Jan Deprest

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. ncbi request reprint Effect of tracheal occlusion on peripheric pulmonary vessel muscularization in a fetal rabbit model for congenital diaphragmatic hernia
    Xenia I Roubliova
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 191:830-6. 2004
  2. ncbi request reprint Persistent elevation of cell-free fetal DNA levels in maternal plasma after selective laser coagulation of chorionic plate anastomoses in severe midgestational twin-twin transfusion syndrome
    Tuangsit Wataganara
    Division of Genetics, Department of Pediatrics, Obstetrics and Gynecology, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Am J Obstet Gynecol 192:604-9. 2005
  3. ncbi request reprint Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO)
    Jacques C Jani
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Obstet Gynecol 195:1646-50. 2006
  4. ncbi request reprint Lung volumes in fetuses with congenital diaphragmatic hernia: comparison of 3D US and MR imaging assessments
    Jacques C Jani
    Unit of Prenatal and Gynaecological Ultrasound and Fetal Therapy, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, 3000 Leuven, Belgium
    Radiology 244:575-82. 2007
  5. doi request reprint Functional assessment of hyperoxia-induced lung injury after preterm birth in the rabbit
    Jute Richter
    Clinical Dept of Obstetrics and Gynaecology and Academic Dept of Development and Regeneration, Organ System Cluster, Univ Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Am J Physiol Lung Cell Mol Physiol 306:L277-83. 2014
  6. doi request reprint Antenatal management of isolated congenital diaphragmatic hernia today and tomorrow: ongoing collaborative research and development. Journal of Pediatric Surgery Lecture
    Jan Deprest
    Division of Woman and Child, Department of Reproduction, Development, and Regeneration, University Hospitals Leuven, 3000 Leuven, Belgium
    J Pediatr Surg 47:282-90. 2012
  7. pmc Hernia repair: the search for ideal meshes
    S Bringman
    Department of Surgery, CLINTEC, Karolinska Institutet, Sodertalje Hospital, Sodertalje, Sweden
    Hernia 14:81-7. 2010
  8. doi request reprint Fetal surgery is a clinical reality
    Jan A Deprest
    Division Woman and Child, University Hospital Gasthuisberg, Leuven, Belgium
    Semin Fetal Neonatal Med 15:58-67. 2010
  9. doi request reprint The making of fetal surgery
    Jan A Deprest
    Division Woman and Child, University Hospitals KU Leuven, Leuven, Belgium
    Prenat Diagn 30:653-67. 2010
  10. ncbi request reprint Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe
    Jan A Deprest
    Woman and Child Division, Fetal Medicine Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Perinatol 36:329-47, ix. 2009

Detail Information

Publications94

  1. ncbi request reprint Effect of tracheal occlusion on peripheric pulmonary vessel muscularization in a fetal rabbit model for congenital diaphragmatic hernia
    Xenia I Roubliova
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 191:830-6. 2004
    ..This study was undertaken to evaluate the effects on peripheric pulmonary vessel muscularization by tracheal occlusion (TO) performed at different gestational ages in fetal rabbits with surgically induced diaphragmatic hernia...
  2. ncbi request reprint Persistent elevation of cell-free fetal DNA levels in maternal plasma after selective laser coagulation of chorionic plate anastomoses in severe midgestational twin-twin transfusion syndrome
    Tuangsit Wataganara
    Division of Genetics, Department of Pediatrics, Obstetrics and Gynecology, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Am J Obstet Gynecol 192:604-9. 2005
    ..This study was undertaken to determine whether laser thermocoagulation for twin-twin transfusion syndrome (TTTS) causes increased cell-free fetal DNA levels in maternal plasma, potentially as a result of placental injury...
  3. ncbi request reprint Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO)
    Jacques C Jani
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Obstet Gynecol 195:1646-50. 2006
    ....
  4. ncbi request reprint Lung volumes in fetuses with congenital diaphragmatic hernia: comparison of 3D US and MR imaging assessments
    Jacques C Jani
    Unit of Prenatal and Gynaecological Ultrasound and Fetal Therapy, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, 3000 Leuven, Belgium
    Radiology 244:575-82. 2007
    ..To prospectively compare three-dimensional (3D) ultrasonography (US) and magnetic resonance (MR) imaging in the assessment of lung volumes in fetuses with congenital diaphragmatic hernia...
  5. doi request reprint Functional assessment of hyperoxia-induced lung injury after preterm birth in the rabbit
    Jute Richter
    Clinical Dept of Obstetrics and Gynaecology and Academic Dept of Development and Regeneration, Organ System Cluster, Univ Hospitals of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Am J Physiol Lung Cell Mol Physiol 306:L277-83. 2014
    ..This model will be used to study novel preventive or therapeutic interventions. ..
