Nathalie Le Bastard

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. doi Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    Nathalie Le Bastard
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 33:117-31. 2013
  2. doi Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia BIODEM, Antwerp, Belgium
    J Alzheimers Dis 33:807-22. 2013
  3. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
  4. doi Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:947-58. 2013
  5. doi Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    J Alzheimers Dis 36:759-67. 2013
  6. doi Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
    Marcel J H Aries
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 25:1186-95. 2010
  7. doi Added diagnostic value of CSF biomarkers in differential dementia diagnosis
    Nathalie Le Bastard
    Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Aging 31:1867-76. 2010
  8. doi Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 35:137-46. 2013
  9. doi Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:265-75. 2013
  10. doi Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 21:291-301. 2010

Collaborators

  • Sebastiaan Engelborghs
  • Peter Paul De Deyn
  • Peter Mariën
  • Christine Van Broeckhoven
  • Kristel Sleegers
  • Ellen Vloeberghs
  • Christopher M Clark
  • Stefan Van der Mussele
  • Sylvie Slaets
  • Yannick Vermeiren
  • Johan Goeman
  • Jean Jacques Martin
  • Nore Somers
  • Hans Debruyne
  • Marcel J H Aries
  • Jos Saerens
  • Ellis Niemantsverdriet
  • Karolien Bettens
  • Michael Van Buggenhout
  • Bart F E Feyen
  • Eugeen Vanmechelen
  • Hilde Decraemer
  • Manu Vandijck
  • Kim Bekelaar
  • An Van Hemelrijck
  • Aline Verstraeten
  • Wilhelmus H Drinkenburg
  • Jessie Theuns
  • Evelyn De Leenheir
  • Jill Luyckx
  • Nathalie Brouwers
  • Karin Peeters
  • Richard Mayeux
  • Peter St George-Hyslop
  • Steven Vermeulen
  • Jean Charles Lambert
  • Ekaterina Rogaeva
  • Florence Pasquier
  • Maria Mattheijssens
  • Rik Vandenberghe
  • Jasper Van Dongen
  • Philippe Amouyel
  • Guy Nagels
  • Kurt Audenaert
  • Marcel Aries
  • Barbara A Pickut
  • Dagmar Gorissen

