ONE 7:e43357. 2012..A large body of evidence indicates that cell death is a major modulating factor of atherogenesis. We examined antioxidant defence systems of human monocyte-derived (mo)DCs and monocytes in response to oxidative stress... - Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse modelTessa Horemans
Laboratory of Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
Helicobacter 17:312-8. 2012..Intervention at the stage of bacterial attachment to the gastric mucosa could be an approach to improve the control/eradication rate of this infection... - Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasisMaya Berg
Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
Antimicrob Agents Chemother 54:1900-8. 2010..b. brucei and that, therefore, it is possible that UAMC-00363 acts on an additional target... - An alternative, sensitive method to detect Helicobacter pylori DNA in fecesTessa Horemans
Laboratory of Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical, and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
Helicobacter 16:113-8. 2011..Even by using specific DNA extraction kits for stools, monitoring of infection by analyzing stool samples remains problematic and endorses the need for improved diagnostic methods... 
Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidantsNina Hermans
Laboratory of Nutrition and Functional Food Science, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
J Pharm Pharmacol 59:131-6. 2007..These findings have provided important information concerning systemic oxidative stress animal models for the in-vivo study of antioxidants...- Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoitesEly Bénéré
Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, B 2020 Antwerp, Belgium
Parasitol Int 59:634-7. 2010..2mg/ml) supported cloning of Assemblage A, while l-glutathione (7.8 mg/ml) was required for Assemblage E. This is a first description of in vitro axenisation of Assemblage E trophozoites from cattle... - Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'Paul Cos
Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
J Ethnopharmacol 106:290-302. 2006.... - Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivativesTim H M Jonckers
Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium
J Med Chem 45:3497-508. 2002..In addition, 2-bromo-, 2-nitro-, and 2-methoxy-9-cyanoneocryptolepine exhibited antitrypanosomal activity in the micromolar range in the absence of obvious cytotoxicity... - Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dyeMonique Kerstens
Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
J Microbiol Methods 92:189-91. 2013..TO-PRO(®)-3 iodide allows an excellent distinction between viable and dead cells. Both quantification methods show a high degree of correlation... - A new quantitative in vitro microculture method for Giardia duodenalis trophozoitesEly Bénéré
Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
J Microbiol Methods 71:101-6. 2007..32 microM. The broad-spectrum antibiotics chloramphenicol, rifampicin, penicillin G+streptomycin and gentamycin were devoid of any inhibitory activity and are considered suitable for decontamination during excystation experiments... - Design and evaluation of Trypanosoma brucei metacaspase inhibitorsMaya Berg
Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
Bioorg Med Chem Lett 20:2001-6. 2010..In this Letter we present the first inhibitors of TbMCA2 with low micromolar enzymatic and antiparasitic activity in vitro combined with low cytotoxicity... - In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory modelsKelly de Wit
Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, Antwerp, Belgium
Antimicrob Agents Chemother 54:4927-9. 2010..In the M. canis guinea pig model and C. albicans vulvovaginitis rat model, pramiconazole was superior to the reference compounds after oral and topical administration... - Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from PeruVanessa Adaui
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Infect Genet Evol 11:1873-80. 2011..2007), hereby questioning the role of transmission and/or chemotherapeutic drug pressure in the observed population structure... - In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivativesSabine Van Miert
Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
Exp Parasitol 108:163-8. 2004.... - Comparative EPR study of different macrophage types stimulated for superoxide and nitric oxide productionMaartje Deschacht
University of Antwerp, Belgium
Free Radic Res 44:763-72. 2010..In conclusion, this study established practical experimental conditions for the EPR analysis of O(2)(.-) and NO produced by different types of activated macrophages... - Plant substances as anti-HIV agents selected according to their putative mechanism of actionPaul Cos
Laboratory of Pharmaceutical Microbiology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
J Nat Prod 67:284-93. 2004..In conclusion, several plant-derived antiviral agents are good candidates to be further studied for their potential in the systemic therapy and/or prophylaxis of HIV infections, most probably in combination with other anti-HIV drugs... - In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivativesNils Germonprez
Tibotec nv, Generaal De Wittelaan 11 bus 4, B-2800 Mechelen, Belgium
J Med Chem 48:32-7. 2005..2-0.4 mg/kg was administered. Several chemical derivatives of maesabalides I-VI were prepared in order to study the structure-activity relationship... - Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivativesAdina Ryckebusch
UMR 8525 CNRS, , Institut de Biologie et Institut Pasteur de Lille, 1 rue du Professeur Calmette, B.P. 447, 59021 Lille Cedex, France
J Med Chem 46:542-57. 2003..Eleven compounds displayed a higher selectivity index (ratio CC50/IC50 activity) than CQ, and one of them cured mice infected by Plasmodium berghei... - The antiplasmodial activity of isolates from Ajuga remotaKimani A M Kuria
Faculty of Pharmacy, University of Nairobi, P.O. Box 19676, Nairobi, Kenya
J Nat Prod 65:789-93. 2002..This iridoid glucoside, which has been formerly isolated from Ajuga decumbens, was identified in A. remota for the first time... - Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstoneiZakaria H Mbwambo
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
J Nat Prod 69:369-72. 2006..The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM)... - A novel isoflavonoid from Millettia puguensisModest C Kapingu
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
Planta Med 72:1341-3. 2006.... - Synthesis and antimalarial activity of new analogues of amodiaquineSandrine Delarue-Cochin
UMR CNRS 8525, Universite de Lille II, Institut Pasteur de Lille 1 rue du Professeur Calmette, B P 447, 59021 Lille Cedex, France
Eur J Med Chem 43:252-60. 2008..Among the compounds synthesized, new amino derivative 5 displayed the greatest selectivity index towards the most CQ-resistant strain tested and was active in mice infected by Plasmodium berghei... - Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linkerAbolfasl Golisade
, , , Bundesstrasse 45, D-20146, Hamburg, Germany
Bioorg Med Chem 10:159-65. 2002..b. brucei blood stream forms with an IC(50) of 0.85 microM in vitro.. - Antitrichomonas in vitro activity of Cussonia holstii EnglWeidong He
Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
Nat Prod Res 17:127-33. 2003..A detailed chromatographic study using centrifugal partition chromatography revealed that a pentacyclic triterpenoid, i.e., hederagenin, is the antitrichomonas constituent of the plant with a IC50 of 2.8 microM... - Liquid chromatographic method for analysis of saponins in Maesa balansae extract active against leishmaniasisStefanie Leonard
Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, E. Van Evenstraat 4, B-3000 Leuven, Belgium
J Chromatogr A 1012:39-46. 2003..The isocratic LC method was optimized and the robustness was evaluated with an experimental design. The method showed good selectivity, repeatability, linearity and sensitivity... - Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazidesRégis Millet
UMR 8525 CNRS, Universite de Lille 2, Institut de Biologie de Lille et Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 447, France
Bioorg Med Chem Lett 12:3601-4. 2002..In vitro antitrypanosomal activities of these compounds were determined against the closely related protozoa Trypanosoma cruzi Trypanosoma brucei and discussed in relation to potential targets...