  6. doi request reprint Antenatal management of isolated congenital diaphragmatic hernia today and tomorrow: ongoing collaborative research and development. Journal of Pediatric Surgery Lecture
    Jan Deprest
    Division of Woman and Child, Department of Reproduction, Development, and Regeneration, University Hospitals Leuven, 3000 Leuven, Belgium
    J Pediatr Surg 47:282-90. 2012
    ..Fetuses with severe hypoplasia usually require postnatal operative repair using prosthetic patches, and tissue engineering offers the potential for ex utero culture...
  7. pmc Hernia repair: the search for ideal meshes
    S Bringman
    Department of Surgery, CLINTEC, Karolinska Institutet, Sodertalje Hospital, Sodertalje, Sweden
    Hernia 14:81-7. 2010
    ..Effective repair of hernia is a difficult task. There have been many advances in hernia repair techniques over the past 50 years, but new strategies must be considered to enhance the success of herniorrhaphy...
  8. doi request reprint Fetal surgery is a clinical reality
    Jan A Deprest
    Division Woman and Child, University Hospital Gasthuisberg, Leuven, Belgium
    Semin Fetal Neonatal Med 15:58-67. 2010
    ..Inclusion of patients into trials whenever possible should be encouraged rather than building up casuistic experience...
  9. doi request reprint The making of fetal surgery
    Jan A Deprest
    Division Woman and Child, University Hospitals KU Leuven, Leuven, Belgium
    Prenat Diagn 30:653-67. 2010
    ..This, as well as fetal intervention for CDH, is currently being investigated in randomised trials...
  10. ncbi request reprint Changing perspectives on the perinatal management of isolated congenital diaphragmatic hernia in Europe
    Jan A Deprest
    Woman and Child Division, Fetal Medicine Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Perinatol 36:329-47, ix. 2009
    ..Postnatal management has been standardized by European high-volume centers for the purpose of this and other trials...
  11. ncbi request reprint Medium term outcome of laparoscopic sacrocolpopexy with xenografts compared to synthetic grafts
    Jan Deprest
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    J Urol 182:2362-8. 2009
    ..We compared the medium term anatomical and subjective outcome, and graft related complications after sacrocolpopexy for apical vaginal prolapse using xenogenic or polypropylene grafts...
  12. ncbi request reprint Clinicopathological study of patients requiring reintervention after sacrocolpopexy with xenogenic acellular collagen grafts
    Jan Deprest
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Urol 183:2249-55. 2010
    ..We describe the operative and histopathological findings of patients requiring reintervention because of symptomatic vault prolapse or graft related complications following sacrocolpopexy using xenografts...
  13. doi request reprint Amniopatch for iatrogenic rupture of the fetal membranes
    Jan Deprest
    Department of Obstetrics and Gynaecology, Division Woman and Child, University Hospital Gasthuisberg, Leuven, Belgium
    Prenat Diagn 31:661-6. 2011
    ..In summary, current experience suggests that in cases of early onset but persistent amniotic fluid leakage following an invasive fetal procedure, amniopatch is an option...
  14. ncbi request reprint Fetal surgery for anesthesiologists
    Jan A Deprest
    Division Woman and Child, Fetal Medicine Unit, University Hospitals Leuven, Belgium
    Curr Opin Anaesthesiol 21:298-307. 2008
    ..We aimed to review the current clinical status and advances in endoscopic and open surgical interventions on the fetus in terms of indications, technical aspects and reported outcomes...
  15. doi request reprint [Amniopatch to treat iatrogenic rupture of the fetal membranes]
    J Deprest
    Département d Obstétrique et de Gynécologie, division femme et enfant, Hôpital Universitaire Gasthuisberg, Leuven, Belgique
    Gynecol Obstet Fertil 39:378-82. 2011
    ..We aimed to describe the use of platelets and fresh frozen plasma for sealing iatrogenic fetal membrane defects...
  16. doi request reprint The role of ultrasound examination in the first trimester and at 16 weeks' gestation to predict fetal complications in monochorionic diamniotic twin pregnancies
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Am J Obstet Gynecol 199:493.e1-7. 2008
    ....
  17. ncbi request reprint Tensile strength and host response towards silk and type i polypropylene implants used for augmentation of fascial repair in a rat model
    Federico Spelzini
    Centre for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Obstet Invest 63:155-62. 2007
    ..We compared host response, architectural integration and tensile strength of two different macroporous silk constructs to a polypropylene type I implant in a rat model for augmentation of primary fascial defect repair...
  18. ncbi request reprint Medium-term anatomic and functional results of laparoscopic sacrocolpopexy beyond the learning curve
    Filip Claerhout
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur Urol 55:1459-67. 2009
    ..Limited prospective data on the anatomic and functional outcome after laparoscopic sacrocolpopexy (LSC) are available in the literature...
