Jean Yves Springael

Summary

Country: Belgium

Publications

  1. Corbisier J, Galès C, Huszagh A, Parmentier M, Springael J. Biased signaling at chemokine receptors. J Biol Chem. 2015;290:9542-54 pubmed publisher
    ..For each receptor, we showed that the relative potency of various agonist chemokines was not identical in all assays, supporting the notion that signaling bias exists at chemokine receptors. ..
  2. Corbisier J, Huszagh A, Gales C, Parmentier M, Springael J. Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5. J Biol Chem. 2017;292:575-584 pubmed publisher
    ..These results highlight the biased nature of the J113863 and UCB35625 that act either as antagonist, partial agonist, or full agonist according to the receptor, the enantiomer, and the signaling pathway investigated. ..