Etienne M Sokal

Summary

Country: Belgium

Publications

  1. doi request reprint End-stage liver disease and liver transplant: current situation and key issues
    E M Sokal
    Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    J Pediatr Gastroenterol Nutr 47:239-46. 2008
  2. ncbi request reprint Hepatitis C in children and adolescents: mode of acquisition, natural history and treatment
    Xavier Stephenne
    Cliniques St Luc, Universite Catholique de Louvain, 10 av Hippocrate, B 1200 Bruxelles, Belgium
    Acta Gastroenterol Belg 65:95-8. 2002
  3. ncbi request reprint Treating inborn errors of liver metabolism with stem cells: current clinical development
    Etienne Marc Sokal
    Pediatric Hepatology and Gastroenterology and Cell Transplant Center, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, 10 av Hippocrate, 1200, Brussels, Belgium
    J Inherit Metab Dis 37:535-9. 2014
  4. pmc Mitochondrial uncouplers inhibit hepatic stellate cell activation
    Eduardo L Guimarães
    Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium
    BMC Gastroenterol 12:68. 2012
  5. doi request reprint From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives
    E M Sokal
    Pediatric Liver Unit, Laboratory of Hepatology and Cell Therapy, Universite Catholique de Louvain, Institut de Recherche Expérimentale et clinique Brussels, Belgium
    Cell Prolif 44:39-43. 2011
  6. ncbi request reprint Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in children and adolescents
    Etienne M Sokal
    Universite Catholique de Louvain, Cliniques Universitaires St Luc, Bruxelles, Belgium
    J Hepatol 52:827-31. 2010
  7. pmc Hepatocyte cryopreservation: is it time to change the strategy?
    Xavier Stephenne
    World J Gastroenterol 16:1-14. 2010
  8. doi request reprint The pharmacokinetics and safety of adefovir dipivoxil in children and adolescents with chronic hepatitis B virus infection
    Etienne M Sokal
    Pediatric Research Institute, Departement de Pediatrie, Université Catholique de Louvain and Cliniques St Luc, 10 av Hippocrate, 1200 Brussels, Belgium
    J Clin Pharmacol 48:512-7. 2008
  9. pmc Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives
    Philippe A Lysy
    Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques Saint Luc, 10 av Hippocrate, Brussels B 1200, Belgium
    World J Gastroenterol 14:3464-70. 2008
  10. ncbi request reprint Safety of living-related liver transplantation for progressive familial intrahepatic cholestasis
    Luisa Cutillo
    Pediatric Liver Transplant Program, Universite Catholique de Louvain, Faculty of Medicine and Cliniques Saint Luc, Brussels, Belgium
    Pediatr Transplant 10:570-4. 2006