  19. doi request reprint Clinical outcome and placental characteristics of monochorionic diamniotic twin pairs with early- and late-onset discordant growth
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Am J Obstet Gynecol 199:511.e1-7. 2008
    ....
  20. ncbi request reprint Porous acellular porcine dermal collagen implants to repair fascial defects in a rat model: biomechanical evaluation up to 180 days
    Yves Ozog
    Center for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Gynecol Obstet Invest 68:205-12. 2009
    ..To investigate the biomechanical properties of porous collagen matrices in a rat abdominal wall defect model...
  21. doi request reprint Fate of collagen-based implants used in pelvic floor surgery: a 2-year follow-up study in a rabbit model
    Filip Claerhout
    Centre for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 198:94.e1-6. 2008
    ..The purpose of this study was to compare the long-term host response to 2 different collagen matrices versus macroporous polypropylene mesh...
  22. doi request reprint The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort study
    Liesbeth Lewi
    Department of Obstetrics, University Hospitals, Leuven, Belgium
    Am J Obstet Gynecol 199:514.e1-8. 2008
    ..The purpose of this study was to document pregnancy and neonatal outcome of monochorionic diamniotic twin pregnancies...
  23. doi request reprint Technical aspects of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia
    Jan Deprest
    Division of Woman and Child, University Hospital Leuven, Leuven, Belgium
    J Pediatr Surg 46:22-32. 2011
    ..FETO is associated with an apparent increase in survival compared with same severity controls, although this needs to be evaluated in a formal trial. The time has come to do so...
  24. doi request reprint Monochorionic diamniotic twin pregnancies: natural history and risk stratification
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Leuven, Belgium
    Fetal Diagn Ther 27:121-33. 2010
    ....
  25. doi request reprint Comparison of Doppler-based and three-dimensional methods for fetal cardiac output measurement
    Philip DeKoninck
    Fetal Medicine Unit, Division of Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium
    Fetal Diagn Ther 32:72-8. 2012
    ..New methods based on 3D measurements of ventricular size in systole and diastole have been proposed. Our aim was to validate these tools against the conventional Doppler-based methods...
  26. doi request reprint Results of fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia and the set up of the randomized controlled TOTAL trial
    Philip DeKoninck
    Division of Woman and Child, University Hospitals Leuven, 3000 Leuven, Belgium
    Early Hum Dev 87:619-24. 2011
    ..Training of European as well as North American centers is taking place, so that the procedure could be safely and more widely offered...
  27. ncbi request reprint Pregnancy and infant outcome of 80 consecutive cord coagulations in complicated monochorionic multiple pregnancies
    Liesbeth Lewi
    UZ Gasthuisberg, Leuven, Belgium
    Am J Obstet Gynecol 194:782-9. 2006
    ..This study was undertaken to document pregnancy and infant outcome after cord coagulation with laser and/or bipolar as a technique for selective feticide in complicated monochorionic multiple pregnancies...
  28. ncbi request reprint Fetoscopic surgery: encouraged by clinical experience and boosted by instrument innovation
    Jan Deprest
    Department of Obstetrics and Gynaecology, Division Woman and Child, University Hospital Leuven, 3000 Leuven, Belgium
    Semin Fetal Neonatal Med 11:398-412. 2006
    ..The latter problem may prove to be a bottleneck for further developments, although treatment modalities are currently being evaluated...
  29. ncbi request reprint Prenatal intervention for isolated congenital diaphragmatic hernia
    Jan Deprest
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Obstet Gynecol 18:355-67. 2006
    ..We aim to review the recent literature regarding early prenatal prediction of outcome in babies diagnosed with isolated congenital diaphragmatic hernia, as well as results of fetal therapy for this condition...
  30. doi request reprint Cross-sectional study of tracheomegaly in children after fetal tracheal occlusion for severe congenital diaphragmatic hernia
    Luc Breysem
    Department of Radiology, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Radiology 257:226-32. 2010
    ..To measure tracheal dimensions in children with congenital diaphragmatic hernia (CDH) who had undergone fetoscopic endoluminal tracheal occlusion (FETO) or were treated expectantly during gestation...
  31. ncbi request reprint Tensile strength and host response towards different polypropylene implant materials used for augmentation of fascial repair in a rat model
    Maja L Konstantinovic
    Centre for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 18:619-26. 2007
    ..At 90 days time point, explants reconstructed with tighter woven multifilament SPM were weaker than sutured or SPMM controls. Overall shrinkage of 10% was comparable for all groups...
  32. doi request reprint Twin anemia polycythemia sequence from a prenatal perspective
    Leonardo Gucciardo
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Prenat Diagn 30:438-42. 2010
    ..To describe the prevalence, management and outcome of spontaneous twin anemia polycythemia sequence (TAPS) diagnosed in the prenatal period...
