Bertrand Tombal

Summary

Country: Belgium

Publications

  1. doi request reprint Clinical judgment versus biomarker prostate cancer gene 3: which is best when determining the need for repeat prostate biopsy?
    Bertrand Tombal
    Cliniques Universitaires Saint Luc, Institut de Recherche Clinique, Universite Catholique de Louvain, Brussels, Belgium
    Urology 81:998-1004. 2013
  2. doi request reprint Access to information and expectations of treatment decisions for prostate cancer patients--results of a European survey
    B Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium
    Eur J Cancer Care (Engl) 22:210-8. 2013
  3. ncbi request reprint Non-metastatic CRPC and asymptomatic metastatic CRPC: which treatment for which patient?
    B Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Ann Oncol 23:x251-8. 2012
  4. pmc Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in Belgium
    Maria E Goossens
    Department of General Practice, University of Leuven, ACHG KU Leuven, Kapucijnenvoer 33, Blok J, Bus 7001, 3000 Leuven, Belgium
    BMC Urol 12:8. 2012
  5. doi request reprint Biopsy and treatment decisions in the initial management of prostate cancer and the role of PCA3; a systematic analysis of expert opinion
    Bertrand Tombal
    Service d Urologie, Cliniques Universitaires Saint Luc UCL, Avenue Hippocrate, 10, 1200 Bruxelles, Belgium
    World J Urol 30:251-6. 2012
  6. ncbi request reprint [Utilization of screening and treatment of prostate cancer in 2011]
    B Tombal
    Service d Urologie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Bruxelles, Belgique
    Bull Mem Acad R Med Belg 166:170-6; discussion 177. 2011
  7. doi request reprint Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics
    Bertrand Tombal
    Cliniques Universitaires Saint Luc Université Catholique de Louvain, Brussels, Belgium
    Eur Urol 57:836-42. 2010
  8. doi request reprint A holistic approach to androgen deprivation therapy: treating the cancer without hurting the patient
    Bertrand Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Urol Int 83:373-8. 2009
  9. doi request reprint Tumor associated antigen PRAME is a marker of favorable prognosis in childhood acute myeloid leukemia patients and modifies the expression of S100A4, Hsp 27, p21, IL-8 and IGFBP-2 in vitro and in vivo
    Nicolas Tajeddine
    Laboratory of Cell Physiology, Universite Catholique de Louvain, Brussels, Belgium
    Leuk Lymphoma 49:1123-31. 2008
  10. doi request reprint One-step TNM staging of high-risk prostate cancer using magnetic resonance imaging (MRI): Toward an upfront simplified "all-in-one" imaging approach?
    Vasiliki Pasoglou
    Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique IREC, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Prostate 74:469-77. 2014

