Nathalie Le Bastard

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. doi request reprint Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia BIODEM, Antwerp, Belgium
    J Alzheimers Dis 33:807-22. 2013
  2. doi request reprint Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    Nathalie Le Bastard
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 33:117-31. 2013
  3. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
  4. doi request reprint Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:947-58. 2013
  5. ncbi request reprint Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    J Alzheimers Dis 36:759-67. 2013
  6. doi request reprint Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
    Marcel J H Aries
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 25:1186-95. 2010
  7. doi request reprint Added diagnostic value of CSF biomarkers in differential dementia diagnosis
    Nathalie Le Bastard
    Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Aging 31:1867-76. 2010
  8. ncbi request reprint Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 35:137-46. 2013
  9. doi request reprint Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:265-75. 2013
  10. ncbi request reprint Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 21:291-301. 2010

Collaborators

  • Sebastiaan Engelborghs
  • Peter Paul De Deyn
  • Christine Van Broeckhoven
  • Kristel Sleegers
  • Peter Mariën
  • Ellen Vloeberghs
  • Christopher M Clark
  • Yannick Vermeiren
  • Sylvie Slaets
  • Stefan Van der Mussele
  • Marcel J H Aries
  • Hans Debruyne
  • Nore Somers
  • Jean Jacques Martin
  • Jos Saerens
  • Johan Goeman
  • Karolien Bettens
  • Michael Van Buggenhout
  • Evelyn De Leenheir
  • Aline Verstraeten
  • Jessie Theuns
  • Jill Luyckx
  • An Van Hemelrijck
  • Kim Bekelaar
  • Wilhelmus H Drinkenburg
  • Philippe Amouyel
  • Richard Mayeux
  • Steven Vermeulen
  • Nathalie Brouwers
  • Maria Mattheijssens
  • Karin Peeters
  • Rik Vandenberghe
  • Jean Charles Lambert
  • Jasper Van Dongen
  • Ekaterina Rogaeva
  • Peter St George-Hyslop
  • Florence Pasquier
  • Guy Nagels
  • Marcel Aries
  • Kurt Audenaert
  • Dagmar Gorissen
  • Barbara A Pickut

Detail Information

Publications19

  1. doi request reprint Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia BIODEM, Antwerp, Belgium
    J Alzheimers Dis 33:807-22. 2013
    ..Only T-tau increased in AD patients in comparison to controls, which does not preclude its use as a diagnostic marker, nor as a potential pharmacodynamic marker...
  2. doi request reprint Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    Nathalie Le Bastard
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 33:117-31. 2013
    ..Since the clinical value of the ELISA (INNOTEST) and Luminex (INNO-BIA) tests is comparable, further research to select the most suitable analytical platform for routine CSF biomarker measurements is needed...
  3. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  4. doi request reprint Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:947-58. 2013
    ....
  5. ncbi request reprint Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    J Alzheimers Dis 36:759-67. 2013
    ....
  6. doi request reprint Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
    Marcel J H Aries
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 25:1186-95. 2010
    ..To study frontal lobe symptoms in relation to dementia severity within and across diagnostic dementia categories, a cross-sectional analysis of behavioural data was performed...
  7. doi request reprint Added diagnostic value of CSF biomarkers in differential dementia diagnosis
    Nathalie Le Bastard
    Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Aging 31:1867-76. 2010
    ....
  8. ncbi request reprint Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 35:137-46. 2013
    ....
  9. doi request reprint Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:265-75. 2013
    ..The aim of this study is to characterize behavior in MCI compared with Alzheimer's disease (AD) and healthy older patients...
  10. ncbi request reprint Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 21:291-301. 2010
    ..CSF biomarker analysis remains superior, although the possible application of longitudinal plasma Abeta measurements as screening tools for dementia remains to be elucidated...
  11. ncbi request reprint No correlation between time-linked plasma and CSF Abeta levels
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, University of Antwerp, Antwerp, Belgium
    Neurochem Int 55:820-5. 2009
    ....
  12. doi request reprint The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease
    Sebastiaan Engelborghs
    Reference Center for Biological Markers of Dementia BIODEM, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Mol Diagn Ther 16:135-41. 2012
    ..Variation in biomarker measurements still jeopardize the introduction of CSF biomarkers into routine clinical practice and clinical trials, but several national and international standardization initiatives are ongoing...
  13. doi request reprint The role of CSF biomarkers in the diagnostic work-up of mixed vascular-degenerative dementia
    Sebastiaan Engelborghs
    Reference Centre for Biological Markers of Dementia BIODEM, Institute Born Bunge, University of Antwerp, BE 2610 Antwerp, Belgium
    J Neurol Sci 322:197-9. 2012
    ....
  14. doi request reprint Reversal of head drop after discontinuation of olanzapine in a DLB patient
    Marcel J H Aries
    Department of Neurology and Memory Clinic, ZNA Middelheim and ZNA Hoge Beuken, Antwerp, Belgium
    Mov Disord 23:1760-2. 2008
    ..Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade...
  15. doi request reprint Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia
    Yannick Vermeiren
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia, University of Antwerp, Antwerp, Belgium
    Alzheimers Dement 9:488-98. 2013
    ..In this study we attempted to identify cerebrospinal fluid (CSF) neurochemical correlates of BPSD to provide further insight into its underlying neurochemical pathophysiological mechanisms...
  16. ncbi request reprint Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, Antwerpen, Belgium
    J Alzheimers Dis 35:67-73. 2013
    ....
  17. doi request reprint Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimer's disease
    Yannick Vermeiren
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Wilrijk, Belgium
    Neurochem Res 36:1858-62. 2011
    ..Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD...
  18. doi request reprint Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment?
    Hans Debruyne
    Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
    Int J Geriatr Psychiatry 24:556-62. 2009
    ....
  19. ncbi request reprint The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Antwerp, Belgium
    Neurochem Int 52:1052-60. 2008
    ....