  33. doi request reprint Shrinkage and biomechanical evaluation of lightweight synthetics in a rabbit model for primary fascial repair
    Yves Ozog
    Center for Surgical Technologies, Faculty of Medicine, Universitair Ziekenhuis Gasthuisberg Leuven, Katholieke Universiteit Leuven, Minderbroedersstraat 19, Box 1034, 3000 Leuven, Belgium
    Int Urogynecol J 22:1099-108. 2011
    ..The experiment evaluated different lightweights (<32 g/m(2)) in terms of shrinkage and biomechanics...
  34. ncbi request reprint Intertwin anastomoses in monochorionic placentas after fetoscopic laser coagulation for twin-to-twin transfusion syndrome: is there more than meets the eye?
    Liesbeth Lewi
    UZ Gasthuisberg, Leuven, Belgium
    Am J Obstet Gynecol 194:790-5. 2006
    ....
  35. ncbi request reprint Current consequences of prenatal diagnosis of congenital diaphragmatic hernia
    Jan Deprest
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven B 3000, Belgium
    J Pediatr Surg 41:423-30. 2006
    ..In these patients, prenatal intervention aiming to reverse pulmonary hypoplasia can be considered...
  36. doi request reprint Prenatal diagnosis, prediction of outcome and in utero therapy of isolated congenital diaphragmatic hernia
    Elisa Done
    Fetal Medicine Unit of University Hospitals Leuven, Leuven, Belgium
    Prenat Diagn 28:581-91. 2008
    ..Early data show that FETO does not increase morbidity in survivors, when compared to historical controls. Several trials are currently under design...
  37. ncbi request reprint T2 quantifications of lungs in the fetal lamb with experimentally-induced congenital diaphragmatic hernia
    Luc Breysem
    Department of Radiology, University Hospitals Gasthuisberg, Leuven, Belgium
    Fetal Diagn Ther 22:143-8. 2007
    ..As an aid to evaluate lung hypoplasia, we investigated the difference between T2 value in fetal lungs of lambs with surgically-induced left-sided diaphragmatic hernia (DH) and gestational age (GA)-matched control littermates (normal [NL])...
  38. ncbi request reprint Monochorionic diamniotic twins: complications and management options
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Centre for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Curr Opin Obstet Gynecol 15:177-94. 2003
    ..This is because of the unpredictable vascular anastomoses and the often asymmetrical distribution of the single placenta between both twins...
  39. ncbi request reprint Biomechanical effects of polyglecaprone fibers in a polypropylene mesh after abdominal and rectovaginal implantation in a rabbit
    Yves Ozog
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J 23:1397-402. 2012
    ..To investigate the biomechanical effects of polyglecaprone fibers in lightweight meshes implanted into the vaginal and abdominal wall of parous rabbits...
  40. ncbi request reprint Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome
    Tim Van Mieghem
    Department of Obstetrics and Gynecology, University Hospitals Leuven, Belgium
    Am J Obstet Gynecol 202:48.e1-7. 2010
    ....
  41. doi request reprint Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy
    Karel Allegaert
    Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Am J Obstet Gynecol 200:170.e1-7. 2009
    ..To study cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy...
  42. ncbi request reprint Prediction of outcome in isolated congenital diaphragmatic hernia and its consequences for fetal therapy
    Leonardo Gucciardo
    Fetal Medicine Unit, University Hospitals Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 22:123-38. 2008
    ..The lung response to, and outcome after, FETO depend on pre-existing lung size respectively gestational age at birth. Prenatal decision making can therefore be stratified according to measured lung size...
  43. ncbi request reprint Prenatal intervention for isolated congenital diaphragmatic hernia
    Jan Deprest
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Obstet Gynecol 18:203-15. 2006
    ..We aim to review the recent literature regarding early prenatal prediction of outcome in babies diagnosed with isolated congenital diaphragmatic hernia, as well as results of fetal therapy for this condition...
  44. ncbi request reprint Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospital, Leuven, Belgium
    Am J Obstet Gynecol 197:587.e1-8. 2007
    ....
  45. ncbi request reprint Fetoscopic surgery in triplet pregnancies: a multicenter case series
    Dominique Van Schoubroeck
    Departments of Obstetrics and Gynecology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Am J Obstet Gynecol 191:1529-32. 2004
    ..The purpose of this study was to evaluate the feasibility of fetoscopic surgery in complicated monochorionic and dichorionic triplet pregnancies...
  46. ncbi request reprint Implementation of laparoscopic sacrocolpopexy--a single centre's experience
    Filip Claerhout
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 20:1119-25. 2009
    ..The aim of this study was to describe the learning curve of a single surgeon to achieve the ability to perform a complication-free and anatomically successful laparoscopic sacrocolpopexy (LSC)...
