Thierry Simonart

Summary

Country: Belgium

Publications

  1. ncbi request reprint Immunotherapy for acne vulgaris: current status and future directions
    Thierry Simonart
    av Gounod 27, 1070, Brussels, Belgium
    Am J Clin Dermatol 14:429-35. 2013
  2. doi request reprint Acne and whey protein supplementation among bodybuilders
    Thierry Simonart
    Dermatology 225:256-8. 2012
  3. doi request reprint Newer approaches to the treatment of acne vulgaris
    Thierry Simonart
    Private Practice, Brussels, Belgium
    Am J Clin Dermatol 13:357-64. 2012
  4. doi request reprint Systemic treatments for cutaneous warts: a systematic review
    Thierry Simonart
    Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Dermatolog Treat 23:72-7. 2012
  5. ncbi request reprint Group a beta-haemolytic streptococcal necrotising fasciitis: early diagnosis and clinical features
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 208:5-9. 2004
  6. pmc Iron: a target for the management of Kaposi's sarcoma?
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    BMC Cancer 4:1. 2004
  7. ncbi request reprint Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Cancer Lett 244:1-7. 2006
  8. ncbi request reprint Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Gynecol Oncol 90:91-5. 2003
  9. ncbi request reprint Interleukin-1 beta increases the BCL-2/BAX ratio in Kaposi's sarcoma cells
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, B 1070 Brussels, Belgium
    Cytokine 19:259-66. 2002
  10. ncbi request reprint The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis
    T Simonart
    Department of Dermatology, Erasme University Hospital, B 1070 Brussels, Belgium
    J Eur Acad Dermatol Venereol 18:687-90. 2004

