S Francque

Summary

Affiliation: University Hospital Antwerp
Country: Belgium

Publications

  1. doi request reprint Non-alcoholic steatohepatitis induces non-fibrosis-related portal hypertension associated with splanchnic vasodilation and signs of a hyperdynamic circulation in vitro and in vivo in a rat model
    Sven Francque
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
    Liver Int 30:365-75. 2010
  2. doi request reprint Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture
    Sven Francque
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
    Lab Invest 92:1428-39. 2012
  3. doi request reprint Noninvasive assessment of nonalcoholic fatty liver disease in obese or overweight patients
    Sven M A Francque
    Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium
    Clin Gastroenterol Hepatol 10:1162-8; quiz e87. 2012
  4. ncbi request reprint Biopsy of focal liver lesions: guidelines, comparison of techniques and cost-analysis
    S M Francque
    Division of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Acta Gastroenterol Belg 66:160-5. 2003
  5. ncbi request reprint Bilateral adrenal haemorrhage and acute adrenal insufficiency in a blunt abdominal trauma: a case-report and literature review
    Sven M Francque
    Department of Emergency Care, University Hospital Antwerp, Edegem, Belgium
    Eur J Emerg Med 11:164-7. 2004
  6. ncbi request reprint High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry
    S Francque
    University Hospital Antwerp, Department of Gastro enterology Hepatology, Antwerp, Belgium
    Acta Gastroenterol Belg 74:9-16. 2011
  7. doi request reprint Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis
    Sven Francque
    Department of Gastroenterology and Hepatology, Diabetes and Metabolism cAbdominal Surgery dPathology, Antwerp University Hospital, Antwerp, Belgium
    Eur J Gastroenterol Hepatol 22:1449-57. 2010
  8. doi request reprint Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension
    S Francque
    Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium
    Int J Obes (Lond) 35:270-8. 2011
  9. ncbi request reprint A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
    A Verrijken
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Belgium
    Obesity (Silver Spring) 21:2138-45. 2013
  10. doi request reprint Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese patients
    A Verrijken
    Department of Endocrinology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
    Int J Obes (Lond) 34:899-907. 2010

