D Souery

Summary

Country: Belgium

Publications

  1. ncbi request reprint Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders
    Isabelle Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 114:177-85. 2002
  2. ncbi request reprint How an internist should deal with psychotropic drugs?
    D Souery
    Service de Psychiatrie, Hopital Erasme, Universite Libre de Bruxelles
    Acta Clin Belg 59:279-84. 2004
  3. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
  4. ncbi request reprint Molecular genetics in the analysis of suicide
    Daniel Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Ann Med 35:191-6. 2003
  5. ncbi request reprint Treatment-resistant depression
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 67:16-22. 2006
  6. ncbi request reprint Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 68:1062-70. 2007
  7. ncbi request reprint Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study
    D Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 88:527-32. 1999
  8. ncbi request reprint Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 10:598-605. 2005
  9. ncbi request reprint Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 7:201-7. 2002
  10. ncbi request reprint A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 96:136-40. 2000

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders
    Isabelle Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 114:177-85. 2002
    ..Our large European sample allowed for replicating of some previous reported positive findings obtained in other study populations...
  2. ncbi request reprint How an internist should deal with psychotropic drugs?
    D Souery
    Service de Psychiatrie, Hopital Erasme, Universite Libre de Bruxelles
    Acta Clin Belg 59:279-84. 2004
  3. pmc Suicidal ideation during treatment of depression with escitalopram and nortriptyline in genome-based therapeutic drugs for depression (GENDEP): a clinical trial
    Nader Perroud
    MRC SGDP Centre, Institute of Psychiatry at King s College London, UK
    BMC Med 7:60. 2009
    ..The aim of the present study is to investigate the course and predictors of emergence and worsening of suicidal ideation during tricyclic antidepressant and serotonin reuptake inhibitor treatment...
  4. ncbi request reprint Molecular genetics in the analysis of suicide
    Daniel Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Ann Med 35:191-6. 2003
    ..In spite of those observations having some limitations, it appears that genetic factors are a serious risk factor, besides environmental aspects of suicidal behavior...
  5. ncbi request reprint Treatment-resistant depression
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 67:16-22. 2006
    ..However, the optimal strategy for treating TRD has yet to be identified. Therefore, further controlled clinical trials are essential to identify the most effective treatment strategies...
  6. ncbi request reprint Clinical factors associated with treatment resistance in major depressive disorder: results from a European multicenter study
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Psychiatry 68:1062-70. 2007
    ....
  7. ncbi request reprint Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: a multicenter association study
    D Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 88:527-32. 1999
    ..The results of this association study do not confirm the possible implication of TH polymorphism in the susceptibility to BPAD...
  8. ncbi request reprint Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 10:598-605. 2005
    ..The COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders...
  9. ncbi request reprint Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 7:201-7. 2002
    ..00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD...
  10. ncbi request reprint A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet 96:136-40. 2000
    ..These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:136-140, 2000...
  11. ncbi request reprint 5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait
    S Blairy
    Department of Psychiatry, Free University of Brussels, Erasme Hospital, Belgium
    Am J Med Genet 96:360-4. 2000
    ..Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect...
  12. ncbi request reprint Lack of association between GABRA3 and unipolar affective disorder: a multicentre study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, B 1070 Brussels, Belgium
    Int J Neuropsychopharmacol 4:273-8. 2001
    ..Our negative results suggest that GABRA3 does not confer susceptibility nor is it in linkage disequilibrium with another close gene involved in the genetic aetiology of UPAD...
  13. ncbi request reprint Social adjustment and self-esteem of bipolar patients: a multicentric study
    S Blairy
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    J Affect Disord 79:97-103. 2004
    ..Further, our results show that bipolar patients have significantly lower self-esteem compared to controls, even after remission...
  14. doi request reprint Identification of clinical factors associated with resistance to antidepressants in bipolar depression: results from an European Multicentre Study
    Julien Mendlewicz
    Free University of Brussels, School of Medicine, Brussels, Belgium
    Int Clin Psychopharmacol 25:297-301. 2010
    ..02, OR=1.8) and severe intensity of current depressive episode (P=0.01, OR=1.8). Our findings identify four clinical variables associated with TRBD, which could be further investigated in controlled prospective trials...
