Marc E De Broe

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. doi request reprint Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy
    Marc E De Broe
    Faculty of Medicine, University of Antwerp, Antwerpen, Belgium
    Kidney Int 81:513-5. 2012
  2. doi request reprint Over-the-counter analgesic use
    Marc E De Broe
    Department of Nursing Sciences, Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium
    J Am Soc Nephrol 20:2098-103. 2009
  3. doi request reprint Phosphate: despite advances in research, the benefits to patients remain limited
    Marc E De Broe
    Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Kidney Int 75:880-1. 2009
  4. ncbi request reprint Tubular regeneration and the role of bone marrow cells: 'stem cell therapy'--a panacea?
    Marc E De Broe
    Department of Nephrology, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerpen, Belgium
    Nephrol Dial Transplant 20:2318-20. 2005
  5. doi request reprint Can the risk of gadolinium be extrapolated to lanthanum?
    Marc E De Broe
    Department of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Semin Dial 21:142-4. 2008
  6. ncbi request reprint Does the phosphate binder lanthanum carbonate affect bone in rats with chronic renal failure?
    Geert J Behets
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    J Am Soc Nephrol 15:2219-28. 2004
  7. doi request reprint Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats
    Ellen Neven
    Department of Pathophysiology, University of Antwerp, Wilrijk, Belgium
    Arterioscler Thromb Vasc Biol 30:1741-50. 2010
  8. ncbi request reprint Development and reversibility of impaired mineralization associated with lanthanum carbonate treatment in chronic renal failure rats
    An R J Bervoets
    Department of Medicine, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Bone 38:803-10. 2006
  9. ncbi request reprint Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats
    Line Oste
    Laboratory of Pathophysiology, Antwerp University, Belgium
    Ren Fail 29:1-12. 2007
  10. ncbi request reprint Acute ischemia/reperfusion injury after isogeneic kidney transplantation is mitigated in a rat model of chronic renal failure
    Sven R Vercauteren
    Department of Nephrology, University of Antwerp, Belgium
    Am J Transplant 3:570-80. 2003

Collaborators

Detail Information

Publications49

  1. doi request reprint Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy
    Marc E De Broe
    Faculty of Medicine, University of Antwerp, Antwerpen, Belgium
    Kidney Int 81:513-5. 2012
    ..It is time to abandon the terms 'CHN' and 'BEN' and introduce 'aristolochic acid nephropathy' to cover both clinical conditions...
  2. doi request reprint Over-the-counter analgesic use
    Marc E De Broe
    Department of Nursing Sciences, Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium
    J Am Soc Nephrol 20:2098-103. 2009
    ..As long as high-risk analgesic mixtures are available over the counter, analgesic nephropathy will continue to be a problem...
  3. doi request reprint Phosphate: despite advances in research, the benefits to patients remain limited
    Marc E De Broe
    Laboratory of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Kidney Int 75:880-1. 2009
    ..In addition, some of these findings have been translated into clinical practice, be it diagnostic or therapeutic...
  4. ncbi request reprint Tubular regeneration and the role of bone marrow cells: 'stem cell therapy'--a panacea?
    Marc E De Broe
    Department of Nephrology, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerpen, Belgium
    Nephrol Dial Transplant 20:2318-20. 2005
  5. doi request reprint Can the risk of gadolinium be extrapolated to lanthanum?
    Marc E De Broe
    Department of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Semin Dial 21:142-4. 2008
    ..However, Gd and La, two trivalent cations, differ substantially in their metabolism, pharmacokinetics, and most importantly in their clinical use and toxicity. Thus, it is extremely unlikely that La can cause NSF...
  6. ncbi request reprint Does the phosphate binder lanthanum carbonate affect bone in rats with chronic renal failure?
    Geert J Behets
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    J Am Soc Nephrol 15:2219-28. 2004
    ..There was no evidence that lanthanum had a direct toxic effect on osteoblasts...
