Claude Szpirer

Summary

Country: Belgium

Publications

  1. pmc BAC CGH-array identified specific small-scale genomic imbalances in diploid DMBA-induced rat mammary tumors
    Emma Samuelson
    Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 40530, Goteborg, Sweden
    BMC Cancer 12:352. 2012
  2. ncbi request reprint Mammary cancer susceptibility: human genes and rodent models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Rue Profs Jeener and Brachet, 12, B 6041, Gosselies Charleroi, Belgium
    Mamm Genome 18:817-31. 2007
  3. ncbi request reprint Rat gene mapping in the post-genome sequencing era: the continued utility of cell hybrids to localize rat genes (Cks2, Ephb4, Fabp5, Il13ra1, Rpl10, Ssr4)
    C Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Cytogenet Genome Res 116:61-4. 2007
  4. doi request reprint Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development
    Géraldine Piessevaux
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12, 6041, Gosselies, Belgium
    Mamm Genome 20:43-52. 2009
  5. ncbi request reprint Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci
    Virginie Lella
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 121:1738-43. 2007
  6. pmc Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
    Christelle De Mees
    Universite Libre de Bruxelles, IBMM, Laboratoire de Biologie du Developpement, Rue Pr Jeener and Brachet 12, B 6041 Gosselies Charleroi, Belgium
    Mol Cell Biol 26:2012-8. 2006
  7. ncbi request reprint Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
    Anthony Rongvaux
    Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 181:4685-95. 2008
  8. doi request reprint A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility
    Sophie Biver
    Universite Libre De Bruxelles U L B, Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Developpement, Gosselies, Belgium
    Nature 456:339-43. 2008
  9. pmc Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility
    Philippe Gabant
    Laboratoire de Biologie du Développement and Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, 12 Rue Profs Jeneer et Brachet, B 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 99:12865-70. 2002
  10. ncbi request reprint Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility
    Daniel Stieber
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 120:1678-83. 2007

Collaborators

  • Carsten A Wagner
  • Fabienne Andris
  • Julie Bakker
  • Olivier Devuyst
  • Jose Russo
  • Josiane Szpirer
  • Daniel Stieber
  • Christelle De Mees
  • Michèle Rivière
  • Géraldine Piessevaux
  • Thierry Van Reeth
  • Virginie Lella
  • Pascale Van Vooren
  • Philippe Gabant
  • Xiaojiang Quan
  • Jean Francois Laes
  • Emma Samuelson
  • Pierre Drèze
  • Valérie Hertveldt
  • Sophie Biver
  • Anthony Rongvaux
  • Johan Smitz
  • Sara Karlsson
  • Staffan Nilsson
  • Karolina Partheen
  • Afrouz Behboudi
  • Frédéric Van Gool
  • Anna Maria Marini
  • Pierre L Drèze
  • Soline Bourgeois
  • Marta Nowik
  • Fabrice Bureau
  • Hendrica Belge
  • Sophie Scohy
  • Oberdan Leo
  • Pascal Houillier
  • Stephane Louryan
  • Sébastien Denanglaire
  • Mara Galli
  • Michel Georges
  • Dirk Wedekind
  • Wouter Coppieters
  • Frédéric Farnir
  • Benoit Hennuy
  • Bernard Pajack
  • Alistair Watt
  • Jennifer Nichols
  • Henri Alexandre
  • Lesley Forrester

