Joris J J Dirckx

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. pmc Morphology and function of Bast's valve: additional insight in its functioning using 3D-reconstruction
    R Hofman
    Department of Otorhinolaryngology, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Eur Arch Otorhinolaryngol 265:153-7. 2008
  2. ncbi request reprint Refractive index of tissue measured with confocal microscopy
    Joris J J Dirckx
    University of Antwerp, Laboratory of Biomedical Physics, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Biomed Opt 10:44014. 2005
  3. ncbi request reprint Middle ear pressure regulation: basic research and clinical observation
    Joris J J Dirckx
    Laboratory of Biomedical Physics, University of Antwerp, Belgium
    Otol Neurotol 26:300-9. 2005
  4. pmc Quasi-static transfer function of the rabbit middle ear' measured with a heterodyne interferometer with high-resolution position decoder
    Joris J J Dirckx
    Laboratory of Biomedical Physics, Department of Physics, University of Antwerp, Groenenborgerlaan 171, B 2020, Wilrijk Antwerpen, Belgium
    J Assoc Res Otolaryngol 7:339-51. 2006
  5. ncbi request reprint Tomographic imaging of macroscopic biomedical objects in high resolution and three dimensions using orthogonal-plane fluorescence optical sectioning
    Jan A N Buytaert
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerpen, Belgium
    Appl Opt 48:941-8. 2009
  6. doi request reprint Open access high-resolution 3D morphology models of cat, gerbil, rabbit, rat and human ossicular chains
    Wasil H M Salih
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Hear Res 284:1-5. 2012
  7. doi request reprint Perfusion and diffusion limitations in middle ear gas exchange: the exchange of CO2 as a test case
    Yael Marcusohn
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, Antwerp B 2020, Belgium
    Hear Res 265:11-4. 2010
  8. ncbi request reprint Design and quantitative resolution measurements of an optical virtual sectioning three-dimensional imaging technique for biomedical specimens, featuring two-micrometer slicing resolution
    Jan A N Buytaert
    University of Antwerp, Laboratory of Biomedical Physics, Department of Physics, Groenenborgerlaan 171, B 2020 Wilrijk Antwerpen, Belgium
    J Biomed Opt 12:014039. 2007
  9. doi request reprint Mechanical properties of human tympanic membrane in the quasi-static regime from in situ point indentation measurements
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Hear Res 290:45-54. 2012
  10. doi request reprint Static versus dynamic gerbil tympanic membrane elasticity: derivation of the complex modulus
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Biomech Model Mechanobiol 11:829-40. 2012

