Gunther Guetens

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi request reprint Oxidative DNA damage: biological significance and methods of analysis
    Gunther Guetens
    Department of Chemistry, University of Antwerp, Belgium
    Crit Rev Clin Lab Sci 39:331-457. 2002
  2. ncbi request reprint Regional differences of melphalan lung levels after isolated lung perfusion in the rat
    Sander Romijn
    Laboratory for Experimental Surgery, University of Antwerp, Wilrijk, Belgium
    J Surg Res 125:157-60. 2005
  3. ncbi request reprint Simultaneous determination of AMN107 and Imatinib (Gleevec, Glivec, STI571) in cultured tumour cells using an isocratic high-performance liquid chromatography procedure with UV detection
    Gunther Guetens
    Lab of Experimental Oncology, KU Leuven UZ Gasthuisberg, Department of General Medical Oncology, Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 846:341-5. 2007
  4. ncbi request reprint Single-pass isolated lung perfusion versus recirculating isolated lung perfusion with melphalan in a rat model
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University of Antwerp, Belgium
    Ann Thorac Surg 74:893-8; discussion 898. 2002
  5. ncbi request reprint Quantification of the anticancer agent STI-571 in erythrocytes and plasma by measurement of sediment technology and liquid chromatography-tandem mass spectrometry
    Gunther Guetens
    Laboratory of Experimental Oncology, KU Leuven UZ Gasthuisberg, Department of Clinical Oncology, Herestraat 49, B 3000 Leuven, Belgium
    J Chromatogr A 1020:27-34. 2003
  6. ncbi request reprint Everolimus alters imatinib blood partition in favour of the erythrocyte
    Hans Prenen
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Catholic University Leuven, Belgium
    J Pharm Pharmacol 58:1063-6. 2006
  7. ncbi request reprint Imatinib (Gleevec, Glivec) tumour tissue analysis by measurement of sediment and by liquid chromatography tandem mass spectrometry
    Gunther Guetens
    Leuven Cancer Institute, Cell Phase I Research, Belgium
    J Sep Sci 29:453-9. 2006
  8. ncbi request reprint Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines
    Hans Prenen
    Laboratory for Experimental Oncology LEO, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Pharmacology 77:11-6. 2006
  9. ncbi request reprint Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Biol Ther 4:747-52. 2005
  10. ncbi request reprint Isolated lung perfusion with gemcitabine in a rat: pharmacokinetics and survival
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Edegem, Belgium
    J Surg Res 109:118-22. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Oxidative DNA damage: biological significance and methods of analysis
    Gunther Guetens
    Department of Chemistry, University of Antwerp, Belgium
    Crit Rev Clin Lab Sci 39:331-457. 2002
    ..The effect of experimental conditions (DNA isolation, hydrolysis, and/or derivatization) on the levels of oxidatively modified bases in DNA is enormous and has been studied intensively in the last 10 years...
  2. ncbi request reprint Regional differences of melphalan lung levels after isolated lung perfusion in the rat
    Sander Romijn
    Laboratory for Experimental Surgery, University of Antwerp, Wilrijk, Belgium
    J Surg Res 125:157-60. 2005
    ..However, the influence of pharmacokinetic parameters on the final melphalan lung concentration (FMLC) is unknown. In this study, we studied the impact of three different perfusion parameters on the FMLC in different areas of the lung...
  3. ncbi request reprint Simultaneous determination of AMN107 and Imatinib (Gleevec, Glivec, STI571) in cultured tumour cells using an isocratic high-performance liquid chromatography procedure with UV detection
    Gunther Guetens
    Lab of Experimental Oncology, KU Leuven UZ Gasthuisberg, Department of General Medical Oncology, Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 846:341-5. 2007
    ..Calibration curves were linear from 50 to 7500 ng/ml with correlation coefficients (r(2)) better than 0.998. The limit of quantitation (LOD) was 50 ng/ml. The method has been successfully applied to a cellular kinetics study...
  4. ncbi request reprint Single-pass isolated lung perfusion versus recirculating isolated lung perfusion with melphalan in a rat model
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University of Antwerp, Belgium
    Ann Thorac Surg 74:893-8; discussion 898. 2002
    ..However, it is unknown whether a bolus injection of MN into the perfusion circuit or ILuP with a fixed concentration of MN will result in the highest lung levels...
  5. ncbi request reprint Quantification of the anticancer agent STI-571 in erythrocytes and plasma by measurement of sediment technology and liquid chromatography-tandem mass spectrometry
    Gunther Guetens
    Laboratory of Experimental Oncology, KU Leuven UZ Gasthuisberg, Department of Clinical Oncology, Herestraat 49, B 3000 Leuven, Belgium
    J Chromatogr A 1020:27-34. 2003
    ....
