Efienne M Sokal
- Early signs and risk factors for the increased incidence of Epstein-Barr virus-related posttransplant lymphoproliferative diseases in pediatric liver transplant recipients treated with tacrolimusE M Sokal
Liver Transplant Program, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium
Transplantation 64:1438-42. 1997..It has been suggested that tacrolimus, a new and potent immunosuppressor, causes an increased incidence of this syndrome...
- Liver transplantation for inborn errors of liver metabolismEfienne M Sokal
Cliniques St Luc, Departement de Pediatrie, Universite Catholique de Louvain, 10 1301 av Hippocrate, B 1200, Brussels, Belgium
J Inherit Metab Dis 29:426-30. 2006..Liver transplantation brings complete recovery from end-stage liver disease, and full correction of liver based inborn errors of metabolism...
- Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adultsEtienne M Sokal
Universite Catholique de Louvain, Cliniques Universitaires St Luc, Avenue Hippocrate 10 1301, 1200 Brussels, Belgium
J Infect Dis 196:1749-53. 2007..To date, there is no commercially available vaccine to prevent infectious mononucleosis, a disease frequently induced by Epstein-Barr virus (EBV) infection in adolescents or adults devoid of preexisting immunity to the virus...
- Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis BEtienne M Sokal
Departement de Pediatrie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
Hepatology 43:225-32. 2006..However, the incidence of YMMD mutations increased over time and resulted in lower response rates. VR was maintained in most patients who had initially responded to lamivudine in the first 12 months...
- Introduction: liver and liver cell transplantation for inborn errors of liver metabolismE M Sokal
Université Catholique de Louvain and Cliniques St Luc, Brussels
Acta Gastroenterol Belg 68:451-2. 2005
- Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-upEtienne M Sokal
Cliniques St Luc, Universite Catholique de Louvain, Brussels, Belgium
Transplantation 76:735-8. 2003..Hepatocyte transplantation is a safe and promising technique in the treatment of rare inborn errors of metabolism. Future improvements of cell viability and prevention of apoptosis may increase engraftment and subsequent re-population...
- Drug treatment of pediatric chronic hepatitis BEtienne Sokal
Department of Pediatrics, Universite Catholique de Louvain, Brussels, Belgium
Paediatr Drugs 4:361-9. 2002..Finally, therapeutic vaccines aiming to induce a cellular immune response towards hepatitis B antigens are being tested in adults, but no clinical benefit has so far been established...
- Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young childrenE M Sokal
Department of Pediatrics, Cliniques Universitaires St Luc, Brussels, Belgium
Lancet 352:1739-41. 1998..We report parvovirus B19 as an agent associated with FH in children and compare clinical characteristics of these patients with those of age-matched patients with FH of other origin...
- Lamivudine for the treatment of chronic hepatitis BEtienne Sokal
Universite Catholique de Louvain, Cliniques St Luc, Av Hippocrate 10 1301, B 1200 Bruxelles, Belgique
Expert Opin Pharmacother 3:329-39. 2002....
- Indications and results of chemotherapy in children with posttransplant lymphoproliferative disease after liver transplantationF Smets
Department of Paediatrics, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
Transplantation 69:982-4. 2000..In Burkitt-like or Hodgkin-like PTLDs, immunomodulatory or antiviral drugs were inefficient. Chemotherapy is indicated and can be safely and successfully used. Long-term arrest of immunosuppression seems feasible without graft rejection...
- Update on prevention and treatment of viral hepatitis in childrenE M Sokal
Pediatric Hepatology, Cliniques St Luc, Universite, Catholique de Louvain, Bruxelles, Belgium
Curr Opin Pediatr 11:384-9. 1999..Treatment with interferon alone has a poor rate of efficiency, although pediatric studies remain scarce. Combination treatment using ribavirin plus interferon yield a higher rate of success in eradicating viral infection in adults...
- Liver transplantation in mitochondrial respiratory chain disordersE M Sokal
Department of Paediatric Hepatology, Cliniques St Luc, Université Catholique de Louvain 10 1301 avenue Hippocrate, B 1200 Brussels, Belgium
Eur J Pediatr 158:S81-4. 1999..All three patients with initial liver and gastro-intestinal disease died early after transplantation, indicating that these may be poor candidates for this procedure...
- A dose ranging study of the pharmacokinetics, safety, and preliminary efficacy of lamivudine in children and adolescents with chronic hepatitis BE M Sokal
Universite Catholique de Louvain, Brussels, Belgium
Antimicrob Agents Chemother 44:590-7. 2000..The 100-mg dose is being evaluated in a large phase III study with HBV-infected pediatric patients...
- Steroid-free, tacrolimus-basiliximab immunosuppression in pediatric liver transplantation: clinical and pharmacoeconomic study in 50 childrenJeremie M Gras
Pediatric Liver Transplant Program, Universite Catholique de Louvain, Brussels, Belgium
Liver Transpl 14:469-77. 2008..Medical care costs were similar in both groups. Steroid avoidance together with basiliximab immunoprophylaxis was not harmful in terms of allograft acceptance, and even seemed to be beneficial in the long term...
- Saccharomyces boulardii enhances N-terminal peptide hydrolysis in suckling rat small intestine by endoluminal release of a zinc-binding metalloproteaseJean Paul Buts
Laboratory of Pediatric Gastroenterology and Nutrition, Unit of Pediatric Research, Faculty of Medicine, Universite Catholique de Louvain, B 1200 Brussels, Belgium
Pediatr Res 51:528-34. 2002....
- Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylationJean Paul Buts
Laboratory of Pediatric Gastroenterolgy and Nutrition, Université Catholic de Louvain, Brussels, Belgium
Pediatr Res 60:24-9. 2006..In conclusion, S. boulardii is able to inhibit toxicity of E. coli surface endotoxins by the release of a protein phosphatase exhibiting a great capacity of dephosphorylation...
- Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational toleranceRaymond Reding
Pediatric Liver Transplant Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
Acta Gastroenterol Belg 68:320-2. 2005..We hypothesize that the recent population of liver transplant recipients with low immunosuppression might be more suitable for progressive immunosuppression withdrawal trial, with the aim to reach ultimately operational tolerance...
- Steroid-free liver transplantation in childrenRaymond Reding
Paediatric Liver Transplant Program, Universite Catholique de Louvain, Saint Luc University Clinics, 10 Hippocrate Avenue, 1200, Brussels, Belgium
Lancet 362:2068-70. 2003..Steroid avoidance was, therefore, not harmful to our patients, and combining tacrolimus with basiliximab as a steroid substitution seems a safe alternative to tacrolimus and steroid immunosuppression...
- Glycogenosis storage type I diseases and evolutive adenomatosis: an indication for liver transplantationJan P Lerut
Cliniques Universitaires St Luc 1400, Universite Catholique de Louvain UCL, Avenue Hippocrate 10, 1200 Brussels, Belgium
Transpl Int 16:879-84. 2003..Regular detailed Doppler ultrasound and magnetic nuclear resonance screening during childhood and adolescence are, therefore, mandatory in order for the timing of transplantation to be optimized...
- Efficacy and pharmacokinetics of tacrolimus oral suspension in pediatric liver transplant recipientsRaymond Reding
Pediatric Liver Transplant Program andHospital Pharmacy, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
Pediatr Transplant 6:124-6. 2002..55%, respectively). Accordingly, the use of OST may constitute an alternative option for tacrolimus administration in low body weight organ recipients, to allow dosage titration in the early post-transplant weeks...
- Impact of surgical and immunological parameters in pediatric liver transplantation: a multivariate analysis in 500 consecutive recipients of primary graftsVeerle Evrard
Pediatric Liver Transplant Program, Saint Luc University Clinics Université catholique de Louvain, Brussels, Belgium
Ann Surg 239:272-80. 2004..To assess the respective impact of surgical and immunologic factors on patient/graft outcome and rejection after pediatric liver transplantation...
- Early occurrence of hepatocellular carcinoma in biliary atresia treated by liver transplantationAndrea Brunati
Pediatric Liver Transplant Program, Universite Catholique de Louvain, St Luc University Clinics, Brussels, Belgium
Pediatr Transplant 11:117-9. 2007..HCC in BA is extremely rare. Screening of AFP and ultrasonographic examination should be performed regularly in patients with secondary biliary cirrhosis for early detection of HCC...
- Early immunological monitoring after pediatric liver transplantation: cytokine immune deviation and graft acceptance in 40 recipientsJérémie Gras
Pediatric Surgical Unit, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
Liver Transpl 13:426-33. 2007..The occurrence of cytokine immune deviation may therefore be related to early graft acceptance in children who receive liver transplants...
- Pediatric liver transplantation using left hepatic segments from living related donors: surgical experience in 100 recipients at Saint-Luc University ClinicsAhmed A Darwish
Pediatric Liver Transplantation Program, Saint Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
Pediatr Transplant 10:345-53. 2006..Donor morbidity was kept to acceptable incidence, and surgical technique in the recipient needs to be tailored to minimize postoperative complications...
- PELD score and posttransplant outcome in pediatric liver transplantation: a retrospective study of 100 recipientsChristophe Bourdeaux
Pediatric Liver Transplant Program, Universite Catholique de Louvain, Saint Luc University Clinics, Brussels, Belgium
Transplantation 79:1273-6. 2005..This study investigated whether PELD may also impact on post-LT results...
- The place of liver transplantation in Caroli's disease and syndromeLaurent De Kerckhove
Abdominal Transplantation Unit, Universite Catholique de Louvain, UCL, Brussels, Belgium
Transpl Int 19:381-8. 2006..In case of associated ARPKD, renal transplantation is often indicated early on because of the more rapid progression of the renal component of the disease...
- Liver transplantation in children with fulminant hepatic failure: The UCL experienceParikshat Mahadeb
Pediatric Liver Transplant Program, St Luc University Clinics, Universite Catholique de Louvain, Brussels, Belgium
Pediatr Transplant 13:414-20. 2009....
- Liver retransplantation in children. A 21-year single-center experienceChristophe Bourdeaux
Pediatric Liver Transplant Program, Pediatric Surgery and Transplant Unit, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
Transpl Int 22:416-22. 2009..The former did not seem to be associated with higher immunologic risk, except for children having withdrawal of immunosuppression following the first graft...
- MRI of iron-oxide labelled transplanted hepatocytes in mice: effect of treatment with cyclophosphamideIsabelle Leconte
Radiodiagnostic Unit, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
J Magn Reson Imaging 32:367-75. 2010..To assess if 1.5T MRI can be used to study the transport to the liver, the intrahepatic distribution and engraftment of iron-oxide labelled hepatocytes in cyclophosphamide-treated and untreated mice...