Thierry Arnould

Summary

Affiliation: University of Namur
Country: Belgium

Publications

  1. pmc Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts
    Guillaume Van Beersel
    Laboratory of Biochemistry and Cellular Biology URBC, NAmur Research Institute for LIfe Sciences NARILIS, University of Namur FUNDP, rue de Bruxelles, 61, 5000 Namur, Belgium
    Biosci Rep 33:e00023. 2013
  2. ncbi request reprint mtCLIC is up-regulated and maintains a mitochondrial membrane potential in mtDNA-depleted L929 cells
    T Arnould
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur F U N D P, 61 rue de Bruxelles, 5000 Namur, Belgium
    FASEB J 17:2145-7. 2003
  3. pmc PGF(2alpha), a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment
    T Arnould
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Namur, Belgium
    Am J Pathol 159:345-57. 2001
  4. pmc CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation
    T Arnould
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur FUNDP, 61 rue de Bruxelles, B 5000 Namur, Belgium
    EMBO J 21:53-63. 2002
  5. ncbi request reprint CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes
    Sebastien Vankoningsloo
    Laboratory of Biochemistry and Cellular Biology, University of Namur F U N D P, rue de Bruxelles, 61, 5000 Namur, Belgium
    J Cell Sci 119:1266-82. 2006
  6. doi request reprint Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction
    Aurélia De Pauw
    Laboratory of Biochemistry and Cellular Biology, Namur Research Institute for Life Sciences, University of Namur, Belgium
    Am J Physiol Endocrinol Metab 302:E1123-41. 2012
  7. doi request reprint Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma dependent
    Silvia Tejerina
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 5000 Namur, Belgium
    J Cell Sci 122:145-55. 2009
  8. doi request reprint Gene expression silencing with 'specific' small interfering RNA goes beyond specificity - a study of key parameters to take into account in the onset of small interfering RNA off-target effects
    Sebastien Vankoningsloo
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur FUNDP, Belgium
    FEBS J 275:2738-53. 2008
  9. pmc TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells
    Lionel Flamant
    URBC NARILIS, University of Namur FUNDP, 61 rue de Bruxelles, 5000, Namur, Belgium
    BMC Cancer 12:391. 2012
  10. doi request reprint Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B
    Guillaume Rommelaere
    Laboratory of Biochemistry and Cell Biology, Faculty of Sciences, University of Namur, 61 rue de Bruxelles, Namur, Belgium
    Am J Physiol Cell Physiol 300:C1090-106. 2011