  7. doi request reprint Chondrocyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats
    Ellen Neven
    Department of Pathophysiology, University of Antwerp, Wilrijk, Belgium
    Arterioscler Thromb Vasc Biol 30:1741-50. 2010
    ..To investigate cell biological changes in calcified aortas of rats that experienced chronic renal failure...
  8. ncbi request reprint Development and reversibility of impaired mineralization associated with lanthanum carbonate treatment in chronic renal failure rats
    An R J Bervoets
    Department of Medicine, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Bone 38:803-10. 2006
    ..In this study, we want to investigate the fate and possible biological activities of La once it is accumulated in bone...
  9. ncbi request reprint Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats
    Line Oste
    Laboratory of Pathophysiology, Antwerp University, Belgium
    Ren Fail 29:1-12. 2007
    ....
  10. ncbi request reprint Acute ischemia/reperfusion injury after isogeneic kidney transplantation is mitigated in a rat model of chronic renal failure
    Sven R Vercauteren
    Department of Nephrology, University of Antwerp, Belgium
    Am J Transplant 3:570-80. 2003
    ..These results will be the basis for studies on modulation of early leukocyte-endothelial interactions resulting from immunological disturbances inherent to the uremic environment...
  11. ncbi request reprint Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate
    Geert J Behets
    Department of Nephrology Hypertension, University of Antwerp, Antwerp, Belgium
    Kidney Int 67:1830-6. 2005
    ..Although bulk bone lanthanum concentrations are low, it is important to consider the localization within a given tissue...
  12. ncbi request reprint Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats
    Line Oste
    Department of Nephrology Hypertension, University of Antwerp, Antwerp, Belgium
    Kidney Int 67:920-30. 2005
    ..Since the target population for strontium treatment consists mainly in postmenopausal osteoporotic women, who may have a reduced renal function, the risk for osteomalacia should be considered...
  13. ncbi request reprint Effect of immunosuppression on damage, leukocyte infiltration, and regeneration after severe warm ischemia/reperfusion renal injury
    Dirk K Ysebaert
    Department of Experimental Surgery, University of Antwerp, Belgium
    Kidney Int 64:864-73. 2003
    ..Influence of immunosuppressive treatment on post-I/R renal damage, nonalloimmune cellular infiltration, and regeneration is not well studied...
  14. ncbi request reprint Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis
    Anja Verhulst
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    Kidney Int 68:1643-7. 2005
    ..This prompted us to investigate the expression of hyaluronan and osteopontin and to correlate this to the appearance of tubular calcifications both in fetal/preterm and transplanted kidneys...
  15. ncbi request reprint Effects of efficient phosphate binding on bone in chronic renal failure rats
    Geert J Behets
    Department of Nephrology, University of Antwerp, Universiteitsplein 1, Wilrijk B 2610, Belgium
    Ren Fail 27:475-84. 2005
    ..To further substantiate these results, in the present study, the effects of lanthanum carbonate on bone were compared to the effects of sevelamer, a nonabsorbed, non-metal-containing polymeric phosphate-binding agent...
  16. doi request reprint Adequate phosphate binding with lanthanum carbonate attenuates arterial calcification in chronic renal failure rats
    Ellen Neven
    Department of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Nephrol Dial Transplant 24:1790-9. 2009
    ..Therefore, the effect of lanthanum carbonate, a non-calcium phosphate binder, on the development of vascular calcification was investigated in uraemic rats...
  17. doi request reprint Differences in gastrointestinal calcium absorption after the ingestion of calcium-free phosphate binders
    Geert J Behets
    Laboratory of Pathophysiology, Univ of Antwerp, Universiteitsplein 1, Antwerp B 2610, Belgium
    Am J Physiol Renal Physiol 306:F61-7. 2014
    ..These findings may help to improve the management of calcium balance in patients with renal failure, including concomitant use of vitamin D...