Detail Information

Publications48

  1. ncbi request reprint Immunotherapy for acne vulgaris: current status and future directions
    Thierry Simonart
    av Gounod 27, 1070, Brussels, Belgium
    Am J Clin Dermatol 14:429-35. 2013
    ..acnes, anti-Toll-like receptors vaccines and natural antimicrobial peptides. This review summarizes the current evidence and explores the challenges to making this a realistic treatment option for the future. ..
  2. doi request reprint Acne and whey protein supplementation among bodybuilders
    Thierry Simonart
    Dermatology 225:256-8. 2012
    ..Further prospective studies are required to determine the possible role of dietary supplements in the fitness and bodybuilding environment...
  3. doi request reprint Newer approaches to the treatment of acne vulgaris
    Thierry Simonart
    Private Practice, Brussels, Belgium
    Am J Clin Dermatol 13:357-64. 2012
    ..Acne vaccines, topical natural antimicrobial peptides, and lauric acid represent other promising therapies...
  4. doi request reprint Systemic treatments for cutaneous warts: a systematic review
    Thierry Simonart
    Universite Libre de Bruxelles ULB, Brussels, Belgium
    J Dermatolog Treat 23:72-7. 2012
    ..Systemic therapies are routinely used for the management of cutaneous warts. However, there is a lack of evidence-based data on their effectiveness...
  5. ncbi request reprint Group a beta-haemolytic streptococcal necrotising fasciitis: early diagnosis and clinical features
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 208:5-9. 2004
    ..The goal of this article was to review the clinical features and diagnostic tools that could facilitate the early recognition of GAS NF...
  6. pmc Iron: a target for the management of Kaposi's sarcoma?
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    BMC Cancer 4:1. 2004
    ....
  7. ncbi request reprint Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Cancer Lett 244:1-7. 2006
    ..This review focuses on the environmental factors thought to be associated with KS, more particularly iron exposure and facilitation of transmission of HHV-8 infection by contact with blood-sucking arthropods...
  8. ncbi request reprint Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Gynecol Oncol 90:91-5. 2003
    ..The present study was designed to investigate the effect of iron deprivation on the growth of human cervical carcinoma xenografts in athymic nude mice...
  9. ncbi request reprint Interleukin-1 beta increases the BCL-2/BAX ratio in Kaposi's sarcoma cells
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, B 1070 Brussels, Belgium
    Cytokine 19:259-66. 2002
    ..Our findings may provide a link between KS cell escape from apoptosis and the immune dysregulation known to be associated with KS...
  10. ncbi request reprint The importance of serum creatine phosphokinase level in the early diagnosis and microbiological evaluation of necrotizing fasciitis
    T Simonart
    Department of Dermatology, Erasme University Hospital, B 1070 Brussels, Belgium
    J Eur Acad Dermatol Venereol 18:687-90. 2004
    ..Early diagnosis and treatment, consisting of surgical debridement along with appropriate antibiotic therapy, are required to reduce morbidity and mortality rates...
  11. ncbi request reprint Treatment of acne with topical antibiotics: lessons from clinical studies
    T Simonart
    Department of Dermatology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Dermatol 153:395-403. 2005
    ..S.A. However, the clinical significance of these resistance patterns is poorly defined so that topical antibiotics remain one of the cornerstones of acne management...
  12. ncbi request reprint Vulvar lichen sclerosus: effect of maintenance treatment with a moisturizer on the course of the disease
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Menopause 15:74-7. 2008
    ..The aim of this study was to investigate the effect of maintenance therapy with a moisturizer in preventing the risk of relapse and progression of vulvar LS in postmenopausal women...
  13. ncbi request reprint Efficacy of tetracyclines in the treatment of acne vulgaris: a review
    T Simonart
    Department of Dermatology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Dermatol 158:208-16. 2008
    ..Oral tetracyclines are routinely used for the management of inflammatory acne. However, there is a lack of evidence-based data on their relative effectiveness and appropriate dosages...
  14. doi request reprint Curettage treatment for molluscum contagiosum: a follow-up survey study
    T Simonart
    Department of Dermatology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Dermatol 159:1144-7. 2008
    ..Although curettage is commonly used to treat molluscum contagiosum, prospective studies on its effectiveness are lacking...
  15. ncbi request reprint Epidermal kinetic alterations required to generate the psoriatic phenotype: a reappraisal
    T Simonart
    Department of Dermatology, Hopital Universitaire Erasme, Brussels, Belgium
    Cell Prolif 43:321-5. 2010
    ..Although there have been major advances in understanding immunopathogenesis of psoriasis, the basic processes causing psoriatic morphology remain to be identified...
  16. doi request reprint Homoeopathic remedies in dermatology: a systematic review of controlled clinical trials
    T Simonart
    Department of Biostatistics and Medical Informatics and IRIBHM, Universite Libre de Bruxelles, Brussels, Belgium
    Br J Dermatol 165:897-905. 2011
    ..Homoeopathic therapies are routinely used for the management of skin diseases. However, there is a lack of evidence-based data on their effectiveness...
  17. ncbi request reprint Stimulation of Kaposi's sarcoma cell growth by urine from women in early pregnancy, the current source for clinical-grade human chorionic gonadotropin preparations
