Louis Maes

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. pmc In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region
    Nawal M Al-Musayeib
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    BMC Complement Altern Med 12:49. 2012
  2. doi request reprint Intravenous and Subcutaneous Toxicity and Absorption Kinetics in Mice and Dogs of the Antileishmanial Triterpene Saponin PX-6518
    Louis Maes
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, Antwerp B 2060, Belgium
    Molecules 18:4803-15. 2013
  3. pmc Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamsters
    Louis Maes
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171 V523, B 2610 Wilrijk, Belgium
    Antimicrob Agents Chemother 48:2056-60. 2004
  4. pmc In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species
    Louis Maes
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 48:130-6. 2004
  5. doi request reprint Phytochemical and biological investigations of Elaeodendron schlechteranum
    Sheila M Maregesi
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerpen, Belgium
    J Ethnopharmacol 129:319-26. 2010
  6. doi request reprint Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae
    Marieke Vermeersch
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
    Phytother Res 23:1404-10. 2009
  7. pmc In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells
    Raquel Inocêncio da Luz
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
    Antimicrob Agents Chemother 53:5197-203. 2009
  8. pmc α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
    Koen Steert
    Department of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    ChemMedChem 5:1734-48. 2010
  9. doi request reprint Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection
    Maartje Deschacht
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Wilrijk, Belgium
    Parasitology 139:1429-37. 2012
  10. doi request reprint Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata
    Kenn Foubert
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Phytochemistry 72:1414-23. 2011

Collaborators

Detail Information

Publications48

  1. pmc In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region
    Nawal M Al-Musayeib
    Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    BMC Complement Altern Med 12:49. 2012
    ..Thus the present study investigated the in vitro antiprotozoal activity of twenty-five plants collected from the Arabian Peninsula...
  2. doi request reprint Intravenous and Subcutaneous Toxicity and Absorption Kinetics in Mice and Dogs of the Antileishmanial Triterpene Saponin PX-6518
    Louis Maes
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, Antwerp B 2060, Belgium
    Molecules 18:4803-15. 2013
    ..It was decided not to pursue further drug development for PX-6518 because of the hepatotoxic risk...
  3. pmc Comparative activities of the triterpene saponin maesabalide III and liposomal amphotericin B (AmBisome) against Leishmania donovani in hamsters
    Louis Maes
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171 V523, B 2610 Wilrijk, Belgium
    Antimicrob Agents Chemother 48:2056-60. 2004
    ..However, multiple-dose pharmacological, toxicological, and pharmacokinetic studies are still needed before it can become a valid drug candidate for development...
  4. pmc In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species
    Louis Maes
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 48:130-6. 2004
    ..This study concludes that triterpenoid saponins from M. balansae show promising in vitro and in vivo antileishmanial potential and can be considered as new lead structures in the search for novel antileishmanial drugs...
  5. doi request reprint Phytochemical and biological investigations of Elaeodendron schlechteranum
    Sheila M Maregesi
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerpen, Belgium
    J Ethnopharmacol 129:319-26. 2010
    ..The aim of this study was to identify the putative active constituents of the plant...
  6. doi request reprint Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae
    Marieke Vermeersch
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
    Phytother Res 23:1404-10. 2009
    ..petelotii. This study indicates that the 13,28-epoxy-oleanane triterpene moiety is essential for selective antileishmania potential and that several other plant species could still be explored for antileishmania drug discovery...
  7. pmc In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells
    Raquel Inocêncio da Luz
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Antwerp, Belgium
    Antimicrob Agents Chemother 53:5197-203. 2009
    ..In conclusion, the proposed conditioning protocol further contributes toward a more standardized laboratory model for evaluation of the drug sensitivities of field isolates...
  8. pmc α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB
    Koen Steert
    Department of Medicinal Chemistry, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    ChemMedChem 5:1734-48. 2010
    ..8; however, in vitro whole-organism screening against a panel of protozoan parasites did not fully correlate with the observed inhibition of the cysteine protease...
  9. doi request reprint Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection
    Maartje Deschacht
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Wilrijk, Belgium
    Parasitology 139:1429-37. 2012
    ..An increased NO production was observed 6 h after infection. Finally, induction of cell death is probably not essential in the survival of the parasite within the macrophage...
  10. doi request reprint Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata
    Kenn Foubert
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Phytochemistry 72:1414-23. 2011
    ....
