Samir Kumar-Singh

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. pmc Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric
    Samir Kumar-Singh
    Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
    Am J Pathol 161:507-20. 2002
  2. doi request reprint Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques
    S Kumar-Singh
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerpen, Belgium
    Genes Brain Behav 7:67-82. 2008
  3. ncbi request reprint Frontotemporal lobar degeneration: current concepts in the light of recent advances
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Laboratory of Neurogenetics, VIB, Institute Born Bunge and University of Antwerp, BE 2610 Antwerpen, Belgium
    Brain Pathol 17:104-14. 2007
  4. ncbi request reprint Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 27:686-95. 2006
  5. pmc Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls
    Samir Kumar-Singh
    Department of Molecular Genetics VIB8, Neurodegenerative Brain Diseases Research Group, Molecular Neuropathology Project, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Am J Pathol 167:527-43. 2005
  6. pmc Progranulin and TDP-43: mechanistic links and future directions
    Samir Kumar-Singh
    Laboratory of Molecular and Cellular Neuropathology, University of Antwerp, Universiteitsplein 1, 2610, Antwerpen, Belgium
    J Mol Neurosci 45:561-73. 2011
  7. doi request reprint Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models
    Sandra Pereson
    Department of Molecular Genetics, VIB, Antwerpen, Belgium
    J Pathol 219:173-81. 2009
  8. ncbi request reprint Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Neurobiol Aging 29:241-52. 2008
  9. doi request reprint Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Neurosci Lett 447:143-7. 2008
  10. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007