    T Simonart
    Department of Dermatology, Erasme University Hospital, B 1070 Brussels, Belgium
    Exp Dermatol 11:365-9. 2002
    ..We, therefore, suggest a cautious use of hCG purified from pregnancy urine for the treatment of KS...
  18. ncbi request reprint Expression of the fibroblast/macrophage marker 1B10 by spindle cells in Kaposi's sarcoma lesions and by Kaposi's sarcoma-derived tumor cells
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    J Cutan Pathol 29:72-8. 2002
    ..KS tissues are characterized by predominant expression of endothelial markers, while KS-derived cell cultures are usually characterized by expression of mesenchymal non-endothelial cell markers...
  19. pmc Cultured Kaposi's sarcoma tumor cells exhibit a chemokine receptor repertoire that does not allow infection by HIV-1
    T Simonart
    Department of Dermatology, Erasme University Hospital, 808 route de Lennick, Brussels, 1070, Belgium
    BMC Dermatol 1:2. 2001
    ..The aim of this study was to investigate the expression of chemokine receptors in KS cell cultures and to determine whether these cells can be infected by HIV-1...
  20. doi request reprint Non-HIV-related Kaposi's sarcoma in former colonists/expatriates in Central Africa
    Thierry Simonart
    Department of Dermatology, Hopital Universitaire Erasme, Brussels, Belgium
    J Travel Med 16:134-5. 2009
    ..The occurrence of KS in this setting may represent a hitherto unrecognized epidemiological form of KS...
  21. ncbi request reprint Antiproliferative and apoptotic effects of iron chelators on human cervical carcinoma cells
    Thierry Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, B 1070, Belgium
    Gynecol Oncol 85:95-102. 2002
    ..As iron may participate in the pathogenesis of viral infections and cancer in several ways, the present study was designed to investigate the effect of iron chelation on HPV-16- and HPV-18-positive cervical carcinoma cell lines...
  22. ncbi request reprint An immunohistochemical study of abnormal keratinocyte proliferation in molluscum contagiosum
    T Simonart
    Department of Dermatology, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Dermatol 146:609-14. 2002
    ..Molluscum contagiosum is a common cutaneous tumour that is characterized by usually spontaneous involution and self-limited spreading in immunocompetent individuals...
  23. ncbi request reprint Treatment of Kaposi's sarcoma with human chorionic gonadotropin
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 204:330-3. 2002
    ..As certain hCG preparations could not only lack the ability to control KS but also contain some contaminant KS growth factor(s), we suggest a cautious use of crude hCG for the treatment of KS...
  24. ncbi request reprint Enhancement of classic Kaposi's sarcoma growth after intralesional injections of desferrioxamine
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 204:290-2. 2002
    ..This suggests that intralesional iron chelators are not indicated in patients with KS...
  25. ncbi request reprint Desferrioxamine enhances AIDS-associated Kaposi's sarcoma tumor development in a xenograft model
    Thierry Simonart
    Department of Renal and Infectious Diseases, Erasme University, Brussels, Belgium
    Int J Cancer 100:140-3. 2002
    ..In conclusion, our data show that DFO has a stimulatory effect on KS growth in immunodeficient mice, suggesting that this drug is not indicated in patients with KS...
  26. ncbi request reprint Iron as a potential co-factor in the pathogenesis of Kaposi's sarcoma?
    T Simonart
    Department of Dermatology, Hopital Universitaire Erasme, Brussels, Belgium
    Int J Cancer 78:720-6. 1998
    ..The inhibitory effect of iron chelation was more pronounced on rapidly dividing basic fibroblast-growth-factor-stimulated cells. These results may point to a novel therapeutic approach to KS...
  27. ncbi request reprint Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis
    Vincent Anaf
    Department of Gynaecology, Academic Hospital Erasme, Free University of Brussels, Brussels, Belgium
    Fertil Steril 86:1336-43. 2006
    ..To detect and quantify mast cells in peritoneal, ovarian, and deep infiltrating endometriosis and to study the relationship between mast cells and nerves in endometriosis...
  28. ncbi request reprint Early- and late-stage Kaposi's sarcoma-derived cells but not activated endothelial cells can invade de-epidermized dermis
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    J Invest Dermatol 116:679-85. 2001
    ..These results confer to Kaposi's sarcoma cells a tumor phenotype and suggest that the in vivo dominant endothelial cell population represents a reactive hyperplasia rather than the true tumor process...
  29. ncbi request reprint Iron chelators inhibit the growth and induce the apoptosis of Kaposi's sarcoma cells and of their putative endothelial precursors
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    J Invest Dermatol 115:893-900. 2000
    ..This suggests that iron chelators may represent a potential therapeutic approach for the treatment of Kaposi's sarcoma...
  30. ncbi request reprint Iron induces Bcl-2 expression in human dermal microvascular endothelial cells
    T Simonart
    Department of Dermatology Erasme University Hospital, Brussels, Belgium
    Free Radic Res 34:221-35. 2001
    ..Taken together, these observations suggest that iron may give a survival advantage to endothelial cells and represent a novel mechanism through which iron may contribute to tumorigenesis...
  31. ncbi request reprint Phenotypic characteristics of Kaposi's sarcoma tumour cells derived from patch-, plaque- and nodular-stage lesions: analysis of cell cultures isolated from AIDS and non-AIDS patients and review of the literature
    T Simonart