  11. doi request reprint In vitro and in vivo prophylactic and curative activity of the triterpene saponin PX-6518 against cutaneous Leishmania species
    Raquel Andreia Inocêncio da Luz
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    J Antimicrob Chemother 66:350-3. 2011
    ....
  12. pmc Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden
    Manu Vanaerschot
    Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 6:e23120. 2011
    ..Our results therefore highlight the need to closely monitor drug efficacy in the field, especially in the context of the Kala-azar elimination programme ongoing in the Indian subcontinent...
  13. doi request reprint Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues
    Gitte Van Baelen
    Laboratory of Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Bioorg Med Chem 17:7209-17. 2009
    ..However, this compound was not active in the Plasmodium berghei mouse model. Structure-activity relationships are discussed and compared with related naturally occurring compounds...
  14. pmc Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol
    Sarah Hendrickx
    Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp, Belgium
    PLoS Negl Trop Dis 6:e1664. 2012
    ..These findings may have important relevance to resistance mechanism investigations and the likelihood of resistance development and detection in the field...
  15. pmc In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences
    Marieke Vermeersch
    Laboratory for Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical, and Veterinary Sciences, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Antimicrob Agents Chemother 53:3855-9. 2009
    ..Axenic systems can be recommended only for compounds for which no cellular mechanisms are involved, for example, amphotericin B and miltefosine...
  16. doi request reprint Intrinsic susceptibility of Giardia duodenalis assemblage subtypes A(I), A(II), B and E(III) for nitric oxide under axenic culture conditions
    Ely Bénéré
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Parasitol Res 110:1315-9. 2012
    ..The underlying mechanisms still need to be elucidated, but assemblage-linked differences in the expression of the genes coding for flavohemoglobin or A-type flavoprotein may certainly deserve further attention...
  17. pmc Linking in vitro and in vivo survival of clinical Leishmania donovani strains
    Manu Vanaerschot
    Unit of Molecular Parasitology, Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 5:e12211. 2010
    ..Treating patients imposes an additional stress on the parasite and sodium stibogluconate (SSG) was used for over 70 years in the Indian subcontinent...
  18. doi request reprint Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii
    Liene Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Phytochemistry 71:785-91. 2010
    ..3+/-3.8 microM, but the selectivity was rather limited. Thus, these constituents may contribute, at least in part, to the antimalarial use of O. kirkii in traditional medicine...
  19. doi request reprint Leishmania-macrophage interactions: insights into the redox biology
    Tim Van Assche
    Laboratory of Microbiology Parasitology, and Hygiene, University of Antwerp, B 2020 Antwerp, Belgium
    Free Radic Biol Med 51:337-51. 2011
    ..In respect to antileishmanial therapy, the effects of current drugs on parasite-macrophage redox biology and its involvement in the development of drug resistance and treatment failure are presented...
  20. doi request reprint Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives
    Ibrahim El Sayed
    Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein, 1, 2610, Antwerp, Belgium
    J Med Chem 52:2979-88. 2009
    ..The most efficient compounds showed antiplasmodial activities in the nanomolar range. N(1),N(1)-Diethyl-N(4)-(5-methyl-5H-indolo[2,3-b]quinolin-8-yl)pentane-1,4-diamine 11c showed an IC(50) of 0.01 microM and a selectivity index of 1800...
  21. doi request reprint Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007)
    Paul Cos
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Department of Pharmaceutical Sciences, University of Antwerp, Belgium
    Planta Med 74:1323-37. 2008
    ..If available, chemical structures, antiviral activity and selectivity, mechanism of action, and structure-activity relationship are presented...
  22. doi request reprint LC-MS analysis of 13,28-epoxy-oleanane saponins in Maesa spp. extracts with antileishmanial activity
    Kenn Foubert
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    Phytochem Anal 20:159-67. 2009
    ..Saponins are natural products that are well known for a wide range of biological activities. For saponins of Maesa balansae, selective antileishmanial activity has been described...
  23. doi request reprint Quantification of Candida albicans by flow cytometry using TO-PRO(®)-3 iodide as a single-stain viability dye
    Monique Kerstens
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    J Microbiol Methods 92:189-91. 2013
    ..TO-PRO(®)-3 iodide allows an excellent distinction between viable and dead cells. Both quantification methods show a high degree of correlation...
