S Cichon

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi request reprint A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Hum Mol Genet 10:2933-44. 2001
  2. ncbi request reprint Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 4:76-84. 1999
  3. ncbi request reprint A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Mol Psychiatry 6:342-9. 2001
  4. ncbi request reprint A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, 53111 Bonn, Germany
    Br J Dermatol 143:811-4. 2000
  5. pmc Localization of a gene for syndactyly type 1 to chromosome 2q34-q36
    K Bosse
    Institute of Human Genetics, University of Bonn, Germany
    Am J Hum Genet 67:492-7. 2000
  6. ncbi request reprint Genetic linkage analysis with dyslexia: evidence for linkage of spelling disability to chromosome 15
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Eur Child Adolesc Psychiatry 8:56-9. 1999
  7. ncbi request reprint The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach
    A M Hillmer
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Br J Dermatol 146:601-8. 2002
  8. ncbi request reprint Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response
    Y Freudenberg-Hua
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Pharmacogenomics J 5:183-92. 2005
  9. ncbi request reprint Multiple testing in the context of haplotype analysis revisited: application to case-control data
    T Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Ann Hum Genet 69:747-56. 2005
  10. ncbi request reprint Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder
    R Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Mol Psychiatry 13:277-84. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Hum Mol Genet 10:2933-44. 2001
    ..Putative paternally imprinted loci were identified in chromosomal regions 2p24-p21 and 2q31-q32. Maternally imprinted susceptibility genes may be located on 14q32 and 16q21-q23...
  2. ncbi request reprint Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 4:76-84. 1999
    ..2 and 18q22-23 support prior evidence for susceptibility loci in these regions. The parent-of-origin effect on 18p11.2 is confirmed in our sample. The delineation of characteristics of 'either' families requires further study...
  3. ncbi request reprint A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Mol Psychiatry 6:342-9. 2001
    ..12 (P = 0.0013). Positive linkage findings that have been reported by two independent studies further support the hypothesis of a susceptibility gene for bipolar affective disorder on 10q25-q26...
  4. ncbi request reprint A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, 53111 Bonn, Germany
    Br J Dermatol 143:811-4. 2000
    ..Hypotrichosis of the Marie Unna type (HMU) is a rare autosomal dominant disorder characterized by male-pattern hair loss with childhood onset and anomalies of the hair shaft...
  5. pmc Localization of a gene for syndactyly type 1 to chromosome 2q34-q36
    K Bosse
    Institute of Human Genetics, University of Bonn, Germany
    Am J Hum Genet 67:492-7. 2000
    ..Key recombination events in affected individuals defined a 9.4-cM region between markers D2S2319 and D2S344. The identification of the responsible gene will give further insights into the molecular basis of limb development...
  6. ncbi request reprint Genetic linkage analysis with dyslexia: evidence for linkage of spelling disability to chromosome 15
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Eur Child Adolesc Psychiatry 8:56-9. 1999
    ..26 with marker D15S143 at theta = 0. A multipoint LOD score of 1.78 (p = 0.0042) was achieved with a maximum at D15S132. Thus, our results provide independent support for a dyslexia gene on the long arm of chromosome 15...
  7. ncbi request reprint The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach
    A M Hillmer
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Br J Dermatol 146:601-8. 2002
    ..The main feature of these disorders is persistent complete absence of hair at or shortly after birth. This suggests that HR is essential and specific for the development of hair...
  8. ncbi request reprint Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response
    Y Freudenberg-Hua
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Pharmacogenomics J 5:183-92. 2005
    ..Estimation of htSNPs reduces the genotyping effort required in capturing common haplotypes, for certain genes, however, this accounts for only a small fraction of haplotype diversity...
  9. ncbi request reprint Multiple testing in the context of haplotype analysis revisited: application to case-control data
    T Becker
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Ann Hum Genet 69:747-56. 2005
    ..Finally, we demonstrate the usefulness of our approach by a real data example...
  10. ncbi request reprint Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder
    R Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Mol Psychiatry 13:277-84. 2008
    ....
  11. ncbi request reprint Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach
    T Wang
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, 53111 Bonn, Germany
    Mol Psychiatry 6:109-11. 2001
    ..83, P = 0.028). Our results provide further evidence for an involvement of the COMT low-activity allele in the development of alcoholism and demonstrate the need for further studies in large samples of alcoholic patients...
  12. ncbi request reprint Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Hum Mol Genet 7:1671-9. 1998
    ..We speculate that this tissue-specific difference in the proportion of hairless transcripts lacking exon 17 sequences could contribute to the tissue-specific disease phenotype observed in individuals with isolated congenital alopecia...
  13. pmc A gene for universal congenital alopecia maps to chromosome 8p21-22
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 62:386-90. 1998
    ..This will aid future identification of the responsible gene, which will be extremely useful for the understanding of the biochemistry of hair development...
  14. ncbi request reprint Caught in the trio trap? Potential selection bias inherent to association studies using parent-offspring trios
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 105:351-3. 2001
    ..Thus, giving up case control designs for the sake of family-based association studies could be at the risk of selecting against several genetically determined factors...
  15. pmc A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3
    R C Betz
    Institute of Human Genetics, University of Bonn, D 53111 Bonn, Germany
    Am J Hum Genet 66:1979-83. 2000
    ..Localization of the locus for HSS to 6p21.3 is a first step toward identification of the gene. The gene will give important insights into the molecular and cellular basis of hair growth on the scalp...
  16. ncbi request reprint Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder
    J Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 9:203-7. 2004
    ..The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background...
  17. doi request reprint Caspase recruitment domain 15 gene haplotypes in sarcoidosis
    S Pabst
    Department of Internal Medicine II, Division of Pneumology, University of Bonn, Bonn, Germany
    Tissue Antigens 77:333-7. 2011
    ..Therefore, we can conclude that there is no association between the CARD15 gene and the development or a special phenotype of sarcoidosis in our cohort...
  18. doi request reprint Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder
    L Priebe
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Mol Psychiatry 17:421-32. 2012
    ..These data suggest that CNVs have an influence on the development of early-onset, but not later-onset BD. Our study provides further support for previous hypotheses of an etiological difference between early-onset and later-onset BD...
  19. ncbi request reprint Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33)
    S Cichon
    Institute of Human Genetics, University of Bonn, Germany
    Mol Membr Biol 15:75-8. 1998
    ..Significant linkage was obtained to genetic marker D5S2654. This localizes the HTR4 gene to human chromosome 5q31-q33...
  20. ncbi request reprint The human complement C8G gene, a member of the lipocalin gene family: polymorphisms and mapping to chromosome 9q34.3
    G Dewald
    Institute of Human Genetics, University of Bonn, Germany
    Ann Hum Genet 60:281-91. 1996
    ..Multipoint analysis placed C8G with 1000:1 support distal to D9S207. C8G is thus located at 9q34.3. Remarkably, this chromosomal region contains at least four other lipocalin genes...
  21. ncbi request reprint Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene
    S Cichon
    Institute of Human Genetics, University of Bonn, Germany
    Psychiatr Genet 5:97-103. 1995
    ..We were unable to detect the deletion in patients with schizophrenia and bipolar affective disorder, nor in healthy controls...