P Cras

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation
    P Cras
    Laboratory of Neuropathology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
    Acta Neuropathol 96:253-60. 1998
  2. ncbi Cerebral amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel presenilin 1 mutation
    B Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Brain 124:2383-92. 2001
  3. ncbi Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    L Hendriks
    Department of Biochemistry, Born Bunge Foundation, University of Antwerp UIA, Belgium
    Nat Genet 1:218-21. 1992
  4. ncbi Cerebrospinal fluid biomarkers in Creutzfeldt-Jakob disease
    B Van Everbroeck
    Born Bunge Foundation, Laboratory of Neurobiology, Department of Neurobiology, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Clin Neurol Neurosurg 107:355-60. 2005
  5. ncbi Eosinophilia-myalgia syndrome: a clinicopathological study of four patients
    M Villanova
    Laboratory of Neuropathology, University of Antwerp, Belgium
    Clin Neuropathol 12:201-3. 1993
  6. pmc A prospective study of CSF markers in 250 patients with possible Creutzfeldt-Jakob disease
    B Van Everbroeck
    Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium Institute of Public Health Louis Pasteur, Brussels, Belgium
    J Neurol Neurosurg Psychiatry 74:1210-4. 2003
  7. ncbi Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation
    S Kumar-Singh
    Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Neurobiol Dis 7:9-22. 2000
  8. ncbi The many faces of human prion diseases in Belgium and the world
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp UIA, Antwerp, Belgium
    Acta Neurol Belg 101:81-7. 2001
  9. ncbi Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-Jakob Disease phenotype
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Neurosci Lett 313:69-72. 2001
  10. pmc 14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias
    B R J Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation BBS, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    J Neurol Neurosurg Psychiatry 76:100-2. 2005