Detail Information

Publications23

  1. doi Comparison of two analytical platforms for the clinical qualification of Alzheimer's disease biomarkers in pathologically-confirmed dementia
    Nathalie Le Bastard
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 33:117-31. 2013
    ..Since the clinical value of the ELISA (INNOTEST) and Luminex (INNO-BIA) tests is comparable, further research to select the most suitable analytical platform for routine CSF biomarker measurements is needed...
  2. doi Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia BIODEM, Antwerp, Belgium
    J Alzheimers Dis 33:807-22. 2013
    ..Only T-tau increased in AD patients in comparison to controls, which does not preclude its use as a diagnostic marker, nor as a potential pharmacodynamic marker...
  3. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  4. doi Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:947-58. 2013
    ....
  5. doi Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
    J Alzheimers Dis 36:759-67. 2013
    ....
  6. doi Relation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
    Marcel J H Aries
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 25:1186-95. 2010
    ..To study frontal lobe symptoms in relation to dementia severity within and across diagnostic dementia categories, a cross-sectional analysis of behavioural data was performed...
  7. doi Added diagnostic value of CSF biomarkers in differential dementia diagnosis
    Nathalie Le Bastard
    Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Aging 31:1867-76. 2010
    ....
  8. doi Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 35:137-46. 2013
    ....
  9. doi Behavioral symptoms in mild cognitive impairment as compared with Alzheimer's disease and healthy older adults
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:265-75. 2013
    ..The aim of this study is to characterize behavior in MCI compared with Alzheimer's disease (AD) and healthy older patients...
  10. doi Plasma amyloid-beta forms in Alzheimer's disease and non-Alzheimer's disease patients
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 21:291-301. 2010
    ..CSF biomarker analysis remains superior, although the possible application of longitudinal plasma Abeta measurements as screening tools for dementia remains to be elucidated...
  11. doi Agitation-associated behavioral symptoms in mild cognitive impairment and Alzheimer's dementia
    Stefan Van der Mussele
    a Laboratory of Neurochemistry and Behavior, Reference Centre for Biological Markers of Dementia BIODEM, Institute Born Bunge, University of Antwerp UA, Antwerp, Belgium
    Aging Ment Health 19:247-57. 2015
    ..The aim of this study is to determine the prevalence of agitation in mild cognitive impairment (MCI, Petersen's criteria) and patients with Alzheimer's dementia (AD), and to characterize the associated behavioral symptoms...
  12. doi No correlation between time-linked plasma and CSF Abeta levels
    Nathalie Le Bastard
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, University of Antwerp, Antwerp, Belgium
    Neurochem Int 55:820-5. 2009
    ....
  13. doi The impact of cerebrospinal fluid biomarkers on the diagnosis of Alzheimer's disease
    Sebastiaan Engelborghs
    Reference Center for Biological Markers of Dementia BIODEM, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Mol Diagn Ther 16:135-41. 2012
    ..Variation in biomarker measurements still jeopardize the introduction of CSF biomarkers into routine clinical practice and clinical trials, but several national and international standardization initiatives are ongoing...
  14. doi The role of CSF biomarkers in the diagnostic work-up of mixed vascular-degenerative dementia
    Sebastiaan Engelborghs
    Reference Centre for Biological Markers of Dementia BIODEM, Institute Born Bunge, University of Antwerp, BE 2610 Antwerp, Belgium
    J Neurol Sci 322:197-9. 2012
    ....
  15. doi Reversal of head drop after discontinuation of olanzapine in a DLB patient
    Marcel J H Aries
    Department of Neurology and Memory Clinic, ZNA Middelheim and ZNA Hoge Beuken, Antwerp, Belgium
    Mov Disord 23:1760-2. 2008
    ..Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade...
  16. doi Increased CSF α-synuclein levels in Alzheimer's disease: Correlation with tau levels
    Sylvie Slaets
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Alzheimers Dement 10:S290-8. 2014
    ....
  17. doi Behavioral correlates of cerebrospinal fluid amino acid and biogenic amine neurotransmitter alterations in dementia
    Yannick Vermeiren
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Dementia, University of Antwerp, Antwerp, Belgium
    Alzheimers Dement 9:488-98. 2013
    ..In this study we attempted to identify cerebrospinal fluid (CSF) neurochemical correlates of BPSD to provide further insight into its underlying neurochemical pathophysiological mechanisms...
  18. doi Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals ZNA, Antwerpen, Belgium
    J Alzheimers Dis 35:67-73. 2013
    ....
  19. doi Serum glutamine synthetase has no value as a diagnostic biomarker for Alzheimer's disease
    Yannick Vermeiren
    Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, Institute Born Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Wilrijk, Belgium
    Neurochem Res 36:1858-62. 2011
    ..Age correlated positively with serum GS concentrations in AD patients and control subjects. This study suggests that serum GS levels have no diagnostic value for AD...
  20. doi Overdiagnosing Vascular Dementia using Structural Brain Imaging for Dementia Work-Up
    Ellis Niemantsverdriet
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, and Biobank, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    J Alzheimers Dis 45:1039-43. 2015
    ..017) had an autopsy-confirmed diagnosis of VaD. Patients with vascular lesions on structural brain imaging were often misdiagnosed as possible or probable VaD as compared to autopsy-confirmed diagnosis. ..
  21. doi Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment?
    Hans Debruyne
    Department of Neurology and Memory Clinic, Middelheim General Hospital, Antwerp, Belgium
    Int J Geriatr Psychiatry 24:556-62. 2009
    ....
  22. doi Importance and impact of preanalytical variables on Alzheimer disease biomarker concentrations in cerebrospinal fluid
    Nathalie Le Bastard
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium Current affiliation Fujirebio Europe, Ghent, Belgium
    Clin Chem 61:734-43. 2015
    ..The aim of this study was to explore the influence of fractionated sampling, centrifugation, freezing temperature, freezing delay, and freeze-thaw cycles on CSF biomarker analyses...
  23. ncbi The dopaminergic neurotransmitter system is associated with aggression and agitation in frontotemporal dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital ZNA, Antwerp, Belgium
    Neurochem Int 52:1052-60. 2008
    ....