Collaborators

Detail Information

Publications31

  1. pmc Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts
    Guillaume Van Beersel
    Laboratory of Biochemistry and Cellular Biology URBC, NAmur Research Institute for LIfe Sciences NARILIS, University of Namur FUNDP, rue de Bruxelles, 61, 5000 Namur, Belgium
    Biosci Rep 33:e00023. 2013
    ..To our knowledge, our results bring the first evidence of a mechanism that links TPP-1 deficiency and oxidative stress-induced changes in mitochondrial morphology. ..
  2. ncbi request reprint mtCLIC is up-regulated and maintains a mitochondrial membrane potential in mtDNA-depleted L929 cells
    T Arnould
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur F U N D P, 61 rue de Bruxelles, 5000 Namur, Belgium
    FASEB J 17:2145-7. 2003
    ..These findings suggest that mtCLIC could be involved in mitochondrial membrane potential generation in mtDNA-depleted cells, a feature required to prevent apoptosis and to drive continuous protein import into mitochondria...
  3. pmc PGF(2alpha), a prostanoid released by endothelial cells activated by hypoxia, is a chemoattractant candidate for neutrophil recruitment
    T Arnould
    Laboratory of Biochemistry and Cellular Biology, University of Namur, Namur, Belgium
    Am J Pathol 159:345-57. 2001
    ..These results suggest that PGF(2alpha), a prostanoid abundantly released by the endothelium of hypoxic or ischemic tissues, is a chemoattractant molecule that might be involved in the early recruitment of neutrophils in ischemic organs...
  4. pmc CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation
    T Arnould
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur FUNDP, 61 rue de Bruxelles, B 5000 Namur, Belgium
    EMBO J 21:53-63. 2002
    ..Finally, our data suggest that phosphorylated CREB recruits p53 tumor suppressor protein, modifies its transcriptional activity and increases the expression of p21(Waf1/Cip1), a p53-regulated cyclin-dependent kinase inhibitor...
  5. ncbi request reprint CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes
    Sebastien Vankoningsloo
    Laboratory of Biochemistry and Cellular Biology, University of Namur F U N D P, rue de Bruxelles, 61, 5000 Namur, Belgium
    J Cell Sci 119:1266-82. 2006
    ..These results highlight a new role for CREB in the control of triglyceride metabolism during the adaptative response of preadipocytes to mitochondrial dysfunction...
  6. doi request reprint Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction
    Aurélia De Pauw
    Laboratory of Biochemistry and Cellular Biology, Namur Research Institute for Life Sciences, University of Namur, Belgium
    Am J Physiol Endocrinol Metab 302:E1123-41. 2012
    ..These results suggest a new mechanism by which the effects of mitochondrial uncoupling might limit triglyceride accumulation in adipocytes...
  7. doi request reprint Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma dependent
    Silvia Tejerina
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 5000 Namur, Belgium
    J Cell Sci 122:145-55. 2009
    ..These results highlight some new mechanisms that might potentially be involved in adipocyte de-differentiation initiated by a mitochondrial uncoupling...
  8. doi request reprint Gene expression silencing with 'specific' small interfering RNA goes beyond specificity - a study of key parameters to take into account in the onset of small interfering RNA off-target effects
    Sebastien Vankoningsloo
    Laboratoire de Biochimie et Biologie Cellulaire, University of Namur FUNDP, Belgium
    FEBS J 275:2738-53. 2008
    ..These results contribute to a better understanding of important parameters that could impact on siRNA side effects in knockdown experiments...
  9. pmc TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells
    Lionel Flamant
    URBC NARILIS, University of Namur FUNDP, 61 rue de Bruxelles, 5000, Namur, Belgium
    BMC Cancer 12:391. 2012
    ..The aim of this study was to identify new mechanisms responsible for hypoxia-induced resistance in breast cancer cells...
  10. doi request reprint Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B
    Guillaume Rommelaere
    Laboratory of Biochemistry and Cell Biology, Faculty of Sciences, University of Namur, 61 rue de Bruxelles, Namur, Belgium
    Am J Physiol Cell Physiol 300:C1090-106. 2011
    ....
  11. doi request reprint Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types
    Audrey Sermeus
    Laboratory of Biochemistry and Cellular Biology URBC, Narilis, University of Namur, Namur, Belgium
    J Cell Physiol 228:2365-76. 2013
    ..Importantly, these results evidenced that hypoxia can prevent cancer cell apoptosis by acting at different levels in the cell and that these effects are strongly cell-type dependent...
  12. ncbi request reprint Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import
    Ludovic Mercy
    Laboratory of Biochemistry and Cellular Biology, University of Namur FUNDP, Belgium
    FEBS J 272:5031-55. 2005
    ..Taken together, these results suggest that mitochondrial biogenesis is stimulated in mtDNA-depleted cells and involves a calcium-CREB signalling pathway but is associated with a reduced mitochondrial import for matrix proteins...
  13. doi request reprint Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells
    Isabelle Hamer
    URPHYM, Unite de Recherche en Physiologie Moleculaire, Laboratoire de Chimie Physiologique, Facultes Universitaires N D de la Paix, rue de Bruxelles, 61, 5000 Namur, Belgium
    Biol Cell 101:31-41. 2009
    ....
  14. doi request reprint The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells
    Laurine Mattart
    Research Unit of Cellular Biology, NARILIS Namur Research Institute for Life Sciences, University of Namur FUNDP, Namur, Belgium
    Cell Signal 24:199-213. 2012
    ....
  15. doi request reprint Hypersensitivity of A8344G MERRF mutated cybrid cells to staurosporine-induced cell death is mediated by calcium-dependent activation of calpains
    Guillaume Rommelaere
    Laboratory of Biochemistry and Cell Biology URBC, NARILIS Namur Research Institute for Life Sciences, University of Namur FUNDP, Namur, Belgium