  24. pmc Transcript and protein analysis reveals better survival skills of monocyte-derived dendritic cells compared to monocytes during oxidative stress
    Ilse Van Brussel
    Laboratory of Cellular and Molecular Cardiology, University of Antwerp, Wilrijk, Antwerp, Belgium
    PLoS ONE 7:e43357. 2012
    ..A large body of evidence indicates that cell death is a major modulating factor of atherogenesis. We examined antioxidant defence systems of human monocyte-derived (mo)DCs and monocytes in response to oxidative stress...
  25. doi request reprint Evaluation of the anti-adhesive effect of milk fat globule membrane glycoproteins on Helicobacter pylori in the human NCI-N87 cell line and C57BL/6 mouse model
    Tessa Horemans
    Laboratory of Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Helicobacter 17:312-8. 2012
    ..Intervention at the stage of bacterial attachment to the gastric mucosa could be an approach to improve the control/eradication rate of this infection...
  26. doi request reprint An alternative, sensitive method to detect Helicobacter pylori DNA in feces
    Tessa Horemans
    Laboratory of Microbiology, Parasitology, and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical, and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Helicobacter 16:113-8. 2011
    ..Even by using specific DNA extraction kits for stools, monitoring of infection by analyzing stool samples remains problematic and endorses the need for improved diagnostic methods...
  27. pmc Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis
    Maya Berg
    Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
    Antimicrob Agents Chemother 54:1900-8. 2010
    ..b. brucei and that, therefore, it is possible that UAMC-00363 acts on an additional target...
  28. ncbi request reprint Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: status of lipid peroxidation and fat-soluble antioxidants
    Nina Hermans
    Laboratory of Nutrition and Functional Food Science, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Pharm Pharmacol 59:131-6. 2007
    ..These findings have provided important information concerning systemic oxidative stress animal models for the in-vivo study of antioxidants...
  29. ncbi request reprint Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'
    Paul Cos
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    J Ethnopharmacol 106:290-302. 2006
    ....
  30. doi request reprint Infectivity of Giardia duodenalis Assemblages A and E for the gerbil and axenisation of duodenal trophozoites
    Ely Bénéré
    Laboratory of Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, B 2020 Antwerp, Belgium
    Parasitol Int 59:634-7. 2010
    ..2mg/ml) supported cloning of Assemblage A, while l-glutathione (7.8 mg/ml) was required for Assemblage E. This is a first description of in vitro axenisation of Assemblage E trophozoites from cattle...
  31. ncbi request reprint Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives
    Tim H M Jonckers
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Med Chem 45:3497-508. 2002
    ..In addition, 2-bromo-, 2-nitro-, and 2-methoxy-9-cyanoneocryptolepine exhibited antitrypanosomal activity in the micromolar range in the absence of obvious cytotoxicity...
  32. doi request reprint Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru
    Vanessa Adaui
    Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
    Infect Genet Evol 11:1873-80. 2011
    ..2007), hereby questioning the role of transmission and/or chemotherapeutic drug pressure in the observed population structure...
  33. pmc Design and evaluation of Trypanosoma brucei metacaspase inhibitors
    Maya Berg
    Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium
    Bioorg Med Chem Lett 20:2001-6. 2010
    ..In this Letter we present the first inhibitors of TbMCA2 with low micromolar enzymatic and antiparasitic activity in vitro combined with low cytotoxicity...
  34. pmc In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models
    Kelly de Wit
    Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, Antwerp, Belgium
    Antimicrob Agents Chemother 54:4927-9. 2010
    ..In the M. canis guinea pig model and C. albicans vulvovaginitis rat model, pramiconazole was superior to the reference compounds after oral and topical administration...
  35. ncbi request reprint A new quantitative in vitro microculture method for Giardia duodenalis trophozoites
    Ely Bénéré
    Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Microbiol Methods 71:101-6. 2007
    ..32 microM. The broad-spectrum antibiotics chloramphenicol, rifampicin, penicillin G+streptomycin and gentamycin were devoid of any inhibitory activity and are considered suitable for decontamination during excystation experiments...
  36. ncbi request reprint Plant substances as anti-HIV agents selected according to their putative mechanism of action
    Paul Cos
    Laboratory of Pharmaceutical Microbiology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    J Nat Prod 67:284-93. 2004
    ..In conclusion, several plant-derived antiviral agents are good candidates to be further studied for their potential in the systemic therapy and/or prophylaxis of HIV infections, most probably in combination with other anti-HIV drugs...
