P E J Bols

Summary

Affiliation: University of Antwerp
Country: Belgium

Publications

  1. ncbi request reprint A comparison of a mechanical sector and a linear array transducer for ultrasound-guided transvaginal oocyte retrieval (OPU) in the cow
    P E J Bols
    Laboratory of Veterinary Physiology, Faculty of Farmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, Gebouw U, 2610 Wilrijk, Belgium
    Theriogenology 62:906-14. 2004
  2. doi request reprint Xenotransplantation in immunodeficient mice to study ovarian follicular development in domestic animals
    P E J Bols
    Laboratory of Veterinary Physiology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Theriogenology 73:740-7. 2010
  3. doi request reprint Unravelling the needs of singly in vitro-produced bovine embryos: from cumulus cell co-culture to semi-defined, oil-free culture conditions
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Reprod Fertil Dev 24:1084-92. 2012
  4. ncbi request reprint Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Reprod Fertil Dev 24:1-12. 2011
  5. doi request reprint Single in vitro bovine embryo production: coculture with autologous cumulus cells, developmental competence, embryo quality and gene expression profiles
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Wilrijk, Belgium
    Theriogenology 76:1293-303. 2011
  6. ncbi request reprint Roles of lipid peroxidation and cytoplasmic droplets on in vitro fertilization capacity of sperm collected from bovine epididymides stored at 4 and 34 degrees C
    M Nichi
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 67:334-40. 2007
  7. doi request reprint Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part I. The importance of negative energy balance and altered corpus luteum function to the reduction of oocyte and embryo quality in high-yielding dairy cows
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Reprod Domest Anim 43:612-22. 2008
  8. ncbi request reprint Quantification and viability assessment of isolated bovine primordial and primary ovarian follicles retrieved through a standardized biopsy pick-up procedure
    J M J Aerts
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Reprod Domest Anim 43:360-6. 2008
  9. doi request reprint Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights
    V Van Hoeck
    Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, Gamete Research Center, University of Antwerp, Universiteitsplein 1 Gebouw U, B 2610 Wilrijk, Belgium
    Reproduction 145:33-44. 2013
  10. ncbi request reprint Seasonal variation in semen quality in Bos indicus and Bos taurus bulls raised under tropical conditions
    M Nichi
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 66:822-8. 2006