Collaborators

Detail Information

Publications17

  1. doi request reprint Non-alcoholic steatohepatitis induces non-fibrosis-related portal hypertension associated with splanchnic vasodilation and signs of a hyperdynamic circulation in vitro and in vivo in a rat model
    Sven Francque
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
    Liver Int 30:365-75. 2010
    ..Steatosis, without fibrosis, may lead to changes in liver blood flow, which are poorly understood, and to date have not been correlated to portal pressure and related haemodynamics...
  2. doi request reprint Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture
    Sven Francque
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
    Lab Invest 92:1428-39. 2012
    ..Both functional (endothelial dysfunction and increased thromboxane and ET-1 synthesis) and structural factors are involved. This phenomenon might significantly contribute to steatosis-related disease...
  3. doi request reprint Noninvasive assessment of nonalcoholic fatty liver disease in obese or overweight patients
    Sven M A Francque
    Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium
    Clin Gastroenterol Hepatol 10:1162-8; quiz e87. 2012
    ..We aimed to identify factors that predicted development of nonalcoholic steatohepatitis (NASH) in a large group of overweight or obese patients and compared these with established factors...
  4. ncbi request reprint Biopsy of focal liver lesions: guidelines, comparison of techniques and cost-analysis
    S M Francque
    Division of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Acta Gastroenterol Belg 66:160-5. 2003
    ..Finally, the cost-analysis of different biopsy techniques is presented for the Belgian situation according to used materials, pathology procedures and hospitalization...
  5. ncbi request reprint Bilateral adrenal haemorrhage and acute adrenal insufficiency in a blunt abdominal trauma: a case-report and literature review
    Sven M Francque
    Department of Emergency Care, University Hospital Antwerp, Edegem, Belgium
    Eur J Emerg Med 11:164-7. 2004
    ..Such patients may benefit from the prompt administration of corticosteroid replacement, which can be life saving...
  6. ncbi request reprint High prevalence of advanced fibrosis in association with the metabolic syndrome in a Belgian prospective cohort of NAFLD patients with elevated ALT. Results of the Belgian NAFLD registry
    S Francque
    University Hospital Antwerp, Department of Gastro enterology Hepatology, Antwerp, Belgium
    Acta Gastroenterol Belg 74:9-16. 2011
    ..Non-alcoholic Fatty Liver Disease (NAFLD) is increasingly recognised as a source of liver related morbidity and mortality. Hard data on epidemiology and natural history are scarce...
  7. doi request reprint Noncirrhotic human nonalcoholic fatty liver disease induces portal hypertension in relation to the histological degree of steatosis
    Sven Francque
    Department of Gastroenterology and Hepatology, Diabetes and Metabolism cAbdominal Surgery dPathology, Antwerp University Hospital, Antwerp, Belgium
    Eur J Gastroenterol Hepatol 22:1449-57. 2010
    ..We earlier showed in an animal model that steatosis, in the absence of fibrosis or inflammation, induces a significant rise in portal pressure. The relevance of these findings for human pathology is unknown till date...
  8. doi request reprint Visceral adiposity and insulin resistance are independent predictors of the presence of non-cirrhotic NAFLD-related portal hypertension
    S Francque
    Department of Gastroenterology and Hepatology, Antwerp University Hospital, Antwerp, Belgium
    Int J Obes (Lond) 35:270-8. 2011
    ..As assessment of portal pressure is an invasive procedure, non-invasive parameters are needed to identify patients at risk...
  9. ncbi request reprint A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population
    A Verrijken
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Belgium
    Obesity (Silver Spring) 21:2138-45. 2013
    ..We studied the association between the genes patatin-like phospholipase domain-containing protein 3 (PNPLA3) and apolipoprotein C3 (APOC3) and metabolic and histological parameters of NAFLD in obese patients...
  10. doi request reprint Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese patients
    A Verrijken
    Department of Endocrinology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
    Int J Obes (Lond) 34:899-907. 2010
    ....
  11. ncbi request reprint The metabolic syndrome and the liver
    A Verrijken
    Division of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Belgium
    Acta Gastroenterol Belg 71:48-59. 2008
    ..In some cases bariatric surgery may be necessary...
  12. ncbi request reprint Diarrhea and the rationale to use Sandostatin
    M Peeters
    Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, Edegem
    Acta Gastroenterol Belg 73:25-36. 2010
    ....
  13. ncbi request reprint The use of ursodeoxycholic acid in patients with primary biliary cirrhosis: sense or nonsense
    E Van Den Bogaert
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Acta Gastroenterol Belg 66:283-7. 2003
    ..We therefore conclude that UDCA has a positive effect on the prognosis of PBC and can slow down the progression to end stage liver disease...
  14. doi request reprint The influence of laboratory-induced MELD score differences on liver allocation: more reality than myth
    J N Schouten
    Department of Gastroenterology and Hepatology, University Hospital Antwerp, Antwerp, Belgium
    Clin Transplant 26:E62-70. 2012
    ..Liver allocation in Eurotransplant (ET) is based on the MELD score. Interlaboratory MELD score differences in INR and creatinine determination have been reported. The clinical implication of this observation has not been demonstrated...
  15. ncbi request reprint Does antiviral therapy reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C?
    P Michielsen
    Division of Gastroenterology and Hepatology, University Hospital, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Minerva Gastroenterol Dietol 58:65-79. 2012
    ..Further prospective studies using the more successful emerging treatments of chronic hepatitis C are to be conducted to evaluate the risk of HCC...
  16. ncbi request reprint Fine needle trucut biopsy in focal liver lesions: a reliable and safe method in identifying the malignant nature of liver lesions
    Filip F De Pauw
    Divisions of Gastroenterology, University Hospital Antwerp, Belgium
    Acta Gastroenterol Belg 70:1-5. 2007
    ..The aim of the study is to see that FNTCB is a reliable method in identifying the malignant or benign character of a focal liver lesion...
  17. ncbi request reprint Bacillus Calmette-Guérin-induced granulomatous hepatitis in a patient with a superficial bladder carcinoma
    Steven M Van Outryve
    Department of Gastroenterology and Hepatology, University Hospital of Antwerp, University of Antwerp, Belgium
    Eur J Gastroenterol Hepatol 16:1027-32. 2004
    ..This suggests that the BCG hepatitis was at least partially caused by a hypersensitivity reaction. Our patient is the first reported case of BCG hepatitis with histological follow-up under therapy...