Collaborators

Detail Information

Publications31

  1. doi request reprint Clinical judgment versus biomarker prostate cancer gene 3: which is best when determining the need for repeat prostate biopsy?
    Bertrand Tombal
    Cliniques Universitaires Saint Luc, Institut de Recherche Clinique, Universite Catholique de Louvain, Brussels, Belgium
    Urology 81:998-1004. 2013
    ..To assess the value of best clinical judgment (BCJ) and the prostate cancer gene 3 (PCA3) assay in guiding the decision to perform a repeat prostate biopsy (PBx) after a previous negative PBx...
  2. doi request reprint Access to information and expectations of treatment decisions for prostate cancer patients--results of a European survey
    B Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium
    Eur J Cancer Care (Engl) 22:210-8. 2013
    ..Results from this survey highlight important gaps in information provision for patients with prostate cancer in terms of information supplied and patient expectations regarding treatment decisions...
  3. ncbi request reprint Non-metastatic CRPC and asymptomatic metastatic CRPC: which treatment for which patient?
    B Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Ann Oncol 23:x251-8. 2012
    ..The data however are mostly limited to phase II trials...
  4. pmc Designing the selenium and bladder cancer trial (SELEBLAT), a phase lll randomized chemoprevention study with selenium on recurrence of bladder cancer in Belgium
    Maria E Goossens
    Department of General Practice, University of Leuven, ACHG KU Leuven, Kapucijnenvoer 33, Blok J, Bus 7001, 3000 Leuven, Belgium
    BMC Urol 12:8. 2012
    ..8%). Previous epidemiological studies have consistently reported that selenium concentrations were inversely associated with the risk of bladder cancer. This suggests that selenium may also be suitable for chemoprevention of recurrence...
  5. doi request reprint Biopsy and treatment decisions in the initial management of prostate cancer and the role of PCA3; a systematic analysis of expert opinion
    Bertrand Tombal
    Service d Urologie, Cliniques Universitaires Saint Luc UCL, Avenue Hippocrate, 10, 1200 Bruxelles, Belgium
    World J Urol 30:251-6. 2012
    ..This study explored the appropriateness of (1) PCA3 testing; (2) biopsy; (3) active surveillance (AS) and the value of the PCA3 Score for biopsy and AS decisions...
  6. ncbi request reprint [Utilization of screening and treatment of prostate cancer in 2011]
    B Tombal
    Service d Urologie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Bruxelles, Belgique
    Bull Mem Acad R Med Belg 166:170-6; discussion 177. 2011
    ..Nevertheless, there is room for an ethical approach of prostate cancer screening, based on information, correct identification of aggressive disease and early integration of new biomarkers...
  7. doi request reprint Additional analysis of the secondary end point of biochemical recurrence rate in a phase 3 trial (CS21) comparing degarelix 80 mg versus leuprolide in prostate cancer patients segmented by baseline characteristics
    Bertrand Tombal
    Cliniques Universitaires Saint Luc Université Catholique de Louvain, Brussels, Belgium
    Eur Urol 57:836-42. 2010
    ..Recent data suggest prostate-specific antigen (PSA) progression may predict overall survival in prostate cancer patients...
  8. doi request reprint A holistic approach to androgen deprivation therapy: treating the cancer without hurting the patient
    Bertrand Tombal
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Urol Int 83:373-8. 2009
    ..Androgen deprivation therapy (ADT) for advanced prostate cancer can be associated with side effects which may negatively impact quality of life (QoL) and induce serious medical problems...
  9. doi request reprint Tumor associated antigen PRAME is a marker of favorable prognosis in childhood acute myeloid leukemia patients and modifies the expression of S100A4, Hsp 27, p21, IL-8 and IGFBP-2 in vitro and in vivo
    Nicolas Tajeddine
    Laboratory of Cell Physiology, Universite Catholique de Louvain, Brussels, Belgium
    Leuk Lymphoma 49:1123-31. 2008
    ..Our results suggest that the favorable prognosis of PRAME could be mediated, at least in part, by the modified expression of those genes...
  10. doi request reprint One-step TNM staging of high-risk prostate cancer using magnetic resonance imaging (MRI): Toward an upfront simplified "all-in-one" imaging approach?
    Vasiliki Pasoglou
    Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique IREC, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Prostate 74:469-77. 2014
    ..Whole-body MRI (wbMRI) has shown capabilities for metastatic screening. This study assesses the feasibility and value of an all-in-one AJCC TNM staging of PCa during a unique MRI session combining mpMRI and wbMRI...
