Caroline Schnakers

Summary

Country: Belgium

Publications

  1. doi Cognitive function in the locked-in syndrome
    Caroline Schnakers
    Cyclotron Research Center, University of Liege, Belgium
    J Neurol 255:323-30. 2008
  2. doi A French validation study of the Coma Recovery Scale-Revised (CRS-R)
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Brain Inj 22:786-92. 2008
  3. doi Voluntary brain processing in disorders of consciousness
    C Schnakers
    Coma Science Group, Centre de Recherches du Cyclotron, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurology 71:1614-20. 2008
  4. doi Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders
    C Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Brain Inj 22:926-31. 2008
  5. ncbi Pain assessment and management in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:620-6. 2007
  6. doi Detecting consciousness in a total locked-in syndrome: an active event-related paradigm
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurocase 15:271-7. 2009
  7. pmc Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Funct Neurol 26:25-30. 2011
  8. pmc Visual fixation in the vegetative state: an observational case series PET study
    Marie Aurelie Bruno
    Coma Science Group and Cyclotron Research Centre, University of Liege, Liege, Belgium
    BMC Neurol 10:35. 2010
  9. doi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008
  10. doi The Nociception Coma Scale: a new tool to assess nociception in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Sart Tilman, Liege, Belgium
    Pain 148:215-9. 2010