  47. ncbi request reprint Invasive antenatal interventions in complicated multiple pregnancies
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Obstet Gynecol Clin North Am 32:105-26, x. 2005
    ....
  48. ncbi request reprint Improved surgical outcome by modification of porcine dermal collagen implant in abdominal wall reconstruction in rats
    Fang Zheng
    Center for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Neurourol Urodyn 24:362-8. 2005
    ..Herein we wanted to evaluate whether creation of pores in Pelvicol, facilitating ingrowth of fibrous tissue and vessels, would result in a higher tensile strength at d30 without compromising longer term results...
  49. ncbi request reprint Posterior intravaginal slingplasty with preservation of the uterus: a modified surgical technique in a young myelomeningocele patient
    Jasper Verguts
    Bekkenbodemcentrum, University Hospital Gasthuisberg, Leuven, Belgium
    Gynecol Obstet Invest 63:203-4. 2007
    ..Posterior intravaginal slingplasty is commonly used to correct vaginal vault prolapse, but may be a valuable alternative to correct uterine prolapse. We compare this technique to other techniques to correct uterine prolapse...
  50. doi request reprint Sacrocolpopexy using xenogenic acellular collagen in patients at increased risk for graft-related complications
    Filip Claerhout
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Neurourol Urodyn 29:563-7. 2010
    ..We studied the long-term anatomical and functional outcome following sacrocolpopexy for apical vaginal prolapse using xenogenic grafts in a population at increased risk for graft-related complications (GRCs)...
  51. ncbi request reprint Host response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model
    Fang Zheng
    Center for Surgical Technologies, Faculty of Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Obstet Gynecol 191:1961-70. 2004
    ..The purpose of this study was to compare the inflammatory response after implantation of Pelvicol with Prolene in a rat model...
  52. doi request reprint Amniopatch procedure after previable iatrogenic rupture of the membranes: a two-center review
    Jute Richter
    Department of Obstetrics and Gynecology, University Hospitals of Leuven, Leuven, Belgium
    Prenat Diagn 33:391-6. 2013
    ..This study aimed to analyze success rates and pregnancy outcomes of amniopatch procedures for previable iatrogenic preterm prelabour rupture of the membranes (PPROM) with associated oligohydramnios...
  53. doi request reprint Psychosocial aspects of invasive fetal therapy as compared to prenatal diagnosis and risk assessment
    Veronika Beck
    Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Leuven, Belgium
    Prenat Diagn 33:334-40. 2013
    ..To explore the psychosocial impact of invasive fetal therapy (FT)...
  54. ncbi request reprint Fetal intervention for congenital diaphragmatic hernia: the European experience
    Jan Deprest
    Fetal Medicine Unit, Department of Obstetrics, University Hospital Gasthuisberg, Leuven, Belgium
    Semin Perinatol 29:94-103. 2005
    ..0) is a good predictor of poor prognosis at different tertiary centers around the world. Severe CDH may be successfully treated with FETO, which is minimally invasive and may improve postnatal survival...
  55. doi request reprint Prenatal assessment and management of sacrococcygeal teratoma
    Leonardo Gucciardo
    Department of Woman and Child, Division Woman, Fetal Medicine Unit, University Hospital Gasthuisberg Leuven, Leuven, Belgium
    Prenat Diagn 31:678-88. 2011
    ..Careful postnatal follow-up is required for timely identification and treatment of complications as well as recurrence. This paper aims to review the perinatal management of this condition...
  56. doi request reprint The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward
    Els Ortibus
    Department of Pediatrics, University Hospitals, Leuven, Belgium
    Am J Obstet Gynecol 200:494.e1-8. 2009
    ..We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment...
  57. doi request reprint Assessment of fetal cardiac function before and after therapy for twin-to-twin transfusion syndrome
    Tim Van Mieghem
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium
    Am J Obstet Gynecol 200:400.e1-7. 2009
    ..We sought to assess fetal cardiac function in monochorionic twins before and after therapy for twin-to-twin transfusion syndrome (TTTS) and compare it with control subjects...
  58. ncbi request reprint Diagnosis and management of heterokaryotypic monochorionic twins
    Liesbeth Lewi
    Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium
    Am J Med Genet A 140:272-5. 2006
    ..In five cases, the anomalous twin was selectively reduced by cord coagulation. All pregnancies ended with a phenotypically normal liveborn and all children are developing normally at 1-7 years of age...
  59. ncbi request reprint Ultrasound prediction of intertwin birth weight discordance in monochorionic diamniotic twin pregnancies
    Tim Van Mieghem
    Division Woman and Child Department of Obstetrics and Gynecology University Hospitals Leuven, Leuven, Belgium
    Prenat Diagn 29:240-4. 2009
    ..To estimate the accuracy of ultrasound to predict birth weight (BW) and BW discordance in monochorionic diamniotic (MCDA) twin pregnancies...
