I Weets

Summary

Affiliation: Universitair Ziekenhuis Brussel
Country: Belgium

Publications

  1. pmc Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age
    Ilse Vermeulen
    Brussels Free University, Brussels, Belgium
    Diabetes Care 34:1760-5. 2011
  2. pmc HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients
    Eric Mbunwe
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 62:1345-50. 2013
  3. ncbi request reprint The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey
    I Weets
    Diabetes Research Center, Free University Brussels, Belgium
    Diabetes Metab Res Rev 23:637-43. 2007
  4. doi request reprint Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients
    E Vandemeulebroucke
    Diabetes Research Centre, Brussels Free University, Belgium
    Diabetes Metab 35:319-27. 2009
  5. ncbi request reprint Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies
    F Winnock
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes Care 24:1181-6. 2001
  6. doi request reprint Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients
    E Vandemeulebroucke
    Diabetes Research Center, Brussels Free University VUB, 1090 Brussels, Belgium
    Diabetologia 53:36-44. 2010
  7. ncbi request reprint Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes
    I Weets
    Diabetes Research Centre, Brussels Free University, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 49:1158-62. 2006
  8. pmc Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients
    F K Gorus
    Diabetes Research Center, Brussels Free University, Brussels, Belgium
    Clin Exp Immunol 171:82-90. 2013
  9. pmc Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Clin Exp Immunol 149:243-50. 2007
  10. ncbi request reprint Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 50:2143-6. 2007

Collaborators

Detail Information

Publications22

  1. pmc Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age
    Ilse Vermeulen
    Brussels Free University, Brussels, Belgium
    Diabetes Care 34:1760-5. 2011
    ..In addition, we studied the correlation of IA-2βA and ZnT8A with other biological and demographic variables...
  2. pmc HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives of type 1 diabetic patients
    Eric Mbunwe
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 62:1345-50. 2013
    ..002). In conclusion, HLA-A*24 independently predicts rapid progression to T1D in Ab(+) relatives and complements IA-2A, ZnT8A, and HLA-DQ2/DQ8 for identifying participants in immunointervention trials...
  3. ncbi request reprint The age at diagnosis of type 1 diabetes continues to decrease in Belgian boys but not in girls: a 15-year survey
    I Weets
    Diabetes Research Center, Free University Brussels, Belgium
    Diabetes Metab Res Rev 23:637-43. 2007
    ..Preliminary Belgian data suggested that this anticipation occurred preferentially in boys. We investigated whether this gender-specific anticipation could be confirmed over a 15-year observation period...
  4. doi request reprint Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients
    E Vandemeulebroucke
    Diabetes Research Centre, Brussels Free University, Belgium
    Diabetes Metab 35:319-27. 2009
    ..We examined whether parenteral regular insulin can prevent diabetes in IA-2 antibody-positive (IA-2A+) relatives of type 1 diabetic patients, using a trial protocol that differed substantially from that of the Diabetes Prevention Trial-1...
  5. ncbi request reprint Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies
    F Winnock
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes Care 24:1181-6. 2001
    ....
  6. doi request reprint Hyperglycaemic clamp test for diabetes risk assessment in IA-2-antibody-positive relatives of type 1 diabetic patients
    E Vandemeulebroucke
    Diabetes Research Center, Brussels Free University VUB, 1090 Brussels, Belgium
    Diabetologia 53:36-44. 2010
    ....
  7. ncbi request reprint Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes
    I Weets
    Diabetes Research Centre, Brussels Free University, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 49:1158-62. 2006
    ....
  8. pmc Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients
    F K Gorus
    Diabetes Research Center, Brussels Free University, Brussels, Belgium
    Clin Exp Immunol 171:82-90. 2013
    ....
  9. pmc Identification of prediabetes in first-degree relatives at intermediate risk of type I diabetes
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Clin Exp Immunol 149:243-50. 2007
    ..Together with initially IA-2A-positive relatives these individuals qualify for standardized beta cell function tests in view of prevention trials...
  10. ncbi request reprint Adiponectin levels do not predict clinical onset of type 1 diabetes in antibody-positive relatives
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090, Brussels, Belgium
    Diabetologia 50:2143-6. 2007
    ..We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients...
  11. pmc An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age
    I Vermeulen
    Diabetes Research Center, Brussels Free University, VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 55:413-20. 2012
    ..In first-degree relatives aged under 40 years, we investigated the frequency of seroconversion to (persistent) Ab positivity, progression to diabetes and baseline characteristics of seroconverters according to age...
  12. ncbi request reprint Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index
    I Weets
    Diabetes Research Center, Free University, Brussels, Belgium
    Diabetologia 44:40-7. 2001
    ....
  13. ncbi request reprint Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes
    K Decochez
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 48:687-94. 2005
    ..We investigated whether specific combinations of immune and genetic markers can identify subgroups with more homogeneous progression to clinical onset...
  14. doi request reprint Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: impli
    J De Grijse
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 53:517-24. 2010
    ....
  15. pmc In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A*24 and HLA-B*18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions
    E Mbunwe
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 56:1964-70. 2013
    ....
  16. ncbi request reprint Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence
    I Weets
    Diabetes Research Center, Brussels Free University, Brussels, Belgium
    Diabetologia 47:614-21. 2004
    ..We investigated whether a seasonal pattern is observed at diagnosis in Belgian Type 1 diabetic patients, and if so whether seasonality varies according to age, sex and genetic risk, all known to affect the incidence of Type 1 diabetes...
  17. ncbi request reprint Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes
    I Truyen
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetologia 48:2322-9. 2005
    ..We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes...
  18. ncbi request reprint [Early diagnosis and prevention of type 1 diabetes: role of the Belgian Diabetes Registry]
    I Weets
    Registre Belge du Diabète, Avenue du Laerbeek 101, 1090 Bruxelles
    Rev Med Liege 60:306-12. 2005
    ..The detection of immune, genetic and hormonal markers allows to identify subjects at risk of rapid destruction of residual beta cells in view of their participation in prevention trials...
  19. ncbi request reprint [Preventative biology of type 1 diabetes: implications for clinical preventative studies]
    F K Gorus
    Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103 B 1090, Brussel
    Verh K Acad Geneeskd Belg 65:203-29; discussion 229-31. 2003
    ..They qualify for participation in intervention studies aiming at beta cell mass preservation. These findings have helped to prepare several prevention studies in Belgium...
  20. ncbi request reprint IA-2 autoantibodies predict impending type I diabetes in siblings of patients
    K Decochez
    Diabetes Research Centre, Free University of Brussels, Belgium
    Diabetologia 45:1658-66. 2002
    ..We compared its predictive value with that of positivity for a particular type of islet autoantibody, directed against the IA-2 antigen...
  21. ncbi request reprint To: T.J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914-921
    F K Gorus
    Diabetologia 45:288-9; author reply 289. 2002
  22. ncbi request reprint Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm
    F K Gorus
    Diabetes Research Center, Faculteit Geneeskunde en Academisch Ziekenhuis, Vrije Universiteit Brussel, Laarbeeklaan 101 103, 1090 Brussel
    Acta Clin Belg 59:1-13. 2004
    ....