  11. doi request reprint Novel imaging techniques reshape the landscape in high-risk prostate cancers
    Frederic E Lecouvet
    Radiology Department, Cliniques Universitaires Saint Luc, Institut de Recherche Clinique, Centre du Cancer, Universite Catholique de Louvain, Brussels, Belgium
    Curr Opin Urol 23:323-30. 2013
    ..Implementing these strategies requires an exhaustive assessment of metastatic spread. This review addresses the latest development in integrated imaging techniques...
  12. ncbi request reprint Assessment of the transcriptional activity of p53 improves the prediction of recurrence in superficial transitional cell carcinoma of the bladder
    Anne France Dekairelle
    Laboratory of Applied Molecular Technologies, Center for Human Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Clin Cancer Res 11:4724-32. 2005
    ..To investigate the value of p53 functional analysis of separated alleles in yeast (FASAY) as a witness of p53/p21 pathway alteration and as a predictor of recurrence in superficial transitional cell carcinomas...
  13. ncbi request reprint [Malacoplakia in children]
    Benoît Debie
    Service d Urologie, Cliniques Universitaires Saint Luc UCL, Bruxelles, Belgique
    Prog Urol 15:511-3. 2005
    ..The authors report a rare case of malakoplakia of the urinary bladder in a 4-year-old child, in whom the initial diagnosis was an anomaly of the urachus...
  14. doi request reprint Androgen deprivation and androgen receptor competition by bicalutamide induce autophagy of hormone-resistant prostate cancer cells and confer resistance to apoptosis
    Benoît Boutin
    Laboratory of Cell Physiology, Universite Catholique de Louvain, Brussels, Belgium
    Prostate 73:1090-102. 2013
    ..Although autophagy confers chemoresistance in some cancers, its role in the development of HRPCa remains unknown...
  15. doi request reprint Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer?
    Frederic E Lecouvet
    Department of Radiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur Urol 62:68-75. 2012
    ..However, this two-step approach has limited sensitivity and specificity...
  16. ncbi request reprint Prognostic value of circulating prostate cells in patients with a rising PSA after radical prostatectomy
    Bertrand Tombal
    Division of Urology, Saint Luc University Hospital, Brussels, Belgium
    Prostate 56:163-70. 2003
    ..e., PSA) recurrence. In the present study, we assess the value of RT-PCR detection circulating prostate cells in blood of patients with a rising PSA...
  17. ncbi request reprint Magnetic resonance imaging of the axial skeleton for detecting bone metastases in patients with high-risk prostate cancer: diagnostic and cost-effectiveness and comparison with current detection strategies
    Frederic E Lecouvet
    Department of Radiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    J Clin Oncol 25:3281-7. 2007
    ..To evaluate the diagnostic performance, costs, and impact on therapy of one-step magnetic resonance imaging (MRI) of the axial skeleton (MRIas) for detecting bone metastases in patients with high-risk prostate cancer (PCa)...
  18. doi request reprint Neutrophil:lymphocyte ratio and intraoperative use of ketorolac or diclofenac are prognostic factors in different cohorts of patients undergoing breast, lung, and kidney cancer surgery
    Patrice Forget
    Department of Anesthesiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Ann Surg Oncol 20:S650-60. 2013
    ..In cancer, nonsteroidal anti-inflammatory drugs (NSAIDs) could be of interest. We investigated the prognostic significance of NLR and the impact of intraoperative NSAIDs in cancer surgeries...
  19. doi request reprint Evaluation of DCE-MRI postprocessing techniques to assess metastatic bone marrow in patients with prostate cancer
    Nicolas Michoux
    Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Clin Imaging 36:308-15. 2012
    ..Bone marrow perfusion is significantly increased in bone metastases of PCa compared to normal bone marrow. Pixel-wise kinetic modeling should be recommended to assess tumoral processes affecting bone marrow microcirculation...
  20. ncbi request reprint Preservation of RNA for functional analysis of separated alleles in yeast: comparison of snap-frozen and RNALater solid tissue storage methods
    Anne France Dekairelle
    Centre for Applied Molecular Technology, Universite Catholique de Louvain, Brussels, Belgium
    Clin Chem Lab Med 45:1283-7. 2007
    ..The aim of the present study was to compare RNALater with the usual method of liquid nitrogen snap freezing as a surrogate mRNA preservation method for functional analysis of separated alleles in yeast (FASAY)...