Collaborators

Detail Information

Publications36

  1. doi Cognitive function in the locked-in syndrome
    Caroline Schnakers
    Cyclotron Research Center, University of Liege, Belgium
    J Neurol 255:323-30. 2008
    ..Classically, communication remains possible by means of spared vertical eye movements and/or blinking. To allow assessing cognitive functions in LIS patients, we propose here a neuropsychological testing based on eye-coded communication...
  2. doi A French validation study of the Coma Recovery Scale-Revised (CRS-R)
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Brain Inj 22:786-92. 2008
    ....
  3. doi Voluntary brain processing in disorders of consciousness
    C Schnakers
    Coma Science Group, Centre de Recherches du Cyclotron, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurology 71:1614-20. 2008
    ..In this study, we explored a new active evoked-related potentials paradigm as an alternative method for the detection of voluntary brain activity...
  4. doi Diagnostic and prognostic use of bispectral index in coma, vegetative state and related disorders
    C Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Belgium
    Brain Inj 22:926-31. 2008
    ....
  5. ncbi Pain assessment and management in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, University of Liege, Liege, Belgium
    Curr Opin Neurol 20:620-6. 2007
    ..This review examines the current knowledge base for guiding decisions regarding assessment and management of pain in persons with disorders of consciousness...
  6. doi Detecting consciousness in a total locked-in syndrome: an active event-related paradigm
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Neurocase 15:271-7. 2009
    ..This study shows that our active event-related paradigm allowed to identify voluntary brain activity in a patient who would behaviorally be diagnosed as comatose...
  7. pmc Automated EEG entropy measurements in coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Funct Neurol 26:25-30. 2011
    ..Future studies are needed before using this tool in routine clinical practice, and these should seek to improve automated EEG quantification paradigms in order to reduce the remaining false negative and false positive findings...
  8. pmc Visual fixation in the vegetative state: an observational case series PET study
    Marie Aurelie Bruno
    Coma Science Group and Cyclotron Research Centre, University of Liege, Liege, Belgium
    BMC Neurol 10:35. 2010
    ..e., represents "automatic" subcortical processing) or is a sufficient sign of consciousness and higher order cortical processing...
  9. doi Perception of pain in the minimally conscious state with PET activation: an observational study
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    Lancet Neurol 7:1013-20. 2008
    ..Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance...
  10. doi The Nociception Coma Scale: a new tool to assess nociception in disorders of consciousness
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, University of Liege, Sart Tilman, Liege, Belgium
    Pain 148:215-9. 2010
    ..e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma...
  11. doi Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Sart Tilman B30, 4000 Liege, Belgium
    Neurocrit Care 15:447-53. 2011
    ..We compared the FOUR and GLS/GCS in intensive care unit patients who were admitted in a comatose state...
  12. doi Metabolic activity in external and internal awareness networks in severely brain-damaged patients
    Aurore Thibaut
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, 4000 Liege, Belgium
    J Rehabil Med 44:487-94. 2012
    ..This study measured brain metabolism in both networks in patients with severe brain damage...
  13. doi Probing command following in patients with disorders of consciousness using a brain-computer interface
    Dorothee Lule
    Coma Science Group, Cyclotron Research Centre, University and University Hospital of Liège, Liege, Belgium
    Clin Neurophysiol 124:101-6. 2013
    ..To determine if brain-computer interfaces (BCIs) could serve as supportive tools for detecting consciousness in patients with disorders of consciousness by detecting response to command and communication...
  14. doi Is there anybody in there? Detecting awareness in disorders of consciousness
    Athena Demertzi
    Coma Science Group, Neurology Department, Cyclotron Research Centre, University of Liege, Liege, Belgium
    Expert Rev Neurother 8:1719-30. 2008
    ....
  15. doi Preserved feedforward but impaired top-down processes in the vegetative state
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, 4000 Liege, Belgium
    Science 332:858-62. 2011
    ..This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception...
  16. doi Locked-in syndrome in children: report of five cases and review of the literature
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Center and Neurology Department, University of Liege, 4000 Luik, Belgium
    Pediatr Neurol 41:237-46. 2009
    ..These findings raise important ethical considerations in terms of quality of life and end-of-life decisions in such challenging cases...
  17. doi "Relevance vector machine" consciousness classifier applied to cerebral metabolism of vegetative and locked-in patients
    Christophe L Phillips
    Cyclotron Research Centre, University of Liege, Liege, Belgium
    Neuroimage 56:797-808. 2011
    ..Therefore, RVM classification of cerebral metabolic images obtained in coma survivors could become a useful tool for the automated PET-based diagnosis of altered states of consciousness...
  18. ncbi Residual cognitive function in comatose, vegetative and minimally conscious states
    Steven Laureys
    Cyclotron Research Centre, University of Liege, Belgium
    Curr Opin Neurol 18:726-33. 2005
    ..In addition to novel behavioural 'consciousness-scales', the role of para-clinical markers of consciousness, such as event related potentials and functional neuroimaging is reviewed...
  19. pmc Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients
    Audrey Vanhaudenhuyse
    Coma Science Group, Cyclotron Research Centre, University of Liege, Allee du 6 Aout, B30, Liege, Belgium
    Brain 133:161-71. 2010
    ..Future prospective studies in a larger patient population are needed in order to evaluate the prognostic value of the presented methodology...