Collaborators

Detail Information

Publications31

  1. pmc Morphology and function of Bast's valve: additional insight in its functioning using 3D-reconstruction
    R Hofman
    Department of Otorhinolaryngology, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Eur Arch Otorhinolaryngol 265:153-7. 2008
    ..We propose that opening and closure of the valve occurs through movement of the flexible base/utricular membrane away from and toward the relatively rigid valve lip...
  2. ncbi request reprint Refractive index of tissue measured with confocal microscopy
    Joris J J Dirckx
    University of Antwerp, Laboratory of Biomedical Physics, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Biomed Opt 10:44014. 2005
    ..We demonstrate the method on bovine muscle tissue and find a value of n=1.382+/-0.004, at 592 nm...
  3. ncbi request reprint Middle ear pressure regulation: basic research and clinical observation
    Joris J J Dirckx
    Laboratory of Biomedical Physics, University of Antwerp, Belgium
    Otol Neurotol 26:300-9. 2005
  4. pmc Quasi-static transfer function of the rabbit middle ear' measured with a heterodyne interferometer with high-resolution position decoder
    Joris J J Dirckx
    Laboratory of Biomedical Physics, Department of Physics, University of Antwerp, Groenenborgerlaan 171, B 2020, Wilrijk Antwerpen, Belgium
    J Assoc Res Otolaryngol 7:339-51. 2006
    ....
  5. ncbi request reprint Tomographic imaging of macroscopic biomedical objects in high resolution and three dimensions using orthogonal-plane fluorescence optical sectioning
    Jan A N Buytaert
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerpen, Belgium
    Appl Opt 48:941-8. 2009
    ..HR-OPFOS is demonstrated on gerbil hearing organs and on mouse and bird brains. The necessary specimen preparation is discussed...
  6. doi request reprint Open access high-resolution 3D morphology models of cat, gerbil, rabbit, rat and human ossicular chains
    Wasil H M Salih
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Hear Res 284:1-5. 2012
    ..The resolution of the CT images, from which the models are segmented, varies from 5.6 to 33.5 μm. Models are freely available in different formats at our website (http://www.ua.ac.be/bimef/models) for research and educational purposes...
  7. doi request reprint Perfusion and diffusion limitations in middle ear gas exchange: the exchange of CO2 as a test case
    Yael Marcusohn
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, Antwerp B 2020, Belgium
    Hear Res 265:11-4. 2010
    ....
  8. ncbi request reprint Design and quantitative resolution measurements of an optical virtual sectioning three-dimensional imaging technique for biomedical specimens, featuring two-micrometer slicing resolution
    Jan A N Buytaert
    University of Antwerp, Laboratory of Biomedical Physics, Department of Physics, Groenenborgerlaan 171, B 2020 Wilrijk Antwerpen, Belgium
    J Biomed Opt 12:014039. 2007
    ..We present quantitative measurements of resolution. A 3-D model reconstructed from our HROPFOS data is compared to SEM results, and the technique is demonstrated with section images and 3-D reconstructions of middle ear specimens...
  9. doi request reprint Mechanical properties of human tympanic membrane in the quasi-static regime from in situ point indentation measurements
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Hear Res 290:45-54. 2012
    ..The relaxation curves in the time domain were transformed to complex moduli in the frequency domain, yielding viscoelastic properties in the quasi-static regime only...
  10. doi request reprint Static versus dynamic gerbil tympanic membrane elasticity: derivation of the complex modulus
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Biomech Model Mechanobiol 11:829-40. 2012
    ..Due to experimental limitations, the indentation frequency upper limit was 8.2 Hz. The average relative modulus increase in this domain was 14% and the increase was the strongest below 6 Hz...
  11. pmc Realistic 3D computer model of the gerbil middle ear, featuring accurate morphology of bone and soft tissue structures
    Jan A N Buytaert
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium
    J Assoc Res Otolaryngol 12:681-96. 2011
    ..In this paper, we discuss the methods used, present the resulting merged model, and discuss the morphological properties of the soft tissue structures, such as muscles and ligaments...
  12. doi request reprint Postnatal development of the middle ear in New Zealand White rabbits: ossicles and tympanic ring
    Yael Marcusohn
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Hear Res 272:148-56. 2011
    ..The conical shape of the tympanic membrane (TM) is formed by retraction and growth of the manubrium, mainly during the first 40 days after birth...
  13. doi request reprint Elasticity modulus of rabbit middle ear ossicles determined by a novel micro-indentation technique
    Joris A M Soons
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Hear Res 263:33-7. 2010
    ..No significant differences between measurement locations were found, and we found an average Young's modulus of 16+/-3 GPa...
  14. doi request reprint Viscoelastic properties of gerbil tympanic membrane at very low frequencies
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    J Biomech 45:919-24. 2012
    ..Finally, relaxation and hysteresis were simulated in a finite element model with viscoelastic material properties...
  15. pmc Tympanic membrane boundary deformations derived from static displacements observed with computerized tomography in human and gerbil
    Stefan L R Gea
    Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium
    J Assoc Res Otolaryngol 11:1-17. 2010
    ....
  16. ncbi request reprint Thickness distribution of fresh and preserved human eardrums measured with confocal microscopy
    Liesbeth C Kuypers
    Department of Physics, University of Antwerp, Antwerpen, Belgium
    Otol Neurotol 27:256-64. 2006
    ..In this study, the thickness distribution of the fresh human eardrum was measured and possible thickness changes in successive stages of preservation and preparation were studied...