Detail Information

Publications23

  1. ncbi Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation
    P Cras
    Laboratory of Neuropathology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
    Acta Neuropathol 96:253-60. 1998
    ....
  2. ncbi Cerebral amyloid angiopathy is a pathogenic lesion in Alzheimer's disease due to a novel presenilin 1 mutation
    B Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Brain 124:2383-92. 2001
    ..Together, these data suggest that, like the dense-cored neuritic plaques, CAA might represent a pathogenic lesion that contributes significantly to the progressive neurodegeneration that occurs in Alzheimer's disease...
  3. ncbi Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
    L Hendriks
    Department of Biochemistry, Born Bunge Foundation, University of Antwerp UIA, Belgium
    Nat Genet 1:218-21. 1992
    ..These results suggest that the clinically distinct entities, presenile dementia and cerebral amyloid angiopathy, can be caused by the same mutation in the APP gene...
  4. ncbi Cerebrospinal fluid biomarkers in Creutzfeldt-Jakob disease
    B Van Everbroeck
    Born Bunge Foundation, Laboratory of Neurobiology, Department of Neurobiology, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Clin Neurol Neurosurg 107:355-60. 2005
    ..Unfortunately, the 14-3-3 protein has a lower sensitivity if the disease duration exceeds beyond 1 year in both sporadic CJD and other CJD types (vCJD, and specific genetic or iatrogenic CJD types)...
  5. ncbi Eosinophilia-myalgia syndrome: a clinicopathological study of four patients
    M Villanova
    Laboratory of Neuropathology, University of Antwerp, Belgium
    Clin Neuropathol 12:201-3. 1993
    ..Our findings confirm the potential importance of lymphocytes and macrophages in this syndrome. In particular, new observations are presented concerning the immunoreactivity of HLA-DR antigen...
  6. pmc A prospective study of CSF markers in 250 patients with possible Creutzfeldt-Jakob disease
    B Van Everbroeck
    Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium Institute of Public Health Louis Pasteur, Brussels, Belgium
    J Neurol Neurosurg Psychiatry 74:1210-4. 2003
    ..To investigate various cerebrospinal fluid (CSF) markers that could assist in the clinical diagnosis of Creutzfeldt-Jakob disease (CJD)...
  7. ncbi Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation
    S Kumar-Singh
    Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Neurobiol Dis 7:9-22. 2000
    ..These accelerate or impinge on the normal process of aging and amyloid deposits per se are not essential for this phenotype...
  8. ncbi The many faces of human prion diseases in Belgium and the world
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp UIA, Antwerp, Belgium
    Acta Neurol Belg 101:81-7. 2001
    ..The sporadic type of CJD was identified in 116 patients, while 4 suffered from a hereditary form. In our series, we could find no evidence for variant or iatrogenic CJD, neither for the more rare types of prion diseases...
  9. ncbi Influence of the prion protein and the apolipoprotein E genotype on the Creutzfeldt-Jakob Disease phenotype
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Neurosci Lett 313:69-72. 2001
    ..The APOE 4 allele was an independent risk factor for developing CJD. We further observed a significant dose dependent APOE 4 effect on the number and type of amyloid-beta plaques in the brain of CJD patients...
  10. pmc 14-3-3 {gamma}-isoform detection distinguishes sporadic Creutzfeldt-Jakob disease from other dementias
    B R J Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation BBS, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    J Neurol Neurosurg Psychiatry 76:100-2. 2005
    ..The gamma-isoform specific antibodies strongly improve the specificity of the immunoblot and might improve worldwide acceptance of the use of the 14-3-3 assay in the differential diagnosis of sCJD...
  11. ncbi Decreased Levels of Amyloid-beta 1-42 in Cerebrospinal Fluid of Creutzfeldt-Jakob Disease Patients
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
    J Alzheimers Dis 1:419-424. 1999
    ..No clear correlation between them was found in this series. This signifies that the deceased Abeta_1-42 levels in CSF are not just due to plaque retention but that other mechanisms must also play a role...
  12. pmc Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt-Jakob disease
    B Van Everbroeck
    Laboratory of Neurobiology and Neuropathology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
    J Neurol Neurosurg Psychiatry 73:79-81. 2002
    ....
  13. ncbi Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3
    M Cruts
    Laboratory of Neurogentics, Flemish Insitute for Biotechnology, Born Bunge Foundation, University of Antwerp, Belgium
    Hum Mol Genet 4:2363-71. 1995
    ....
  14. ncbi Gamma-enolase and glial fibrillary acidic protein in nervous system tumors. An immunohistochemical study using specific monoclonal antibodies
    P Cras
    Laboratory of Neuropathology, Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium
    Acta Neuropathol 75:377-84. 1988
    ..The advantages inherent to mAbs and a highly sensitive detection system turn GFAP stainings into a specific and readily reproducible technique...
  15. ncbi Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism
    M Villanova
    Laboratory of Neuropathology Born Bunge Foundation UlA, University of Antwerp, Belgium
    Acta Neurol Belg 94:200-4. 1994
    ..These observations suggest that the fasciitis in EMS involves a cellular rather than a humoral reaction and that complement activation could be of importance...
  16. ncbi The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease
    B Van Everbroeck
    Laboratory of Neurobiology, Born Bunge Foundation BBF, University of Antwerp UIA, Universiteitsplein 1, B 2610, Antwerp, Belgium
    Neurobiol Aging 23:59-64. 2002
    ..In conclusion, apoptotic neurons in CJD correlates to the neuropathological lesions and are probably related to the presence of inflammatory cells and cytokines which are present during the whole CJD disease process...
  17. ncbi Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies
    F W Van Leeuwen
    The Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, Amsterdam, The Netherlands
    Neurology 66:S86-92. 2006
    ..These data suggest that accumulation of +1 proteins contributes to the early stages of dementia and plays a pathogenic role in a number of diseases that involve the accumulation of tau...
  18. ncbi [The practice guideline 'Dementia' (second revision) from the Dutch College of General Practitioners]
    W R G Verslegers
    Ned Tijdschr Geneeskd 148:1843; author reply 1843-4. 2004
  19. ncbi Increased incidence of sporadic Creutzfeldt-Jakob disease in the age groups between 70 and 90 years in Belgium
    B Van Everbroeck
    Born Bunge Institute BBI, University of Antwerp UA, Campus Drie Eiken CDE, Antwerp, Belgium
    Eur J Epidemiol 21:443-7. 2006
    ..In conclusion, our study identified that in the past sCJD may have been underestimated in patients over age 70 although these patients are both clinically and neurobiochemically similar to the general sCJD phenotype...
  20. ncbi Opsoclonus-myoclonus syndrome: a clinicopathological confrontation
    J Baets
    Department of Neurology, University Hospital of Antwerp, Antwerp, Belgium
    Acta Neurol Belg 106:142-6. 2006
    ..However none of these findings seem to be pathognomonic. As for the possible therapy of OMS, several immunomodulating strategies can be used with varying success. At present there is no established standard therapy...
  21. ncbi Campylobacter jejuni-induced acute transverse myelitis
    I Baar
    Department of Neurology, University Hospital of Antwerp, Edegem, Belgium
    Spinal Cord 45:690-4. 2007
    ..Case report...
  22. doi Safety and efficacy of galantamine in subjects with mild cognitive impairment
    B Winblad
    Karolinska Institutet, Alzheimer s Disease Research Center, Division of Geriatric Medicine, Stockholm, Sweden
    Neurology 70:2024-35. 2008
    ....
  23. doi Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
    K Haugarvoll
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurology 70:1456-60. 2008
    ..Several dominantly inherited pathogenic substitutions have been identified in different domains of the Lrrk2 protein. Herein, we characterize the clinical and genetic features associated with Lrrk2 p.R1441C...