Collaborators

Detail Information

Publications43

  1. doi request reprint End-stage liver disease and liver transplant: current situation and key issues
    E M Sokal
    Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    J Pediatr Gastroenterol Nutr 47:239-46. 2008
  2. ncbi request reprint Hepatitis C in children and adolescents: mode of acquisition, natural history and treatment
    Xavier Stephenne
    Cliniques St Luc, Universite Catholique de Louvain, 10 av Hippocrate, B 1200 Bruxelles, Belgium
    Acta Gastroenterol Belg 65:95-8. 2002
    ..Combination treatment using Ribavirin plus interferon, or Ribavirin + pegylated interferon yield a higher success in eradicating viral infection in adults. These treatments can be considered for children in selected cases...
  3. ncbi request reprint Treating inborn errors of liver metabolism with stem cells: current clinical development
    Etienne Marc Sokal
    Pediatric Hepatology and Gastroenterology and Cell Transplant Center, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, 10 av Hippocrate, 1200, Brussels, Belgium
    J Inherit Metab Dis 37:535-9. 2014
    ....
  4. pmc Mitochondrial uncouplers inhibit hepatic stellate cell activation
    Eduardo L Guimarães
    Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium
    BMC Gastroenterol 12:68. 2012
    ..In this study we investigated the role of mitochondrial activity through mild uncoupling during in vitro activation of HSCs...
  5. doi request reprint From hepatocytes to stem and progenitor cells for liver regenerative medicine: advances and clinical perspectives
    E M Sokal
    Pediatric Liver Unit, Laboratory of Hepatology and Cell Therapy, Universite Catholique de Louvain, Institut de Recherche Expérimentale et clinique Brussels, Belgium
    Cell Prolif 44:39-43. 2011
    ..In this respect, liver derived progenitor cells may have some advantages over stem cells derived from other tissues...
  6. ncbi request reprint Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in children and adolescents
    Etienne M Sokal
    Universite Catholique de Louvain, Cliniques Universitaires St Luc, Bruxelles, Belgium
    J Hepatol 52:827-31. 2010
    ....
  7. pmc Hepatocyte cryopreservation: is it time to change the strategy?
    Xavier Stephenne
    World J Gastroenterol 16:1-14. 2010
    ..Such strategies, such as vitrification, will be discussed with respect to their potential to significantly improve the quality of cell suspensions dedicated to liver cell-based therapies...
  8. doi request reprint The pharmacokinetics and safety of adefovir dipivoxil in children and adolescents with chronic hepatitis B virus infection
    Etienne M Sokal
    Pediatric Research Institute, Departement de Pediatrie, Université Catholique de Louvain and Cliniques St Luc, 10 av Hippocrate, 1200 Brussels, Belgium
    J Clin Pharmacol 48:512-7. 2008
    ..There was 1 serious adverse event reported that was not related to study medication. No patient discontinued the study prematurely due to an adverse event related to the study drug...
  9. pmc Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives
    Philippe A Lysy
    Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques Saint Luc, 10 av Hippocrate, Brussels B 1200, Belgium
    World J Gastroenterol 14:3464-70. 2008
    ..We discuss the future developments of the technique and new emerging perspectives...
  10. ncbi request reprint Safety of living-related liver transplantation for progressive familial intrahepatic cholestasis
    Luisa Cutillo
    Pediatric Liver Transplant Program, Universite Catholique de Louvain, Faculty of Medicine and Cliniques Saint Luc, Brussels, Belgium
    Pediatr Transplant 10:570-4. 2006
    ..We conclude that PFIC heterozygote status of the donor does not increase the risk of liver dysfunction in either recipients or donors, with a similar course compared with BA recipients and donors...
  11. ncbi request reprint Liver allograft radiotherapy to treat rejection in children: efficacy in orthotopic liver transplantation and long-term safety
    Xavier Stephenne
    Departement de Pediatrie, Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    Liver Int 25:1108-13. 2005
    ..Long-term safety data were collected with the prospect of possible use of RT in liver cell transplantation (LCT)...
  12. ncbi request reprint Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up
    Etienne M Sokal
    Cliniques St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Transplantation 76:735-8. 2003
    ..Hepatocyte transplantation is a safe and promising technique in the treatment of rare inborn errors of metabolism. Future improvements of cell viability and prevention of apoptosis may increase engraftment and subsequent re-population...
  13. ncbi request reprint Leukemia inhibitory factor contributes to hepatocyte-like differentiation of human bone marrow mesenchymal stem cells
    Philippe A Lysy
    HPED Department, PEDI Unit, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Differentiation 76:1057-67. 2008
    ..In conclusion, we demonstrated that LIF can play a similar role as OSM in the hepatocyte differentiation process of human MSCs...
  14. ncbi request reprint Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation
    Philippe A Lysy
    Université Catholique de Louvain et Cliniques Universitaires Saint Luc, HPED Department, PEDI Unit, Laboratory of Pediatric Hepatology and Cell Therapy, 1200 Brussels, Belgium
    Hepatology 46:1574-85. 2007
    ....
  15. ncbi request reprint Tissue factor-dependent procoagulant activity of isolated human hepatocytes: relevance to liver cell transplantation
    Xavier Stephenne
    Laboratory of Paediatric Hepatology and Cell Therapy, Unité Pé diatrie PEDI, Universite Catholique de Louvain, Brussels, Belgium
    Liver Transpl 13:599-606. 2007
    ..In conclusion, hepatocytes exert TF-dependent PCA, which may contribute to early loss of infused cells. Addition of N-acetyl-L-cysteine to the suspensions of hepatocytes might be beneficial in LCT by inhibiting activation of coagulation...