  60. ncbi request reprint Experimental comparison of abdominal wall repair using different methods of enhancement by small intestinal submucosa graft
    Yves Ozog
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 20:435-41. 2009
    ..To assess the biomechanical properties of full-thickness abdominal wall defects, either using Native tissues, with or without Overlay, and by substitution of the Defect by small intestinal submucosa mesh...
  61. ncbi request reprint Fetal heart pathology on postmortem 3-T magnetic resonance imaging
    Inga Sandaite
    Department of Radiology, University Hospitals Leuven, Leuven, Belgium Department of Obstetrics and Gynaecology, Fondazione Csa Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Prenat Diagn 34:223-9. 2014
    ..Overall, it provides reliable information on structural malformations but was shown to be of limited use in examining the fetal heart...
  62. doi request reprint A pictorial essay on fetal rabbit anatomy using micro-ultrasound and magnetic resonance imaging
    Philip DeKoninck
    Organ systems cluster, Department of Development and Regeneration, KU Leuven, Leuven, Belgium Center for Surgical Technologies, KU Leuven, Leuven, Belgium
    Prenat Diagn 34:84-9. 2014
    ..With this pictorial essay, we aimed to provide gestational age specific reference ranges of relevant fetal structures using micro-ultrasound, as well as its correlation with postmortem MRI and whole body sections...
  63. ncbi request reprint Minimally invasive fetal therapy
    Tim Van Mieghem
    Department of Obstetrics and Gynecology, Fetal Medicine Unit, University Hospitals Leuven, Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 26:711-25. 2012
    ....
  64. doi request reprint Prospective assessment of fetal cardiac function with speckle tracking in healthy fetuses and recipient fetuses of twin-to-twin transfusion syndrome
    Tim Van Mieghem
    Department of Woman and Child, Division Woman, Fetal Medicine Unit, University Hospitals Leuven, Leuven, Belgium
    J Am Soc Echocardiogr 23:301-8. 2010
    ..The aim of this study was to assess speckle tracking-derived fetal cardiac function in a normal population and in recipient fetuses of twin-to-twin transfusion syndrome (TTTS)...
  65. ncbi request reprint Cytokine production following experimental implantation of xenogenic dermal collagen and polypropylene grafts in mice
    Fang Zheng
    Center for Surgical Technologies, University Hospitals Leuven, Katholieke Universiteit Leuven, Minderbroedersstraat 17, 3000 Leuven, Belgium
    Neurourol Urodyn 26:280-9. 2007
    ..The hypothesis was that Pelvicol would induce a "T-helper2" (Th2) rather than T-helper1 (Th1) type of inflammatory response...
  66. ncbi request reprint Evidence and patterns in lung response after fetal tracheal occlusion: clinical controlled study
    Mieke M Cannie
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Radiology 252:526-33. 2009
    ....
  67. doi request reprint The pharmacokinetics of a high intravenous dose of paracetamol after caesarean delivery: the effect of gestational age
    Karel Allegaert
    Department of Reproduction, Development and Regeneration, University Hospitals Leuven, Belgium
    Eur J Anaesthesiol 29:484-8. 2012
    ..Pregnancy affects intravenous paracetamol pharmacokinetics, but there are no studies on covariates of intravenous paracetamol pharmacokinetics around delivery...
  68. doi request reprint Morphological and functional adaptation of the maternal heart during pregnancy
    Oana Savu
    Department of Cardiovascular Diseases, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000 Leuven, Belgium
    Circ Cardiovasc Imaging 5:289-97. 2012
    ..The aim of this study was to assess the performance of the left ventricle (LV) in normal, uncomplicated pregnancies while considering the actual LV load and shape...
  69. ncbi request reprint Percutaneous fetal endoscopic tracheal occlusion (FETO) for severe left-sided congenital diaphragmatic hernia
    J Jani
    Fetal Medicine Unit, Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Clin Obstet Gynecol 48:910-22. 2005
  70. doi request reprint Cefazolin plasma protein binding saturability during pregnancy
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Leuven, Belgium
    Methods Find Exp Clin Pharmacol 31:25-8. 2009
    ..4). The concept of saturability of CFZ plasma protein binding has been confirmed during pregnancy, but the free CFZ fraction is higher, likely explained by the lower albuminemia during pregnancy...
  71. pmc Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats
    Tim Van Mieghem
    Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Leuven, Belgium
    Am J Physiol Regul Integr Comp Physiol 297:R1615-21. 2009
    ..Further studies should clarify whether IGF-II directly affects vascular function and/or indirectly promotes the secretion of placenta-derived vasoactive substances...