  18. ncbi request reprint Lanthanum: a safe phosphate binder
    Veerle P Persy
    University of Antwerp, Antwerp, Belgium
    Semin Dial 19:195-9. 2006
    ..The liver is the main route of excretion for lanthanum carbonate, which can be localized in the lysosomes of hepatocytes. No lanthanum could be detected in brain tissue...
  19. doi request reprint Hepatocellular transport and gastrointestinal absorption of lanthanum in chronic renal failure
    An R J Bervoets
    Laboratory of Pathophysiology, Faculty of Medicine, Pharmaceutical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Kidney Int 75:389-98. 2009
    ..We suggest that the kinetics of lanthanum in the liver are consistent with a transcellular transport pathway, with higher levels in the liver of uremic rats due to higher intestinal absorption...
  20. doi request reprint An active renal crystal clearance mechanism in rat and man
    Benjamin A Vervaet
    Laboratory of Pathophysiology, Department of Medicine, University of Antwerp, Antwerp, Belgium
    Kidney Int 75:41-51. 2009
    ..Our study found a quantitative association between changes in tubular and crystalline morphology and crystal clearance, demonstrating the presence of an important and active nephrocalcinosis-clearing mechanism in both rat and man...
  21. ncbi request reprint Lanthanum carbonate: a new phosphate binder
    Geert J Behets
    Department of Nephrology, University of Antwerp, Antwerp, Belgium
    Curr Opin Nephrol Hypertens 13:403-9. 2004
    ..Although the available human efficacy and safety data over 3 years are encouraging, the consequences of low-level tissue deposition continue to be evaluated in longer-term clinical studies...
  22. doi request reprint Human proximal tubular epithelium actively secretes but does not retain rosuvastatin
    Anja Verhulst
    Laboratory of Pathophysiology, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium
    Mol Pharmacol 74:1084-91. 2008
    ..These data, obtained in an intact human tubule cell model, provide a detailed insight into rosuvastatin's renal handling and the possible factors influencing it...
  23. doi request reprint Crystalluric and tubular epithelial parameters during the onset of intratubular nephrocalcinosis: illustration of the 'fixed particle' theory in vivo
    Benjamin A Vervaet
    Laboratory of Pathophysiology, Department of Medicine, University of Antwerp, Antwerp, Belgium
    Nephrol Dial Transplant 24:3659-68. 2009
    ..It has been hypothesized that the tubular epithelium, in order to bind crystals, needs to be phenotypically altered. Whereas most evidence hereto is provided by in vitro experiments, we set out to illustrate this theory in vivo...
  24. doi request reprint The tubular epithelium in the initiation and course of intratubular nephrocalcinosis
    Benjamin A Vervaet
    Laboratory of Pathophysiology, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Antwerp, Belgium
    Urol Res 38:249-56. 2010
    ..This review summarizes our current understanding on how the tubular epithelium mechanistically appears to be involved both in the initiation and in the course of nephrocalcinosis, with emphasis on in vivo observations...
  25. ncbi request reprint T cells as mediators in renal ischemia/reperfusion injury
    Dirk K Ysebaert
    Departments of Nephrology and Transplantation Surgery, University of Antwerp, Belgium
    Kidney Int 66:491-6. 2004
    ..It seems worthwhile to study a combination therapy using anti-inflammatory/anti-adhesion molecules in the early phase of I/R...
  26. doi request reprint Cell biological and physicochemical aspects of arterial calcification
    Ellen Neven
    Department of Pathophysiology, University of Antwerp, Belgium
    Kidney Int 79:1166-77. 2011
    ..This review focuses on the cellular and structural similarities between bone formation and vascular calcification and discusses the initial events in this pathological mineralization process...
  27. ncbi request reprint ICAM-1 expression and leukocyte accumulation in inner stripe of outer medulla in early phase of ischemic compared to HgCl2-induced ARF
    Kathleen E De Greef
    Department of Experimental Surgery, University of Antwerp, Antwerp, Belgium
    Kidney Int 63:1697-707. 2003
    ..The aim of this study was to compare the early ICAM-1 expression and leukocyte accumulation in different zones of ischemic and toxic injury...
