Jean Paul Thissen

Summary

Country: Belgium

Publications

  1. ncbi Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture
    J P Thissen
    Unite de Diabetologie et Nutrition, School of Medicine, University of Louvain, Brussels, Belgium
    Endocrinology 138:1078-84. 1997
  2. ncbi Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes
    Mischael Dehoux
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Endocrinology 145:4806-12. 2004
  3. ncbi IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA
    Mischael Dehoux
    Division of Diabetology and Nutrition, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 292:E145-50. 2007
  4. ncbi Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha
    Laura Fernández-Celemín
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 283:E1279-90. 2002
  5. ncbi Impairment of liver GH receptor signaling by fasting
    Váronique Beauloye
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 143:792-800. 2002
  6. ncbi Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, 1200 Brussels, Belgium
    Heart Vessels 27:202-7. 2012
  7. ncbi Gene therapy with anabolic growth factors to prevent muscle atrophy
    Olivier Schakman
    Department of Diabetology and Nutrition, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 9:207-13. 2006
  8. ncbi Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
  9. ncbi Creatine increases IGF-I and myogenic regulatory factor mRNA in C(2)C(12) cells
    Magali Louis
    Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Place Pierre de Coubertin 1, B 1348 Louvain la Neuve, Belgium
    FEBS Lett 557:243-7. 2004
  10. ncbi Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin
    Hélène Gilson
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, 54 Ave Hippocrate, B 1200, Brussels, Belgium
    Am J Physiol Endocrinol Metab 297:E157-64. 2009

Collaborators

  • O Schakman
  • Luc Bertrand
  • Damien Gruson
  • Corinne Grangette
  • Karen P Scott
  • Magali Louis
  • Sophie Gerkens
  • Hélène Gilson
  • Didier Attaix
  • Michael J Rennie
  • Mischael Dehoux
  • Laure B Bindels
  • Jean-Marie Ketelslegers
  • Pascale Lause
  • Jean Marie Ketelslegers
  • Louise Deldicque
  • Nevi Pasko
  • Laura Fernández-Celemín
  • Bonaventure L Awede
  • Váronique Beauloye
  • Evelyne M Dewulf
  • Fabienne De Backer
  • Pedro Buc Calderon
  • Patrice D Cani
  • Audrey M Neyrinck
  • Julien Verrax
  • Jennifer C Martin
  • L Fernández-Celemín
  • Barbara D Pachikian
  • Florence M Sohet
  • Bruno Pot
  • Nathalie M Delzenne
  • Raphael Beck
  • Catherine Gobier
  • Marc Francaux
  • Daniel Theisen
  • Henri Nielens
  • Ronald Van Beneden
  • Josiane Verniers
  • Louis Underwood
  • Jean Lebacq
  • Stuart J Frank
  • Marc Edery
  • Bertrand Willems
  • Virginie de Coninck
  • Valerie Blomart

