Research Topics
| Bertrand TombalSummaryCountry: Belgium Publications
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Publications
Clinical judgment versus biomarker prostate cancer gene 3: which is best when determining the need for repeat prostate biopsy?Bertrand Tombal
Cliniques Universitaires Saint Luc, Institut de Recherche Clinique, Universite Catholique de Louvain, Brussels, Belgium Electronic address
Urology 81:998-1004. 2013..To assess the value of best clinical judgment (BCJ) and the prostate cancer gene 3 (PCA3) assay in guiding the decision to perform a repeat prostate biopsy (PBx) after a previous negative PBx...- Access to information and expectations of treatment decisions for prostate cancer patients--results of a European surveyB Tombal
Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium
Eur J Cancer Care (Engl) 22:210-8. 2013..Results from this survey highlight important gaps in information provision for patients with prostate cancer in terms of information supplied and patient expectations regarding treatment decisions... 
Non-metastatic CRPC and asymptomatic metastatic CRPC: which treatment for which patient?B Tombal
Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Ann Oncol 23:x251-8. 2012..The data however are mostly limited to phase II trials...
Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in BelgiumMaria E Goossens
Department of General Practice, University of Leuven, ACHG KU Leuven, Kapucijnenvoer 33, Blok J, Bus 7001, 3000 Leuven, Belgium
BMC Urol 12:8. 2012..8%). Previous epidemiological studies have consistently reported that selenium concentrations were inversely associated with the risk of bladder cancer. This suggests that selenium may also be suitable for chemoprevention of recurrence...- Biopsy and treatment decisions in the initial management of prostate cancer and the role of PCA3; a systematic analysis of expert opinionBertrand Tombal
Service d Urologie, Cliniques Universitaires Saint Luc UCL, Avenue Hippocrate, 10, 1200 Bruxelles, Belgium
World J Urol 30:251-6. 2012..This study explored the appropriateness of (1) PCA3 testing; (2) biopsy; (3) active surveillance (AS) and the value of the PCA3 Score for biopsy and AS decisions... - [Utilization of screening and treatment of prostate cancer in 2011]B Tombal
Service d Urologie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Bruxelles, Belgique
Bull Mem Acad R Med Belg 166:170-6; discussion 177. 2011..Nevertheless, there is room for an ethical approach of prostate cancer screening, based on information, correct identification of aggressive disease and early integration of new biomarkers... - Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristicsBertrand Tombal
Cliniques Universitaires Saint Luc Université Catholique de Louvain, Brussels, Belgium
Eur Urol 57:836-42. 2010..Recent data suggest prostate-specific antigen (PSA) progression may predict overall survival in prostate cancer patients... - A holistic approach to androgen deprivation therapy: treating the cancer without hurting the patientBertrand Tombal
Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Urol Int 83:373-8. 2009..Androgen deprivation therapy (ADT) for advanced prostate cancer can be associated with side effects which may negatively impact quality of life (QoL) and induce serious medical problems... - Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer?Frederic E Lecouvet
Department of Radiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Eur Urol 62:68-75. 2012..However, this two-step approach has limited sensitivity and specificity... - Magnetic resonance imaging of the axial skeleton for detecting bone metastases in patients with high-risk prostate cancer: diagnostic and cost-effectiveness and comparison with current detection strategiesFrederic E Lecouvet
Department of Radiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
J Clin Oncol 25:3281-7. 2007..To evaluate the diagnostic performance, costs, and impact on therapy of one-step magnetic resonance imaging (MRI) of the axial skeleton (MRIas) for detecting bone metastases in patients with high-risk prostate cancer (PCa)... - Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancerJean Pascal Machiels
Department of Medical Oncology and Urology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
J Clin Oncol 26:5261-8. 2008..To assess the efficacy and toxicity of the addition of estramustine to docetaxel (D) for the treatment of metastatic hormone-refractory prostate cancer... - Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancerNicolas Michoux
Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
Clin Imaging 36:308-15. 2012..Bone marrow perfusion is significantly increased in bone metastases of PCa compared to normal bone marrow. Pixel-wise kinetic modeling should be recommended to assess tumoral processes affecting bone marrow microcirculation... - Prostate cancer screening: clinical impact of WHO calibration of Beckman Coulter Access prostate-specific antigen assaysCatherine Fillee
Department of Clinical Biochemistry, Cliniques Universitaires Saint Luc, Brussels, Belgium
Clin Chem Lab Med 48:285-8. 2010..The goal of this study was to evaluate the clinical impact of using the same total prostate-specific antigen (tPSA) and free PSA (fPSA) assays calibrated with World Health Organization (WHO) materials or with Hybritech Tandem-R calibrator... - Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer?Patrice Forget
Department of Anesthesiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
Eur J Anaesthesiol 28:830-5. 2011..Some investigators have suggested that use of opioids favour relapse, whereas regional analgesia and NSAIDs improve oncological outcomes... - Expert opinion on 6-monthly luteinizing hormone-releasing hormone agonist treatment with the single-sphere depot system for prostate cancerClaude Schulman
Department of Urology, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
BJU Int 100:1-5. 2007 - [Malacoplakia in children]Benoît Debie
Service d Urologie, Cliniques Universitaires Saint Luc UCL, Bruxelles, Belgique
Prog Urol 15:511-3. 2005..The authors report a rare case of malakoplakia of the urinary bladder in a 4-year-old child, in whom the initial diagnosis was an anomaly of the urachus... - Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastasesBertrand Tombal
Division of Urology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc Brussels, Belgium
Prostate 65:178-87. 2005..There is currently no technique to image quantitatively bone metastases. Here, we assessed the value of MRI of the axial skeleton (AS-MRI) as a single step technique to quantify bone metastases and measure tumor response... - [Fournier's gangrene on ischial pressure ulcer: use of vacuum-assisted closure and therapeutic strategy]Annabelle Stainier
Service d Urologie, UCL Mont Godinne, Yvoir, Belgique
Prog Urol 17:1000-2. 2007..Vacuum-assisted closure (V.A.C.) was used in two paraplegic patients with Fournier's gangrene in a context of ischial pressure ulcer This type of dressing facilitated preparation of reconstruction... - Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomyBertrand Tombal
Division of Urology, Saint-Luc University Hospital, Brussels, Belgium
Prostate 56:163-70. 2003..CONCLUSIONS: These preliminary results suggest that RT-PCR detection of prostate cells in blood of patients after RP correlates with rapidly progressing biochemical failure after RP... - Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomyBertrand Tombal
Division of Urology, , Brussels, Belgium
Urology 59:256-60. 2002..314) and in multivariate analysis (Wald statistic 0.2 for P = 0.97). CONCLUSIONS: These results suggest that the F/T PSA ratio is not helpful for the prediction of organ-confined disease and PSA recurrence after radical prostatectomy...