  15. ncbi request reprint Short-term and long-term treatment for bipolar patients: beyond the guidelines
    J Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Belgium
    J Affect Disord 55:79-85. 1999
    ..Particular caution must be exercised in those with a history of antidepressant-induced switches; many such patients appear prone to course aggravation and even rapid-cycling and will often need combined mood-stabilizer combinations...
  16. ncbi request reprint Treatment resistant depression: methodological overview and operational criteria
    D Souery
    Department of Psychiatry, University of Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Eur Neuropsychopharmacol 9:83-91. 1999
    ..Major depression with poor response to two adequate trials of different classes of antidepressants is proposed for an operational definition of TRD. Rationale for this definition is discussed in contrast to alternative definitions...
  17. ncbi request reprint Molecular genetic and family studies in affective disorders: state of the art
    D Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, 808 Route de Lennik, 1070, Brussels, Belgium
    J Affect Disord 62:45-55. 2001
    ..In parallel, specific hypotheses have been implicated, such as anticipation and dynamic mutations. Further research should concentrate on these hypotheses and confirm positive findings through interdisciplinary and multicenter projects...
  18. ncbi request reprint Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study
    Dimitris G Dikeos
    Department of Psychiatry, Athens University Medical School and University Mental Health Research Institute, Greece, and Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Psychiatr Genet 16:169-71. 2006
    ..On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder...
  19. ncbi request reprint Current issues in bipolar disorder: a critical review
    Pierre Oswald
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Brussels, Belgium
    Eur Neuropsychopharmacol 17:687-95. 2007
    ..Recent research has also allowed for the redefinition of the concept of mood stabilizer and for improving existing guidelines on the clinical management of Bipolar disorder...
  20. doi request reprint The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study
    Neslihan Aygun Kocabas
    aFonds de la Recherche Scientifique FNRS, Laboratoire de Neurologie Expérimentale, Universite Libre de Bruxelles, Bruxelles, Belgium
    Int Clin Psychopharmacol 25:218-27. 2010
    ..Despite the limited power of our analysis, this finding suggests that the polymorphic COMT gene that influences catecholaminergic neurotransmission may play a role in the individual response to antidepressants...
  21. ncbi request reprint Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder
    Neslihan Aygun Kocabas
    Laboratoire de Neurologie Expérimentale, Universite Libre de Bruxelles, Laboratoire de Neurologie Expérimentale, Campus Hôpital Erasme C2 124, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Int Clin Psychopharmacol 26:1-10. 2011
    ..Despite the limited power of analysis, our results suggest that these three SNPs may play a role in antidepressant treatment response phenotypes in MDD...
  22. ncbi request reprint Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study
    Julien Mendlewicz
    Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium
    Int Clin Psychopharmacol 21:227-31. 2006
    ..Potential physiological and biochemical mechanisms may involve an anti-inflammatory and/or neurotrophic effect...
  23. ncbi request reprint Patient-control association study of substance P-related genes in unipolar and bipolar affective disorders
    Julien Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Int J Neuropsychopharmacol 8:505-13. 2005
    ..In conclusion, our findings do not support a major contribution of SP-related genes in UPAD and BPAD, but provides some evidence of an ace influence in treatment response to antidepressants...
  24. doi request reprint Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes
    Neslihan Aygun Kocabas
    Fonds de la Recherche Scientifique FNRS, Laboratoire de Neurologie Expérimentale, Universite Libre de Bruxelles, Belgium
    World J Biol Psychiatry 11:985-90. 2010
    ..Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain...
  25. doi request reprint 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder
    Magali Noro
    Fonds de la Recherche Scientifique FNRS, Laboratoire de Psychologie Médicale, Universite Libre de Bruxelles, Belgium
    Int Clin Psychopharmacol 25:228-31. 2010
    ..Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result...
  26. ncbi request reprint Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study
    Julien Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, Belgium
    Eur J Hum Genet 12:377-82. 2004
    ..Our negative findings are not attributable to the lack of statistical power, and may contribute to clarify the role of 5-HTTLPR polymorphism in AD...
  27. ncbi request reprint Molecular genetics of affective disorders
    Pierre Oswald
    Department of Psychiatry, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, B 1070, Brussels, Belgium
    Prog Neuropsychopharmacol Biol Psychiatry 28:865-77. 2004
    ..In addition, recent advances in technology, such as microarrays, provide new tools in psychiatric genetics. These different approaches offer a new optimism era in the search of genetic factors in AD...
  28. ncbi request reprint Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study
    Pierre Oswald
