Claude Szpirer

Summary

Country: Belgium

Publications

  1. ncbi Mammary cancer susceptibility: human genes and rodent models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Rue Profs Jeener and Brachet, 12, B 6041, Gosselies Charleroi, Belgium
    Mamm Genome 18:817-31. 2007
  2. ncbi Rat gene mapping in the post-genome sequencing era: the continued utility of cell hybrids to localize rat genes (Cks2, Ephb4, Fabp5, Il13ra1, Rpl10, Ssr4)
    C Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Cytogenet Genome Res 116:61-4. 2007
  3. ncbi Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development
    Géraldine Piessevaux
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12, 6041, Gosselies, Belgium
    Mamm Genome 20:43-52. 2009
  4. ncbi Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci
    Virginie Lella
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 121:1738-43. 2007
  5. ncbi Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
    Christelle De Mees
    Universite Libre de Bruxelles, IBMM, Laboratoire de Biologie du Developpement, Rue Pr Jeener and Brachet 12, B 6041 Gosselies Charleroi, Belgium
    Mol Cell Biol 26:2012-8. 2006
  6. ncbi A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility
    Sophie Biver
    Universite Libre De Bruxelles U L B, Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Developpement, Gosselies, Belgium
    Nature 456:339-43. 2008
  7. ncbi Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
    Anthony Rongvaux
    Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 181:4685-95. 2008
  8. ncbi Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility
    Philippe Gabant
    Laboratoire de Biologie du Développement and Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, 12 Rue Profs Jeneer et Brachet, B 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 99:12865-70. 2002
  9. ncbi Cancer research in rat models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Charleroi, Belgium
    Methods Mol Biol 597:445-58. 2010
  10. ncbi Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility
    Daniel Stieber
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 120:1678-83. 2007

Collaborators

  • Carsten A Wagner
  • Fabienne Andris
  • Julie Bakker
  • Olivier Devuyst
  • Jose Russo
  • Josiane Szpirer
  • Daniel Stieber
  • Christelle De Mees
  • Michèle Rivière
  • Géraldine Piessevaux
  • Thierry Van Reeth
  • Virginie Lella
  • Pascale Van Vooren
  • Philippe Gabant
  • Jean Francois Laes
  • Xiaojiang Quan
  • Pierre Drèze
  • Valérie Hertveldt
  • Sophie Biver
  • Anthony Rongvaux
  • Johan Smitz
  • Oberdan Leo
  • Fabrice Bureau
  • Hendrica Belge
  • Pascal Houillier
  • Sébastien Denanglaire
  • Anna Maria Marini
  • Soline Bourgeois
  • Sophie Scohy
  • Marta Nowik
  • Stephane Louryan
  • Mara Galli
  • Frédéric Van Gool
  • Pierre L Drèze
  • Michel Georges
  • Frédéric Farnir
  • Wouter Coppieters
  • Benoit Hennuy
  • Dirk Wedekind
  • Lesley Forrester
  • Henri Alexandre
  • Jennifer Nichols
  • Alistair Watt
  • Bernard Pajack

Detail Information

Publications14

  1. ncbi Mammary cancer susceptibility: human genes and rodent models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Rue Profs Jeener and Brachet, 12, B 6041, Gosselies Charleroi, Belgium
    Mamm Genome 18:817-31. 2007
    ....
  2. ncbi Rat gene mapping in the post-genome sequencing era: the continued utility of cell hybrids to localize rat genes (Cks2, Ephb4, Fabp5, Il13ra1, Rpl10, Ssr4)
    C Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Cytogenet Genome Res 116:61-4. 2007
    ..On the basis of the sample we examined, it thus appears that a classical gene mapping method is still required to localize about 3% of the rat genes, as if 3% of the rat gene sequences were lacking in the current rat genome sequence...
  3. ncbi Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development
    Géraldine Piessevaux
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12, 6041, Gosselies, Belgium
    Mamm Genome 20:43-52. 2009
    ..On Chr 5, Pla2g2a is subject to a syntenic control while expression of the Tp53 (Chr 10) and Pmai1/Noxa (Chr 18) genes appears to be controlled by several mammary cancer resistance QTLs...
  4. ncbi Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci
    Virginie Lella
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 121:1738-43. 2007
    ..These 2 traits are thus associated, supporting the hypothesis that there might be a cause-effect relationship between precocious mammary differentiation and cancer resistance...
  5. ncbi Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
    Christelle De Mees
    Universite Libre de Bruxelles, IBMM, Laboratoire de Biologie du Developpement, Rue Pr Jeener and Brachet 12, B 6041 Gosselies Charleroi, Belgium
    Mol Cell Biol 26:2012-8. 2006
    ..These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation...
  6. ncbi A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility
    Sophie Biver
    Universite Libre De Bruxelles U L B, Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Developpement, Gosselies, Belgium
    Nature 456:339-43. 2008
    ..We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract...
  7. ncbi Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
    Anthony Rongvaux
    Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 181:4685-95. 2008
    ..Collectively, these data demonstrate that Nampt participates in cellular resistance to genotoxic/oxidative stress, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation...
  8. ncbi Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility
    Philippe Gabant
    Laboratoire de Biologie du Développement and Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, 12 Rue Profs Jeneer et Brachet, B 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 99:12865-70. 2002
    ..Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation...
  9. ncbi Cancer research in rat models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Charleroi, Belgium
    Methods Mol Biol 597:445-58. 2010
    ....
  10. ncbi Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility
    Daniel Stieber
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 120:1678-83. 2007
    ..5 Mb. This analysis points to limited regions that could harbor the causative genes and also indicates that at least Mcstm2 is a novel QTL...
  11. ncbi The development of several organs and appendages is impaired in mice lacking Sp6
    Valérie Hertveldt
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Dev Dyn 237:883-92. 2008
    ..In conclusion, this work indicates that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis...
  12. ncbi Alpha-fetoprotein: from a diagnostic biomarker to a key role in female fertility
    Christelle De Mees
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12 B 6041 Gosselies Charleroi, Belgium
    Biomark Insights 1:82-5. 2007
    ..AFP sequestrates estrogens and by so doing protects the female developing brain from deleterious (defeminizing/masculinizing) effects of these hormones...
  13. ncbi Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat
    Xiaojiang Quan
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, Gosselies, B 6041, Belgium
    Mamm Genome 17:310-21. 2006
    ....
  14. ncbi Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation
    Thierry Van Reeth
    , Dept. de Biologie Moleculaire, IBMM, , Rue Profs. Jeener and Brachet 12, B-6041 Gosselies, Belgium
    Mol Cell Endocrinol 188:99-109. 2002
    ....