  72. ncbi request reprint The biology behind fascial defects and the use of implants in pelvic organ prolapse repair
    Jan Deprest
    Centre for Surgical Technologies, Faculty of Medicine, and Pelvic Floor Centre, Department of Obstetrics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 17:S16-25. 2006
    ..As we discuss the different materials available on the market, we will summarize some results of recent experiments by our group...
  73. ncbi request reprint Single incision mini-sling versus a transobutaror sling: a comparative study on MiniArc and Monarc slings
    Dirk De Ridder
    Department of Urology, University Hospitals K U Leuven, Leuven, Belgium
    Int Urogynecol J 21:773-8. 2010
    ..A retrospective, dual-center, cohort study on the single incision MiniArc sling and the transobturator Monarc sling in the treatment of stress urinary incontinence is presented. We hypothesized that both systems would perform equally well...
  74. doi request reprint The effect of extracellular adenosine triphosphate on the spontaneous contractility of human myometrial strips
    Graham Hutchings
    Department of Obstetrics and Gynaecology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Obstet Gynecol Reprod Biol 143:79-83. 2009
    ..We hypothesised that extracellular ATP was involved in the control of myometrial contractile frequency and/or force...
  75. ncbi request reprint Complete chorioamniotic membrane separation. Case report and review of the literature
    Liesbeth Lewi
    Department of Gynaecology and Obstetrics, University Hospitals Gasthuisberg, Leuven, Belgium
    Fetal Diagn Ther 19:78-82. 2004
    ..A review of the literature shows that extensive CMS is associated with miscarriage, in utero fetal death, umbilical cord complications, and preterm delivery. Most reported cases occurred after invasive intrauterine procedures...
  76. doi request reprint Feasibility of in utero telemetric fetal ECG monitoring in a lamb model
    Bart Hermans
    Department ESAT MICAS, Faculty of Engineering, Katholieke Universiteit Leuven, Leuven, Belgium
    Fetal Diagn Ther 24:81-5. 2008
    ..We set up an experiment to evaluate the feasibility of in utero direct fECG monitoring and telemetric transmission using a small implantable device in a lamb model...
  77. doi request reprint MR volumetry of the normal fetal kidney: reference values
    Katrijn Michielsen
    Department of Radiology, University Hospitals Leuven, Leuven, Belgium
    Prenat Diagn 30:1044-8. 2010
    ..The aim of this study is to provide reference values for normal fetal kidney growth based on magnetic resonance (MR) volumetry. Differences in side and gender will be investigated...
  78. doi request reprint Validity, reliability and responsiveness of a Dutch version of the prolapse quality-of-life (P-QoL) questionnaire
    Filip Claerhout
    Pelvic Floor Unit, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J 21:569-78. 2010
    ..We aimed to test validity, reliability and responsiveness of a Dutch version of a prolapse quality-of-life questionnaire (P-QoL)...
  79. ncbi request reprint Laparoscopic hysterectomy for benign diseases
    Filip Claerhout
    Department Obstetrics and Gynaecology, University Hospital Leuven, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Best Pract Res Clin Obstet Gynaecol 19:357-75. 2005
    ..LH carries a higher risk for adjacent organ injury, and may be cost-effective, despite higher direct costs, because of the shorter hospital stay and quicker recovery...
  80. ncbi request reprint The baboon as a research model for the study of endometrial biology, uterine receptivity and embryo implantation
    Atunga Nyachieo
    Leuven University Fertility Center, Department of Obstetrics and Gynecology, Gasthuisberg, Leuven, Belgium
    Gynecol Obstet Invest 64:149-55. 2007
    ..In this paper we present an overview regarding the potential of the baboon model to study in vivo uterine receptivity and embryo implantation using invasive and non-invasive approaches...
  81. ncbi request reprint Postnatal cranial ultrasonographic findings in feto-fetal transfusion syndrome
    Luc Breysem
    Department of Radiology, University Hospitals, Herestraat 49, 3000 Leuven, Belgium
    Eur Radiol 12:2926-32. 2002
    ..In utero cranial hemorrhage dominated the antenatal brain insults; however, pregnancy survivors remain at risk for severe peripartal and/or postnatal brain insults...
  82. ncbi request reprint Pulmonary effects of gastroschisis in a fetal rabbit model
    Jean Marc Biard
    Center for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Pediatr Pulmonol 37:99-103. 2004
    ..0821). No effect on lung growth and maturation could be demonstrated in this study...
  83. ncbi request reprint Circulating cell-free fetal messenger RNA levels after fetoscopic interventions of complicated pregnancies
    May Lee Tjoa
    Department of Pediatrics, Division of Genetics, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Obstet Gynecol 195:230-5. 2006
    ..The aim of this study was to examine fetal gene expression in maternal plasma after fetoscopic intervention for twin-twin transfusion syndrome or congenital diaphragmatic hernia...