  6. ncbi request reprint Everolimus alters imatinib blood partition in favour of the erythrocyte
    Hans Prenen
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Catholic University Leuven, Belgium
    J Pharm Pharmacol 58:1063-6. 2006
    ..The shift is enforced by combination with everolimus, another signal transduction inhibitor. These data warrant routine erythrocyte versus plasma monitoring to prevent unexpected alterations in drug efficacy during long-term treatment...
  7. ncbi request reprint Imatinib (Gleevec, Glivec) tumour tissue analysis by measurement of sediment and by liquid chromatography tandem mass spectrometry
    Gunther Guetens
    Leuven Cancer Institute, Cell Phase I Research, Belgium
    J Sep Sci 29:453-9. 2006
    ..The assay is selective and sensitive, with its robustness favouring the experimental application in clinical oncology and its routine use in animal experiments. The LOD was 4.5 ng per gram in tumour tissue...
  8. ncbi request reprint Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines
    Hans Prenen
    Laboratory for Experimental Oncology LEO, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Pharmacology 77:11-6. 2006
    ....
  9. ncbi request reprint Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Biol Ther 4:747-52. 2005
    ....
  10. ncbi request reprint Isolated lung perfusion with gemcitabine in a rat: pharmacokinetics and survival
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Edegem, Belgium
    J Surg Res 109:118-22. 2003
    ..Toxicity and pharmacokinetics of gemcitabine (GCB) were evaluated in a rat model of isolated lung perfusion (ILuP) and compared to intravenous (iv) infusion...
  11. ncbi request reprint In vitro partition of docetaxel and gemcitabine in human volunteer blood: the influence of concentration and gender
    Herlinde Dumez
    Department of Clinical Oncology Laboratory of Experimental Oncology, UZ Gasthuisberg, Leuven, Belgium
    Anticancer Drugs 16:885-91. 2005
    ..We conclude that the incorporation of drugs into the RBC pool may be important for transportation to tumor tissue and efficacy. In combination, one anti-cancer agent can alter the partition ratios of other anti-cancer agents...
  12. ncbi request reprint Anterograde versus retrograde isolated lung perfusion with melphalan in the WAG-Rij rat
    Sander Romijn
    Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Eur J Cardiothorac Surg 27:1083-5. 2005
    ....
  13. ncbi request reprint Pharmacokinetics after pulmonary artery perfusion with gemcitabine
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University Hospital, Antwerp, Edegem, Belgium
    Ann Thorac Surg 76:1036-40; discussion 1040. 2003
    ..Lung levels of GCB were examined with different exposure times and flow rates and compared with ILuP and i.v.. Cell kill was studied in vitro...
  14. ncbi request reprint The relevance of therapeutic drug monitoring in plasma and erythrocytes in anti-cancer drug treatment
    Herlinde Dumez
    LabExp Oncology, KULeuven, Leuven, Belgium
    Clin Chem Lab Med 42:1219-27. 2004
    ..Data for complex Bayesian statistical approaches and population kinetics studies are beyond the scope of this review, since this is generally limited to the plasma compartment only...
  15. ncbi request reprint Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies
    Flavia Brunstein
    Department of Surgical Oncology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Natl Cancer Inst 96:1603-10. 2004
    ..Taking into account that other vasoactive drugs could also improve tumor response to ILP, we evaluated histamine (Hi) as an alternative to TNF-alpha...
  16. ncbi request reprint Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib
    Erin R Gardner
    Clinical Pharmacology Research Core, SAIC Frederick, Frederick, USA
    Clin Pharmacol Ther 80:192-201. 2006
    ....
  17. ncbi request reprint Modified approach of administering cytostatics to the lung: more efficient isolated lung perfusion
    Bart P Van Putte
    Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands
    Ann Thorac Surg 82:1033-7. 2006
    ..Therefore, we investigated gemcitabine uptake at different inflow concentrations, and the effect of delayed clamp release after ILuP on lung levels was studied...
  18. ncbi request reprint In vitro partition of irinotecan (CPT-11) in human volunteer blood: the influence of concentration, gender and smoking
    Herlinde Dumez
    Department of Clinical Oncology Laboratory of Experimental Oncology, UZ Gasthuisberg, Leuven, Belgium
    Anticancer Drugs 16:893-5. 2005
    ..The incorporation of drugs into the RBC pool may be important for transportation to tumor tissue and efficacy. Smoking can have a significant influence on drug partition in the blood...