Detail Information

Publications21

  1. ncbi Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture
    J P Thissen
    Unite de Diabetologie et Nutrition, School of Medicine, University of Louvain, Brussels, Belgium
    Endocrinology 138:1078-84. 1997
    ..These findings suggest that decreased circulating IGF-I, in response to infection and trauma, may be caused by a direct effect of cytokines at the hepatocyte level...
  2. ncbi Role of the insulin-like growth factor I decline in the induction of atrogin-1/MAFbx during fasting and diabetes
    Mischael Dehoux
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Endocrinology 145:4806-12. 2004
    ..We conclude that IGF-I inhibits atrogin-1/MAFbx expression and speculate that this effect might contribute to the antiproteolytic action of IGF-I in muscle...
  3. ncbi IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA
    Mischael Dehoux
    Division of Diabetology and Nutrition, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 292:E145-50. 2007
    ..Our study suggests therefore that factors other than IGF-I decrease are responsible for the muscle atrophy caused by proinflammatory cytokines...
  4. ncbi Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha
    Laura Fernández-Celemín
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 283:E1279-90. 2002
    ..Taken together, our data suggest that TNF-alpha induced in muscle after LPS injection can locally inhibit IGF-I expression. The inhibition of muscle IGF-I production could contribute to the catabolic effect of TNF-alpha...
  5. ncbi Impairment of liver GH receptor signaling by fasting
    Váronique Beauloye
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 143:792-800. 2002
    ..In conclusion, the GH resistance induced by fasting is associated with impairment of the JAK-STAT signaling pathway. This might contribute to the decrease in liver IGF-I production observed in fasting...
  6. ncbi Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Tour Claude Bernard, 54 Avenue Hippocrate, 1200 Brussels, Belgium
    Heart Vessels 27:202-7. 2012
    ..Furthermore, the pharmacological blockade of UCN receptors was able to prevent UCN-induced hypertrophy, which leads to inhibition of the Akt/GSK-3β pathway...
  7. ncbi Gene therapy with anabolic growth factors to prevent muscle atrophy
    Olivier Schakman
    Department of Diabetology and Nutrition, Catholic University of Louvain, Brussels, Belgium
    Curr Opin Clin Nutr Metab Care 9:207-13. 2006
    ..Despite recent better understanding of the metabolic and molecular derangements leading to muscle wasting, therapy of muscle atrophy still has a poor success rate...
  8. ncbi Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
    ..This effect was associated with a twofold increase of Mstn gene expression. We have established for the first time that the two hypertrophic peptides UII and UCN stimulate the expression of Mstn...
  9. ncbi Creatine increases IGF-I and myogenic regulatory factor mRNA in C(2)C(12) cells
    Magali Louis
    Département d Education Physique et de Réadaptation, Universite Catholique de Louvain, Place Pierre de Coubertin 1, B 1348 Louvain la Neuve, Belgium
    FEBS Lett 557:243-7. 2004
    ..Our results suggest therefore that creatine-induced hypertrophy of C(2)C(12) cells is at least partially mediated by overexpression of IGF-I and MRFs...
  10. ncbi Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin
    Hélène Gilson
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, 54 Ave Hippocrate, B 1200, Brussels, Belgium
    Am J Physiol Endocrinol Metab 297:E157-64. 2009
    ..In conclusion, our results show that satellite cell proliferation and both Mstn and Act inhibition are involved in the FS-induced muscle hypertrophy...
  11. ncbi Interleukin-6 stimulates hepatic insulin-like growth factor binding protein-4 messenger ribonucleic acid and protein
    L Fernández-Celemín
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, 54 B 1200 Brussels, Belgium
    Endocrinology 142:241-8. 2001
    ..05). In conclusion, our results show that IL-6 stimulates hepatic IGFBP-4 gene expression and production in vitro and in vivo, thereby suggesting another mechanism by which cytokines could control IGF-I action...
  12. ncbi Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model
    Laure B Bindels
    Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    PLoS ONE 7:e37971. 2012
    ..Altogether, these results suggest that the gut microbiota could constitute a novel therapeutic target in the management of leukemia-associated inflammation and related disorders in the muscle...
  13. ncbi Comparison of three instruments assessing the quality of economic evaluations: a practical exercise on economic evaluations of the surgical treatment of obesity
    Sophie Gerkens
    School of Public Health Unité de Socioéconomie de la santé SESA, Universite Catholique de Louvain, Brussels, Belgium
    Int J Technol Assess Health Care 24:318-25. 2008
    ..The analysis was based on a practical exercise on economic evaluations of the surgical treatment of obesity...
  14. ncbi Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats
    O Schakman
    Universite Catholique de Louvain, School of Medicine, Diabetes and Nutrition Unit, B 1200 Bruxelles, Belgium
    Endocrinology 149:3900-8. 2008
    ..In conclusion, this work indicates that Akt, GSK-3beta, and beta-catenin probably contribute together to the IGF-I anti-atrophic effect in GC-induced muscle atrophy...
  15. ncbi Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats
    O Schakman
    , , 54 Avenue Hippocrate, B-1200 Brussels, Belgium
    Endocrinology 146:1789-97. 2005
    ..Our observation supports the important role of decreased muscle IGF-I in the muscle atrophy caused by glucocorticoids...
  16. ncbi Mechanisms of glucocorticoid-induced myopathy
    O Schakman
    Unite de Diabetologie et Nutrition, Faculte de Medecine, Universite Catholique de Louvain, 54 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Endocrinol 197:1-10. 2008
    ..Promising new therapeutic approaches for treating glucocorticoid-induced muscle atrophy are also presented in this review...
  17. ncbi Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy
    H Gilson
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Endocrinology 148:452-60. 2007
    ....
  18. ncbi Mechanisms of muscle atrophy induced by glucocorticoids
    O Schakman
    Unite de Diabetologie et Nutrition, Universite Catholique de Louvain, Brussels, Belgium
    Horm Res 72:36-41. 2009
    ..CONCLUSIONS: Recent progress in understanding the role of growth factors in GC-induced muscle atrophy allows investigation into new therapies to minimize this myopathy...
  19. ncbi Role of IGF-I and IGFBPs in the changes of mass and phenotype induced in rat soleus muscle by clenbuterol
    Bonaventure L Awede
    , , 1200 Brussels, Belgium
    Am J Physiol Endocrinol Metab 282:E31-7. 2002
    ..These data show that muscle hypertrophy induced by clenbuterol is associated with a local increase in muscle IGF-I content. They suggest that clenbuterol-induced muscle hypertrophy could be mediated by local production of IGF-I...
  20. ncbi Towards an understanding of molecular mechanisms of muscle atrophy
    Jean-Paul Thissen
    Curr Opin Clin Nutr Metab Care 8:245-7; discussion 271-5. 2005
  21. ncbi Increased IGF mRNA in human skeletal muscle after creatine supplementation
    Louise Deldicque
    Department of Physical Education and Rehabilitation, Faculty of Medicine, Catholic University of Louvain, Louvain-la-Neuve, Belgium
    Med Sci Sports Exerc 37:731-6. 2005
    ..CONCLUSION: The increase in lean body mass often reported after creatine supplementation could be mediated by signaling pathway(s) involving IGF and 4E-BP1...