  17. doi request reprint Elastic characterization of the gerbil pars flaccida from in situ inflation experiments
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium
    Biomech Model Mechanobiol 10:727-41. 2011
    ....
  18. ncbi request reprint Thickness of the gerbil tympanic membrane measured with confocal microscopy
    Liesbeth C Kuypers
    Laboratory of Biomedical Physics, Department of Physics, University of Antwerp Campus Middelheim, Belgium
    Hear Res 209:42-52. 2005
    ..The average thickness in the inferior region is slightly larger than in the superior region. The pars flaccida thickens steeply, up to about 80 microm, near the edges...
  19. ncbi request reprint Moiré profilometry using liquid crystals for projection and demodulation
    Jan A N Buytaert
    Laboratory of Biomedical Physics, Department of Physics, University of Antwerp, Groenenborgerlaan 171, B 2020 Wilrijk Antwerpen, Belgium
    Opt Express 16:179-93. 2008
    ..The device is able to perform topographic measurements with a height resolution of 15 microm on every pixel of the recording device...
  20. doi request reprint Quantification of tympanic membrane elasticity parameters from in situ point indentation measurements: validation and preliminary study
    Jef Aernouts
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Hear Res 263:177-82. 2010
    ..In this way our method takes into account the complex geometry of the membrane, and parameters are obtained in a physiologically relevant range of strain...
  21. pmc Full-field thickness distribution of human tympanic membrane obtained with optical coherence tomography
    Sam Van der Jeught
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, Antwerp, Belgium
    J Assoc Res Otolaryngol 14:483-94. 2013
    ..The change of form at the pathological site of the membrane corresponds well with the decreased thickness values that can be measured there. ..
  22. pmc High-resolution measurements of middle ear gas volume changes in the rabbit enables estimation of its mucosal CO(2) conductance
    Yael Marcusohn
    Laboratory of Biomedical Physics, University of Antwerp, Antwerp, B 2020, Belgium
    J Assoc Res Otolaryngol 7:236-45. 2006
    ..05 microL (h x Pa)(-1) and compared to the G(CO(2)) estimated for humans in a different study...
  23. pmc The OPFOS Microscopy Family: High-Resolution Optical Sectioning of Biomedical Specimens
    Jan A N Buytaert
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Anat Res Int 2012:206238. 2012
    ..which we all briefly discuss. All these optical sectioning methods create images showing histological detail. We illustrate the applicability of LSFM on several specimen types with application in biomedical and life sciences...
  24. ncbi request reprint High resolution gas volume change sensor
    Joris J J Dirckx
    Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, Antwerp, Flanders B 2020, Belgium
    Rev Sci Instrum 78:054705. 2007
    ..06 microl. At the onset of a gas quantity change the sensor shows a small pressure artifact of less than 15 Pa, and at constant change rates the pressure artifact is smaller than 10 Pa or 0.01% of ambient pressure...
  25. ncbi request reprint Do Swiftlets have an ear for echolocation? The functional morphology of Swiftlets' middle ears
    Henri A Thomassen
    Section of Evolutionary Morphology, Institute of Biology Leiden, Leiden University, P O Box 9516, 2300 RA Leiden, The Netherlands
    Hear Res 225:25-37. 2007
    ..Echolocation is unlikely to depend on adaptations in the middle ear tympano-ossicular chain...
  26. ncbi request reprint Pars flaccida displacement pattern in otitis media with effusion in the gerbil
    Christina Larsson
    Department of Otorhinolaryngology, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden
    Otol Neurotol 26:337-43. 2005
    ..Our hypothesis is that otitis media with effusion causes stiffness loss in the pars flaccida of the tympanic membrane. This loss of stiffness may be persistent and may trigger the development of retraction pockets and cholesteatoma...
  27. ncbi request reprint Response of the cat eardrum to static pressures: mobile versus immobile malleus
    Hanif M Ladak
    Department of Biomedical Engineering, McGill University, Montreal H3A 2B4, Canada
    J Acoust Soc Am 116:3008-21. 2004
    ..The response is asymmetric, with lateral displacements being larger than medial displacements. With a mobile malleus, manubrial displacements exhibit more pronounced asymmetry than do pars-tensa displacements...
  28. ncbi request reprint Pars flaccida displacement pattern in purulent otitis media in the gerbil
    Christina Larsson
    Department of Otorhinolaryngology, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden
    Otol Neurotol 24:358-64. 2003
    ..Our hypothesis is that purulent otitis media and otitis media with effusion cause stiffness loss of the tympanic membrane. This loss of stiffness may be persistent and precede the development of retraction pockets and cholesteatoma...
  29. ncbi request reprint A geometrically nonlinear finite-element model of the cat eardrum
    Hanif M Ladak
    Department of Medical Biophysics, The University of Western Ontario, London, Canada
    J Acoust Soc Am 119:2859-68. 2006
    ..At higher pressures, material nonlinearity may become more important...
  30. ncbi request reprint High-resolution gas volume change measurements bring new insights in pressure regulation of the middle ear
    Joris J J Dirckx
    J Appl Physiol 101:1275-6. 2006
  31. ncbi request reprint Embryonic stem cells enhance the healing of tympanic membrane perforations
    Magnus von Unge
    Department of ENT, Karolinska Institute and Hospital, 17176 Stockholm, Sweden
    Int J Pediatr Otorhinolaryngol 67:215-9. 2003
    ..Tympanic membrane perforations may cause hearing impairment and otorhea. It is a common indication for ear surgery. The aim of the study was to test whether stem cells may enhance the healing of fresh tympanic membrane perforations...