R F Kooy

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi Fragile X syndrome at the turn of the century
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Mol Med Today 6:193-8. 2000
  2. ncbi CAG repeat contraction in the androgen receptor gene in three brothers with mental retardation
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Med Genet 85:209-13. 1999
  3. ncbi Neuroanatomy of the fragile X knockout mouse brain studied using in vivo high resolution magnetic resonance imaging
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 7:526-32. 1999
  4. ncbi Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Eur J Hum Genet 9:153-9. 2001
  5. ncbi Restoring the phenotype of fragile X syndrome: insight from the mouse model
    I Gantois
    Department of Medical Genetics, University of Antwerp, Belgium
    Curr Mol Med 1:447-55. 2001
  6. ncbi Mildly impaired water maze performance in male Fmr1 knockout mice
    R D'hooge
    Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, University of Antwerp, Belgium
    Neuroscience 76:367-76. 1997
  7. ncbi Transgenic mouse model for the fragile X syndrome
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Belgium
    Am J Med Genet 64:241-5. 1996
  8. ncbi Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice
    D Van Dam
    Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, University of Antwerp, Universiteitsplein 1, B2610 Wilrijk, Antwerp, Belgium
    Behav Brain Res 117:127-36. 2000
  9. ncbi FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis
    V Errijgers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Genes Brain Behav 6:552-7. 2007
  10. ncbi Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice
    E Reyniers
    Department of Medical Genetics, University of Antwerp, Belgium
    Hum Genet 97:49-50. 1996

Collaborators

Detail Information

Publications15

  1. ncbi Fragile X syndrome at the turn of the century
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Mol Med Today 6:193-8. 2000
    ..The fragile X story also provides a sobering example of how much time and effort might be necessary to develop beneficial treatment through understanding gene function...
  2. ncbi CAG repeat contraction in the androgen receptor gene in three brothers with mental retardation
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Med Genet 85:209-13. 1999
    ....
  3. ncbi Neuroanatomy of the fragile X knockout mouse brain studied using in vivo high resolution magnetic resonance imaging
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 7:526-32. 1999
    ..We did not find evidence for size alterations in various brain regions of the fragile X mouse model, but the method described may find a wide application in the study of mutant mouse models with neurological involvement...
  4. ncbi Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI)
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Eur J Hum Genet 9:153-9. 2001
    ..This review focuses on the potential of the MRI technique to image the brain of (transgenic) mouse models for neurological diseases, and aims to introduce these exciting new technological developments to the non-specialist reader...
  5. ncbi Restoring the phenotype of fragile X syndrome: insight from the mouse model
    I Gantois
    Department of Medical Genetics, University of Antwerp, Belgium
    Curr Mol Med 1:447-55. 2001
    ..The results implicate that, even if FMR1 production is cell type specific, the quantity of the FMRP expression is highly critical as overproduction may have a harmful effect...
  6. ncbi Mildly impaired water maze performance in male Fmr1 knockout mice
    R D'hooge
    Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, University of Antwerp, Belgium
    Neuroscience 76:367-76. 1997
    ..It remains unclear, however, which brain region or neurochemical system might be involved in these disabilities. We conclude that Fmr1 knockout mice might be a valid model of fragile X mental retardation...
  7. ncbi Transgenic mouse model for the fragile X syndrome
    R F Kooy
    Department of Medical Genetics, University of Antwerp, Belgium
    Am J Med Genet 64:241-5. 1996
    ..In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome...
  8. ncbi Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice
    D Van Dam
    Laboratory of Neurochemistry and Behaviour, Born Bunge Foundation, University of Antwerp, Universiteitsplein 1, B2610 Wilrijk, Antwerp, Belgium
    Behav Brain Res 117:127-36. 2000
    ..Neither protocol revealed significant differences between controls and knockouts...
  9. ncbi FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis
    V Errijgers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Genes Brain Behav 6:552-7. 2007
    ..129P2-Pde6b(+) Tyr(c-ch)/Ant mice, for which we propose the name FVBS/Ant, demonstrated a clear visual evoked potential in the presence of normal eye histology and improved performance in the Morris water maze test...
  10. ncbi Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice
    E Reyniers
    Department of Medical Genetics, University of Antwerp, Belgium
    Hum Genet 97:49-50. 1996
    ..None of the knockout mice showed increased MCH levels when compared with normal littermates. We conclude that it is unlikely that the FMR1 gene product has an effect on MCH...
  11. ncbi L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns
    E Fransen
    Department of Medical Genetics, University of Antwerp, B 2610 Antwerp, Belgium
    Hum Mol Genet 7:999-1009. 1998
    ..Additionally, the cerebellar vermis of the KO mice is hypoplastic. Their exploratory behavior is characterized by stereotype peripheral circling reminiscent of that of rodents with induced cerebellar lesions...
  12. ncbi Genetic modifiers in mice: the example of the fragile X mouse model
    V Errijgers
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Cytogenet Genome Res 105:448-54. 2004
    ..In this review we compare the test results obtained in different laboratories and provide evidence that modifiers may affect disease severity in the fragile X knockout mouse...
  13. ncbi Multiplex ligation-dependent probe amplification to detect subtelomeric rearrangements in routine diagnostics
    L Rooms
    Department of Medical Genetics, University of Antwerp, Antwerp and University Hospital Antwerp, Belgium
    Clin Genet 69:58-64. 2006
    ..This high frequency of subtelomeric abnormalities detected in an unselected population warrants further investigation about the feasibility of routine screening for subtelomeric aberrations in mentally retarded patients...
  14. doi Fragile X syndrome: from molecular genetics to therapy
    C D'Hulst
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    J Med Genet 46:577-84. 2009
    ..As no current clinical treatments are directed specifically at the underlying neuronal defect due to absence of FMRP, this might open new powerful therapeutic strategies...
  15. ncbi Long-term potentiation in the hippocampus of fragile X knockout mice
    J M Godfraind
    Department of Physiology and Pharmacology, Université Catholique de Louvain la Neuve, Woluwe, Brussels, Belgium
    Am J Med Genet 64:246-51. 1996
    ..In conclusion, we found no evidence for a function of FMR1 in STP or LTP...