  28. ncbi request reprint Dose-dependent effects of strontium on osteoblast function and mineralization
    Steven C Verberckmoes
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    Kidney Int 64:534-43. 2003
    ..To confirm these in vivo findings an in vitro set-up, consisting of primary rat osteoblast cultures, was applied. Sr was added to the culture medium at concentrations of 0, 0.5, 1.0, 2.0, 5.0, 20, and 100 microg/mL, respectively...
  29. ncbi request reprint Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge?
    Ellen G Neven
    Department of Pathophysiology, University of Antwerp, Antwerp, Belgium
    Kidney Int 75:580-2. 2009
    ..report that the doses of etidronate and pamidronate that are effective in attenuating aortic calcification also decrease bone formation and mineralization in uremic rats, limiting their therapeutic use as anticalcifying agents...
  30. pmc Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia-reperfusion
    Bart P Van Putte
    Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Antwerp, Belgium
    Crit Care 9:R1-8. 2005
    ..Very little is known about cells infiltrating the lung during ischemia-reperfusion. Therefore, a model of warm ischemia-reperfusion injury was applied to differentiate cellular infiltrates and to quantify tissue damage...
  31. pmc Management of hyperphosphatemia in patients with end-stage renal disease: focus on lanthanum carbonate
    Veerle P Persy
    Laboratory of Pathophysiology, University of Antwerp, Belgium
    Int J Nephrol Renovasc Dis 2:1-8. 2009
    ..Clinical studies now document the absence of toxic effects of lanthanum for up to 6 years of follow-up. The effects of lanthanum on bone, vasculature and brain are discussed and put in perspective with lanthanum pharmacokinetics...
  32. ncbi request reprint Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells
    Anja Verhulst
    University of Antwerp, Department of Nephrology Hypertension, p a Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerpen, Belgium
    J Am Soc Nephrol 15:2249-57. 2004
    ..It is suggested that these data help to explain the occurrence of proteinuria in some patients treated with high statin doses...
  33. ncbi request reprint Prevention and transplantation in chronic kidney disease: what is achievable in emerging countries? Meeting report: Bamako meeting December 4-6, 2008
    Veerle P Persy
    Hugin Mugin Research, Antwerp, Belgium
    Nephron Clin Pract 115:c122-32. 2010
    ..International as well as regional collaborations need to be stimulated and strengthened in order to allow emerging countries to acquire the information, technology, experience and skills necessary to achieve these ambitious goals...
  34. ncbi request reprint Useful biochemical markers for diagnosing renal osteodystrophy in predialysis end-stage renal failure patients
    An R J Bervoets
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    Am J Kidney Dis 41:997-1007. 2003
    ..Various biochemical markers have been evaluated in dialysis patients for the diagnosis of renal osteodystrophy (ROD). However, their value in predialysis patients with end-stage renal failure (ESRF) is not yet clear...
  35. ncbi request reprint Kidney injury from alternative medicines
    Conny R D Colson
    Department of Nephrology, University of Antwerp, Antwerp, Belgium
    Adv Chronic Kidney Dis 12:261-75. 2005
    ..This review deals with acute and chronic kidney toxicity caused by animal-, plant-, and mineral-based, nonconventional medicine and kidney failure caused by drug interactions with AM...
  36. ncbi request reprint Reduced postischemic macrophage infiltration and interstitial fibrosis in osteopontin knockout mice
    Veerle P Persy
    Department of Nephrology, University of Antwerp, Belgium
    Kidney Int 63:543-53. 2003
    ..However, the precise role of this protein in renal pathophysiology remains unclear...