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Am J Med Genet B Neuropsychiatr Genet 129:34-5. 2004
    ..44). We failed to replicate previous findings implicating BDNF in the aetiology of BPAD. However, BDNF remains an interesting target for future genetic studies and should be tested in prospective pharmacogenetic therapeutic trials...
  29. ncbi request reprint Expanded RED products and loci containing CAG/CTG repeats on chromosome 17 (ERDA1) and chromosome 18 (CTG18.1) in trans-generational pairs with bipolar affective disorder
    Julien Mendlewicz
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, B 1070 Brussels, Belgium
    Am J Med Genet B Neuropsychiatr Genet 128:71-5. 2004
    ..We were not able to detect any correlation for CTG18.1. Earlier age at onset in offspring generation was also not associated with expanded RED products explained by expanded ERDA1 alleles...
  30. ncbi request reprint Molecular genetics of affective disorders
    Pierre Oswald
    Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium
    Int J Neuropsychopharmacol 6:155-69. 2003
    ..Improved methodologies and updated tools in genetic studies will improve in the future our knowledge of affective disorders...
  31. ncbi request reprint No implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies
    Pierre Oswald
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, 808 Route de Lennik, B 1070, Brussels, Belgium
    Eur Neuropsychopharmacol 15:491-5. 2005
    ..A statistical difference was found between cases and controls in the first sample but not in the second. These results are not in favour of an implication of BDNF in UPAD but need to be replicated before final conclusion...
  32. ncbi request reprint Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study
    Pierre Oswald
    University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Eur Neuropsychopharmacol 13:365-8. 2003
    ..Therefore, to exclude the implication of HTR2A in UPAD, this result must be replicated in larger samples and in other populations using the transmission disequilibrium test and different polymorphisms around HTR2A...
  33. ncbi request reprint Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study
    D Souery
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Biol Psychiatry 49:405-9. 2001
    ..Several studies have investigated the possible role of TPH polymorphisms in affective disorders and suicidal behavior...
  34. ncbi request reprint The multiple facets of treatment-resistant depression
    Daniel Souery
    Department of Psychiatry, Erasme Hospital, Brussels, Belgium
    CNS Spectr 9:803-7. 2004
  35. ncbi request reprint Dissociation in major depressive disorder: a pilot study
    Almudena Molina-Serrano
    Department of Psychiatry, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
    J Trauma Dissociation 9:411-21. 2008
    ..Screening methods and structured interview for dissociative disorders are useful in psychiatric and psychological practice. Further studies should analyze the role and clinical consequence of different forms of dissociation experiences...
  36. ncbi request reprint Introduction to the Special Section. New advances in the understanding and treatment of bipolar disorder
    Daniel Souery
    Erasme Hospital, Department of Psychiatry, Universit Libre de Bruxelles, Brussels
    Int J Neuropsychopharmacol 6:123-5. 2003
    ..Novel therapeutic approaches will be covered in a second part in Volume 6, Number 3 (September 2003)...
  37. ncbi request reprint Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression
    Sandra M Villafuerte
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Am J Med Genet 114:222-6. 2002
    ..04). However, a replication study of this cSNP in a bipolar sample of Belgian origin and a Swedish UP sample did not show significant differences in allele and genotype frequencies...
  38. ncbi request reprint Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder
    Filip Van Den Eede
    Department of Molecular Genetics VIB8, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Psychiatry Res 153:17-25. 2007
    ..The association between genetic CRF-BP variants and MDD may be sexually dimorphic, but this issue requires further investigation in a larger sample...
  39. ncbi request reprint Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression
    Dirk van West
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Antwerp, Antwerp, Belgium
    Neuropsychopharmacology 31:620-7. 2006
    ..This study suggests that polymorphisms in the 5' region of the NR3C1 gene may play a role in the genetic vulnerability for MDD...
  40. ncbi request reprint Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study
    George N Papadimitriou
    Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece
    Psychiatr Genet 13:211-20. 2003
    ..02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder...
  41. ncbi request reprint Consensus statement and research needs: the role of dopamine and norepinephrine in depression and antidepressant treatment
    David J Nutt
    Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
    J Clin Psychiatry 67:46-9. 2006
    ..In addition, the faculty discussed the importance of patient psychoeducation and self-management as well as the ways in which disease models of depression affect treatment...
  42. ncbi request reprint Noradrenaline in mood and anxiety disorders: basic and clinical studies
    Nicoletta Brunello
    Center of Neuropharmacology, Intsitute of Pharmacological Science, University of Milan, Italy
    Int Clin Psychopharmacol 18:191-202. 2003
    ....