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A comparison of a mechanical sector and a linear array transducer for ultrasound-guided transvaginal oocyte retrieval (OPU) in the cow
    P E J Bols
    Laboratory of Veterinary Physiology, Faculty of Farmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, Gebouw U, 2610 Wilrijk, Belgium
    Theriogenology 62:906-14. 2004
    ..In conclusion, both systems can be effectively used for oocyte retrieval in the cow, however, the MAP transducer demonstrated superior visualization of small follicles...
  2. doi request reprint Xenotransplantation in immunodeficient mice to study ovarian follicular development in domestic animals
    P E J Bols
    Laboratory of Veterinary Physiology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Theriogenology 73:740-7. 2010
    ..Different grafting strategies will be discussed as well as the consequences of this procedure on the viability and dynamic behavior of the grafted tissue and follicles...
  3. doi request reprint Unravelling the needs of singly in vitro-produced bovine embryos: from cumulus cell co-culture to semi-defined, oil-free culture conditions
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Reprod Fertil Dev 24:1084-92. 2012
    ..This research additionally stresses the fact that specific interaction mechanisms between somatic cells and a developing in vitro embryo are far from unravelled...
  4. ncbi request reprint Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Reprod Fertil Dev 24:1-12. 2011
    ..Finally, there is growing evidence that adverse conditions for oocyte growth and maturation may also jeopardise the health and performance of the offspring...
  5. doi request reprint Single in vitro bovine embryo production: coculture with autologous cumulus cells, developmental competence, embryo quality and gene expression profiles
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Wilrijk, Belgium
    Theriogenology 76:1293-303. 2011
    ....
  6. ncbi request reprint Roles of lipid peroxidation and cytoplasmic droplets on in vitro fertilization capacity of sperm collected from bovine epididymides stored at 4 and 34 degrees C
    M Nichi
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 67:334-40. 2007
    ..We hypothesize that this protection against ROS is one of the functions of distal sperm droplets in the epididymis...
  7. doi request reprint Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part I. The importance of negative energy balance and altered corpus luteum function to the reduction of oocyte and embryo quality in high-yielding dairy cows
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Reprod Domest Anim 43:612-22. 2008
    ..This may partly account for the low conception rates and the high incidence of early embryonic mortality in high yielding dairy cows...
  8. ncbi request reprint Quantification and viability assessment of isolated bovine primordial and primary ovarian follicles retrieved through a standardized biopsy pick-up procedure
    J M J Aerts
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Reprod Domest Anim 43:360-6. 2008
    ..We conclude that the standardized BPU procedure generates sufficiently large numbers of vital primordial and primary follicles, thus validating BPU as a new tool for research into early bovine follicular development...
  9. doi request reprint Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights
    V Van Hoeck
    Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, Gamete Research Center, University of Antwerp, Universiteitsplein 1 Gebouw U, B 2610 Wilrijk, Belgium
    Reproduction 145:33-44. 2013
    ....
  10. ncbi request reprint Seasonal variation in semen quality in Bos indicus and Bos taurus bulls raised under tropical conditions
    M Nichi
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 66:822-8. 2006
    ....
  11. doi request reprint Effect of cumulus cell coculture and oxygen tension on the in vitro developmental competence of bovine zygotes cultured singly
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 71:729-38. 2009
    ..These results were consistently achieved after acquiring experience and expertise in the handling of single zygotes...
  12. doi request reprint 85 THE EFFECT OF 17α-ETHINYL ESTRADIOL EXPOSURE OF IN VITRO-CULTURED BOVINE MORULAE ON SUBSEQUENT EMBRYONIC DEVELOPMENT AND QUALITY
    E P A Jorssen
    University of Antwerp, Gamete Research Center, Wilrijk, Belgium
    Reprod Fertil Dev 26:156. 2013
    ....
  13. doi request reprint Endocrine disruptors and female fertility: focus on (bovine) ovarian follicular physiology
    E M L Petro
    Gamete Research Center, Laboratory for Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Theriogenology 78:1887-900. 2012
    ..In this review, we explore how EDCs can interfere with the well-balanced conditions in the ovarian follicle. In addition, we highlight the bovine ovarian follicle as an alternative in vitro model for EDC and broader toxicology research...
  14. doi request reprint 94 a polarized cell-culture system to study the effects of elevated serum nonesterified Fatty Acid concentrations on the bovine oviductal microenvironment in vitro
    L Jordaens
    University of Antwerp, Wilrijk, Antwerp, Belgium
    Reprod Fertil Dev 25:195. 2012
    ..Further research should focus on transport and metabolisation of the fatty acids added...
  15. doi request reprint 181 xenotransplantation of bovine ovarian cortex in severe combined immunodeficient mice to study pre-antral follicular development: determination of the optimal graft site
    A Langbeen
    University of Antwerp, Wilrijk, Antwerp, Belgium
    Reprod Fertil Dev 25:239-40. 2012
    ....
  16. doi request reprint The effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Hum Reprod 25:768-78. 2010
    ..We aimed to induce hyperlipidaemia nutritionally and investigate the consequences of hyperlipidaemic culture conditions on bovine in vitro embryo development, embryo quality and gene expression patterns...
  17. doi request reprint Noninvasive bovine oocyte quality assessment: possibilities of a single oocyte culture
    I G F Goovaerts
    University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Veterinary Physiology, Wilrijk, Belgium
    Theriogenology 74:1509-20. 2010
    ....
  18. doi request reprint Reduced fertility in high-yielding dairy cows: are the oocyte and embryo in danger? Part II. Mechanisms linking nutrition and reduced oocyte and embryo quality in high-yielding dairy cows
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Reprod Domest Anim 43:623-32. 2008
    ..Several nutrition-linked mechanisms, through which oocyte and/or embryo quality can be affected in modern dairy cows, well after the period of NEB, are proposed and comprehensively reviewed in the present report...
  19. doi request reprint The effect of animal handling procedures on the blood non-esterified fatty acid and glucose concentrations of lactating dairy cows
    J L M R Leroy
    Laboratory for Veterinary Physiology, Department of Veterinary Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk B 2610, Belgium
    Vet J 187:81-4. 2011
    ..The findings suggest that handling lactating cows prior to blood-sampling should be minimised in order to reduce the effect on blood glucose and NEFA concentrations and possible consequent misinterpretation of the animals' energy status...