  20. ncbi Response to comment on "preserved feedforward but impaired top-down processes in the vegetative state"
    Melanie Boly
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University of Liège and CHU Sart Tilman Hospital, Liege, Belgium
    Science 334:1203. 2011
    ..We welcome the opportunity to provide more details about our methods and results and to resolve their concerns. We substantiate our interpretation of the results and provide a point-by-point response to the issues raised...
  21. doi Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness
    Pierre Boveroux
    Department of Anesthesia and Intensive Care Medicine, University of Liege, Liege, Belgium
    Anesthesiology 113:1038-53. 2010
    ..Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness...
  22. doi Functional neuroanatomy underlying the clinical subcategorization of minimally conscious state patients
    Marie Aurelie Bruno
    Coma Science Group, Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    J Neurol 259:1087-98. 2012
    ..MCS+ patients showed preserved metabolism and functional connectivity in language networks arguably reflecting some additional higher order or extended consciousness albeit devoid of clinical verbal or nonverbal expression...
  23. pmc Diagnostic accuracy of the vegetative and minimally conscious state: clinical consensus versus standardized neurobehavioral assessment
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Center, University of Liege, Belgium
    BMC Neurol 9:35. 2009
    ..In this study, we compared consensus-based diagnoses of VS and MCS to those based on a well-established standardized neurobehavioral rating scale, the JFK Coma Recovery Scale-Revised (CRS-R)...
  24. doi Nociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex
    Camille Chatelle
    1University of Liege, Liege, Belgium
    Neurorehabil Neural Repair 28:149-52. 2014
    ..The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness...
  25. ncbi Bispectral analysis of electroencephalogram signals during recovery from coma: preliminary findings
    Caroline Schnakers
    University of Liege, Liege, Belgium
    Neuropsychol Rehabil 15:381-8. 2005
    ..These preliminary findings are encouraging in the search for electrophysiological correlates of consciousness in severe acute brain damage...
  26. doi Assessment and detection of pain in noncommunicative severely brain-injured patients
    Caroline Schnakers
    Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of Liege, 4000 Liege, Belgium
    Expert Rev Neurother 10:1725-31. 2010
    ..Pain monitoring in these patients is hence of medical and ethical importance. In this article, we will focus on the possible use of behavioral scales for the assessment and detection of pain in noncommunicative patients...
  27. doi Disorders of consciousness: what's in a name?
    Olivia Gosseries
    Coma Science Group, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Liege, Belgium
    NeuroRehabilitation 28:3-14. 2011
    ....
  28. doi The problem of aphasia in the assessment of consciousness in brain-damaged patients
    Steve Majerus
    Center for Cognitive and Behavioral Neuroscience and Coma Science Group, University of Liege, Belgium
    Prog Brain Res 177:49-61. 2009
    ..The combined use of behavioral and neuroimaging assessment techniques appears to be particularly promising for disentangling impaired consciousness and aphasia...
  29. doi Consciousness and cerebral baseline activity fluctuations
    Melanie Boly
    Coma Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium
    Hum Brain Mapp 29:868-74. 2008
    ..We place these findings in light of recent findings on the architecture of spontaneous BOLD fluctuations in the awake human brain, and discuss the possible origins of the observed baseline brain activity fluctuations...
  30. doi A sensitive scale to assess nociceptive pain in patients with disorders of consciousness
    Camille Chatelle
    Coma Science Group, Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium
    J Neurol Neurosurg Psychiatry 83:1233-7. 2012
    ....
  31. pmc Neural plasticity lessons from disorders of consciousness
    Athena Demertzi
    Coma Science Group, Cyclotron Research Centre and Neurology Department, Sart Tilman, University and University Hospital of Liège Liège, Belgium
    Front Psychol 1:245. 2010
    ..e., medical management and rehabilitation) but also from a scientific-theoretical perspective (i.e., the brain's plastic abilities and the pursuit of the neural correlate of consciousness)...
  32. ncbi Eye gaze and conscious processing in severely brain-injured patients
    Camille Chatelle
    Coma Science Group, Cyclotron Research Centre, University of Liege, 4000 Liege, Belgium http www ulg ac be www coma ulg ac be
    Behav Brain Sci 33:442-3. 2010
    ..In this commentary, we illustrate the relationship between oriented eye movements, consciousness, and emotion by using the case of severely brain-injured patients recovering from coma (i.e., vegetative and minimally conscious patients)...
  33. ncbi The locked-in syndrome : what is it like to be conscious but paralyzed and voiceless?
    Steven Laureys
    Neurology Department and Cyclotron Research Center, University of Liege, Sart Tilman B30, 4000 Liege, Belgium
    Prog Brain Res 150:495-511. 2005
    ..In our opinion, there is an urgent need for a renewed ethical and medicolegal framework for our care of locked-in patients...
  34. ncbi Brain response to one's own name in vegetative state, minimally conscious state, and locked-in syndrome
    Fabien Perrin
    Laboratoire de Neurosciences and Systèmes Sensoriels, UMR 5020, Université Claude Bernard Lyon 1 CNRS, 50 avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Arch Neurol 63:562-9. 2006
    ..A major challenge in the management of severely brain-injured patients with altered states of consciousness is to estimate their residual perception of the environment...
  35. doi A twitch of consciousness: defining the boundaries of vegetative and minimally conscious states
    Quentin Noirhomme
    J Neurol Neurosurg Psychiatry 79:741-2. 2008
  36. ncbi Does the FOUR score correctly diagnose the vegetative and minimally conscious states?
    Caroline Schnakers
    Ann Neurol 60:744-5; author reply 745. 2006