Detail Information

Publications15

  1. pmc BAC CGH-array identified specific small-scale genomic imbalances in diploid DMBA-induced rat mammary tumors
    Emma Samuelson
    Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 40530, Goteborg, Sweden
    BMC Cancer 12:352. 2012
    ..To identify chromosomal regions potentially involved in the initiation and progression of mammary cancer, in the present work we subjected a subset of experimental mammary tumors to cytogenetic and molecular genetic analysis...
  2. ncbi request reprint Mammary cancer susceptibility: human genes and rodent models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Rue Profs Jeener and Brachet, 12, B 6041, Gosselies Charleroi, Belgium
    Mamm Genome 18:817-31. 2007
    ....
  3. ncbi request reprint Rat gene mapping in the post-genome sequencing era: the continued utility of cell hybrids to localize rat genes (Cks2, Ephb4, Fabp5, Il13ra1, Rpl10, Ssr4)
    C Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
    Cytogenet Genome Res 116:61-4. 2007
    ..On the basis of the sample we examined, it thus appears that a classical gene mapping method is still required to localize about 3% of the rat genes, as if 3% of the rat gene sequences were lacking in the current rat genome sequence...
  4. doi request reprint Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development
    Géraldine Piessevaux
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12, 6041, Gosselies, Belgium
    Mamm Genome 20:43-52. 2009
    ..On Chr 5, Pla2g2a is subject to a syntenic control while expression of the Tp53 (Chr 10) and Pmai1/Noxa (Chr 18) genes appears to be controlled by several mammary cancer resistance QTLs...
  5. ncbi request reprint Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci
    Virginie Lella
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 121:1738-43. 2007
    ..These 2 traits are thus associated, supporting the hypothesis that there might be a cause-effect relationship between precocious mammary differentiation and cancer resistance...
  6. pmc Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
    Christelle De Mees
    Universite Libre de Bruxelles, IBMM, Laboratoire de Biologie du Developpement, Rue Pr Jeener and Brachet 12, B 6041 Gosselies Charleroi, Belgium
    Mol Cell Biol 26:2012-8. 2006
    ..These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation...
  7. ncbi request reprint Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress
    Anthony Rongvaux
    Laboratoire de Physiologie Animale, Institut de Biologie et Médecine Moléculaire IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 181:4685-95. 2008
    ..Collectively, these data demonstrate that Nampt participates in cellular resistance to genotoxic/oxidative stress, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation...
  8. doi request reprint A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility
    Sophie Biver
    Universite Libre De Bruxelles U L B, Institut de Biologie et de Médecine Moléculaires, Laboratoire de Biologie du Developpement, Gosselies, Belgium
    Nature 456:339-43. 2008
    ..We anticipate a critical role for Rhcg in ammonium handling and pH homeostasis both in the kidney and the male reproductive tract...
  9. pmc Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility
    Philippe Gabant
    Laboratoire de Biologie du Développement and Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, 12 Rue Profs Jeneer et Brachet, B 6041 Gosselies, Belgium
    Proc Natl Acad Sci U S A 99:12865-70. 2002
    ..Whereas mutant homozygous adult males are viable and fertile, AFP null females are infertile. Our analyses of these mice indicate that the defect is caused by a dysfunction of the hypothalamic/pituitary system, leading to anovulation...
  10. ncbi request reprint Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility
    Daniel Stieber
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Int J Cancer 120:1678-83. 2007
    ..5 Mb. This analysis points to limited regions that could harbor the causative genes and also indicates that at least Mcstm2 is a novel QTL...
  11. doi request reprint Cancer research in rat models
    Claude Szpirer
    Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Charleroi, Belgium
    Methods Mol Biol 597:445-58. 2010
    ....
  12. doi request reprint The development of several organs and appendages is impaired in mice lacking Sp6
    Valérie Hertveldt
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, B 6041 Gosselies Charleroi, Belgium
    Dev Dyn 237:883-92. 2008
    ..In conclusion, this work indicates that Sp6 plays a critical role in the development of several epithelium-containing organs or appendages, possibly by regulating apoptosis...
  13. pmc Alpha-fetoprotein: from a diagnostic biomarker to a key role in female fertility
    Christelle De Mees
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12 B 6041 Gosselies Charleroi, Belgium
    Biomark Insights 1:82-5. 2007
    ..AFP sequestrates estrogens and by so doing protects the female developing brain from deleterious (defeminizing/masculinizing) effects of these hormones...
  14. ncbi request reprint Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat
    Xiaojiang Quan
    Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires, Rue Profs Jeener and Brachet, 12, Gosselies, B 6041, Belgium
    Mamm Genome 17:310-21. 2006
    ....
  15. ncbi request reprint Stimulation of the alpha-fetoprotein promoter by unliganded thyroid hormone receptor in association with protein deacetylation
    Thierry Van Reeth
    Laboratoire de Biologie du Developpement, Dept de Biologie Moléculaire, IBMM, Universite Libre de Bruxelles, rue Profs Jeener and Brachet 12, B 6041 Gosselies, Belgium
    Mol Cell Endocrinol 188:99-109. 2002
    ....