    Departments of Dermatology, Immunology and Internal Medicine, Erasme University Hospital, 808 Route de Lennik, B 1070 Brussels, Belgium
    Br J Dermatol 143:557-63. 2000
    ..Cultured KS-derived spindle cells constitutively overexpress antiapoptotic proteins and exhibit invasive properties, which suggests that they may adequately represent the tumour cells of KS...
  32. doi request reprint Black Skin Dermatology Online, from the project to the website: a needed collaboration between North and South
    K Ezzedine
    Department of Dermatology, Hopital Universitaire Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    J Eur Acad Dermatol Venereol 22:1193-9. 2008
    ..Whereas teledermatology is an emerging discipline, to date, no teledermatology service has been developed, which is specifically dedicated to black skins...
  33. ncbi request reprint Treatment of axillary hyperhidrosis with botulinum toxin type A reconstituted in lidocaine or in normal saline: a randomized, side-by-side, double-blind study
    J Vadoud-Seyedi
    Department of Dermatology, Erasme University Hospital, 808 Route de Lennik, Brussels, Belgium
    Br J Dermatol 156:986-9. 2007
    ..However, the current recommendations are that botulinum toxin A should be reconstituted in normal saline...
  34. ncbi request reprint [The dermatology department]
    M Heenen
    Rev Med Brux 23:43-4. 2002
    ..The department of dermatology has developed a broad clinical activity with a particular expertise in oncology, allergology, psoriasis and gynecological dermatology. Research has also been developed in these areas...
  35. ncbi request reprint Treatment of idiopathic palmar hyperhidrosis with botulinum toxin. Report of 23 cases and review of the literature
    J Vadoud-Seyedi
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 203:318-21. 2001
    ..However, so far there is no consensus on the way to administer botulinum toxin in this indication. Moreover, its use is limited by severe pain during the injections, especially with subepidermal injections close to 'free nerve endings'...
  36. ncbi request reprint Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis
    Vincent Anaf
    Department of Gynaecology, Hospital Erasme, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Hum Reprod 17:1895-900. 2002
    ....
  37. doi request reprint Androgen receptor expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix
    Jean Christophe Noel
    Service d Anatomie Pathologique, Hopital Universitaire Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
    Int J Gynecol Pathol 27:437-41. 2008
    ..These data provide new insights concerning a potential role of androgen and AR in cervical carcinogenesis, which should be confirmed in furthers studies...
  38. ncbi request reprint PCR assay fails to detect molluscum contagiosum virus-related sequences in AIDS-related Kaposi's sarcoma
    T Simonart
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    J Virol Methods 73:83-7. 1998
    ..If this is so, the failure to detect MCV DNA sequences in KS tissues by PCR indicates that locally produced or released cyotokines are not involved in the latter process...
  39. pmc Concomitant Xeroderma pigmentosum and disseminated small plaque psoriasis: first case of an antinomic association
    Khaled Ezzedine
    Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, 808, Route de Lennik, Brussels, B 1070 Belgium
    Cases J 1:74. 2008
    ..To our knowledge, the association between psoriasis and xeroderma pigmentosum has not been previously reported and may be regarded as unlikely when considering the pathogenesis of both diseases...
  40. ncbi request reprint Immunologic and virologic response after tetanus toxoid booster among HIV-1- and HIV-2-infected Senegalese individuals
    T N Dieye
    Immunodeficiency Unit, Erasme Hospital, ULB, Brussels, Belgium
    Vaccine 20:905-13. 2001
    ..However, the response to TT vaccination was lower in HIV-1- and in HIV-2-infected individuals than in healthy HIV-negative controls...
  41. ncbi request reprint Impact of surgical resection of rectovaginal pouch of douglas endometriotic nodules on pelvic pain and some elements of patients' sex life
    V Anaf
    Department of Gynecology, Hospital Erasme, , Brussels, Belgium, 1070
    J Am Assoc Gynecol Laparosc 8:55-60. 2001
    ..Laparoscopic resection of the nodules significantly improves these conditions. (J Am Assoc Gynecol Laparosc 8(1):55-60, 2001)..
  42. ncbi request reprint Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update
    S Tas
    Department of Dermatology, Erasme University Hospital, Brussels, Belgium
    Dermatology 206:353-6. 2003
    ..In the absence of a well-established therapy, primary and secondary prevention have a key role in the management of DRESS syndrome...
  43. ncbi request reprint How far can we trust cell cycle biomarkers for the identification of high-risk melanoma patients?
    Thierry Simonart
    J Cutan Pathol 32:383-4. 2005
  44. ncbi request reprint Early diagnosis of fulminant group A streptococcal necrotizing fasciitis
    Thierry Simonart
    J Am Acad Dermatol 49:1199-200; author reply 1200. 2003
  45. ncbi request reprint Inhibition of vascular cell adhesion molecule-1 expression in human dermal microvascular endothelial cells by iron chelators
    Thierry Simonart
    J Invest Dermatol 121:1229-30. 2003
  46. ncbi request reprint New approaches to the treatment of Sjögren's syndrome: soon beyond symptomatic relief?
    Serge Steinfeld
    Dermatology 207:6-9. 2003
    ..Our goal is to focus on these recent therapeutic progresses...
  47. ncbi request reprint The epidermal vitamin D system and innate immunity: some more light shed on this unique photoendocrine system?
    Siegfried Segaert
    Dermatology 217:7-11. 2008
  48. doi request reprint Apoptosis in psoriatic epidermis
    Michel Heenen
    J Cutan Pathol 35:346. 2008