  21. doi request reprint Does genotyping of risk-associated single nucleotide polymorphisms improve patient selection for prostate biopsy when combined with a prostate cancer risk calculator?
    Valentina Butoescu
    Service d Urologie, Institut de Recherche Expérimentale et Clinique IREC, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Prostate 74:365-71. 2014
    ..This study aimed to evaluate whether published SNPs improve the performance of a clinical risk-calculator in predicting prostate biopsy result...
  22. ncbi request reprint Prospective randomized evaluation of emergency extracorporeal shock wave lithotripsy (ESWL) on the short-time outcome of symptomatic ureteral stones
    Bertrand Tombal
    Service d Urologie, UCL Saint Luc, Avenue Hippocrate, 10, B 1200 Brussels, Belgium
    Eur Urol 47:855-9. 2005
    ..Here, we report the results of a randomized controlled trial (RCT) assessing the efficacy of emergency ESWL (eESWL) on the short-term outcome of symptomatic ureteral stones...
  23. doi request reprint Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer?
    Patrice Forget
    Department of Anesthesiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Anaesthesiol 28:830-5. 2011
    ..Some investigators have suggested that use of opioids favour relapse, whereas regional analgesia and NSAIDs improve oncological outcomes...
  24. ncbi request reprint Magnetic resonance imaging of the axial skeleton enables objective measurement of tumor response on prostate cancer bone metastases
    Bertrand Tombal
    Division of Urology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc Brussels, Belgium
    Prostate 65:178-87. 2005
    ..There is currently no technique to image quantitatively bone metastases. Here, we assessed the value of MRI of the axial skeleton (AS-MRI) as a single step technique to quantify bone metastases and measure tumor response...
  25. ncbi request reprint Expert opinion on 6-monthly luteinizing hormone-releasing hormone agonist treatment with the single-sphere depot system for prostate cancer
    Claude Schulman
    Department of Urology, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
    BJU Int 100:1-5. 2007
  26. doi request reprint Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer
    Jean Pascal Machiels
    Department of Medical Oncology and Urology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Clin Oncol 26:5261-8. 2008
    ..To assess the efficacy and toxicity of the addition of estramustine to docetaxel (D) for the treatment of metastatic hormone-refractory prostate cancer...
  27. doi request reprint Prostate cancer screening: clinical impact of WHO calibration of Beckman Coulter Access prostate-specific antigen assays
    Catherine Fillee
    Department of Clinical Biochemistry, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Clin Chem Lab Med 48:285-8. 2010
    ..The goal of this study was to evaluate the clinical impact of using the same total prostate-specific antigen (tPSA) and free PSA (fPSA) assays calibrated with World Health Organization (WHO) materials or with Hybritech Tandem-R calibrator...
  28. ncbi request reprint [Rupture of the renal artery and renal parenchyma in a pregnant woman with vascular form of Ehlers-Danlos syndrome]
    Benoît Debie
    Service d Urologie, Cliniques Universitaires UCL Saint Luc, Bruxelles, Belgique
    Prog Urol 15:303-5. 2005
    ..Magnetic resonance imaging is useful in this setting to elucidate complex cases of renal colic in pregnant women presenting an increased risk of ischaemic or haemorrhagic disorders...
  29. ncbi request reprint [Fournier's gangrene on ischial pressure ulcer: use of vacuum-assisted closure and therapeutic strategy]
    Annabelle Stainier
    Service d Urologie, UCL Mont Godinne, Yvoir, Belgique
    Prog Urol 17:1000-2. 2007
    ..Vacuum-assisted closure (V.A.C.) was used in two paraplegic patients with Fournier's gangrene in a context of ischial pressure ulcer This type of dressing facilitated preparation of reconstruction...
  30. ncbi request reprint Tumor-associated antigen preferentially expressed antigen of melanoma (PRAME) induces caspase-independent cell death in vitro and reduces tumorigenicity in vivo
    Nicolas Tajeddine
    Laboratory of Cell Physiology, Center for Human Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 65:7348-55. 2005
    ..We suggest that all these observations might explain the favorable prognosis of the leukemias expressing high levels of PRAME...
  31. ncbi request reprint Free/total PSA ratio does not improve prediction of pathologic stage and biochemical recurrence after radical prostatectomy
    Bertrand Tombal
    Division of Urology, Universite Catholique de Louvain, Brussels, Belgium
    Urology 59:256-60. 2002
    ..In addition, its ability to predict biochemical recurrence after radical prostatectomy has not yet been reported...