  16. doi request reprint Assessment of risk of bleeding from esophageal varices during management of biliary atresia in children
    Catherine Wanty
    Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Service de Gastroentérologie et Hépatologie Pédiatrique, Bruxelles, Belgium
    J Pediatr Gastroenterol Nutr 56:537-43. 2013
    ..Our study was aimed at assessing the risk of bleeding from EV in a series of patients with BA, identifying risk factors for bleeding to develop a predictive model of bleeding...
  17. doi request reprint Recovery of graft steatosis and protein-losing enteropathy after biliary diversion in a PFIC 1 liver transplanted child
    Emanuele Nicastro
    Departement de Pediatrie, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Pediatr Transplant 16:E177-82. 2012
    ..EBD can be considered a valuable treatment option to avoid organ disfunction and loss in PFIC 1 transplanted patients who develop graft steatohepatitis...
  18. doi request reprint Two-step transplantation for primary hyperoxaluria: cadaveric liver followed by living donor related kidney transplantation
    Ivone Malla
    Departement de Pediatrie, Hépatologie et transplantation hépatique pédiatrique, Université catholique de Louvain and Cliniques Universitaires Saint Luc, Brussels, Belgium
    Pediatr Transplant 13:782-4. 2009
    ..This strategy seems to be a reasonable approach in order to avoid acute renal tubular injury because of oxalate excretion in these patients...
  19. ncbi request reprint Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency
    Xavier Stephenne
    Laboratoire d hépatologie Pédiatrique et Transplantation Cellulaire, Département GYPE, Service de Pediatrie, Université Catholique de Louvain and Cliniques St Luc, Brussels, Belgium
    Gastroenterology 130:1317-23. 2006
    ..Donor cell engraftment with expression of enzyme activity is the goal of liver cell transplantation for inborn errors of liver metabolism with a view to achieving sustained metabolic control...
  20. ncbi request reprint Lymphoproliferation in children after liver transplantation
    Francoise Smets
    Pediatrics Department, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    J Pediatr Gastroenterol Nutr 34:499-505. 2002
  21. ncbi request reprint Epithelial cells with hepatobiliary phenotype: is it another stem cell candidate for healthy adult human liver?
    Dung Ngoc Khuu
    Universite Catholique de Louvain, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    World J Gastroenterol 13:1554-60. 2007
    ..To investigate the presence and role of liver epithelial cells in the healthy human adult liver...
  22. ncbi request reprint Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1
    Xavier Stephenne
    Laboratory of Paediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    Cell Transplant 16:409-19. 2007
    ..They also suggest that, in addition to technical progress in the cryopreservation procedure, protection of the respiratory chain complex 1 should be considered to improve the quality of cryopreserved hepatocytes...
  23. doi request reprint Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A
    Florence Defresne
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium Electronic address
    Nucl Med Biol 41:371-5. 2014
    ..These cells present high proliferative capacity, good resistance to cryopreservation and ability to differentiate into hepatocyte-like cells displaying mature hepatocyte functions...
  24. ncbi request reprint Cryopreserved liver cell transplantation controls ornithine transcarbamylase deficient patient while awaiting liver transplantation
    Xavier Stephenne
    Pediatric Research Laboratory and Pediatric Liver Unit, Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    Am J Transplant 5:2058-61. 2005
    ..We conclude that use of cryopreserved cells allowed short- to medium-term metabolic control and urea synthesis in this male OTC-deficient patient while waiting for OLT...
  25. ncbi request reprint Long-term survival and late graft loss in pediatric liver transplant recipients--a 15-year single-center experience
    Michael A Wallot
    Department of Pediatric Transplantation, Saint Luc Clinic, Catholic University of Louvain, Brussels, Belgium
    Liver Transpl 8:615-22. 2002
    ..Technical complications are only a minor factor in late graft loss, but complications related to immunosuppression and infection remain a major hazard and must be addressed...
  26. doi request reprint Differentiated umbilical cord matrix stem cells as a new in vitro model to study early events during hepatitis B virus infection
    Massimiliano Paganelli
    Pediatric Gastroenterology and Hepatology Unit, Université catholique de Louvain and Cliniques Universitaires Saint Luc, Brussels, Belgium
    Hepatology 57:59-69. 2013
    ....
  27. ncbi request reprint Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease
    Francoise Smets
    Pediatrics Department, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Transplantation 73:1603-10. 2002
    ..However, EBV load is so far the only marker proposed to evaluate PTLD risk, and no study has investigated the role of specific anti-EBV T lymphocytes (EBV-TL)...
  28. ncbi request reprint Partial proximal 10q trisomy: a new case associated with biliary atresia
    Philippe A Lysy
    Gastroenterology and Hepatology Unit, HPED Department, Université Catholique de Louvain and Cliniques Saint Luc, Brussels, Belgium
    Hereditas 144:191-4. 2007
    ..A review of the literature confirmed that the patient displayed characteristic dysmorphic features of the recently defined partial proximal trisomy 10q syndrome and emphasized the interindividual variability of visceral malformations...
  29. ncbi request reprint Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B
    Etienne M Sokal
    Departement de Pediatrie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 43:225-32. 2006