Collaborators

Detail Information

Publications32

  1. pmc Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric
    Samir Kumar-Singh
    Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium
    Am J Pathol 161:507-20. 2002
    ....
  2. doi request reprint Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques
    S Kumar-Singh
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerpen, Belgium
    Genes Brain Behav 7:67-82. 2008
    ....
  3. ncbi request reprint Frontotemporal lobar degeneration: current concepts in the light of recent advances
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Laboratory of Neurogenetics, VIB, Institute Born Bunge and University of Antwerp, BE 2610 Antwerpen, Belgium
    Brain Pathol 17:104-14. 2007
    ..These findings are pivotal for dissecting the pathways by which different etiologies lead to the varied clinicopathological presentations of FTLD...
  4. ncbi request reprint Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 27:686-95. 2006
    ..Also, the in vitro method we describe here is a valid tool for assaying the pathogenic potential of clinical PSEN mutations in a molecular diagnostic setting...
  5. pmc Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls
    Samir Kumar-Singh
    Department of Molecular Genetics VIB8, Neurodegenerative Brain Diseases Research Group, Molecular Neuropathology Project, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Am J Pathol 167:527-43. 2005
    ....
  6. pmc Progranulin and TDP-43: mechanistic links and future directions
    Samir Kumar-Singh
    Laboratory of Molecular and Cellular Neuropathology, University of Antwerp, Universiteitsplein 1, 2610, Antwerpen, Belgium
    J Mol Neurosci 45:561-73. 2011
    ..Continued multitiered efforts on genetic, cell biological, and animal modeling approaches would prove crucial in finding a cure for GRN-related diseases...
  7. doi request reprint Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models
    Sandra Pereson
    Department of Molecular Genetics, VIB, Antwerpen, Belgium
    J Pathol 219:173-81. 2009
    ..Because loss of GRN has recently been shown to cause frontotemporal dementia and serves as a risk factor for AD, the strong GRN reactivity around dense-core plaques is consistent with an important role of this factor in AD pathogenesis...
  8. ncbi request reprint Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Neurobiol Aging 29:241-52. 2008
    ..These data support earlier observations of A beta accumulation in the endosomal-lysosomal pathway and the hypothesis that intraneuronal accumulation of A beta could be an important factor in the AD pathogenesis...
  9. doi request reprint Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Neurosci Lett 447:143-7. 2008
    ..These data also provide a first in vivo indication of altered processing of APP-Swedish at sub-endogenous levels, an effect not observed in mouse models expressing the APP-Swedish mutation in high amounts...
  10. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007
    ..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)...
  11. doi request reprint Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice
    Hans Wils
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    J Pathol 228:67-76. 2012
    ..Our data suggest that progranulin deficiency in mice leads to reduced survival in adulthood and increased cellular ageing accompanied by hyperphosphorylation of TDP-43, and recapitulates key aspects of FTLD-TDP neuropathology...
  12. ncbi request reprint Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family
    Daniel Pirici
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB8, Institute Born Bunge, University of Antwerp, Belgium
    J Neuropathol Exp Neurol 65:289-301. 2006
    ..Whereas the precise nature of the protein remains elusive, characterization of such familial FTLD-U patients would be helpful in identifying a common denominator in the pathogenesis of familial and the more prevalent sporadic FTLD-U...
  13. ncbi request reprint A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques
    Bart Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
    Ann Neurol 55:617-26. 2004
    ..Our results suggest PS1 as a candidate gene for Pick-type tauopathy without MAPT mutations...
  14. doi request reprint Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Ilse Gijselinck
    University of Antwerp, B 2610 Antwerp, Belgium
    Arch Neurol 67:606-16. 2010
    ..Frontotemporal lobar degeneration (FTLD) is a neurodegenerative brain disorder that can be accompanied by signs of amyotrophic lateral sclerosis (ALS)...
  15. ncbi request reprint Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
    ..Furthermore, in a Belgian series of familial FTD patients, PGRN mutations were 3.5 times more frequent than mutations in MAPT, underscoring a principal involvement of PGRN in FTD pathogenesis...
  16. ncbi request reprint Frontotemporal lobar degeneration with ubiquitin-positive inclusions: a molecular genetic update
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Laboratory of Neurogenetics, Institute Born Bunge, and University of Antwerp, Antwerp, Belgium
    Neurodegener Dis 4:227-35. 2007
    ..This review focuses on the molecular genetic processes underlying FTLD-U pathology...
  17. doi request reprint Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures
    Gernot Kleinberger
    Department of Molecular Genetics, VIB, Universiteitsplein 1, Antwerpen, Belgium
    J Neurochem 115:735-47. 2010
    ..This leads to increased aggregation and accumulation of full-length TDP-43 along with its C-terminal derivatives by both caspase-dependent and independent mechanisms...
  18. ncbi request reprint A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder
    Veerle Bogaerts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Institute Born Bunge, Antwerpen, Belgium
    Brain 130:2277-91. 2007
    ..Once identified this will be the first novel causal gene for DLB and can be expected to open new avenues for biological studies of the disease process...
  19. ncbi request reprint Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches
    Bianca Van Broeck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, University of Antwerp, Universiteitsplein I, BE 2610 Antwerp, Belgium
    Neurodegener Dis 4:349-65. 2007
    ..Secondly, considering these mechanistic insights, we will discuss some therapeutic strategies which are currently in clinical or preclinical trials for AD...
  20. pmc TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
    Hans Wils
    Department of Molecular Genetics, VIB, B 2610 Antwerpen, Belgium
    Proc Natl Acad Sci U S A 107:3858-63. 2010
    ..These findings suggest that approximately 25-kDa TDP-43 CTFs are noxious to neurons by a gain of aberrant nuclear function...
  21. ncbi request reprint In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity
    Samir Kumar-Singh
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Born Bunge Foundation, University of Antwerp, B 2610 Antwerp, Belgium
    Neurobiol Dis 11:330-40. 2002
    ....
  22. ncbi request reprint Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum
    Bart Dermaut
    Department of Molecular Genetics VIB 8, Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Trends Genet 21:664-72. 2005
    ..Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player...
  23. pmc Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice
    Jonathan Janssens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, 2610, Antwerp, Belgium
    Mol Neurobiol 48:22-35. 2013
    ..Furthermore, we show that cellular aggregate formation or accumulation of TDP-43 C-terminal fragments (CTFs) are not primarily responsible for development of the observed disease phenotype in both mutant and wild-type TDP-43 mice...
  24. ncbi request reprint Genetics and pathology of alpha-secretase site AbetaPP mutations in the understanding of Alzheimer's disease
    Christine Van Broeckhoven
    Department of Molecular Genetics, Neurodegenerative Brain Diseases Research Group, Flanders Interuniversity Institute for Biotechnology, Institute Born Bunge and University of Antwerp, Antwerpen, Belgium
    J Alzheimers Dis 9:389-98. 2006
    ..In addition, this review will also point directions that warrant additional studies...
  25. ncbi request reprint Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium
    Curr Alzheimer Res 3:485-91. 2006
    ..These findings open promising novel targets for therapeutic intervention against neurodegeneration...
  26. pmc Antibody elution method for multiple immunohistochemistry on primary antibodies raised in the same species and of the same subtype
    Daniel Pirici
    Department of Histology, University of Medicine and Pharmacy Craiova, Petru Rares Street 2, 200349 Craiova Dolj, Romania
    J Histochem Cytochem 57:567-75. 2009
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  27. doi request reprint Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology, Flanders, and Laboratory of Neurogenetics, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Arch Neurol 65:700-4. 2008
  28. doi request reprint Fractal analysis of amyloid plaques in Alzheimer's disease patients and mouse models
    Daniel Pirici
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Neurobiol Aging 32:1579-87. 2011
    ..001). Our data suggest that plaque FD could be a valuable tool for objective, computer-oriented AD diagnosis as well as for genotype-phenotype correlations of AD...
  29. pmc Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse models
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerpen CDE, Universiteitsplein 1, B 2610, Antwerpen, Belgium
    Int J Mol Sci 10:1872-95. 2009
    ..These data would be important in the development of therapies targeting amyloid in vessels...
  30. doi request reprint Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia
    Karlien Van den Eynde
    Experimental Laboratory of Translational Neuroscience and Otolaryngology, University of Antwerp, Campus Drie Eiken, D T 420, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Behav Brain Res 258:179-86. 2014
    ....
  31. ncbi request reprint A novel drug target in Alzheimer's disease
    Marjolijn Bornebroek
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, 3000 DR Rotterdam, Netherlands
    Lancet 364:1738-9. 2004
  32. ncbi request reprint Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration
    Marjolijn Bornebroek
    Department of Neurology K5Q, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Neurobiol Dis 14:619-23. 2003
    ..Therefore it is suggested that the Dutch AbetaPP693 mutation located within the Abeta coding region of the AbetaPP gene has a different effect not only on clinical and pathological expression but also on Abeta processing...