  20. doi request reprint 139 the effect of starch and saturated or polyunsaturated rich diets on in vitro bovine embryo development and quality
    V Van Hoeck
    University of Antwerp, Wilrijk, Antwerp, Belgium
    Reprod Fertil Dev 25:217. 2012
    ..Changing the fat source to polyunsaturated eliminated these negative effects. Furthermore, we showed that the order in which different fat types are fed affects the zygote's ability to sustain further development...
  21. doi request reprint Ovarian follicular dynamics. A review with emphasis on the bovine species. Part II: Antral development, exogenous influence and future prospects
    J M J Aerts
    Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    Reprod Domest Anim 45:180-7. 2010
    ..The next section expounds upon the mechanisms for exogenous modulation of follicular dynamics with the aim of superovulation/superstimulation, and finally prospective future research directions are sketched...
  22. doi request reprint Ovarian follicular dynamics: a review with emphasis on the bovine species. Part I: Folliculogenesis and pre-antral follicle development
    J M J Aerts
    Department of Veterinary Sciences, University of Antwerp, Wilrijk, Belgium
    Reprod Domest Anim 45:171-9. 2010
    ..Finally, an in-depth discussion of pre-antral follicle development engages in the current hypotheses regarding primordial follicle activation, and the role of gonadotrophins and angiogenesis...
  23. doi request reprint Nutrient prioritization in dairy cows early postpartum: mismatch between metabolism and fertility?
    J L M R Leroy
    Veterinary Centre Someren, Someren, The Netherlands
    Reprod Domest Anim 43:96-103. 2008
    ..All this, with one question in mind: is there a mismatch between metabolism and fertility and what can the dairy manager learn from research to tackle the problem of reduced fertility?..
  24. ncbi request reprint Dietary fat supplementation and the consequences for oocyte and embryo quality: hype or significant benefit for dairy cow reproduction?
    J L M R Leroy
    Gamete Research Centre, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Reprod Domest Anim 49:353-61. 2014
    ..However, to date, research results remain somewhat conflicting most probably due to differences in fat sources used, in diet and duration of supplementation and in experimental set-up in general. ..
  25. doi request reprint BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality
    S D M Valckx
    Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, 2610 Wilrijk, Belgium
    Hum Reprod 27:3531-9. 2012
    ..Is the metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment (ART) related to serum composition and BMI and is it associated with oocyte and embryo quality?..
  26. doi request reprint 5 the effect of elevated nonesterified Fatty Acid concentrations on murine in vitro folliculogenesis and subsequent oocyte developmental competence
    S Valckx
    University of Antwerp, Wilrijk, Antwerp, Belgium
    Reprod Fertil Dev 25:150. 2012
    ..Ongoing research focuses on the pathways involved...
  27. ncbi request reprint The consequences of metabolic changes in high-yielding dairy cows on oocyte and embryo quality
    J L M R Leroy
    1Laboratory for Veterinary Physiology, Department of Veterinary Sciences, Faculty of Biomedical, Pharmaceutical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Animal 2:1120-7. 2008
    ..This important observation may be linked to the typical diet provided to stimulate milk yield, or to physiological adaptations sustaining the high milk production. Research into this phenomenon is ongoing...
  28. ncbi request reprint Evaluation of epididymal semen quality using the Hamilton-Thorne analyser indicates variation between the two caudae epididymides of the same bull
    I G F Goovaerts
    Laboratory of Veterinary Physiology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, Gebouw U, B 2610 Wilrijk, Belgium
    Theriogenology 66:323-30. 2006
    ....
  29. ncbi request reprint Hormonal treatments for increasing the oocyte and embryo production in an OPU-IVP system
    S A Chaubal
    Center for Regenerative Biology, University of Connecticut, 1392 Storrs Road, Storrs, CT 06269 4243, USA
    Theriogenology 67:719-28. 2007
    ..05) available follicles for aspiration. Moreover, when ovarian stimulation in the absence of CIDR was followed by administration of LH 6h prior to OPU, it increased (P<0.05) the number of blastocysts per OPU session...
  30. ncbi request reprint Comparison of different transvaginal ovum pick-up protocols to optimise oocyte retrieval and embryo production over a 10-week period in cows
    S A Chaubal
    Center for Regenerative Biology Department of Animal Science, University of Connecticut, 1392 Storrs Rd, Storrs, CT 06269 4243, USA
    Theriogenology 65:1631-48. 2006
    ..However, the protocol that consisted of DFR, FSH treatment and a subsequent single OPU per week, was the most productive and cost-effective, with potential commercial appeal...
  31. ncbi request reprint Characterisation of low, medium and high responders following FSH stimulation prior to ultrasound-guided transvaginal oocyte retrieval in cows
    R De Roover
    Universite de Liege, Faculte de Medecine Veterinaire, Service d Obstétrique et de Pathologie de la Reproduction des ruminants, équidés et porcs, B42 Sart Tilman, B 4000 Liege, Belgium
    Theriogenology 63:1902-13. 2005
    ..Selection of animals with extreme (high or low) follicle and COC production results allows us to distinguish three populations: 'low, medium, and high responders' to FSH stimulation...
  32. ncbi request reprint Comparison of embryo quality in high-yielding dairy cows, in dairy heifers and in beef cows
    J L M R Leroy
    Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Theriogenology 64:2022-36. 2005
    ..Producing milk or not seems to be significantly associated with embryo quality. Therefore, reduced embryo quality on Day 7 following AI, could be an important factor in the subfertility problem in modern high-yielding dairy cows...
  33. ncbi request reprint Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early post partum
    J L M R Leroy
    Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Theriogenology 62:1131-43. 2004
    ....
  34. ncbi request reprint Puncture of immature ovarian follicles in bovine assisted reproduction
    P E J Bols
    Verh K Acad Geneeskd Belg 67:177-202. 2005
    ....
  35. doi request reprint Effects of ovum pick-up frequency and FSH stimulation: a retrospective study on seven years of beef cattle in vitro embryo production
    R De Roover
    Faculte de Medecine Veterinaire, Service d Obstétrique et de Pathologie de la Reproduction des ruminants, équidés et porcs, Universite de Liege, Sart Tilman, Boulevard de Colonster 20, 4000 Liege, Belgium
    Reprod Domest Anim 43:239-45. 2008
    ....
  36. ncbi request reprint Metabolite and ionic composition of follicular fluid from different-sized follicles and their relationship to serum concentrations in dairy cows
    J L M R Leroy
    Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B 9820, Belgium
    Anim Reprod Sci 80:201-11. 2004
    ....