    ..However, the incidence of YMMD mutations increased over time and resulted in lower response rates. VR was maintained in most patients who had initially responded to lamivudine in the first 12 months...
  30. doi request reprint Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
    Etienne M Sokal
    Universite Catholique de Louvain, Cliniques Universitaires St Luc, Avenue Hippocrate 10 1301, 1200 Brussels, Belgium
    J Infect Dis 196:1749-53. 2007
    ..To date, there is no commercially available vaccine to prevent infectious mononucleosis, a disease frequently induced by Epstein-Barr virus (EBV) infection in adolescents or adults devoid of preexisting immunity to the virus...
  31. doi request reprint Prevention and treatment for Epstein-Barr virus infection and related cancers
    Francoise Smets
    Universite Catholique de Louvain, Cliniques Universitaires St Luc, Avenue Hippocrate 10 1301, 1200, Brussels, Belgium
    Recent Results Cancer Res 193:173-90. 2014
    ..Possible prevention by EBV vaccination would be a more global approach of this public health problem, but further active research is needed before this goal could be reached...
  32. ncbi request reprint Pediatric liver transplantation for biliary atresia: results of primary grafts in 328 recipients
    H Vo Thi Diem
    Pediatric Liver Transplant Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
    Transplantation 75:1692-7. 2003
    ....
  33. ncbi request reprint Liver transplantation in mitochondrial respiratory chain disorders
    E M Sokal
    Department of Paediatric Hepatology, Cliniques St Luc, Université Catholique de Louvain 10 1301 avenue Hippocrate, B 1200 Brussels, Belgium
    Eur J Pediatr 158:S81-4. 1999
    ..All three patients with initial liver and gastro-intestinal disease died early after transplantation, indicating that these may be poor candidates for this procedure...
  34. ncbi request reprint Characteristics of Epstein-Barr virus primary infection in pediatric liver transplant recipients
    F Smets
    Department of Pediatrics, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Hepatol 32:100-4. 2000
    ..The aim of this study was to monitor the clinical and biochemical events associated with primary Epstein-Barr virus infection...
  35. ncbi request reprint Epstein-Barr virus-related lymphoproliferation in children after liver transplant: role of immunity, diagnosis, and management
    F Smets
    Pediatrics Department, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Pediatr Transplant 6:280-7. 2002
    ..The level of immunity is correlated to the viral load and improves during recovery from PTLD. These recent findings add further knowledge to PTLD pathogenesis and management...
  36. ncbi request reprint Early signs and risk factors for the increased incidence of Epstein-Barr virus-related posttransplant lymphoproliferative diseases in pediatric liver transplant recipients treated with tacrolimus
    E M Sokal
    Liver Transplant Program, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium
    Transplantation 64:1438-42. 1997
    ..It has been suggested that tacrolimus, a new and potent immunosuppressor, causes an increased incidence of this syndrome...
  37. ncbi request reprint Introduction: liver and liver cell transplantation for inborn errors of liver metabolism
    E M Sokal
    Université Catholique de Louvain and Cliniques St Luc, Brussels
    Acta Gastroenterol Belg 68:451-2. 2005
  38. ncbi request reprint Fifteen years single center experience in the management of progressive familial intrahepatic cholestasis of infancy
    C Wanty
    Hepatology Unit, Pediatric Department, UCL St Luc, Brussels, Belgium
    Acta Gastroenterol Belg 67:313-9. 2004
    ..Transplantation is indicated whenever medical treatment fails to restore normal social life, growth and well being of the child and it is associated with excellent survival (> 90%)...
  39. ncbi request reprint Liver and intestinal transplantation in children: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Etienne M Sokal
    European Society for Paediatric Gastroenterology, Hepatology, and Nutrition
    J Pediatr Gastroenterol Nutr 35:S159-72. 2002
  40. ncbi request reprint Clinical trial of lamivudine in children with chronic hepatitis B
    Maureen M Jonas
    of Gastroenterology, Children s Hospital, Boston, MA 02115, USA
    N Engl J Med 346:1706-13. 2002
    ..Lamivudine therapy is effective for chronic hepatitis B infection in adults. We evaluated the efficacy and tolerability of lamivudine as a treatment for chronic infection with hepatitis B virus (HBV) in children...
  41. ncbi request reprint An investigation of the steady-state pharmacokinetics of oral valacyclovir in immunocompromised children
    David Nadal
    Division of Infectious Diseases, University Children s Hospital of Zurich, CH 8032 Zurich, Switzerland
    J Infect Dis 186:S123-30. 2002
    ..In general, adverse events were not attributable to valacyclovir and were consistent with disease-related expectations and concomitant therapies. Dosage options for using valacyclovir in children are discussed...
  42. pmc Stem cells for liver tissue repair: current knowledge and perspectives
    Philippe A Lysy
    Université catholique de Louvain and Cliniques Universitaires Saint Luc, HPED Department, Unit PEDI, Laboratory of Pediatric Hepatology and Cell Therapy, Bussels 1200, Belgium
    World J Gastroenterol 14:864-75. 2008
    ..We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated...
  43. ncbi request reprint Repeated detection of gas in the portal vein after liver transplantation: A sign of EBV-associated post-transplant lymphoproliferation?
    Michael A Wallot
    Department of Pediatrics, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Pediatr Transplant 6:332-6. 2002
    ..We suggest that the detection of portal vein gas in pediatric liver transplant recipients beyond the early post-operative period may be a sign of intra-abdominal post-transplant lymphoproliferative disease...