  37. doi request reprint Comparative EPR study of different macrophage types stimulated for superoxide and nitric oxide production
    Maartje Deschacht
    University of Antwerp, Belgium
    Free Radic Res 44:763-72. 2010
    ..In conclusion, this study established practical experimental conditions for the EPR analysis of O(2)(.-) and NO produced by different types of activated macrophages...
  38. ncbi request reprint In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives
    Sabine Van Miert
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Exp Parasitol 108:163-8. 2004
    ....
  39. ncbi request reprint Synthesis and antimalarial activity of new analogues of amodiaquine
    Sandrine Delarue-Cochin
    UMR CNRS 8525, Universite de Lille II, Institut Pasteur de Lille 1 rue du Professeur Calmette, B P 447, 59021 Lille Cedex, France
    Eur J Med Chem 43:252-60. 2008
    ..Among the compounds synthesized, new amino derivative 5 displayed the greatest selectivity index towards the most CQ-resistant strain tested and was active in mice infected by Plasmodium berghei...
  40. ncbi request reprint Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei
    Zakaria H Mbwambo
    Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    J Nat Prod 69:369-72. 2006
    ..The dimeric xanthone garcilivin A (4) showed a higher and nonselective antiparasitic activity and cytotoxicity (IC(50) 2.0 microM against MRC-5 cells) than its diastereoisomer garcilivin C (5) (IC(50) 52.3 microM)...
  41. ncbi request reprint The antiplasmodial activity of isolates from Ajuga remota
    Kimani A M Kuria
    Faculty of Pharmacy, University of Nairobi, P O Box 19676, Nairobi, Kenya
    J Nat Prod 65:789-93. 2002
    ..This iridoid glucoside, which has been formerly isolated from Ajuga decumbens, was identified in A. remota for the first time...
  42. ncbi request reprint Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives
    Adina Ryckebusch
    UMR 8525 CNRS, Universite de Lille II, Institut de Biologie et Institut Pasteur de Lille, 1 rue du Professeur Calmette, B P 447, 59021 Lille Cedex, France
    J Med Chem 46:542-57. 2003
    ..Eleven compounds displayed a higher selectivity index (ratio CC50/IC50 activity) than CQ, and one of them cured mice infected by Plasmodium berghei...
  43. ncbi request reprint In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives
    Nils Germonprez
    Tibotec nv, Generaal De Wittelaan 11 bus 4, B 2800 Mechelen, Belgium
    J Med Chem 48:32-7. 2005
    ..2-0.4 mg/kg was administered. Several chemical derivatives of maesabalides I-VI were prepared in order to study the structure-activity relationship...
  44. ncbi request reprint A novel isoflavonoid from Millettia puguensis
    Modest C Kapingu
    Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania
    Planta Med 72:1341-3. 2006
    ....
  45. ncbi request reprint Liquid chromatographic method for analysis of saponins in Maesa balansae extract active against leishmaniasis
    Stefanie Leonard
    Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
    J Chromatogr A 1012:39-46. 2003
    ..The isocratic LC method was optimized and the robustness was evaluated with an experimental design. The method showed good selectivity, repeatability, linearity and sensitivity...
  46. ncbi request reprint Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides
    Régis Millet
    UMR 8525 CNRS, Universite de Lille 2, Institut de Biologie de Lille et Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 447, France
    Bioorg Med Chem Lett 12:3601-4. 2002
    ..In vitro antitrypanosomal activities of these compounds were determined against the closely related protozoa Trypanosoma cruzi Trypanosoma brucei and discussed in relation to potential targets...
  47. ncbi request reprint Antitrichomonas in vitro activity of Cussonia holstii Engl
    Weidong He
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Nat Prod Res 17:127-33. 2003
    ..A detailed chromatographic study using centrifugal partition chromatography revealed that a pentacyclic triterpenoid, i.e., hederagenin, is the antitrichomonas constituent of the plant with a IC50 of 2.8 microM...
  48. ncbi request reprint Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker
    Abolfasl Golisade
    Institut fur Pharmazie, Abteilung für Pharmazeutische Chemie, Universitat Hamburg, Bundesstrasse 45, D 20146, Hamburg, Germany
    Bioorg Med Chem 10:159-65. 2002
    ..b. brucei blood stream forms with an IC(50) of 0.85 microM in vitro..