    Int J Biochem Cell Biol 44:139-49. 2012
    ....
  16. doi request reprint Crosstalk between mitochondrial (dys)function and mitochondrial abundance
    Sébastien Michel
    Laboratory of Biochemistry and Cell Biology URBC, NARILIS Namur Research Institute for Life Sciences, University of Namur FUNDP, Namur, Belgium
    J Cell Physiol 227:2297-310. 2012
    ..In addition, mitochondrial dysfunction might also initiate a retrograde response, enabling cell adaptation through increased mitochondrial biogenesis...
  17. pmc Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types
    Audrey Sermeus
    Laboratory of Biochemistry and Cellular Biology URBC, Narilis, University of Namur FUNDP, Belgium
    PLoS ONE 7:e47519. 2012
    ..A better understanding of these cell-to-cell variations is crucial in order to overcome hypoxia-induced resistance and to ameliorate cancer therapy...
  18. pmc Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations
    Aurélia De Pauw
    Laboratory of Biochemistry and Cell Biology, University of Namur, 61 rue de Bruxelles, Namur, Belgium
    Am J Pathol 175:927-39. 2009
    ....
  19. ncbi request reprint Lipids and lysosomes
    Isabelle Hamer
    URΦM, Unite de Recherche en Physiologie Moleculaire, University of Namur FUNDP, rue de Bruxelles, 61, B 5000 Namur, Belgium
    Curr Drug Metab 13:1371-87. 2012
    ..Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity...
  20. doi request reprint Functional and morphological impact of ER stress on mitochondria
    Kayleen Vannuvel
    Laboratory of Biochemistry and Cellular Biology, URBC NARILIS, University of Namur, Namur, Belgium
    J Cell Physiol 228:1802-18. 2013
    ..Relevance and implication of these mitochondrial changes in response to ER stress conditions for human diseases such as type II diabetes and Alzheimer's disease will also be considered...
  21. doi request reprint A sensitive three-step protocol for fluorescence-based Western blot detection
    Edouard Delaive
    Laboratory of Biochemistry and Cell Biology URBC, University of Namur FUNDP, 61 rue de Bruxelles, 5000 Namur, Belgium
    J Immunol Methods 334:51-8. 2008
    ..CyDye-conjugated anti-biotin antibody did not generate any unspecific bands and led to a 30-fold increase in sensitivity, compared to detection with CyDye-conjugated secondary antibody...
  22. ncbi request reprint ERK activation upon hypoxia: involvement in HIF-1 activation
    E Minet
    Laboratoire de Biochimie et Biologie Cellulaire, Facultés Universitaires de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    FEBS Lett 468:53-8. 2000
    ..These results evidence the role of mitogen-activated protein kinase in the transcriptional response to hypoxia...
  23. ncbi request reprint Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions
    C Michiels
    Laboratory of Biochemistry and Cellular Biology, Facult es Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000, Namur, Belgium
    Biochim Biophys Acta 1497:1-10. 2000
    ....
  24. doi request reprint BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway
    Jean Philippe Cosse
    Laboratory of Biochemistry and Cellular Biology URBC, NAmur Research Institute for LIfe Science NARILIS, FUNDP University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochem Pharmacol 80:1160-9. 2010
    ....
  25. ncbi request reprint Effect of hydroxyethylrutosides on hypoxial-induced neutrophil adherence to umbilical vein endothelium
    I H Roland
    Laboratoire de Biochimie et Biologie Cellulaire, Facultes Universitaires Notre Dame de la Paix, Namur, Belgium
    Cardiovasc Drugs Ther 12:375-81. 1998
    ....
  26. ncbi request reprint Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose
    Sebastien Vankoningsloo
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 5000 Namur, Belgium
    J Lipid Res 46:1133-49. 2005
    ..Taken together, these results could explain how mitochondrial impairment leads to the multivesicular phenotype found in some mitochondria-originating diseases associated with a dysfunction in fat metabolism...
  27. pmc miR-212/132 expression and functions: within and beyond the neuronal compartment
    Anaïs Wanet
    Laboratory of Biochemistry and Cell Biology URBC, NAmur Research Institute for LIfe Sciences NARILIS, University of Namur FUNDP, 61 rue de Bruxelles, 5000 Namur, Belgium
    Nucleic Acids Res 40:4742-53. 2012
    ....
  28. ncbi request reprint Hypoxia-induced increase in intracellular calcium concentration in endothelial cells: role of the Na(+)-glucose cotransporter
    N Berna
    Laboratoire de Biochimie et Biologie Cellulaire, , 61, rue de Bruxelles, B-5000 Namur, Belgium
    J Cell Biochem 84:115-31. 2001
    ....
  29. doi request reprint Copper and myeloperoxidase-modified LDLs activate Nrf2 through different pathways of ROS production in macrophages
    Damien Calay
    Laboratory of Biochemistry and Cellular Biology, University of Namur FUNDP URBC, Namur, Belgium
    Antioxid Redox Signal 13:1491-502. 2010
    ..These data clearly suggest that results obtained until now with copper oxidized-LDLs should be carefully reevaluated, taking into consideration physiologically more relevant oxidized LDLs...
  30. ncbi request reprint Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells
    Jean Pascal Piret
    Laboratory of Biochemistry and Cellular Biology, Facultes Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, 5000 Namur, Belgium
    Biochem Pharmacol 67:611-20. 2004
    ..Taken together, these results emphasize the central role played by mitochondria in the initiation of apoptosis in HepG2 cells exposed to oxidant agents...
  31. ncbi request reprint 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity
    T Benzing
    Department of Medicine, University Hospital of Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    J Biol Chem 275:28167-72. 2000
    ..Collectively, these data indicate that phosphorylation-dependent binding of 14-3-3 may act as molecular switch that controls the GAP activity keeping a substantial fraction of RGS proteins in a dormant state...