  37. ncbi request reprint Improving outcomes in hyperphosphataemia
    Marc E De Broe
    University Hospital Antwerp, Department of Nephrology Hypertension, Wilrijkstraat 1B 2650, Edegem, Belgium
    Nephrol Dial Transplant 19:i14-8. 2004
    ..Patients treated with lanthanum carbonate for 1 year did not experience any of the aluminium-like toxic effects on bone expressed as either osteomalacia or adynamic bone disease...
  38. ncbi request reprint Nephrology in the Low Countries in the 17-18th century. Frederik Ruysch, Hermann Boerhaave
    Marc E De Broe
    Department of Nephrology Hypertension, p a University Hospital, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
    Am J Nephrol 22:202-6. 2002
  39. ncbi request reprint Evolution of bone and plasma concentration of lanthanum in dialysis patients before, during 1 year of treatment with lanthanum carbonate and after 2 years of follow-up
    Goce B Spasovski
    Department of Nephrology, University Clinical Center, Vodnjanska 17, 1000 Skopje, Macedonia
    Nephrol Dial Transplant 21:2217-24. 2006
    ..Bone biopsies were performed at baseline, after 1 year of treatment and after a further 2-year follow-up period to assess the lanthanum concentration in bone and plasma...
  40. ncbi request reprint Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium
    Anja Verhulst
    Department of Nephrology Hypertension, University of Antwerp, Antwerp, Belgium
    J Am Soc Nephrol 14:107-15. 2003
    ....
  41. ncbi request reprint Hyaluronan is apically secreted and expressed by proliferating or regenerating renal tubular cells
    Marino Asselman
    Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands
    Kidney Int 68:71-83. 2005
    ..Crystal retention is a crucial early event in the etiology of kidney stones. The present study was performed to determine the polarized distribution of hyaluronan and CD44 by renal tubular cells...
  42. ncbi request reprint Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis
    Goce B Spasovski
    Department of Nephrology, Clinical Center Skopje, University of Skopje, Macedonia
    Nephrol Dial Transplant 18:1159-66. 2003
    ..Much less is known about the spectrum of ROD in end-stage renal failure (ESRF) patients not yet on dialysis...
  43. ncbi request reprint Clinical manifestations of systemic paraphenylene diamine intoxication
    Hatem Kallel
    Unit of Medical Resuscitation, CHU Habib Bourguiba, Sfax, Tunisia
    J Nephrol 18:308-11. 2005
    ..To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication...
  44. ncbi request reprint Decreased short-term renal graft survival in Maghrebian recipients
    Willem E Boer
    Department of Nephrology Hypertension, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium
    Transpl Int 15:254-8. 2002
    ..01). This study provides evidence for significantly lower short-term renal graft survival in Maghrebian recipients of a Caucasian graft. Acute rejection seems to play a major causative role in graft loss in this group...
  45. ncbi request reprint Osteopontin synthesis and localization along the human nephron
    Anja Verhulst
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    J Am Soc Nephrol 13:1210-8. 2002
    ..It is reported for the first time that intracellular OPN is located in the Golgi apparatus of both PTC and DTC and that PTC and DTC are able to produce and secrete the same OPN isoforms, in comparable amounts...
  46. ncbi request reprint Lanthanum pharmacokinetics: are rat data misleading?
    Patrick C D'Haese
    Kidney Int 68:2907-8; author reply 2908-9. 2005
  47. ncbi request reprint Dose-dependent effects of strontium on bone of chronic renal failure rats
    Iris Schrooten
    Department of Nephrology Hypertension, University of Antwerp, Belgium
    Kidney Int 63:927-35. 2003
    ..A causal role of strontium in the development of osteomalacia was established in a chronic renal failure (CRF) rat model...
  48. ncbi request reprint Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys
    Marino Asselman
    Department of Urology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Soc Nephrol 14:3155-66. 2003
    ..In conclusion, the expression of HA, OPN, and CD44 by injured/regenerating tubular cells seems to play a role in retention of crystals in the rat kidney...
  49. ncbi request reprint Incredulous effects of lanthanum?
    Stephen J P Damment
    Toxicol Lett 168:186-9. 2007