  84. ncbi request reprint Fetal lung volume after endoscopic tracheal occlusion in the prediction of postnatal outcome
    Cleisson F A Peralta
    Department of Obstetrics and Gynecology, Fetal Medicine Units, King s College Hospital, London, United Kingdom
    Am J Obstet Gynecol 198:60.e1-5. 2008
    ..The objective of the study was to investigate the volume response of the contralateral lung in the prediction of postnatal outcome in fetuses with congenital diaphragmatic hernia (CDH) treated by fetoscopic endotracheal occlusion (FETO)...
  85. ncbi request reprint Nitrous oxide amniodistention compared with fluid amniodistention reduces operation time while inducing no changes in fetal acid-base status in a sheep model for endoscopic fetal surgery
    Eduard Gratacos
    Center for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg and Katholieke Universiteit Leuven, Belgium
    Am J Obstet Gynecol 186:538-43. 2002
    ..Our purpose was to evaluate in a sheep model for endoscopic fetal surgery the impact of nitrous oxide-gas amniodistention compared with fluid amniodistention on duration of surgery, hemorrhagic events, and fetomaternal acid-base status...
  86. ncbi request reprint Increased polymorphonuclear infiltration and iatrogenic amniotic band after closure of fetoscopic access sites with a bioactive membrane in the rabbit at midgestation
    Roland Devlieger
    Centre for Surgical Technologies, Faculty of Medicine and Department of Obstetrics and Gynaecology, University Hospitals, K U Leuven, Belgium
    Am J Obstet Gynecol 188:844-8. 2003
    ..This study was undertaken to evaluate the efficacy and safety of closing the fetoscopy access site in a midgestational rabbit model by using a commercially available bioactive membrane...
  87. ncbi request reprint Ex vivo testing of a temperature- and pressure-controlled amnio-irrigator for fetoscopic surgery
    Francesca Bonati
    Centre for Surgical Technologies, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pediatr Surg 37:18-24. 2002
    ..In the current study, a prototype amnio-irrigator and fluid heater were evaluated...
  88. ncbi request reprint Lung growth induced by prenatal instillation of perfluorocarbon into the fetal rabbit lung
    Oliver J Muensterer
    Department of Pediatric Surgery, University of Munich, Dr von Hauner Children s Hospital, Lindwurmstrasse 4, 80337 Munich, Germany
    Pediatr Surg Int 20:248-52. 2004
    ..This novel technique may be a less invasive and less noxious treatment strategy for pulmonary hypoplasia associated with diaphragmatic hernia...
  89. ncbi request reprint Remifentanil for fetal immobilization and maternal sedation during fetoscopic surgery: a randomized, double-blind comparison with diazepam
    Marc Van de Velde
    Department of Anaesthesiology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Anesth Analg 101:251-8, table of contents. 2005
    ..We conclude that remifentanil produces improved fetal immobilization with good maternal sedation and only minimal effects on maternal respiration...
  90. ncbi request reprint Pulmonary effects of in utero tracheal occlusion are dependent on gestational age in a rabbit model of diaphragmatic hernia
    Jun Wu
    Surgical Technologies, Faculty of Medicine, Departments of Pathology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pediatr Surg 37:11-7. 2002
    ..The authors investigated the effect of gestational age on lung development and maturation after in utero tracheal occlusion (TO) in a rabbit model of congenital diaphragmatic hernia (CDH)...
  91. ncbi request reprint Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model
    Jaan Toelen
    Department of Pediatrics, University Hospital Gasthuisberg, Belgium
    Am J Obstet Gynecol 196:352.e1-6. 2007
    ..The purpose of this study was to evaluate the long-term expression of a transgene and subsequent immune response after the injection of lentiviral vectors in a fetal rats...
  92. ncbi request reprint Lung tissue mechanics predict lung hypoplasia in a rabbit model for congenital diaphragmatic hernia
    Andreas W Flemmer
    Division of Neonatology, University Children s Hospital, Perinatal Center, Ludwig Maximilian University Munich, Grosshadern, Germany
    Pediatr Pulmonol 42:505-12. 2007
    ..Our results for lung tissue mechanics support the concept of delayed pulmonary tissue modeling. We propose to employ functional studies in future experiments when evaluating prenatal interventions aimed at reversing pulmonary hypoplasia...
  93. doi request reprint Fetal body volume at MR imaging to quantify total fetal lung volume: normal ranges
    Mieke M Cannie
    Departments of Radiology and Obstetrics and Gynaecology, University Hospital Gasthuisberg, 3000 Leuven, Belgium
    Radiology 247:197-203. 2008
    ..To prospectively determine normal ranges of total fetal lung volume (TFLV) based on fetal body volume (FBV) and to determine whether prediction of TFLV based on such ranges is independent of fetal biometric indexes...