Liene Dhooghe

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi request reprint A new decomposition product of dihydroartemisinin
    L Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Pharmazie 62:900-1. 2007
  2. doi request reprint Development and validation of an HPLC-method for the determination of alkaloids in the stem bark extract of Nauclea pobeguinii
    L Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Talanta 76:462-8. 2008
  3. doi request reprint The quantification of ellagic acid in the crude extract of Phyllanthus amarus Schum. & Thonn. (Euphorbiaceae)
    Liene Dhooghe
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Phytochem Anal 22:361-6. 2011
  4. doi request reprint Quantification of xanthohumol, isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin in hop extracts and derived capsules using secondary standards
    Liene Dhooghe
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Talanta 83:448-56. 2010
  5. doi request reprint Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii
    Liene Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Phytochemistry 71:785-91. 2010
  6. doi request reprint Rapid isolation and identification of minor natural products by LC-MS, LC-SPE-NMR and ECD: isoflavanones, biflavanones and bisdihydrocoumarins from Ormocarpum kirkii
    Yong Jiang Xu
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Phytochemistry 79:121-8. 2012
  7. doi request reprint Herbal medicines and infectious diseases: characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria
    Yong Jiang Xu
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 77:1139-48. 2011
  8. doi request reprint Phytochemical and biological investigations of Elaeodendron schlechteranum
    Sheila M Maregesi
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerpen, Belgium
    J Ethnopharmacol 129:319-26. 2010
  9. doi request reprint Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues
    Gitte Van Baelen
    Laboratory of Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Bioorg Med Chem 17:7209-17. 2009
  10. doi request reprint Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives
    Ibrahim El Sayed
    Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein, 1, 2610, Antwerp, Belgium
    J Med Chem 52:2979-88. 2009

Collaborators

  • Louis Maes
  • Kenn Foubert
  • L Pieters
  • Pieter Van der Veken
  • Arne Heyerick
  • Nina Hermans
  • A J Vlietinck
  • S Apers
  • Yong Jiang Xu
  • Paul Cos
  • Gitte Van Baelen
  • Filip Lemiere
  • Sheila Maregesi
  • Daneel Ferreira
  • Sheila M Maregesi
  • Guy Lemiere
  • Ibrahim El Sayed
  • Bert U W Maes
  • Steven Hostyn
  • Yike Zou
  • Christina M Coleman
  • Rica Capistrano
  • Aliou Baldé
  • Dirk A Vanden Berghe
  • Christophe Pannecouque
  • Kanyanga Cimanga
  • Jurgen Joossens
  • Marcel Kaiser
  • Koen Augustyns
  • Ildikó Nagy
  • Koen Steert
  • Peter Matyus
  • Achiel Haemers
  • Pál Tapolcsányi
  • György Hajós
  • Zsuzsanna Riedl
  • Roger Dommisse
  • Reto Brun

Detail Information

Publications10

  1. ncbi request reprint A new decomposition product of dihydroartemisinin
    L Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Pharmazie 62:900-1. 2007
    ..Most probably this product was formed by oxidation of the aldehyde functionality of the former decomposition product and subsequent decarboxylation...
  2. doi request reprint Development and validation of an HPLC-method for the determination of alkaloids in the stem bark extract of Nauclea pobeguinii
    L Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Talanta 76:462-8. 2008
    ..S.D. of 9.4%) which was acceptable. The method has been proven to be suitable for the determination of alkaloids in the extract of the stem bark of N. pobeguinii, according to the ICH guidelines on the validation of analytical methods...
  3. doi request reprint The quantification of ellagic acid in the crude extract of Phyllanthus amarus Schum. & Thonn. (Euphorbiaceae)
    Liene Dhooghe
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Phytochem Anal 22:361-6. 2011
    ..The major constituent of the crude extract of the whole plant was isolated and identified in this research to be ellagic acid, for which antiplasmodial activity already has been reported...
  4. doi request reprint Quantification of xanthohumol, isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin in hop extracts and derived capsules using secondary standards
    Liene Dhooghe
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Talanta 83:448-56. 2010
    ....
  5. doi request reprint Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii
    Liene Dhooghe
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Phytochemistry 71:785-91. 2010
    ..3+/-3.8 microM, but the selectivity was rather limited. Thus, these constituents may contribute, at least in part, to the antimalarial use of O. kirkii in traditional medicine...
  6. doi request reprint Rapid isolation and identification of minor natural products by LC-MS, LC-SPE-NMR and ECD: isoflavanones, biflavanones and bisdihydrocoumarins from Ormocarpum kirkii
    Yong Jiang Xu
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Phytochemistry 79:121-8. 2012
    ..Eight compounds were identified for the first time and six have been previously reported. The present approach offers a strategy for accelerating research on natural products...
  7. doi request reprint Herbal medicines and infectious diseases: characterization by LC-SPE-NMR of some medicinal plant extracts used against malaria
    Yong Jiang Xu
    Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 77:1139-48. 2011
    ..In addition, herbal medicinal products can completely be characterized, both with regard to their major as well as their minor constituents...
  8. doi request reprint Phytochemical and biological investigations of Elaeodendron schlechteranum
    Sheila M Maregesi
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerpen, Belgium
    J Ethnopharmacol 129:319-26. 2010
    ..The aim of this study was to identify the putative active constituents of the plant...
  9. doi request reprint Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues
    Gitte Van Baelen
    Laboratory of Organic Synthesis, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    Bioorg Med Chem 17:7209-17. 2009
    ..However, this compound was not active in the Plasmodium berghei mouse model. Structure-activity relationships are discussed and compared with related naturally occurring compounds...
  10. doi request reprint Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives
    Ibrahim El Sayed
    Laboratory of Medicinal Chemistry, University of Antwerp, Universiteitsplein, 1, 2610, Antwerp, Belgium
    J Med Chem 52:2979-88. 2009
    ..The most efficient compounds showed antiplasmodial activities in the nanomolar range. N(1),N(1)-Diethyl-N(4)-(5-methyl-5H-indolo[2,3-b]quinolin-8-yl)pentane-1,4-diamine 11c showed an IC(50) of 0.01 microM and a selectivity index of 1800...