Wim Janssens

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. ncbi request reprint Vitamin D and chronic obstructive pulmonary disease: hype or reality?
    Wim Janssens
    Laboratory of Pneumology, Department of Experimental and Clinical Medicine, Katholieke Universiteit Leuven, Leuven, Belgium Electronic address
    Lancet Respir Med 1:804-12. 2013
  2. pmc Computer quantification of airway collapse on forced expiration to predict the presence of emphysema
    Marko Topalovic
    Respiratory Division, University Hospital Leuven, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    Respir Res 14:131. 2013
  3. doi request reprint Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®)
    W Janssens
    University Hospital Leuven, Leuven, Belgium
    Respir Med 107:1409-16. 2013
  4. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
  5. pmc Daily physical activity in subjects with newly diagnosed COPD
    Hans Van Remoortel
    Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Thorax 68:962-3. 2013
  6. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
  7. doi request reprint Chronic obstructive pulmonary disease
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Leuven, Belgium
    Lancet 379:1341-51. 2012
  8. doi request reprint Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease
    Manuela Rinaldi
    Laboratory of Pneumology, Respiratory Medicine, University of Leuven, Onderwijs en Navorsing 1 bus 706, Herestraat 49, Leuven 3000, Belgium
    Thorax 67:694-700. 2012
  9. pmc Impaired postural control reduces sit-to-stand-to-sit performance in individuals with chronic obstructive pulmonary disease
    Lotte Janssens
    KU Leuven Department of Rehabilitation Sciences, University of Leuven, Leuven, Belgium
    PLoS ONE 9:e88247. 2014
  10. pmc Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice
    Manuela Rinaldi
    Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, Onderwijs en Navorsing 1, bus 706, Herestraat 49, 3000 Leuven, Belgium
    Dis Model Mech 5:333-41. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Vitamin D and chronic obstructive pulmonary disease: hype or reality?
    Wim Janssens
    Laboratory of Pneumology, Department of Experimental and Clinical Medicine, Katholieke Universiteit Leuven, Leuven, Belgium Electronic address
    Lancet Respir Med 1:804-12. 2013
    ....
  2. pmc Computer quantification of airway collapse on forced expiration to predict the presence of emphysema
    Marko Topalovic
    Respiratory Division, University Hospital Leuven, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    Respir Res 14:131. 2013
    ..We then explored and validated the relationship of airway collapse with computed tomography (CT) diagnosed emphysema in two large independent cohorts...
  3. doi request reprint Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®)
    W Janssens
    University Hospital Leuven, Leuven, Belgium
    Respir Med 107:1409-16. 2013
    ..This study explores spirometry quality and reproducibility in the Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT(®)) trial...
  4. pmc Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial
    Miek Hornikx
    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium
    Respir Res 13:84. 2012
    ..As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease...
  5. pmc Daily physical activity in subjects with newly diagnosed COPD
    Hans Van Remoortel
    Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
    Thorax 68:962-3. 2013
    ..This study aims to assess PA and to investigate the associations between PA and clinical characteristics in subjects with newly diagnosed COPD...
  6. doi request reprint Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    ..Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD)...
  7. doi request reprint Chronic obstructive pulmonary disease
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Leuven, Belgium
    Lancet 379:1341-51. 2012
    ..Besides improving symptoms, these treatments are also thought to lead to some degree of disease modification. Future research should be directed towards the development of agents that notably affect the course of disease...
  8. doi request reprint Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease
    Manuela Rinaldi
    Laboratory of Pneumology, Respiratory Medicine, University of Leuven, Onderwijs en Navorsing 1 bus 706, Herestraat 49, Leuven 3000, Belgium
    Thorax 67:694-700. 2012
    ..The authors aimed to explore antibody responses against elastin in a large and extensively characterised COPD population and to assess elastin-specific peripheral T-cell reactivity in a representative subgroup...
  9. pmc Impaired postural control reduces sit-to-stand-to-sit performance in individuals with chronic obstructive pulmonary disease
    Lotte Janssens
    KU Leuven Department of Rehabilitation Sciences, University of Leuven, Leuven, Belgium
    PLoS ONE 9:e88247. 2014
    ..It remains unknown whether postural control deficits contribute to the decreased STSTS performance in individuals with COPD...
  10. pmc Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice
    Manuela Rinaldi
    Respiratory Muscle Research Unit, Katholieke Universiteit Leuven, Herestraat 49, Onderwijs en Navorsing 1, bus 706, Herestraat 49, 3000 Leuven, Belgium
    Dis Model Mech 5:333-41. 2012
    ..In this model, muscular changes became apparent only after 6 months, particularly in muscles with a mixed fiber-type composition...
  11. pmc Moderate Intense Physical Activity Depends on Selected Metabolic Equivalent of Task (MET) Cut-Off and Type of Data Analysis
    Hans Van Remoortel
    Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium Respiratory Division and Rehabilitation, UZ Gasthuisberg, Leuven, Belgium
    PLoS ONE 8:e84365. 2013
    ....
  12. pmc The influence of comorbidities on outcomes of pulmonary rehabilitation programs in patients with COPD: a systematic review
    Miek Hornikx
    Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium Respiratory Division and Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Biomed Res Int 2013:146148. 2013
    ..The aim of the present review was to investigate to what extent the presence of comorbidities can affect pulmonary rehabilitation outcomes...
