J Hendrickx

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi Complete genomic structure and mutational spectrum of PHKA2 in patients with x-linked liver glycogenosis type I and II
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 64:1541-9. 1999
  2. ncbi Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family
    W Van Hul
    Department of Medical Genetics, University of Antwerp, Belgium
    Genomics 47:230-7. 1998
  3. ncbi X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase
    J Hendrickx
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Hum Mol Genet 5:649-52. 1996
  4. ncbi Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Belgium
    Am J Hum Genet 62:346-54. 1998
  5. ncbi Identification and characterization of a novel member of the EXT gene family, EXTL2
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 5:382-9. 1997
  6. ncbi X-linked liver glycogenosis: localization and isolation of a candidate gene
    J Hendrickx
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Hum Mol Genet 2:583-9. 1993
  7. ncbi Mutations in the phosphorylase kinase gene PHKA2 are responsible for X-linked liver glycogen storage disease
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Belgium
    Hum Mol Genet 4:77-83. 1995
  8. ncbi Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Pediatr 157:919-23. 1998
  9. ncbi Positional cloning of a gene involved in hereditary multiple exostoses
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Hum Mol Genet 5:1547-57. 1996
  10. ncbi Regional mapping of a liver alpha-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp
    J G Wauters
    Department of Medical Genetics, University of Antwerp U I A, Belgium
    Cytogenet Cell Genet 60:194-6. 1992

Collaborators

Detail Information

Publications14

  1. ncbi Complete genomic structure and mutational spectrum of PHKA2 in patients with x-linked liver glycogenosis type I and II
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 64:1541-9. 1999
    ....
  2. ncbi Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family
    W Van Hul
    Department of Medical Genetics, University of Antwerp, Belgium
    Genomics 47:230-7. 1998
    ..In view of its putative tumor suppressor function, the EXTL3 gene can be considered a candidate gene for the breast cancer locus on chromosome 8p12-p22...
  3. ncbi X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase
    J Hendrickx
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Hum Mol Genet 5:649-52. 1996
    ..These findings might explain why the in vitro PHK enzymatic activity is not deficient in XLG II, whereas it is in XLG I...
  4. ncbi Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Belgium
    Am J Hum Genet 62:346-54. 1998
    ..The development is thus mainly due to loss of function of the EXT genes, consistent with the hypothesis that the EXT genes have a tumor- suppressor function...
  5. ncbi Identification and characterization of a novel member of the EXT gene family, EXTL2
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Hum Genet 5:382-9. 1997
    ..In addition, a putative pseudogene, EXTL2P was also identified. The EXTL2 gene was assigned to chromosome 1p11-p12, whereas EXTL2P was mapped on chromosome 2q24-q31...
  6. ncbi X-linked liver glycogenosis: localization and isolation of a candidate gene
    J Hendrickx
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Hum Mol Genet 2:583-9. 1993
    ..Fluorescent in situ hybridization mapped human PHKA2 to Xp22. As this physical mapping coincides with the genetic mapping of XLG by linkage analysis, PHKA2 most probably harbours the mutation(s) responsible for XLG...
  7. ncbi Mutations in the phosphorylase kinase gene PHKA2 are responsible for X-linked liver glycogen storage disease
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Belgium
    Hum Mol Genet 4:77-83. 1995
    ..These findings indicate that PHKA2 is the XLG I gene...
  8. ncbi Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years
    J Hendrickx
    Department of Medical Genetics, University of Antwerp, Belgium
    Eur J Pediatr 157:919-23. 1998
    ..In patients with XLG having normal or residual PHK activity where XLG II is suspected, the identification of mutations in PHKA2 leads to the final classification...
  9. ncbi Positional cloning of a gene involved in hereditary multiple exostoses
    W Wuyts
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Hum Mol Genet 5:1547-57. 1996
    ..EXT2 has an open reading frame encoding 718 amino acids with an overall homology of 30.9% with EXT1, suggesting that a family of related genes might be responsible for the development of EXT...
  10. ncbi Regional mapping of a liver alpha-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp
    J G Wauters
    Department of Medical Genetics, University of Antwerp U I A, Belgium
    Cytogenet Cell Genet 60:194-6. 1992
    ..The localization of this gene in the same chromosomal region as the disease gene responsible for XLG suggests that the liver PHKA gene is a highly likely candidate gene for the XLG mutation...
  11. ncbi A point mutation in the FMR-1 gene associated with fragile X mental retardation
    K De Boulle
    Department of Medical Genetics, University of Antwerp UIA, Belgium
    Nat Genet 3:31-5. 1993
    ..Our results suggest that mutations in FMR-1 are directly responsible for fragile X syndrome, irrespective of possible secondary effects caused by FRAXA...
  12. ncbi Distribution and role of Na(+)/K(+) ATPase in endocardial endothelium
    P Fransen
    Department of Physiology and Medicine, University of Antwerp RUCA, Groenenborgerlaan, 171, B 2020, Antwerp, Belgium
    Cardiovasc Res 52:487-99. 2001
    ..In mammalian cardiomyocytes, alpha isoforms of Na(+)/K(+) ATPase have specific localisation and function, but their role in endocardial endothelium is unknown...
  13. ncbi Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome
    Y Geng
    MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom
    Genomics 15:191-3. 1993
    ..This mapping position would suggest a location for the human liver alpha-subunit gene on the proximal short arm of the X chromosome, a region recently implicated in X-linked liver glycogenosis (XLG)...
  14. ncbi Location of the hydroxyl functions in hydroxylated metabolites of nebivolol in different animal species and human subjects as determined by on-line high-performance liquid chromatography-diode-array detection
    J Hendrickx
    Department of Drug Metabolism and Pharmacokinetics, Janssen Research Foundation, Beerse, Belgium
    J Chromatogr A 729:341-54. 1996
    ..With this technique it is possible to differentiate between glucuronidation at the automatic and aliphatic or alicyclic hydroxyl functions...