  13. doi request reprint Alveolar and bronchial exhaled nitric oxide in chronic obstructive pulmonary disease
    An Lehouck
    Respiratory Division, University Hospital Gasthuisberg Katholieke Universiteit Leuven, Herestraat 49, bus 706, 3000 Leuven, Belgium
    Respir Med 104:1020-6. 2010
    ..We examined whether the use of Fe,NO, CAlv,NO and J'aw,NO may contribute to the clinical diagnosis of COPD...
  14. doi request reprint Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle
    Wim Janssens
    Respiratory Division, University of Leuven, Leuven, Belgium
    Vitam Horm 86:379-99. 2011
    ..The burning question in COPD is whether prevention of vitamin D deficiency or adequate supplementation may reverse the natural course of the disease...
  15. doi request reprint Repeated invasive lung function measurements in intubated mice: an approach for longitudinal lung research
    Stephanie I De Vleeschauwer
    Research Unit of Lung Transplantation, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Lab Anim 45:81-9. 2011
    ..This may open new perspectives for longitudinal research in animal models of respiratory diseases...
  16. ncbi request reprint Pulmonary rehabilitation: timing, location, and duration
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, University Hospital Leuven, Leuven, Belgium KU Leuven, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, 3000 Leuven, Belgium Electronic address
    Clin Chest Med 35:303-11. 2014
    ..In terms of election, patients with muscle dysfunction are likely the best candidates for exercise training. Patients with exercise-induced symptoms and those after exacerbations should also be referred. ..
  17. ncbi request reprint Pulmonary rehabilitation
    Thierry Troosters
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Leuven, Belgium Faculty of Kinesiology and Rehabilitation Sciences, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, 3000 Leuven, Belgium Electronic address
    Clin Chest Med 35:241-9. 2014
    ..Several settings and programs have shown to spin off in significant immediate results. The challenge lies in maintaining the benefits outside the program. ..
  18. ncbi request reprint Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Controversy still exists on whether the beta-defensins genes determine susceptibility for chronic obstructive pulmonary disease (COPD)...
  19. doi request reprint COPD, bone metabolism, and osteoporosis
    An Lehouck
    Respiratory Division, Center of Metabolic Bone Diseases, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Chest 139:648-57. 2011
    ..As long as intervention studies focusing on the bone in COPD are lacking, a more rigorous application of existing treatment guidelines of osteoporosis in general is mandatory...
  20. doi request reprint Modification of COPD presentation during the last 25 years
    Antoine Fremault
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    COPD 7:345-51. 2010
    ..As the length of hospitalization and the overall survival were not different between the two samples, a currently improved management of COPD can be hypothesized...
  21. ncbi request reprint Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms: a prospective cohort study
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Belgium Electronic address
    Lancet Respir Med 1:705-13. 2013
    ..Few studies of the diagnostic value of pulmonary function testing are available. We assessed the diagnostic contribution of four basic pulmonary function tests: spirometry, lung volume, airway resistance, and diffusing capacity...
  22. pmc Proprioceptive changes impair balance control in individuals with chronic obstructive pulmonary disease
    Lotte Janssens
    Department of Rehabilitation Sciences, University of Leuven, KU Leuven, Leuven, Belgium
    PLoS ONE 8:e57949. 2013
    ..The objective was to determine the specific proprioceptive control strategy during postural balance in individuals with COPD and healthy controls, and to assess whether this was related to inspiratory muscle weakness...
  23. doi request reprint The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema
    Diether Lambrechts
    Vesalius Research Center, K U Leuven, Leuven, Belgium
    Am J Respir Crit Care Med 181:486-93. 2010
    ..Assessment of bronchial obstruction by spirometry, typically used for diagnosing COPD, fails, however, to detect emphysema...
  24. doi request reprint Effectiveness of exercise training in patients with COPD: the role of muscle fatigue
    Chris Burtin
    Faculty of Kinesiology and Rehabilitation Sciences, Dept of Rehabilitation Sciences, Katholieke Universiteit Leuven, Belgium
    Eur Respir J 40:338-44. 2012
    ..Patients who develop quadriceps contractile fatigue during exercise training show greater training effects in terms of functional exercise capacity and health-related quality of life...
  25. ncbi request reprint Chronic obstructive pulmonary disease and comorbidities
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium Electronic address
    Lancet Respir Med 1:73-83. 2013
    ..Whether reduction of so-called spill-over of local inflammation from the lungs or systemic inflammation with inhaled or systemic anti-inflammatory drugs, respectively, would also reduce COPD-related comorbidities is doubtful. ..
  26. pmc Increased synapse formation obtained by T cell epitopes containing a CxxC motif in flanking residues convert CD4+ T cells into cytolytic effectors
    Vincent A Carlier
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    PLoS ONE 7:e45366. 2012
    ..Cytolytic CD4+ T cells induce apoptosis on APCs by Fas-FasL interaction. These findings potentially open the way towards a novel form of antigen-specific immunosuppression...
  27. pmc Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2
    Roxana R Ahangarani
    Department of Molecular and Cellular Medicine, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Mol Ther 19:711-22. 2011
    ..These findings open new perspectives for controlling immune responses following gene therapy and genetic vaccination...
  28. doi request reprint Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...